Affinity DataKi: 1nMAssay Description:Inhibition of bovine trypsinMore data for this Ligand-Target Pair
Affinity DataKi: 2.10nMAssay Description:Inhibition of bovine trypsinMore data for this Ligand-Target Pair
TargetChymase(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development
Curated by ChEMBL
Johnson & Johnson Pharmaceutical Research And Development
Curated by ChEMBL
Affinity DataKi: 2.30nMAssay Description:Inhibition of human skin chymaseMore data for this Ligand-Target Pair
Affinity DataKi: 2.5nMAssay Description:Inhibition of bovine trypsinMore data for this Ligand-Target Pair
Affinity DataKi: 3.10nMAssay Description:Inhibition of human thrombinMore data for this Ligand-Target Pair
Affinity DataKi: 4.10nMAssay Description:Inhibition of human thrombinMore data for this Ligand-Target Pair
Affinity DataKi: 5.20nMAssay Description:Inhibition of bovine trypsinMore data for this Ligand-Target Pair
Affinity DataKi: 5.30nMAssay Description:Inhibition of human thrombinMore data for this Ligand-Target Pair
Affinity DataKi: 9.90nMAssay Description:Inhibition of human thrombinMore data for this Ligand-Target Pair
Affinity DataKi: 10nMAssay Description:Inhibition of bovine trypsinMore data for this Ligand-Target Pair
Affinity DataKi: 11nMAssay Description:Inhibition of bovine trypsinMore data for this Ligand-Target Pair
TargetChymase(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development
Curated by ChEMBL
Johnson & Johnson Pharmaceutical Research And Development
Curated by ChEMBL
Affinity DataKi: 11nMAssay Description:Inhibition of human skin chymaseMore data for this Ligand-Target Pair
Affinity DataKi: 13nMAssay Description:Inhibition of bovine trypsinMore data for this Ligand-Target Pair
Affinity DataKi: 14nMAssay Description:Inhibition of bovine trypsinMore data for this Ligand-Target Pair
Affinity DataKi: 15nMAssay Description:Inhibition of human thrombinMore data for this Ligand-Target Pair
Affinity DataKi: 20nMAssay Description:Inhibition of human thrombinMore data for this Ligand-Target Pair
Affinity DataKi: 24nMAssay Description:Inhibition of human thrombinMore data for this Ligand-Target Pair
Affinity DataKi: 25nMAssay Description:Inhibition of bovine trypsinMore data for this Ligand-Target Pair
Affinity DataKi: 33nM ΔG°: -39.7kJ/molepH: 7.4 T: 2°CAssay Description:Full-length human GCGR (Accession Number: NM000160) subcloned into pcDNA3.1 was stably transfected into HEK293 cells (hGluc-1 HEK) and maintained und...More data for this Ligand-Target Pair
TargetChymase(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development
Curated by ChEMBL
Johnson & Johnson Pharmaceutical Research And Development
Curated by ChEMBL
Affinity DataKi: 36nMAssay Description:Inhibition of human skin chymaseMore data for this Ligand-Target Pair
TargetCathepsin G(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development
Curated by ChEMBL
Johnson & Johnson Pharmaceutical Research And Development
Curated by ChEMBL
Affinity DataKi: 38nMAssay Description:Inhibition of human neutrophil Cat GMore data for this Ligand-Target Pair
Affinity DataKi: 38nM ΔG°: -39.4kJ/molepH: 7.4 T: 2°CAssay Description:Full-length human GCGR (Accession Number: NM000160) subcloned into pcDNA3.1 was stably transfected into HEK293 cells (hGluc-1 HEK) and maintained und...More data for this Ligand-Target Pair
Affinity DataKi: 45nM ΔG°: -39.0kJ/molepH: 7.4 T: 2°CAssay Description:Full-length human GCGR (Accession Number: NM000160) subcloned into pcDNA3.1 was stably transfected into HEK293 cells (hGluc-1 HEK) and maintained und...More data for this Ligand-Target Pair
Affinity DataKi: 60nM ΔG°: -38.3kJ/molepH: 7.4 T: 2°CAssay Description:Full-length human GCGR (Accession Number: NM000160) subcloned into pcDNA3.1 was stably transfected into HEK293 cells (hGluc-1 HEK) and maintained und...More data for this Ligand-Target Pair
Affinity DataKi: 66nMAssay Description:Inhibition of bovine trypsinMore data for this Ligand-Target Pair
Affinity DataKi: 86nMAssay Description:Inhibition of human thrombinMore data for this Ligand-Target Pair
Affinity DataKi: 120nM ΔG°: -36.7kJ/molepH: 7.4 T: 2°CAssay Description:Full-length human GCGR (Accession Number: NM000160) subcloned into pcDNA3.1 was stably transfected into HEK293 cells (hGluc-1 HEK) and maintained und...More data for this Ligand-Target Pair
Affinity DataKi: 159nMAssay Description:Inhibition of human thrombinMore data for this Ligand-Target Pair
Affinity DataKi: 163nMAssay Description:Inhibition of human thrombinMore data for this Ligand-Target Pair
Affinity DataKi: 240nM ΔG°: -35.1kJ/molepH: 7.4 T: 2°CAssay Description:Full-length human GCGR (Accession Number: NM000160) subcloned into pcDNA3.1 was stably transfected into HEK293 cells (hGluc-1 HEK) and maintained und...More data for this Ligand-Target Pair
Affinity DataKi: 240nM ΔG°: -35.1kJ/molepH: 7.4 T: 2°CAssay Description:Full-length human GCGR (Accession Number: NM000160) subcloned into pcDNA3.1 was stably transfected into HEK293 cells (hGluc-1 HEK) and maintained und...More data for this Ligand-Target Pair
Affinity DataKi: 270nM ΔG°: -34.9kJ/molepH: 7.4 T: 2°CAssay Description:Full-length human GCGR (Accession Number: NM000160) subcloned into pcDNA3.1 was stably transfected into HEK293 cells (hGluc-1 HEK) and maintained und...More data for this Ligand-Target Pair
Affinity DataKi: 280nMAssay Description:Inhibition of bovine trypsinMore data for this Ligand-Target Pair
Affinity DataKi: 473nMAssay Description:Inhibition of human thrombinMore data for this Ligand-Target Pair
Affinity DataKi: 710nMAssay Description:Inhibition of bovine trypsinMore data for this Ligand-Target Pair
Affinity DataKi: 770nM ΔG°: -32.4kJ/molepH: 7.4 T: 2°CAssay Description:Full-length human GCGR (Accession Number: NM000160) subcloned into pcDNA3.1 was stably transfected into HEK293 cells (hGluc-1 HEK) and maintained und...More data for this Ligand-Target Pair
Affinity DataKi: 1.80E+3nMAssay Description:Inhibition of human thrombinMore data for this Ligand-Target Pair
TargetCathepsin G(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development
Curated by ChEMBL
Johnson & Johnson Pharmaceutical Research And Development
Curated by ChEMBL
Affinity DataKi: 9.50E+3nMAssay Description:Inhibition of human neutrophil Cat GMore data for this Ligand-Target Pair
Affinity DataIC50: 0.800nMAssay Description:The reaction procedure was conducted as follows:1) Prepare substrate in freshly prepared Reaction Buffer.2) MnCl2 (2 mM) was added as a co-factor lis...More data for this Ligand-Target Pair
TargetVasopressin V2 receptor(Rattus norvegicus (Rat))
Johnson & Johnson Pharmaceutical Research & Development
Curated by ChEMBL
Johnson & Johnson Pharmaceutical Research & Development
Curated by ChEMBL
Affinity DataIC50: 1nMAssay Description:Binding affinity towards V2 receptorMore data for this Ligand-Target Pair
Affinity DataIC50: 1.20nMAssay Description:Displacement of [3H]-CP-55940 from human CB1 receptor expressed in CHO-K1 cell membranesMore data for this Ligand-Target Pair
Affinity DataIC50: 1.30nMAssay Description:Displacement of [3H]-rimonabant from human CB1 receptor expressed in CHO cell membranes after 60 mins by TopCount methodMore data for this Ligand-Target Pair
Affinity DataIC50: 2.10nMAssay Description:The reaction procedure was conducted as follows:1) Prepare substrate in freshly prepared Reaction Buffer.2) MnCl2 (2 mM) was added as a co-factor lis...More data for this Ligand-Target Pair
TargetChymase(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development
Curated by ChEMBL
Johnson & Johnson Pharmaceutical Research And Development
Curated by ChEMBL
Affinity DataIC50: 3.5nMAssay Description:Inhibition of human skin chymaseMore data for this Ligand-Target Pair
Affinity DataIC50: 4nMpH: 7.2Assay Description:To assay for cell surface lipase activity, cells expressing human endothelial lipase (EL) or LPL were plated in CellBIND® 384-well plates (Corning, L...More data for this Ligand-Target Pair
Affinity DataIC50: 4nMpH: 7.2Assay Description:To assay for cell surface lipase activity, cells expressing human endothelial lipase (EL) or LPL were plated in CellBIND® 384-well plates (Corning, L...More data for this Ligand-Target Pair
Affinity DataIC50: 4.30nMAssay Description:The reaction procedure was conducted as follows:1) Prepare substrate in freshly prepared Reaction Buffer.2) MnCl2 (2 mM) was added as a co-factor lis...More data for this Ligand-Target Pair
Affinity DataIC50: 4.40nMAssay Description:Displacement of [3H]-CP-55940 from human CB1 receptor expressed in CHO-K1 cell membranesMore data for this Ligand-Target Pair
TargetChymase(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development
Curated by ChEMBL
Johnson & Johnson Pharmaceutical Research And Development
Curated by ChEMBL
Affinity DataIC50: 4.5nMAssay Description:Inhibition of human skin chymaseMore data for this Ligand-Target Pair
Affinity DataIC50: 4.60nMAssay Description:Displacement of [3H]-rimonabant from human CB1 receptor expressed in CHO cell membranes after 60 mins by TopCount methodMore data for this Ligand-Target Pair