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Found 127 with Last Name = 'gibbs' and Initial = 'em'
TargetGlycogen phosphorylase, liver form(Homo sapiens (Human))
Pfizer

LigandPNGBDBM39807(CP-526,423)
Affinity DataIC50:  6nMpH: 7.2 T: 2°CAssay Description:Human liver glycogen phsphorylase (HLGP) activity was measured in the direction of glycogen synthesis by the release of phosphate from glucose-1-phos...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDiacylglycerol O-acyltransferase 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50355142(CHEMBL1835919)
Affinity DataIC50:  8nMAssay Description:Inhibition of DGAT1-mediated triglyceride synthesis in human HT-29 cells using [3H]glycerol as substrate after 6 hrs by beta countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen phosphorylase, liver form(Homo sapiens (Human))
Pfizer

LigandPNGBDBM50158278(5-Chloro-1H-indole-2-carboxylic acid {[(1,1-dioxo-...)
Affinity DataIC50:  12nMAssay Description:Inhibitory concentration against glycogen phosphorylaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen phosphorylase, liver form(Homo sapiens (Human))
Pfizer

LigandPNGBDBM50158249(5-Chloro-1H-indole-2-carboxylic acid {[cyclopentyl...)
Affinity DataIC50:  16nMAssay Description:Inhibitory concentration against glycogen phosphorylaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDiacylglycerol O-acyltransferase 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM27947(2-[4-(4-{4-amino-7,7-dimethyl-7H-pyrimido[4,5-b][1...)
Affinity DataIC50:  16nMAssay Description:Inhibition of DGAT1-mediated triglyceride synthesis in human HT-29 cells using [3H]glycerol as substrate after 6 hrs by beta countingMore data for this Ligand-Target Pair
TargetDiacylglycerol O-acyltransferase 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50355142(CHEMBL1835919)
Affinity DataIC50:  19nMAssay Description:Inhibition of full length human microsomal DGAT-1 expressed in baculovirus infected insect Sf9 cells using [14C]decanoylCoA as substrate after 1.5 hr...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen phosphorylase, liver form(Homo sapiens (Human))
Pfizer

LigandPNGBDBM50158254(5-Chloro-1H-indole-2-carboxylic acid [(cyanomethyl...)
Affinity DataIC50:  30nMAssay Description:Inhibitory concentration against glycogen phosphorylaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen phosphorylase, liver form(Homo sapiens (Human))
Pfizer

LigandPNGBDBM50158255(5-Chloro-1H-indole-2-carboxylic acid {[cycloheptyl...)
Affinity DataIC50:  30nMAssay Description:Inhibitory concentration against glycogen phosphorylaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen phosphorylase, liver form(Homo sapiens (Human))
Pfizer

LigandPNGBDBM50158283(5-Chloro-1H-indole-2-carboxylic acid {[cyclooctyl-...)
Affinity DataIC50:  32nMAssay Description:Inhibitory concentration against glycogen phosphorylaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen phosphorylase, liver form(Homo sapiens (Human))
Pfizer

LigandPNGBDBM50158308(5-Chloro-1H-indole-2-carboxylic acid {[cyclopentyl...)
Affinity DataIC50:  42nMAssay Description:Inhibitory concentration against glycogen phosphorylaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen phosphorylase, liver form(Homo sapiens (Human))
Pfizer

LigandPNGBDBM50136446(1-{(S)-2-[(5-Chloro-1H-indole-2-carbonyl)-amino]-3...)
Affinity DataIC50:  45nMpH: 7.2 T: 2°CAssay Description:Human liver glycogen phsphorylase (HLGP) activity was measured in the direction of glycogen synthesis by the release of phosphate from glucose-1-phos...More data for this Ligand-Target Pair
TargetGlycogen phosphorylase, liver form(Homo sapiens (Human))
Pfizer

LigandPNGBDBM50158303(5-Chloro-1H-indole-2-carboxylic acid {[(2-hydroxy-...)
Affinity DataIC50:  49nMAssay Description:Inhibitory concentration against glycogen phosphorylaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen phosphorylase, liver form(Homo sapiens (Human))
Pfizer

LigandPNGBDBM50158295(5-Chloro-1H-indole-2-carboxylic acid {[cyclopentyl...)
Affinity DataIC50:  54nMAssay Description:Inhibitory concentration against glycogen phosphorylaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen phosphorylase, liver form(Homo sapiens (Human))
Pfizer

LigandPNGBDBM50158245(5-Chloro-1H-indole-2-carboxylic acid {[(2-hydroxy-...)
Affinity DataIC50:  55nMAssay Description:Inhibitory concentration against glycogen phosphorylaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen phosphorylase, liver form(Homo sapiens (Human))
Pfizer

LigandPNGBDBM50158304(5-Chloro-1H-indole-2-carboxylic acid [(cyclopentyl...)
Affinity DataIC50:  55nMAssay Description:Inhibitory concentration against glycogen phosphorylaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDiacylglycerol O-acyltransferase 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50363956(CHEMBL1952025)
Affinity DataIC50:  60nMAssay Description:Inhibition of full length human microsomal DGAT-1 expressed in baculovirus infected insect Sf9 cells using [14C]decanoylCoA as substrate after 1.5 hr...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDiacylglycerol O-acyltransferase 1(Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50355142(CHEMBL1835919)
Affinity DataIC50:  64nMAssay Description:Inhibition of rat DGAT-1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDiacylglycerol O-acyltransferase 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50363956(CHEMBL1952025)
Affinity DataIC50:  71nMAssay Description:Inhibition of DGAT1-mediated triglyceride synthesis in human HT-29 cells using [3H]glycerol as substrate after 6 hrs by beta countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDiacylglycerol O-acyltransferase 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM27947(2-[4-(4-{4-amino-7,7-dimethyl-7H-pyrimido[4,5-b][1...)
Affinity DataIC50:  72nMAssay Description:Inhibition of full length human microsomal DGAT-1 expressed in baculovirus infected insect Sf9 cells using [14C]decanoylCoA as substrate after 1.5 hr...More data for this Ligand-Target Pair
TargetGlycogen phosphorylase, liver form(Homo sapiens (Human))
Pfizer

LigandPNGBDBM50065954((S)-5-chloro-N-(1-(dimethylamino)-1-oxo-3-phenylpr...)
Affinity DataIC50:  82nMAssay Description:In vitro inhibitory activity against recombinant human liver glycogen phosphorylase a (rHLGPa) catalyzed release of phosphate from glucose-1-phosphat...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen phosphorylase, liver form(Homo sapiens (Human))
Pfizer

LigandPNGBDBM50158310(5-Chloro-1H-indole-2-carboxylic acid {[cyclononyl-...)
Affinity DataIC50:  82nMAssay Description:Inhibitory concentration against glycogen phosphorylaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen phosphorylase, liver form(Homo sapiens (Human))
Pfizer

LigandPNGBDBM50158315(5-Chloro-1H-indole-2-carboxylic acid [(butyl-cyclo...)
Affinity DataIC50:  82nMAssay Description:Inhibitory concentration against glycogen phosphorylaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen phosphorylase, liver form(Homo sapiens (Human))
Pfizer

LigandPNGBDBM50158261(5-Chloro-1H-indole-2-carboxylic acid {[cyclopentyl...)
Affinity DataIC50:  83nMAssay Description:Inhibitory concentration against glycogen phosphorylaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen phosphorylase, liver form(Homo sapiens (Human))
Pfizer

LigandPNGBDBM50158264(5-Chloro-1H-indole-2-carboxylic acid [(allyl-cyclo...)
Affinity DataIC50:  96nMAssay Description:Inhibitory concentration against glycogen phosphorylaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen phosphorylase, liver form(Homo sapiens (Human))
Pfizer

LigandPNGBDBM50065955(5-Bromo-1H-indole-2-carboxylic acid ((1S,2R)-1-ben...)
Affinity DataIC50:  97nMAssay Description:In vitro inhibitory activity against recombinant human liver glycogen phosphorylase a (rHLGPa) catalyzed release of phosphate from glucose-1-phosphat...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen phosphorylase, liver form(Homo sapiens (Human))
Pfizer

LigandPNGBDBM50158274(5-Chloro-1H-indole-2-carboxylic acid {[cyclohexyl-...)
Affinity DataIC50:  99nMAssay Description:Inhibitory concentration against glycogen phosphorylaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen phosphorylase, liver form(Homo sapiens (Human))
Pfizer

LigandPNGBDBM50158276(5-Chloro-1H-indole-2-carboxylic acid {[cyclopentyl...)
Affinity DataIC50:  100nMAssay Description:Inhibitory concentration against glycogen phosphorylaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen phosphorylase, liver form(Homo sapiens (Human))
Pfizer

LigandPNGBDBM50065965(5-Chloro-1H-indole-2-carboxylic acid ((1S,2R)-1-be...)
Affinity DataIC50:  110nMAssay Description:Inhibitory concentration against glycogen phosphorylaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen phosphorylase, liver form(Homo sapiens (Human))
Pfizer

LigandPNGBDBM50065965(5-Chloro-1H-indole-2-carboxylic acid ((1S,2R)-1-be...)
Affinity DataIC50:  110nMAssay Description:In vitro inhibitory activity against recombinant human liver glycogen phosphorylase a (rHLGPa) catalyzed release of phosphate from glucose-1-phosphat...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen phosphorylase, liver form(Homo sapiens (Human))
Pfizer

LigandPNGBDBM50065944(5-Bromo-1H-indole-2-carboxylic acid ((S)-1-dimethy...)
Affinity DataIC50:  110nMAssay Description:In vitro inhibitory activity against recombinant human liver glycogen phosphorylase a (rHLGPa) catalyzed release of phosphate from glucose-1-phosphat...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen phosphorylase, liver form(Homo sapiens (Human))
Pfizer

LigandPNGBDBM50065951(5-Chloro-1H-indole-2-carboxylic acid ((S)-1-methyl...)
Affinity DataIC50:  110nMAssay Description:In vitro inhibitory activity against recombinant human liver glycogen phosphorylase a (rHLGPa) catalyzed release of phosphate from glucose-1-phosphat...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen phosphorylase, liver form(Homo sapiens (Human))
Pfizer

LigandPNGBDBM50158288(5-Chloro-1H-indole-2-carboxylic acid {[butyl-(2-hy...)
Affinity DataIC50:  120nMAssay Description:Inhibitory concentration against glycogen phosphorylaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen phosphorylase, liver form(Homo sapiens (Human))
Pfizer

LigandPNGBDBM50158272(5-Chloro-1H-indole-2-carboxylic acid {[(2-hydroxy-...)
Affinity DataIC50:  120nMAssay Description:Inhibitory concentration against glycogen phosphorylaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen phosphorylase, liver form(Homo sapiens (Human))
Pfizer

LigandPNGBDBM50158248(5-Chloro-1H-indole-2-carboxylic acid {[cyclobutyl-...)
Affinity DataIC50:  130nMAssay Description:Inhibitory concentration against glycogen phosphorylaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen phosphorylase, liver form(Homo sapiens (Human))
Pfizer

LigandPNGBDBM50065943((S)-2-[(5-Chloro-1H-indole-2-carbonyl)-amino]-3-ph...)
Affinity DataIC50:  140nMAssay Description:In vitro inhibitory activity against recombinant human liver glycogen phosphorylase a (rHLGPa) catalyzed release of phosphate from glucose-1-phosphat...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen phosphorylase, liver form(Homo sapiens (Human))
Pfizer

LigandPNGBDBM50158247(5-Chloro-1H-indole-2-carboxylic acid {[(2-cyano-et...)
Affinity DataIC50:  140nMAssay Description:Inhibitory concentration against glycogen phosphorylaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen phosphorylase, liver form(Homo sapiens (Human))
Pfizer

LigandPNGBDBM50158301(5-Chloro-1H-indole-2-carboxylic acid {[(2-hydroxy-...)
Affinity DataIC50:  150nMAssay Description:Inhibitory concentration against glycogen phosphorylaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen phosphorylase, liver form(Homo sapiens (Human))
Pfizer

LigandPNGBDBM50158277(5-Chloro-1H-indole-2-carboxylic acid {[cyclopentyl...)
Affinity DataIC50:  150nMAssay Description:Inhibitory concentration against glycogen phosphorylaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen phosphorylase, liver form(Homo sapiens (Human))
Pfizer

LigandPNGBDBM50158294(5-Chloro-1H-indole-2-carboxylic acid [(cyclohexyl-...)
Affinity DataIC50:  150nMAssay Description:Inhibitory concentration against glycogen phosphorylaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen phosphorylase, liver form(Homo sapiens (Human))
Pfizer

LigandPNGBDBM50158290(5-Chloro-1H-indole-2-carboxylic acid [(butyl-methy...)
Affinity DataIC50:  150nMAssay Description:Inhibitory concentration against glycogen phosphorylaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen phosphorylase, liver form(Homo sapiens (Human))
Pfizer

LigandPNGBDBM50158252(5-Chloro-1H-indole-2-carboxylic acid {[cyclopropyl...)
Affinity DataIC50:  160nMAssay Description:Inhibitory concentration against glycogen phosphorylaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen phosphorylase, liver form(Homo sapiens (Human))
Pfizer

LigandPNGBDBM50065962(5-Fluoro-1H-indole-2-carboxylic acid ((1S,2R)-1-be...)
Affinity DataIC50:  170nMAssay Description:In vitro inhibitory activity against recombinant human liver glycogen phosphorylase a (rHLGPa) catalyzed release of phosphate from glucose-1-phosphat...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen phosphorylase, liver form(Homo sapiens (Human))
Pfizer

LigandPNGBDBM50158296(5-Chloro-1H-indole-2-carboxylic acid [(cyclobutyl-...)
Affinity DataIC50:  170nMAssay Description:Inhibitory concentration against glycogen phosphorylaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen phosphorylase, liver form(Homo sapiens (Human))
Pfizer

LigandPNGBDBM50158240(5-Chloro-1H-indole-2-carboxylic acid {[(2-hydroxy-...)
Affinity DataIC50:  180nMAssay Description:Inhibitory concentration against glycogen phosphorylaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen phosphorylase, liver form(Homo sapiens (Human))
Pfizer

LigandPNGBDBM50158287(5-Chloro-1H-indole-2-carboxylic acid {[cyclopropyl...)
Affinity DataIC50:  200nMAssay Description:Inhibitory concentration against glycogen phosphorylaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen phosphorylase, liver form(Homo sapiens (Human))
Pfizer

LigandPNGBDBM35346((S)-5-chloro-N-(3-(4-fluorophenyl)-1-(4-hydroxypip...)
Affinity DataIC50:  205nMAssay Description:In vitro inhibitory activity against recombinant human liver glycogen phosphorylase a (rHLGPa) catalyzed release of phosphate from glucose-1-phosphat...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen phosphorylase, liver form(Homo sapiens (Human))
Pfizer

LigandPNGBDBM50158286(5-Chloro-1H-indole-2-carboxylic acid [(cyclopentyl...)
Affinity DataIC50:  210nMAssay Description:Inhibitory concentration against glycogen phosphorylaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen phosphorylase, liver form(Homo sapiens (Human))
Pfizer

LigandPNGBDBM50158307(5-Chloro-1H-indole-2-carboxylic acid {[cyclopentyl...)
Affinity DataIC50:  210nMAssay Description:Inhibitory concentration against glycogen phosphorylaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen phosphorylase, liver form(Homo sapiens (Human))
Pfizer

LigandPNGBDBM50158271(5-Chloro-1H-indole-2-carboxylic acid {[cyclodecyl-...)
Affinity DataIC50:  210nMAssay Description:Inhibitory concentration against glycogen phosphorylaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen phosphorylase, liver form(Homo sapiens (Human))
Pfizer

LigandPNGBDBM50158262(5-Chloro-1H-indole-2-carboxylic acid {[(2-hydroxy-...)
Affinity DataIC50:  210nMAssay Description:Inhibitory concentration against glycogen phosphorylaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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