Affinity DataKi: 1nMAssay Description:Reversible Inhibition constants of the compound against IL-1 beta converting enzyme (ICE)More data for this Ligand-Target Pair
Affinity DataKi: 1nMAssay Description:Reversible Inhibition constants of the compound against IL-1 beta converting enzyme (ICE)More data for this Ligand-Target Pair
Affinity DataKi: 5nMAssay Description:Reversible Inhibition constants of the compound against IL-1 beta converting enzyme (ICE)More data for this Ligand-Target Pair
Affinity DataKi: 6nMAssay Description:Reversible Inhibition constants of the compound against IL-1 beta converting enzyme (ICE)More data for this Ligand-Target Pair
Affinity DataKi: 15nMAssay Description:Reversible Inhibition constants of the compound against IL-1 beta converting enzyme (ICE)More data for this Ligand-Target Pair
Affinity DataKi: 15nMAssay Description:Binding affinity against IL-1 beta converting enzymeMore data for this Ligand-Target Pair
Affinity DataKi: 15nMAssay Description:Binding affinity against IL-1 beta converting enzymeMore data for this Ligand-Target Pair
Affinity DataKi: 25nMAssay Description:Reversible Inhibition constants of the compound against IL-1 beta converting enzyme (ICE)More data for this Ligand-Target Pair
Affinity DataKi: 70nMAssay Description:Displacement of [33P]2-Mes-ADP from human recombinant P2Y1 receptor expressed in human U20S cellsMore data for this Ligand-Target Pair
Affinity DataKi: 100nMAssay Description:Displacement of [33P]2-Mes-ADP from human recombinant P2Y1 receptor expressed in human U20S cellsMore data for this Ligand-Target Pair
Affinity DataKi: 100nMAssay Description:Displacement of [33P]2-Mes-ADP from human recombinant P2Y1 receptor expressed in human U20S cellsMore data for this Ligand-Target Pair
Affinity DataKi: 100nMAssay Description:Displacement of [33P]2-Mes-ADP from human recombinant P2Y1 receptor expressed in human U20S cellsMore data for this Ligand-Target Pair
Affinity DataKi: 200nMAssay Description:Displacement of [33P]2-Mes-ADP from human recombinant P2Y1 receptor expressed in human U20S cellsMore data for this Ligand-Target Pair
Affinity DataKi: 300nMAssay Description:Displacement of [33P]2-Mes-ADP from human recombinant P2Y1 receptor expressed in human U20S cellsMore data for this Ligand-Target Pair
Affinity DataKi: 300nMAssay Description:Displacement of [33P]2-Mes-ADP from human recombinant P2Y1 receptor expressed in human U20S cellsMore data for this Ligand-Target Pair
Affinity DataKi: 400nMAssay Description:Displacement of [33P]2-Mes-ADP from human recombinant P2Y1 receptor expressed in human U20S cellsMore data for this Ligand-Target Pair
Affinity DataKi: 400nMAssay Description:Displacement of [33P]2-Mes-ADP from human recombinant P2Y1 receptor expressed in human U20S cellsMore data for this Ligand-Target Pair
Affinity DataKi: 400nMAssay Description:Displacement of [33P]2-Mes-ADP from human recombinant P2Y1 receptor expressed in human U20S cellsMore data for this Ligand-Target Pair
Affinity DataKi: 500nMAssay Description:Displacement of [33P]2-Mes-ADP from human recombinant P2Y1 receptor expressed in human U20S cellsMore data for this Ligand-Target Pair
Affinity DataKi: 500nMAssay Description:Displacement of [33P]2-Mes-ADP from human recombinant P2Y1 receptor expressed in human U20S cellsMore data for this Ligand-Target Pair
Affinity DataKi: 800nMAssay Description:Displacement of [33P]2-Mes-ADP from human recombinant P2Y1 receptor expressed in human U20S cellsMore data for this Ligand-Target Pair
TargetNAD-dependent protein deacetylase sirtuin-2(Homo sapiens (Human))
Sirtris A Gsk
Curated by ChEMBL
Sirtris A Gsk
Curated by ChEMBL
Affinity DataIC50: 1.10nMAssay Description:Inhibition of His-tagged SIRT2 (1 to 389) (unknown origin)-mediated deacetylation of Ac-RHKKAcW-NH2 substrate incubated for 20 mins prior to substrat...More data for this Ligand-Target Pair
TargetNAD-dependent protein deacetylase sirtuin-2(Homo sapiens (Human))
Sirtris A Gsk
Curated by ChEMBL
Sirtris A Gsk
Curated by ChEMBL
Affinity DataIC50: 1.30nMAssay Description:Inhibition of His-tagged SIRT2 (1 to 389) (unknown origin)-mediated deacetylation of Ac-RHKKAcW-NH2 substrate incubated for 20 mins prior to substrat...More data for this Ligand-Target Pair
Affinity DataIC50: 1.70nMAssay Description:Inhibition of HCV NS5B RNA dependent RNA polymeraseMore data for this Ligand-Target Pair
TargetNAD-dependent protein deacetylase sirtuin-2(Homo sapiens (Human))
Sirtris A Gsk
Curated by ChEMBL
Sirtris A Gsk
Curated by ChEMBL
Affinity DataIC50: 1.80nMAssay Description:Inhibition of His-tagged SIRT2 (1 to 389) (unknown origin)-mediated deacetylation of Ac-RHKKAcW-NH2 substrate incubated for 20 mins prior to substrat...More data for this Ligand-Target Pair
Affinity DataIC50: 2.51nMAssay Description:Agonist activity at progesterone receptor in human T47D cell after 24 hrs by alkaline phosphatase assayMore data for this Ligand-Target Pair
TargetNAD-dependent protein deacetylase sirtuin-2(Homo sapiens (Human))
Sirtris A Gsk
Curated by ChEMBL
Sirtris A Gsk
Curated by ChEMBL
Affinity DataIC50: 2.70nMAssay Description:Inhibition of His-tagged SIRT2 (1 to 389) (unknown origin)-mediated deacetylation of Ac-RHKKAcW-NH2 substrate incubated for 20 mins prior to substrat...More data for this Ligand-Target Pair
TargetNAD-dependent protein deacetylase sirtuin-3, mitochondrial(Homo sapiens (Human))
Sirtris A Gsk
Curated by ChEMBL
Sirtris A Gsk
Curated by ChEMBL
Affinity DataIC50: 3.20nMAssay Description:Inhibition of human His-tagged SIRT3 (102 to 399) expressed in Escherichia coli BL21(DE3) assessed as inhibition of deacetylation of Ac-RHKKAcW-NH2 s...More data for this Ligand-Target Pair
TargetNAD-dependent protein deacetylase sirtuin-1(Homo sapiens (Human))
Sirtris A Gsk
Curated by ChEMBL
Sirtris A Gsk
Curated by ChEMBL
Affinity DataIC50: 3.60nMAssay Description:Inhibition of His-tagged SIRT1 (1 to 747) (unknown origin)-mediated deacetylation of Ac-RHKKAcW-NH2 substrate preincubated for 20 mins measured after...More data for this Ligand-Target Pair
TargetNAD-dependent protein deacetylase sirtuin-3, mitochondrial(Homo sapiens (Human))
Sirtris A Gsk
Curated by ChEMBL
Sirtris A Gsk
Curated by ChEMBL
Affinity DataIC50: 4nMAssay Description:Inhibition of human His-tagged SIRT3 (102 to 399) expressed in Escherichia coli BL21(DE3) assessed as inhibition of deacetylation of Ac-RHKKAcW-NH2 s...More data for this Ligand-Target Pair
TargetNAD-dependent protein deacetylase sirtuin-1(Homo sapiens (Human))
Sirtris A Gsk
Curated by ChEMBL
Sirtris A Gsk
Curated by ChEMBL
Affinity DataIC50: 4.30nMAssay Description:Inhibition of His-tagged SIRT1 (1 to 747) (unknown origin)-mediated deacetylation of Ac-RHKKAcW-NH2 substrate preincubated for 20 mins measured after...More data for this Ligand-Target Pair
TargetNAD-dependent protein deacetylase sirtuin-2(Homo sapiens (Human))
Sirtris A Gsk
Curated by ChEMBL
Sirtris A Gsk
Curated by ChEMBL
Affinity DataIC50: 4.40nMAssay Description:Inhibition of His-tagged SIRT2 (1 to 389) (unknown origin)-mediated deacetylation of Ac-RHKKAcW-NH2 substrate incubated for 20 mins prior to substrat...More data for this Ligand-Target Pair
TargetNAD-dependent protein deacetylase sirtuin-2(Homo sapiens (Human))
Sirtris A Gsk
Curated by ChEMBL
Sirtris A Gsk
Curated by ChEMBL
Affinity DataIC50: 4.80nMAssay Description:Inhibition of His-tagged SIRT2 (1 to 389) (unknown origin)-mediated deacetylation of Ac-RHKKAcW-NH2 substrate incubated for 20 mins prior to substrat...More data for this Ligand-Target Pair
TargetNAD-dependent protein deacetylase sirtuin-3, mitochondrial(Homo sapiens (Human))
Sirtris A Gsk
Curated by ChEMBL
Sirtris A Gsk
Curated by ChEMBL
Affinity DataIC50: 4.90nMAssay Description:Inhibition of human His-tagged SIRT3 (102 to 399) expressed in Escherichia coli BL21(DE3) assessed as inhibition of deacetylation of Ac-RHKKAcW-NH2 s...More data for this Ligand-Target Pair
TargetNAD-dependent protein deacetylase sirtuin-1(Homo sapiens (Human))
Sirtris A Gsk
Curated by ChEMBL
Sirtris A Gsk
Curated by ChEMBL
Affinity DataIC50: 5.30nMAssay Description:Inhibition of His-tagged SIRT1 (1 to 747) (unknown origin)-mediated deacetylation of Ac-RHKKAcW-NH2 substrate preincubated for 20 mins measured after...More data for this Ligand-Target Pair
TargetNAD-dependent protein deacetylase sirtuin-2(Homo sapiens (Human))
Sirtris A Gsk
Curated by ChEMBL
Sirtris A Gsk
Curated by ChEMBL
Affinity DataIC50: 5.40nMAssay Description:Inhibition of His-tagged SIRT2 (1 to 389) (unknown origin)-mediated deacetylation of Ac-RHKKAcW-NH2 substrate incubated for 20 mins prior to substrat...More data for this Ligand-Target Pair
TargetNAD-dependent protein deacetylase sirtuin-1(Homo sapiens (Human))
Sirtris A Gsk
Curated by ChEMBL
Sirtris A Gsk
Curated by ChEMBL
Affinity DataIC50: 5.80nMAssay Description:Inhibition of His-tagged SIRT1 (1 to 747) (unknown origin)-mediated deacetylation of Ac-RHKKAcW-NH2 substrate preincubated for 20 mins measured after...More data for this Ligand-Target Pair
TargetNAD-dependent protein deacetylase sirtuin-2(Homo sapiens (Human))
Sirtris A Gsk
Curated by ChEMBL
Sirtris A Gsk
Curated by ChEMBL
Affinity DataIC50: 6.5nMAssay Description:Inhibition of His-tagged SIRT2 (1 to 389) (unknown origin)-mediated deacetylation of Ac-RHKKAcW-NH2 substrate incubated for 20 mins prior to substrat...More data for this Ligand-Target Pair
TargetNAD-dependent protein deacetylase sirtuin-1(Homo sapiens (Human))
Sirtris A Gsk
Curated by ChEMBL
Sirtris A Gsk
Curated by ChEMBL
Affinity DataIC50: 6.70nMAssay Description:Inhibition of His-tagged SIRT1 (1 to 747) (unknown origin)-mediated deacetylation of Ac-RHKKAcW-NH2 substrate preincubated for 20 mins measured after...More data for this Ligand-Target Pair
TargetNAD-dependent protein deacetylase sirtuin-3, mitochondrial(Homo sapiens (Human))
Sirtris A Gsk
Curated by ChEMBL
Sirtris A Gsk
Curated by ChEMBL
Affinity DataIC50: 7.20nMAssay Description:Inhibition of human His-tagged SIRT3 (102 to 399) expressed in Escherichia coli BL21(DE3) assessed as inhibition of deacetylation of Ac-RHKKAcW-NH2 s...More data for this Ligand-Target Pair
TargetNAD-dependent protein deacetylase sirtuin-3, mitochondrial(Homo sapiens (Human))
Sirtris A Gsk
Curated by ChEMBL
Sirtris A Gsk
Curated by ChEMBL
Affinity DataIC50: 7.60nMAssay Description:Inhibition of human His-tagged SIRT3 (102 to 399) expressed in Escherichia coli BL21(DE3) assessed as inhibition of deacetylation of Ac-RHKKAcW-NH2 s...More data for this Ligand-Target Pair
TargetNAD-dependent protein deacetylase sirtuin-2(Homo sapiens (Human))
Sirtris A Gsk
Curated by ChEMBL
Sirtris A Gsk
Curated by ChEMBL
Affinity DataIC50: 10nMAssay Description:Inhibition of His-tagged SIRT2 (1 to 389) (unknown origin)-mediated deacetylation of Ac-RHKKAcW-NH2 substrate incubated for 20 mins prior to substrat...More data for this Ligand-Target Pair
TargetNAD-dependent protein deacetylase sirtuin-2(Homo sapiens (Human))
Sirtris A Gsk
Curated by ChEMBL
Sirtris A Gsk
Curated by ChEMBL
Affinity DataIC50: 10nMAssay Description:Inhibition of His-tagged SIRT2 (1 to 389) (unknown origin)-mediated deacetylation of Ac-RHKKAcW-NH2 substrate incubated for 20 mins prior to substrat...More data for this Ligand-Target Pair
TargetNAD-dependent protein deacetylase sirtuin-3, mitochondrial(Homo sapiens (Human))
Sirtris A Gsk
Curated by ChEMBL
Sirtris A Gsk
Curated by ChEMBL
Affinity DataIC50: 13nMAssay Description:Inhibition of human His-tagged SIRT3 (102 to 399) expressed in Escherichia coli BL21(DE3) assessed as inhibition of deacetylation of Ac-RHKKAcW-NH2 s...More data for this Ligand-Target Pair
TargetNAD-dependent protein deacetylase sirtuin-1(Homo sapiens (Human))
Sirtris A Gsk
Curated by ChEMBL
Sirtris A Gsk
Curated by ChEMBL
Affinity DataIC50: 14nMAssay Description:Inhibition of His-tagged SIRT1 (1 to 747) (unknown origin)-mediated deacetylation of Ac-RHKKAcW-NH2 substrate preincubated for 20 mins measured after...More data for this Ligand-Target Pair
TargetNAD-dependent protein deacetylase sirtuin-1(Homo sapiens (Human))
Sirtris A Gsk
Curated by ChEMBL
Sirtris A Gsk
Curated by ChEMBL
Affinity DataIC50: 15nMAssay Description:Inhibition of His-tagged SIRT1 (1 to 747) (unknown origin)-mediated deacetylation of Ac-RHKKAcW-NH2 substrate preincubated for 20 mins measured after...More data for this Ligand-Target Pair
TargetNAD-dependent protein deacetylase sirtuin-2(Homo sapiens (Human))
Sirtris A Gsk
Curated by ChEMBL
Sirtris A Gsk
Curated by ChEMBL
Affinity DataIC50: 16nMAssay Description:Inhibition of His-tagged SIRT2 (1 to 389) (unknown origin)-mediated deacetylation of Ac-RHKKAcW-NH2 substrate incubated for 20 mins prior to substrat...More data for this Ligand-Target Pair
TargetNAD-dependent protein deacetylase sirtuin-2(Homo sapiens (Human))
Sirtris A Gsk
Curated by ChEMBL
Sirtris A Gsk
Curated by ChEMBL
Affinity DataIC50: 17nMAssay Description:Inhibition of His-tagged SIRT2 (1 to 389) (unknown origin)-mediated deacetylation of Ac-RHKKAcW-NH2 substrate incubated for 20 mins prior to substrat...More data for this Ligand-Target Pair
TargetNAD-dependent protein deacetylase sirtuin-1(Homo sapiens (Human))
Sirtris A Gsk
Curated by ChEMBL
Sirtris A Gsk
Curated by ChEMBL
Affinity DataIC50: 17nMAssay Description:Inhibition of His-tagged SIRT1 (1 to 747) (unknown origin)-mediated deacetylation of Ac-RHKKAcW-NH2 substrate preincubated for 20 mins measured after...More data for this Ligand-Target Pair
Affinity DataIC50: 18nMAssay Description:Inhibition of HCV NS5B RNA dependent RNA polymeraseMore data for this Ligand-Target Pair