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Found 84 with Last Name = 'hammonds' and Initial = 't'
TargetLIM domain kinase 1(Homo sapiens (Human))
Cancer Research Technology

Curated by ChEMBL
LigandPNGBDBM50124354(CHEMBL3623439)
Affinity DataIC50:  0.300nMAssay Description:Inhibition of recombinant N-terminal 6His-tagged LIMK1 (unknown origin) expressed in Sf21 cells by HTRF assay using cofilin as a substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLIM domain kinase 2(Homo sapiens (Human))
Cancer Research Technology

Curated by ChEMBL
LigandPNGBDBM50124354(CHEMBL3623439)
Affinity DataIC50:  1nMAssay Description:Inhibition of human N-terminal GST-tagged LIMK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLIM domain kinase 1(Homo sapiens (Human))
Cancer Research Technology

Curated by ChEMBL
LigandPNGBDBM50124355(CHEMBL3623442)
Affinity DataIC50:  1nMAssay Description:Inhibition of recombinant N-terminal 6His-tagged LIMK1 (unknown origin) expressed in Sf21 cells by HTRF assay using cofilin as a substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 5(Homo sapiens (Human))
Newcastle University

Curated by ChEMBL
LigandPNGBDBM50434072(CHEMBL2381342)
Affinity DataIC50:  1.5nMAssay Description:Inhibition of GST-tagged MEK5 (unknown origin) expressed in baculovirus expression system incubated for 90 mins by HTS assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLIM domain kinase 2(Homo sapiens (Human))
Cancer Research Technology

Curated by ChEMBL
LigandPNGBDBM50124355(CHEMBL3623442)
Affinity DataIC50:  3nMAssay Description:Inhibition of human N-terminal GST-tagged LIMK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLIM domain kinase 1(Homo sapiens (Human))
Cancer Research Technology

Curated by ChEMBL
LigandPNGBDBM50124352(CHEMBL3623441)
Affinity DataIC50:  3nMAssay Description:Inhibition of recombinant N-terminal 6His-tagged LIMK1 (unknown origin) expressed in Sf21 cells by HTRF assay using cofilin as a substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLIM domain kinase 1(Homo sapiens (Human))
Cancer Research Technology

Curated by ChEMBL
LigandPNGBDBM50124400(CHEMBL3623438)
Affinity DataIC50:  3nMAssay Description:Inhibition of recombinant N-terminal 6His-tagged LIMK1 (unknown origin) expressed in Sf21 cells by HTRF assay using cofilin as a substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLIM domain kinase 1(Homo sapiens (Human))
Cancer Research Technology

Curated by ChEMBL
LigandPNGBDBM50124399(CHEMBL3623437)
Affinity DataIC50:  4nMAssay Description:Inhibition of recombinant N-terminal 6His-tagged LIMK1 (unknown origin) expressed in Sf21 cells by HTRF assay using cofilin as a substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLIM domain kinase 1(Homo sapiens (Human))
Cancer Research Technology

Curated by ChEMBL
LigandPNGBDBM50124397(CHEMBL3623435)
Affinity DataIC50:  5nMAssay Description:Inhibition of recombinant N-terminal 6His-tagged LIMK1 (unknown origin) expressed in Sf21 cells by HTRF assay using cofilin as a substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLIM domain kinase 1(Homo sapiens (Human))
Cancer Research Technology

Curated by ChEMBL
LigandPNGBDBM50124353(CHEMBL3623443)
Affinity DataIC50:  8nMAssay Description:Inhibition of recombinant N-terminal 6His-tagged LIMK1 (unknown origin) expressed in Sf21 cells by HTRF assay using cofilin as a substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 7(Homo sapiens (Human))
Newcastle University

Curated by ChEMBL
LigandPNGBDBM50508013(CHEMBL4541479)
Affinity DataIC50:  8nMAssay Description:Inhibition of ERK5 in human HeLa cells by KiNativ profiling methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLIM domain kinase 1(Homo sapiens (Human))
Cancer Research Technology

Curated by ChEMBL
LigandPNGBDBM50124363(CHEMBL3622874)
Affinity DataIC50:  13nMAssay Description:Inhibition of recombinant N-terminal 6His-tagged LIMK1 (unknown origin) expressed in Sf21 cells by HTRF assay using cofilin as a substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLIM domain kinase 1(Homo sapiens (Human))
Cancer Research Technology

Curated by ChEMBL
LigandPNGBDBM50124356(CHEMBL3622867)
Affinity DataIC50:  15nMAssay Description:Inhibition of recombinant N-terminal 6His-tagged LIMK1 (unknown origin) expressed in Sf21 cells by HTRF assay using cofilin as a substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLIM domain kinase 1(Homo sapiens (Human))
Cancer Research Technology

Curated by ChEMBL
LigandPNGBDBM50124351(CHEMBL3623440)
Affinity DataIC50:  20nMAssay Description:Inhibition of recombinant N-terminal 6His-tagged LIMK1 (unknown origin) expressed in Sf21 cells by HTRF assay using cofilin as a substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLIM domain kinase 1(Homo sapiens (Human))
Cancer Research Technology

Curated by ChEMBL
LigandPNGBDBM50124362(CHEMBL3622873)
Affinity DataIC50:  37nMAssay Description:Inhibition of recombinant N-terminal 6His-tagged LIMK1 (unknown origin) expressed in Sf21 cells by HTRF assay using cofilin as a substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLIM domain kinase 1(Homo sapiens (Human))
Cancer Research Technology

Curated by ChEMBL
LigandPNGBDBM50124398(CHEMBL3623436)
Affinity DataIC50:  40nMAssay Description:Inhibition of recombinant N-terminal 6His-tagged LIMK1 (unknown origin) expressed in Sf21 cells by HTRF assay using cofilin as a substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLIM domain kinase 2(Homo sapiens (Human))
Cancer Research Technology

Curated by ChEMBL
LigandPNGBDBM50124353(CHEMBL3623443)
Affinity DataIC50:  48nMAssay Description:Inhibition of human N-terminal GST-tagged LIMK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 7(Homo sapiens (Human))
Newcastle University

Curated by ChEMBL
LigandPNGBDBM50434072(CHEMBL2381342)
Affinity DataIC50:  59nMAssay Description:Inhibition of GST-tagged ERK5 (unknown origin) expressed in baculovirus expression system incubated for 90 mins by HTS assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLIM domain kinase 1(Homo sapiens (Human))
Cancer Research Technology

Curated by ChEMBL
LigandPNGBDBM50124360(CHEMBL3622871)
Affinity DataIC50:  82nMAssay Description:Inhibition of recombinant N-terminal 6His-tagged LIMK1 (unknown origin) expressed in Sf21 cells by HTRF assay using cofilin as a substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLIM domain kinase 1(Homo sapiens (Human))
Cancer Research Technology

Curated by ChEMBL
LigandPNGBDBM50124396(CHEMBL3623434)
Affinity DataIC50:  120nMAssay Description:Inhibition of recombinant N-terminal 6His-tagged LIMK1 (unknown origin) expressed in Sf21 cells by HTRF assay using cofilin as a substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLIM domain kinase 1(Homo sapiens (Human))
Cancer Research Technology

Curated by ChEMBL
LigandPNGBDBM50124364(CHEMBL3622875)
Affinity DataIC50:  270nMAssay Description:Inhibition of recombinant N-terminal 6His-tagged LIMK1 (unknown origin) expressed in Sf21 cells by HTRF assay using cofilin as a substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 7(Homo sapiens (Human))
Newcastle University

Curated by ChEMBL
LigandPNGBDBM50337134(2-((2-ethoxy-4-(4-hydroxypiperidin-1-yl)phenyl)ami...)
Affinity DataIC50:  300nMAssay Description:Inhibition of ERK5 in human HeLa cells incubated for 15 mins prior to ATP addition by KiNativ profiling methodMore data for this Ligand-Target Pair
TargetLIM domain kinase 1(Homo sapiens (Human))
Cancer Research Technology

Curated by ChEMBL
LigandPNGBDBM50124403(CHEMBL3623445)
Affinity DataIC50:  327nMAssay Description:Inhibition of recombinant N-terminal 6His-tagged LIMK1 (unknown origin) expressed in Sf21 cells by HTRF assay using cofilin as a substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Newcastle University

Curated by ChEMBL
LigandPNGBDBM50516392(CHEMBL4526143)
Affinity DataIC50:  360nMAssay Description:Inhibition of recombinant N-terminal GST-tagged full length human p38alpha expressed in Escherichia coli cells assessed as substrate phosphorylation ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetLIM domain kinase 1(Homo sapiens (Human))
Cancer Research Technology

Curated by ChEMBL
LigandPNGBDBM50124357(CHEMBL3622868)
Affinity DataIC50:  500nMAssay Description:Inhibition of recombinant N-terminal 6His-tagged LIMK1 (unknown origin) expressed in Sf21 cells by HTRF assay using cofilin as a substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLIM domain kinase 1(Homo sapiens (Human))
Cancer Research Technology

Curated by ChEMBL
LigandPNGBDBM50124404(CHEMBL3623446)
Affinity DataIC50:  574nMAssay Description:Inhibition of recombinant N-terminal 6His-tagged LIMK1 (unknown origin) expressed in Sf21 cells by HTRF assay using cofilin as a substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Newcastle University

Curated by ChEMBL
LigandPNGBDBM50516390(CHEMBL4449117)
Affinity DataIC50:  580nMAssay Description:Inhibition of recombinant N-terminal GST-tagged full length human p38alpha expressed in Escherichia coli cells assessed as substrate phosphorylation ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 7(Homo sapiens (Human))
Newcastle University

Curated by ChEMBL
LigandPNGBDBM50516388(CHEMBL4453232)
Affinity DataIC50:  600nMAssay Description:Inhibition of recombinant N-terminal His-tagged human ERK5 (2 to 409 residues) co-expressed with GST-tagged human truncated MEK5DD lacking N-terminal...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 7(Homo sapiens (Human))
Newcastle University

Curated by ChEMBL
LigandPNGBDBM50516381(CHEMBL4557683)
Affinity DataIC50:  600nMAssay Description:Inhibition of recombinant N-terminal His-tagged human ERK5 (2 to 409 residues) co-expressed with GST-tagged human truncated MEK5DD lacking N-terminal...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetLIM domain kinase 1(Homo sapiens (Human))
Cancer Research Technology

Curated by ChEMBL
LigandPNGBDBM50124400(CHEMBL3623438)
Affinity DataIC50:  600nMAssay Description:Inhibition of LIMK1 in human ZR75-1 cells assessed as inhibition of cofilin phosphorylation after 5 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLIM domain kinase 1(Homo sapiens (Human))
Cancer Research Technology

Curated by ChEMBL
LigandPNGBDBM50124358(CHEMBL3622869)
Affinity DataIC50:  620nMAssay Description:Inhibition of recombinant N-terminal 6His-tagged LIMK1 (unknown origin) expressed in Sf21 cells by HTRF assay using cofilin as a substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 7(Homo sapiens (Human))
Newcastle University

Curated by ChEMBL
LigandPNGBDBM50516389(CHEMBL4527483)
Affinity DataIC50:  700nMAssay Description:Inhibition of recombinant N-terminal His-tagged human ERK5 (2 to 409 residues) co-expressed with GST-tagged human truncated MEK5DD lacking N-terminal...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetLIM domain kinase 1(Homo sapiens (Human))
Cancer Research Technology

Curated by ChEMBL
LigandPNGBDBM50124352(CHEMBL3623441)
Affinity DataIC50:  800nMAssay Description:Inhibition of LIMK1 in human ZR75-1 cells assessed as inhibition of cofilin phosphorylation after 5 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 7(Homo sapiens (Human))
Newcastle University

Curated by ChEMBL
LigandPNGBDBM50516382(CHEMBL4436895)
Affinity DataIC50:  820nMAssay Description:Inhibition of recombinant N-terminal His-tagged human ERK5 (2 to 409 residues) co-expressed with GST-tagged human truncated MEK5DD lacking N-terminal...More data for this Ligand-Target Pair
TargetLIM domain kinase 1(Homo sapiens (Human))
Cancer Research Technology

Curated by ChEMBL
LigandPNGBDBM50124359(CHEMBL3622870)
Affinity DataIC50:  850nMAssay Description:Inhibition of recombinant N-terminal 6His-tagged LIMK1 (unknown origin) expressed in Sf21 cells by HTRF assay using cofilin as a substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 7(Homo sapiens (Human))
Newcastle University

Curated by ChEMBL
LigandPNGBDBM50516386(CHEMBL4443724)
Affinity DataIC50:  900nMAssay Description:Inhibition of recombinant N-terminal His-tagged human ERK5 (2 to 409 residues) co-expressed with GST-tagged human truncated MEK5DD lacking N-terminal...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 7(Homo sapiens (Human))
Newcastle University

Curated by ChEMBL
LigandPNGBDBM50516387(CHEMBL4515859)
Affinity DataIC50:  1.10E+3nMAssay Description:Inhibition of recombinant N-terminal His-tagged human ERK5 (2 to 409 residues) co-expressed with GST-tagged human truncated MEK5DD lacking N-terminal...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetLIM domain kinase 1(Homo sapiens (Human))
Cancer Research Technology

Curated by ChEMBL
LigandPNGBDBM50124351(CHEMBL3623440)
Affinity DataIC50:  1.40E+3nMAssay Description:Inhibition of LIMK1 in human ZR75-1 cells assessed as inhibition of cofilin phosphorylation after 5 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLIM domain kinase 1(Homo sapiens (Human))
Cancer Research Technology

Curated by ChEMBL
LigandPNGBDBM50124397(CHEMBL3623435)
Affinity DataIC50:  1.50E+3nMAssay Description:Inhibition of LIMK1 in human ZR75-1 cells assessed as inhibition of cofilin phosphorylation after 5 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLIM domain kinase 1(Homo sapiens (Human))
Cancer Research Technology

Curated by ChEMBL
LigandPNGBDBM50124353(CHEMBL3623443)
Affinity DataIC50:  2.00E+3nMAssay Description:Inhibition of LIMK1 in human ZR75-1 cells assessed as inhibition of cofilin phosphorylation after 5 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 7(Homo sapiens (Human))
Newcastle University

Curated by ChEMBL
LigandPNGBDBM50516380(CHEMBL4443714)
Affinity DataIC50:  2.00E+3nMAssay Description:Inhibition of ERK5 (unknown origin) using R7129 as substrate incubated for 2 hrs by IMAP fluorescence polarization analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetLIM domain kinase 1(Homo sapiens (Human))
Cancer Research Technology

Curated by ChEMBL
LigandPNGBDBM50124399(CHEMBL3623437)
Affinity DataIC50:  2.10E+3nMAssay Description:Inhibition of LIMK1 in human ZR75-1 cells assessed as inhibition of cofilin phosphorylation after 5 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLIM domain kinase 1(Homo sapiens (Human))
Cancer Research Technology

Curated by ChEMBL
LigandPNGBDBM50124362(CHEMBL3622873)
Affinity DataIC50:  2.20E+3nMAssay Description:Inhibition of LIMK1 in human ZR75-1 cells assessed as inhibition of cofilin phosphorylation after 5 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 7(Homo sapiens (Human))
Newcastle University

Curated by ChEMBL
LigandPNGBDBM50516381(CHEMBL4557683)
Affinity DataIC50:  2.30E+3nMAssay Description:Inhibition of HA-tagged ERK5 (unknown origin) coexpressed with mutationally activated EGFP-MEK5D and Gal4-MEF2D in HEK293 cells assessed as reduction...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Newcastle University

Curated by ChEMBL
LigandPNGBDBM50516394(CHEMBL4458451)
Affinity DataIC50:  2.40E+3nMAssay Description:Inhibition of recombinant N-terminal GST-tagged full length human p38alpha expressed in Escherichia coli cells assessed as substrate phosphorylation ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetLIM domain kinase 1(Homo sapiens (Human))
Cancer Research Technology

Curated by ChEMBL
LigandPNGBDBM50124363(CHEMBL3622874)
Affinity DataIC50:  2.50E+3nMAssay Description:Inhibition of LIMK1 in human ZR75-1 cells assessed as inhibition of cofilin phosphorylation after 5 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 7(Homo sapiens (Human))
Newcastle University

Curated by ChEMBL
LigandPNGBDBM50516382(CHEMBL4436895)
Affinity DataIC50:  3.00E+3nMAssay Description:Inhibition of HA-tagged ERK5 (unknown origin) coexpressed with mutationally activated EGFP-MEK5D and Gal4-MEF2D in HEK293 cells assessed as reduction...More data for this Ligand-Target Pair
TargetLIM domain kinase 1(Homo sapiens (Human))
Cancer Research Technology

Curated by ChEMBL
LigandPNGBDBM50124365(CHEMBL3623433)
Affinity DataIC50:  3.10E+3nMAssay Description:Inhibition of recombinant N-terminal 6His-tagged LIMK1 (unknown origin) expressed in Sf21 cells by HTRF assay using cofilin as a substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLIM domain kinase 1(Homo sapiens (Human))
Cancer Research Technology

Curated by ChEMBL
LigandPNGBDBM50124361(CHEMBL3622872)
Affinity DataIC50:  3.30E+3nMAssay Description:Inhibition of recombinant N-terminal 6His-tagged LIMK1 (unknown origin) expressed in Sf21 cells by HTRF assay using cofilin as a substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLIM domain kinase 1(Homo sapiens (Human))
Cancer Research Technology

Curated by ChEMBL
LigandPNGBDBM50124356(CHEMBL3622867)
Affinity DataIC50:  3.80E+3nMAssay Description:Inhibition of LIMK1 in human ZR75-1 cells assessed as inhibition of cofilin phosphorylation after 5 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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