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Found 383 with Last Name = 'green' and Initial = 'mj'
TargetHistamine H3 receptor(GUINEA PIG)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50034711((1R,2S)-2-(1H-Imidazol-4-yl)-1-methyl-propylamine ...)
Affinity DataKi:  0.800nMAssay Description:Binding afinity against Histamine H3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(GUINEA PIG)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50071491(4-(1H-Imidazol-4-yl)-butyramidine | CHEMBL72156 | ...)
Affinity DataKi:  1.20nMAssay Description:Inhibition of N-alpha-methylhistamine binding to histamine H3 receptor of guinea pig brain membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor VII/Tissue factor(Homo sapiens (Human))
Celera Genomics

Curated by ChEMBL
LigandPNGBDBM50189939(5-(4-amino-1H-pyrrolo[3,2-c]pyridin-2-yl)-6-hydrox...)
Affinity DataKi:  1.30nMAssay Description:Binding affinity to f7a/TF complexMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(GUINEA PIG)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM22904((2R)-1-(1H-imidazol-5-yl)propan-2-amine | (R)-alph...)
Affinity DataKi:  1.5nMAssay Description:Binding afinity against Histamine H3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(GUINEA PIG)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM22904((2R)-1-(1H-imidazol-5-yl)propan-2-amine | (R)-alph...)
Affinity DataKi:  1.5nMAssay Description:Binding affinity of compound towards Histamine H3 receptor was determined in guinea pig brain tissue using [3H]- N alpha-methylhistamine radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDimer of Tryptase beta-2(Homo sapiens (Human))
Celera

Curated by ChEMBL
LigandPNGBDBM50187167(CHEMBL211357 | N-[(S)-5-amino-1-(5-{4-[2-(3-chloro...)
Affinity DataKi:  1.5nMAssay Description:Inhibition of human beta tryptaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDimer of Tryptase beta-2(Homo sapiens (Human))
Celera

Curated by ChEMBL
LigandPNGBDBM50187177(CHEMBL212774 | N-[(2S)-6-amino-1-{5-[(4-{[2-(3-chl...)
Affinity DataKi:  1.70nMAssay Description:Inhibition of human beta tryptaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDimer of Tryptase beta-2(Homo sapiens (Human))
Celera

Curated by ChEMBL
LigandPNGBDBM50187166(CHEMBL380293 | N-[(S)-5-amino-1-(5-{4-[2-(3-chloro...)
Affinity DataKi:  1.70nMAssay Description:Inhibition of human beta tryptaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDimer of Tryptase beta-2(Homo sapiens (Human))
Celera

Curated by ChEMBL
LigandPNGBDBM50187163((S)-benzyl 1-(5-(4-((3-chlorophenethyl)carbamoyl)b...)
Affinity DataKi:  1.80nMAssay Description:Inhibition of human beta tryptaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDimer of Tryptase beta-2(Homo sapiens (Human))
Celera

Curated by ChEMBL
LigandPNGBDBM50187160(CHEMBL213928 | N-[(2S)-6-amino-1-{5-[(4-{[2-(3-chl...)
Affinity DataKi:  1.80nMAssay Description:Inhibition of human beta tryptaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDimer of Tryptase beta-2(Homo sapiens (Human))
Celera

Curated by ChEMBL
LigandPNGBDBM50187168(CHEMBL377656 | N-[(2S)-6-amino-1-{5-[(4-{[2-(3-chl...)
Affinity DataKi:  1.90nMAssay Description:Inhibition of human beta tryptaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDimer of Tryptase beta-2(Homo sapiens (Human))
Celera

Curated by ChEMBL
LigandPNGBDBM50187176((S)-ethyl 1-(5-(4-((3-chlorophenethyl)carbamoyl)be...)
Affinity DataKi:  1.90nMAssay Description:Inhibition of human beta tryptaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDimer of Tryptase beta-2(Homo sapiens (Human))
Celera

Curated by ChEMBL
LigandPNGBDBM50187162((S)-N-(3-chlorophenethyl)-4-((3-(6-amino-2-pivalam...)
Affinity DataKi:  2nMAssay Description:Inhibition of human beta tryptaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(GUINEA PIG)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50069825(4-Pyrrolidin-3-yl-1H-imidazole | CHEMBL79983)
Affinity DataKi:  2nMAssay Description:Inhibition of [3H]-N-alpha-methylhistamine binding to guinea pig brain Histamine H3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor VII/Tissue factor(Homo sapiens (Human))
Celera Genomics

Curated by ChEMBL
LigandPNGBDBM50180400(2-[5-(5-carbamimidoyl-1H-benzoimidazol-2-yl)-6,2'-...)
Affinity DataKi:  2nMAssay Description:Binding affinity to F7a/TF complexMore data for this Ligand-Target Pair
TargetDimer of Tryptase beta-2(Homo sapiens (Human))
Celera

Curated by ChEMBL
LigandPNGBDBM50187182((S)-N-(1-(5-(4-((3-chlorophenethyl)carbamoyl)benzy...)
Affinity DataKi:  2.10nMAssay Description:Inhibition of human beta tryptaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(GUINEA PIG)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50069816(4-((3R,4R)-4-Methyl-pyrrolidin-3-yl)-1H-imidazole ...)
Affinity DataKi:  2.30nMAssay Description:Inhibition of [3H]-N-alpha-methylhistamine binding to guinea pig brain Histamine H3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDimer of Tryptase beta-2(Homo sapiens (Human))
Celera

Curated by ChEMBL
LigandPNGBDBM50187164((S)-benzyl 1-(5-(4-((2-(thiophen-2-yl)ethyl)carbam...)
Affinity DataKi:  2.40nMAssay Description:Inhibition of human beta tryptaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor VII/Tissue factor(Homo sapiens (Human))
Celera Genomics

Curated by ChEMBL
LigandPNGBDBM50189938(2-{5-(4-amino-1H-pyrrolo[3,2-c]pyridin-2-yl)-3'-[3...)
Affinity DataKi:  2.60nMAssay Description:Binding affinity to f7a/TF complexMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDimer of Tryptase beta-2(Homo sapiens (Human))
Celera

Curated by ChEMBL
LigandPNGBDBM14312(CHEMBL214368 | CRA23 | ethyl N-[(2S)-6-amino-1-(5-...)
Affinity DataKi:  2.80nMAssay Description:Inhibition of human beta tryptaseMore data for this Ligand-Target Pair
TargetHistamine H3 receptor(GUINEA PIG)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50034708(4-((2R,3S)-2-Methyl-pyrrolidin-3-yl)-1H-imidazole ...)
Affinity DataKi:  2.80nMAssay Description:Binding afinity against Histamine H3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(GUINEA PIG)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50034708(4-((2R,3S)-2-Methyl-pyrrolidin-3-yl)-1H-imidazole ...)
Affinity DataKi:  2.80nMAssay Description:Binding afinity against Histamine H3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDimer of Tryptase beta-2(Homo sapiens (Human))
Celera

Curated by ChEMBL
LigandPNGBDBM50187169((S)-benzyl 1-(5-(4-((2-(4-fluorophenoxy)ethyl)carb...)
Affinity DataKi:  2.90nMAssay Description:Inhibition of human beta tryptaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDimer of Tryptase beta-2(Homo sapiens (Human))
Celera

Curated by ChEMBL
LigandPNGBDBM50187179((S)-benzyl 1-(5-(4-((3-phenylpropyl)carbamoyl)benz...)
Affinity DataKi:  3nMAssay Description:Inhibition of human beta tryptaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(GUINEA PIG)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50034708(4-((2R,3S)-2-Methyl-pyrrolidin-3-yl)-1H-imidazole ...)
Affinity DataKi:  3nMAssay Description:Inhibition of [3H]-N-alpha-methylhistamine binding to guinea pig brain Histamine H3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(GUINEA PIG)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50069823(4-((3S,4R)-4-Methyl-pyrrolidin-3-yl)-1H-imidazole ...)
Affinity DataKi:  3nMAssay Description:Inhibition of [3H]-N-alpha-methylhistamine binding to guinea pig brain Histamine H3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptase beta-2(Homo sapiens (Human))
Celera

LigandPNGBDBM14312(CHEMBL214368 | CRA23 | ethyl N-[(2S)-6-amino-1-(5-...)
Affinity DataKi:  3nMAssay Description:Each enzyme was assayed with a set of different concentrations of each inhibitor. After addition of the appropriate substrate, the rate of hydrolysis...More data for this Ligand-Target Pair
TargetDimer of Tryptase beta-2(Homo sapiens (Human))
Celera

Curated by ChEMBL
LigandPNGBDBM50187154((S)-benzyl 1-(5-(4-(phenethylcarbamoyl)benzyl)-1,2...)
Affinity DataKi:  3.20nMAssay Description:Inhibition of human beta tryptaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDimer of Tryptase beta-2(Homo sapiens (Human))
Celera

Curated by ChEMBL
LigandPNGBDBM50187157((S)-benzyl 1-(5-(4-((3,5-difluorophenethyl)carbamo...)
Affinity DataKi:  3.5nMAssay Description:Inhibition of human beta tryptaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDimer of Tryptase beta-2(Homo sapiens (Human))
Celera

Curated by ChEMBL
LigandPNGBDBM50187165((S)-benzyl 1-(5-(4-(cinnamylcarbamoyl)benzyl)-1,2,...)
Affinity DataKi:  3.60nMAssay Description:Inhibition of human beta tryptaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDimer of Tryptase beta-2(Homo sapiens (Human))
Celera

Curated by ChEMBL
LigandPNGBDBM50187158((S)-benzyl 1-(5-(4-((2,3-dihydro-1H-inden-2-yl)car...)
Affinity DataKi:  3.70nMAssay Description:Inhibition of human beta tryptaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H1 receptor(RAT)
Schering-Plough

Curated by ChEMBL
LigandPNGBDBM22868(11-(1-methylpiperidin-4-ylidene)-6,11-dihydro-5H-b...)
Affinity DataKi:  3.90nMAssay Description:Binding affinity to histamine H1 receptor in rat brain membranes was evaluated using [3H]-pyrilamine as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor VII/Tissue factor(Homo sapiens (Human))
Celera Genomics

Curated by ChEMBL
LigandPNGBDBM14898(2-[3-(5-carbamimidoyl-1H-1,3-benzodiazol-2-yl)-5-(...)
Affinity DataKi:  4nMAssay Description:Binding affinity to F7a/TF complexMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptase beta-2(Homo sapiens (Human))
Celera

LigandPNGBDBM14311(CRA22 | N-[(2S)-6-amino-1-(5-{[4-(2,3-dihydro-1H-i...)
Affinity DataKi:  4nMAssay Description:Each enzyme was assayed with a set of different concentrations of each inhibitor. After addition of the appropriate substrate, the rate of hydrolysis...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(GUINEA PIG)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50069822(4-((3S,4S)-4-Methyl-pyrrolidin-3-yl)-1H-imidazole ...)
Affinity DataKi:  5nMAssay Description:Inhibition of [3H]-N-alpha-methylhistamine binding to guinea pig brain Histamine H3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptase beta-2(Homo sapiens (Human))
Celera

LigandPNGBDBM50187800((S)-ethyl 1-(5-(4-phenethoxybenzyl)-1,2,4-oxadiazo...)
Affinity DataKi:  5.40nMAssay Description:Binding affinity to human tryptase beta2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H1 receptor(RAT)
Schering-Plough

Curated by ChEMBL
LigandPNGBDBM35938(1-(p-chlorophenyl)-1-(2-pyridyl)-3-N,N-dimethylpro...)
Affinity DataKi:  5.5nMAssay Description:Binding affinity against Histamine H1 receptor using receptor binding assay in rat brain membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptase(Rattus norvegicus)
Celera Genomics

Curated by ChEMBL
LigandPNGBDBM50187800((S)-ethyl 1-(5-(4-phenethoxybenzyl)-1,2,4-oxadiazo...)
Affinity DataKi:  5.5nMAssay Description:Binding affinity to rat tryptaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H1 receptor(RAT)
Schering-Plough

Curated by ChEMBL
LigandPNGBDBM35938(1-(p-chlorophenyl)-1-(2-pyridyl)-3-N,N-dimethylpro...)
Affinity DataKi:  5.5nMAssay Description:Binding affinity to histamine H1 receptor in rat brain membranes was evaluated using [3H]-pyrilamine as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDimer of Tryptase beta-2(Homo sapiens (Human))
Celera

Curated by ChEMBL
LigandPNGBDBM50187172((S)-benzyl 6-amino-1-oxo-1-(5-((4-(4-phenylbutyl)p...)
Affinity DataKi:  5.80nMAssay Description:Inhibition of human beta tryptaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptase beta-2(Homo sapiens (Human))
Celera

LigandPNGBDBM14316((2R)-N-[(2S)-1-(5-{[4-(2,3-dihydro-1H-inden-2-ylca...)
Affinity DataKi:  6nMAssay Description:Each enzyme was assayed with a set of different concentrations of each inhibitor. After addition of the appropriate substrate, the rate of hydrolysis...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H1 receptor(RAT)
Schering-Plough

Curated by ChEMBL
LigandPNGBDBM50063449(8-Chloro-11-piperazin-1-yl-6,11-dihydro-5H-benzo[5...)
Affinity DataKi:  6.40nMAssay Description:Binding affinity against Histamine H1 receptor using receptor binding assay in rat brain membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H1 receptor(RAT)
Schering-Plough

Curated by ChEMBL
LigandPNGBDBM50073184(8-Chloro-11-(4-methyl-piperazin-1-yl)-6,11-dihydro...)
Affinity DataKi:  6.5nMAssay Description:Binding affinity against Histamine H1 receptor using receptor binding assay in rat brain membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(GUINEA PIG)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50069818(4-((2R,3S)-2-Methyl-azetidin-3-yl)-1H-imidazole | ...)
Affinity DataKi:  7nMAssay Description:Inhibition of [3H]-N-alpha-methylhistamine binding to guinea pig brain Histamine H3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(GUINEA PIG)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50071496(CHEMBL73053 | N-(4-Chloro-benzyl)-2-[4-(1H-imidazo...)
Affinity DataKi:  7.20nMAssay Description:Inhibition of N-alpha-methylhistamine binding to histamine H3 receptor of guinea pig brain membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(GUINEA PIG)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM22914(CHEMBL260374 | N-cyclohexyl-4-(1H-imidazol-5-yl)pi...)
Affinity DataKi:  7.30nMAssay Description:Inhibition of N-alpha-methylhistamine binding to histamine H3 receptor of guinea pig brain membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDimer of Tryptase beta-2(Homo sapiens (Human))
Celera

Curated by ChEMBL
LigandPNGBDBM50187178((S)-benzyl 1-(5-(4-((3-(trifluoromethyl)phenethyl)...)
Affinity DataKi:  8.20nMAssay Description:Inhibition of human beta tryptaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDimer of Tryptase beta-2(Homo sapiens (Human))
Celera

Curated by ChEMBL
LigandPNGBDBM50187151((S)-benzyl 1-(5-(4-(isopentylcarbamoyl)benzyl)-1,2...)
Affinity DataKi:  9.90nMAssay Description:Inhibition of human beta tryptaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H1 receptor(RAT)
Schering-Plough

Curated by ChEMBL
LigandPNGBDBM50281832(1-[4-(3-Bromo-8-chloro-5,6-dihydro-benzo[5,6]cyclo...)
Affinity DataKi:  10nMAssay Description:Ability to displace [3H]-pyrilamine from H1 receptor in rat brain membrane.More data for this Ligand-Target Pair
In DepthDetails Article
TargetDimer of Tryptase beta-2(Homo sapiens (Human))
Celera

Curated by ChEMBL
LigandPNGBDBM50187175((S)-benzyl 6-amino-1-oxo-1-(5-((4-(3-phenylpropyl)...)
Affinity DataKi:  11nMAssay Description:Inhibition of human beta tryptaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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