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Found 256 with Last Name = 'gopinathan' and Initial = 's'
TargetAP2-associated protein kinase 1(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM311206((S)-1-(2-(difluoromethyl)-4-(2-methylpyridin-4-yl)...)
Affinity DataIC50:  0.400nMAssay Description:Inhibition of GST-Xa tagged human AAK1 (30 to 330 residues) expresssed in bacteria using (5-FAM)-Aha-KEEQSQITSQVTGQIGWR-NH2 peptide as substrate incu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAP2-associated protein kinase 1(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM311193((S)-1-(2-(difluoromethyl)-4-(2-(difluoromethyl)pyr...)
Affinity DataIC50:  0.400nMAssay Description:Inhibition of GST-Xa tagged human AAK1 (30 to 330 residues) expresssed in bacteria using (5-FAM)-Aha-KEEQSQITSQVTGQIGWR-NH2 peptide as substrate incu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetLIM domain kinase 1(Homo sapiens (Human))
Lexicon Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50299583((S)-N-(3-bromophenyl)-N'-cyano-2-methyl-4-(5-methy...)
Affinity DataIC50:  0.5nMAssay Description:Inhibition of LIMK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAP2-associated protein kinase 1(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM311191((S)-1-(4-(2-(difluoromethyl)pyridin-4-yl)-2-(trifl...)
Affinity DataIC50:  0.600nMAssay Description:Inhibition of GST-Xa tagged human AAK1 (30 to 330 residues) expresssed in bacteria using (5-FAM)-Aha-KEEQSQITSQVTGQIGWR-NH2 peptide as substrate incu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAP2-associated protein kinase 1(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM311192((S)-2-((2-amino-2,4-dimethylpentyl)oxy)-5-(2-(difl...)
Affinity DataIC50:  0.600nMAssay Description:Inhibition of GST-Xa tagged human AAK1 (30 to 330 residues) expresssed in bacteria using (5-FAM)-Aha-KEEQSQITSQVTGQIGWR-NH2 peptide as substrate incu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAP2-associated protein kinase 1(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM311199((S)-2,4-dimethyl-1-(4-(pyridin-4-yl)-2-(trifluorom...)
Affinity DataIC50:  0.600nMAssay Description:Inhibition of GST-Xa tagged human AAK1 (30 to 330 residues) expresssed in bacteria using (5-FAM)-Aha-KEEQSQITSQVTGQIGWR-NH2 peptide as substrate incu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAP2-associated protein kinase 1(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM311270((S)-1-(2-cyclopropyl-4-(2-(difluoromethyl)pyridin-...)
Affinity DataIC50:  0.700nMAssay Description:Inhibition of GST-Xa tagged human AAK1 (30 to 330 residues) expresssed in bacteria using (5-FAM)-Aha-KEEQSQITSQVTGQIGWR-NH2 peptide as substrate incu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetLIM domain kinase 2(Homo sapiens (Human))
Lexicon Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50299619((S)-3-(N'-cyano-2-methyl-4-(5-methyl-7H-pyrrolo[2,...)
Affinity DataIC50:  0.800nMAssay Description:Inhibition of human recombinant LIMK2 expressed in baculovirus-Sf9 system by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAP2-associated protein kinase 1(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM311206((S)-1-(2-(difluoromethyl)-4-(2-methylpyridin-4-yl)...)
Affinity DataIC50:  0.800nMAssay Description:Inhibition of AKK1 in HEK293F cells assessed as reduction in phospho mu2 formation incubated for 3 hrs by Western blot analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAP2-associated protein kinase 1(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM311166( (S)-2-((2-amino-4-methylpentyl)oxy)-5-(2-methylpy...)
Affinity DataIC50:  0.800nMAssay Description:Inhibition of GST-Xa tagged human AAK1 (30 to 330 residues) expresssed in bacteria using (5-FAM)-Aha-KEEQSQITSQVTGQIGWR-NH2 peptide as substrate incu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAP2-associated protein kinase 1(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM311193((S)-1-(2-(difluoromethyl)-4-(2-(difluoromethyl)pyr...)
Affinity DataIC50:  0.900nMAssay Description:Inhibition of AKK1 in HEK293F cells assessed as reduction in phospho mu2 formation incubated for 3 hrs by Western blot analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSodium/glucose cotransporter 2(Homo sapiens (Human))
Lexicon Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50235018(CHEMBL4072070)
Affinity DataIC50:  0.900nMAssay Description:Inhibition of human HA-tagged SGLT2 expressed in HEK293 cells assessed as decrease in [14C]-AMG uptake measured after 1 to 2 hrs by scintillation cou...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLIM domain kinase 2(Homo sapiens (Human))
Lexicon Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50299583((S)-N-(3-bromophenyl)-N'-cyano-2-methyl-4-(5-methy...)
Affinity DataIC50:  0.900nMAssay Description:Inhibition of human recombinant LIMK2 expressed in baculovirus-Sf9 system by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAP2-associated protein kinase 1(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM311201((S)-2,4-dimethyl-1-(4-(2-methylpyridin-4-yl)-2-(tr...)
Affinity DataIC50:  0.900nMAssay Description:Inhibition of GST-Xa tagged human AAK1 (30 to 330 residues) expresssed in bacteria using (5-FAM)-Aha-KEEQSQITSQVTGQIGWR-NH2 peptide as substrate incu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetLIM domain kinase 2(Homo sapiens (Human))
Lexicon Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50044006(CHEMBL3356431)
Affinity DataIC50:  1nMAssay Description:Inhibition of human full-length LIMK2 assessed as incorporation of P33 from ATP into biotinylated-cofilin substrate by scintillation counting analysi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium/glucose cotransporter 1(Homo sapiens (Human))
Lexicon Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM176693(US9688710, 116 4-(4-(2-methyl-5-((2S,3R,4R,5S,6R)-...)
Affinity DataIC50:  1.10nMAssay Description:Inhibition of human HA-tagged SGLT1 expressed in HEK293 cells assessed as decrease in [14C]-AMG uptake measured after 1 to 2 hrs by scintillation cou...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetLIM domain kinase 2(Homo sapiens (Human))
Lexicon Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50299616((S)-N-(3-tert-butylphenyl)-N'-cyano-2-methyl-4-(5-...)
Affinity DataIC50:  1.10nMAssay Description:Inhibition of human recombinant LIMK2 expressed in baculovirus-Sf9 system by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLIM domain kinase 2(Homo sapiens (Human))
Lexicon Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50299586((S)-3-(2-methyl-4-(5-methyl-7H-pyrrolo[2,3-d]pyrim...)
Affinity DataIC50:  1.20nMAssay Description:Inhibition of human recombinant LIMK2 expressed in baculovirus-Sf9 system by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLIM domain kinase 2(Homo sapiens (Human))
Lexicon Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50299615((S)-N'-cyano-N-(3-cyanophenyl)-2-methyl-4-(5-methy...)
Affinity DataIC50:  1.20nMAssay Description:Inhibition of human recombinant LIMK2 expressed in baculovirus-Sf9 system by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLIM domain kinase 2(Homo sapiens (Human))
Lexicon Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50044086(CHEMBL3356064)
Affinity DataIC50:  1.20nMAssay Description:Inhibition of human full-length LIMK2 assessed as incorporation of P33 from ATP into biotinylated-cofilin substrate by scintillation counting analysi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLIM domain kinase 2(Homo sapiens (Human))
Lexicon Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50299586((S)-3-(2-methyl-4-(5-methyl-7H-pyrrolo[2,3-d]pyrim...)
Affinity DataIC50:  1.20nMAssay Description:Inhibition of human full-length LIMK2 assessed as incorporation of P33 from ATP into biotinylated-cofilin substrate by scintillation counting analysi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLIM domain kinase 2(Homo sapiens (Human))
Lexicon Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50299607((S)-N-(3-bromophenyl)-4-(5-chloro-7H-pyrrolo[2,3-d...)
Affinity DataIC50:  1.20nMAssay Description:Inhibition of human recombinant LIMK2 expressed in baculovirus-Sf9 system by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium/glucose cotransporter 2(Homo sapiens (Human))
Lexicon Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM176709(US9688710, 132 N-(1-((2-(dimethylamino)ethyl)(meth...)
Affinity DataIC50:  1.30nMAssay Description:Inhibition of human HA-tagged SGLT2 expressed in HEK293 cells assessed as decrease in [14C]-AMG uptake measured after 1 to 2 hrs by scintillation cou...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetLIM domain kinase 2(Homo sapiens (Human))
Lexicon Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50299584((S)-N-(3-bromo-4-fluorophenyl)-N'-cyano-2-methyl-4...)
Affinity DataIC50:  1.5nMAssay Description:Inhibition of human recombinant LIMK2 expressed in baculovirus-Sf9 system by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAP2-associated protein kinase 1(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM311304(((S)-1-((6-chloro-2′-(difluoromethyl)-[2,4&#...)
Affinity DataIC50:  1.5nMAssay Description:Inhibition of GST-Xa tagged human AAK1 (30 to 330 residues) expresssed in bacteria using (5-FAM)-Aha-KEEQSQITSQVTGQIGWR-NH2 peptide as substrate incu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSodium/glucose cotransporter 1(Homo sapiens (Human))
Lexicon Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM176697(US9688710, 120 N-(2-methyl-1-(4-methylpiperidin-1-...)
Affinity DataIC50:  1.60nMAssay Description:Inhibition of human HA-tagged SGLT1 expressed in HEK293 cells assessed as decrease in [14C]-AMG uptake measured after 1 to 2 hrs by scintillation cou...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSodium/glucose cotransporter 2(Homo sapiens (Human))
Lexicon Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM176724(US9688710, 146 (3R,4R,5S,6R)-2-(3-(4-(3-((3-(dimet...)
Affinity DataIC50:  1.60nMAssay Description:Inhibition of human HA-tagged SGLT2 expressed in HEK293 cells assessed as decrease in [14C]-AMG uptake measured after 1 to 2 hrs by scintillation cou...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetLIM domain kinase 2(Homo sapiens (Human))
Lexicon Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50299611((S)-N-(3-chlorophenyl)-N'-cyano-2-methyl-4-(5-meth...)
Affinity DataIC50:  1.60nMAssay Description:Inhibition of human recombinant LIMK2 expressed in baculovirus-Sf9 system by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium/glucose cotransporter 1(Homo sapiens (Human))
Lexicon Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM176709(US9688710, 132 N-(1-((2-(dimethylamino)ethyl)(meth...)
Affinity DataIC50:  1.70nMAssay Description:Inhibition of human HA-tagged SGLT1 expressed in HEK293 cells assessed as decrease in [14C]-AMG uptake measured after 1 to 2 hrs by scintillation cou...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetLIM domain kinase 2(Homo sapiens (Human))
Lexicon Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50299623((S)-N'-cyano-N-(3-(N-isopropylsulfamoyl)phenyl)-2-...)
Affinity DataIC50:  1.70nMAssay Description:Inhibition of human recombinant LIMK2 expressed in baculovirus-Sf9 system by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLIM domain kinase 2(Homo sapiens (Human))
Lexicon Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50299613((S)-N'-cyano-N-(3-fluorophenyl)-2-methyl-4-(5-meth...)
Affinity DataIC50:  1.80nMAssay Description:Inhibition of human recombinant LIMK2 expressed in baculovirus-Sf9 system by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium/glucose cotransporter 1(Homo sapiens (Human))
Lexicon Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM176414(US9688710, 113 N-(2-methyl-1-(4-methylpiperazin-1-...)
Affinity DataIC50:  1.80nMAssay Description:Inhibition of human HA-tagged SGLT1 expressed in HEK293 cells assessed as decrease in [14C]-AMG uptake measured after 1 to 2 hrs by scintillation cou...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSodium/glucose cotransporter 2(Homo sapiens (Human))
Lexicon Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50235017(LP-802034 | LX-4211 | Sotagliflozin)
Affinity DataIC50:  1.80nMAssay Description:Inhibition of human HA-tagged SGLT2 expressed in HEK293 cells assessed as decrease in [14C]-AMG uptake measured after 1 to 2 hrs by scintillation cou...More data for this Ligand-Target Pair
TargetLIM domain kinase 2(Homo sapiens (Human))
Lexicon Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50299614((S)-N'-cyano-2-methyl-4-(5-methyl-7H-pyrrolo[2,3-d...)
Affinity DataIC50:  1.90nMAssay Description:Inhibition of human recombinant LIMK2 expressed in baculovirus-Sf9 system by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAP2-associated protein kinase 1(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM311337((S)-1-((5-(difluoromethyl)-2′-methyl-[3,4...)
Affinity DataIC50:  1.90nMAssay Description:Inhibition of GST-Xa tagged human AAK1 (30 to 330 residues) expresssed in bacteria using (5-FAM)-Aha-KEEQSQITSQVTGQIGWR-NH2 peptide as substrate incu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSodium/glucose cotransporter 2(Homo sapiens (Human))
Lexicon Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM176414(US9688710, 113 N-(2-methyl-1-(4-methylpiperazin-1-...)
Affinity DataIC50:  1.90nMAssay Description:Inhibition of human HA-tagged SGLT2 expressed in HEK293 cells assessed as decrease in [14C]-AMG uptake measured after 1 to 2 hrs by scintillation cou...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetLIM domain kinase 2(Homo sapiens (Human))
Lexicon Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50044012(CHEMBL3356424)
Affinity DataIC50:  1.90nMAssay Description:Inhibition of human full-length LIMK2 assessed as incorporation of P33 from ATP into biotinylated-cofilin substrate by scintillation counting analysi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAP2-associated protein kinase 1(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM311267((S)-1-((2′,6-bis(difluoromethyl)-[2,4′...)
Affinity DataIC50:  2nMAssay Description:Inhibition of AKK1 in HEK293F cells assessed as reduction in phospho mu2 formation incubated for 3 hrs by Western blot analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAP2-associated protein kinase 1(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM311267((S)-1-((2′,6-bis(difluoromethyl)-[2,4′...)
Affinity DataIC50:  2nMAssay Description:Inhibition of GST-Xa tagged human AAK1 (30 to 330 residues) expresssed in bacteria using (5-FAM)-Aha-KEEQSQITSQVTGQIGWR-NH2 peptide as substrate incu...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium/glucose cotransporter 1(Homo sapiens (Human))
Lexicon Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM176724(US9688710, 146 (3R,4R,5S,6R)-2-(3-(4-(3-((3-(dimet...)
Affinity DataIC50:  2nMAssay Description:Inhibition of human HA-tagged SGLT1 expressed in HEK293 cells assessed as decrease in [14C]-AMG uptake measured after 1 to 2 hrs by scintillation cou...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetLIM domain kinase 2(Homo sapiens (Human))
Lexicon Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50044010(CHEMBL3356426)
Affinity DataIC50:  2.20nMAssay Description:Inhibition of human full-length LIMK2 assessed as incorporation of P33 from ATP into biotinylated-cofilin substrate by scintillation counting analysi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium/glucose cotransporter 1(Homo sapiens (Human))
Lexicon Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM176714(US9688710, 136 N-(1-((2-(dimethylamino)ethyl)amino...)
Affinity DataIC50:  2.20nMAssay Description:Inhibition of human HA-tagged SGLT1 expressed in HEK293 cells assessed as decrease in [14C]-AMG uptake measured after 1 to 2 hrs by scintillation cou...More data for this Ligand-Target Pair
TargetAP2-associated protein kinase 1(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM311200((S)-1-(4-(2-fluoropyridin-4-yl)-2-(trifluoromethyl...)
Affinity DataIC50:  2.20nMAssay Description:Inhibition of GST-Xa tagged human AAK1 (30 to 330 residues) expresssed in bacteria using (5-FAM)-Aha-KEEQSQITSQVTGQIGWR-NH2 peptide as substrate incu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSodium/glucose cotransporter 1(Homo sapiens (Human))
Lexicon Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM176544(US9688710, 104 2,2-dimethyl-3-((4-(4-(2-methyl-5-(...)
Affinity DataIC50:  2.30nMAssay Description:Inhibition of human HA-tagged SGLT1 expressed in HEK293 cells assessed as decrease in [14C]-AMG uptake measured after 1 to 2 hrs by scintillation cou...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetLIM domain kinase 2(Homo sapiens (Human))
Lexicon Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50299612((S)-N-(3-chlorophenyl)-2-methyl-4-(5-methyl-7H-pyr...)
Affinity DataIC50:  2.30nMAssay Description:Inhibition of human recombinant LIMK2 expressed in baculovirus-Sf9 system by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAP2-associated protein kinase 1(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM311205((S)-1-(2-cyclopropyl-4-(2-methylpyridin-4-yl)pheno...)
Affinity DataIC50:  2.30nMAssay Description:Inhibition of GST-Xa tagged human AAK1 (30 to 330 residues) expresssed in bacteria using (5-FAM)-Aha-KEEQSQITSQVTGQIGWR-NH2 peptide as substrate incu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSodium/glucose cotransporter 1(Homo sapiens (Human))
Lexicon Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50235018(CHEMBL4072070)
Affinity DataIC50:  2.40nMAssay Description:Inhibition of human HA-tagged SGLT1 expressed in HEK293 cells assessed as decrease in [14C]-AMG uptake measured after 1 to 2 hrs by scintillation cou...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium/glucose cotransporter 2(Homo sapiens (Human))
Lexicon Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM176701(US9688710, 124 4-(4-(2-methyl-5-((2S,3R,4R,5S,6R)-...)
Affinity DataIC50:  2.5nMAssay Description:Inhibition of human HA-tagged SGLT2 expressed in HEK293 cells assessed as decrease in [14C]-AMG uptake measured after 1 to 2 hrs by scintillation cou...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSodium/glucose cotransporter 2(Homo sapiens (Human))
Lexicon Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM176712(US9688710, 135 (3R,4R,5S,6R)-2-(3-(4-(3-((1-hydrox...)
Affinity DataIC50:  2.5nMAssay Description:Inhibition of human HA-tagged SGLT2 expressed in HEK293 cells assessed as decrease in [14C]-AMG uptake measured after 1 to 2 hrs by scintillation cou...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSodium/glucose cotransporter 2(Homo sapiens (Human))
Lexicon Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM176697(US9688710, 120 N-(2-methyl-1-(4-methylpiperidin-1-...)
Affinity DataIC50:  2.5nMAssay Description:Inhibition of human HA-tagged SGLT2 expressed in HEK293 cells assessed as decrease in [14C]-AMG uptake measured after 1 to 2 hrs by scintillation cou...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
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