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Found 75 with Last Name = 'holt' and Initial = 'dp'
TargetNeuronal acetylcholine receptor subunit alpha-2(Rattus norvegicus (Rat))
The Johns Hopkins University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50295955(5-(((S)-Pyrrolidin-2-yl)methoxy)-3-((6-chloropyrid...)
Affinity DataKi:  0.00560nMAssay Description:Displacement of [3H]epibatidine from rat alpha2beta2 nicotinic receptor expressed in human HEK293 cells by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-2(Rattus norvegicus (Rat))
The Johns Hopkins University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50295954(2-Chloro-3-(2-fluoro-4-(pyridinyl)methoxy)-5-((1-m...)
Affinity DataKi:  0.0220nMAssay Description:Displacement of [3H]epibatidine from rat alpha2beta2 nicotinic receptor expressed in human HEK293 cells by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-2(Rattus norvegicus (Rat))
The Johns Hopkins University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50049757(()-2-(6-Chloro-pyridin-3-yl)-7-aza-bicyclo[2.2.1]h...)
Affinity DataKi:  0.0250nMAssay Description:Displacement of [3H]epibatidine from rat alpha2beta2 nicotinic receptor expressed in human HEK293 cells by liquid scintillation countingMore data for this Ligand-Target Pair
TargetNeuronal acetylcholine receptor subunit alpha-4(Rattus norvegicus (Rat))
The Johns Hopkins University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50295955(5-(((S)-Pyrrolidin-2-yl)methoxy)-3-((6-chloropyrid...)
Affinity DataKi:  0.0280nMAssay Description:Displacement of [3H]epibatidine from rat alpha4beta2 nicotinic receptor expressed in human HEK293 cells by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-4(Rattus norvegicus (Rat))
The Johns Hopkins University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50295959((S)-2-chloro-5-((1-methylpyrrolidin-2-yl)methoxy)-...)
Affinity DataKi:  0.0280nMAssay Description:Displacement of [125I]5-A-85380 from alpha4beta2 nicotinic receptor in rat brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-2(Rattus norvegicus (Rat))
The Johns Hopkins University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50295956(2-Chloro-3-(2-chloro-5-(pyridinyl)methoxy)-5-((1-m...)
Affinity DataKi:  0.0310nMAssay Description:Displacement of [3H]epibatidine from rat alpha2beta2 nicotinic receptor expressed in human HEK293 cells by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-3(Rattus norvegicus (Rat))
The Johns Hopkins University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50049757(()-2-(6-Chloro-pyridin-3-yl)-7-aza-bicyclo[2.2.1]h...)
Affinity DataKi:  0.0350nMAssay Description:Displacement of [3H]epibatidine from rat alpha3beta2 nicotinic receptor expressed in human HEK293 cells by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-2(Rattus norvegicus (Rat))
The Johns Hopkins University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50295953(2-Chloro-3-(2-fluoro-4-(pyridinyl)methoxy)-5-(2-(S...)
Affinity DataKi:  0.0350nMAssay Description:Displacement of [3H]epibatidine from rat alpha2beta2 nicotinic receptor expressed in human HEK293 cells by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-3(Rattus norvegicus (Rat))
The Johns Hopkins University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50295955(5-(((S)-Pyrrolidin-2-yl)methoxy)-3-((6-chloropyrid...)
Affinity DataKi:  0.0410nMAssay Description:Displacement of [3H]epibatidine from rat alpha3beta2 nicotinic receptor expressed in human HEK293 cells by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-2(Rattus norvegicus (Rat))
The Johns Hopkins University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50295958((S)-2-chloro-2'-fluoro-5-((1-methylpyrrolidin-2-yl...)
Affinity DataKi:  0.0500nMAssay Description:Displacement of [3H]epibatidine from rat alpha2beta2 nicotinic receptor expressed in human HEK293 cells by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-4(Rattus norvegicus (Rat))
The Johns Hopkins University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50295956(2-Chloro-3-(2-chloro-5-(pyridinyl)methoxy)-5-((1-m...)
Affinity DataKi:  0.0550nMAssay Description:Displacement of [3H]epibatidine from rat alpha4beta2 nicotinic receptor expressed in human HEK293 cells by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-4(Rattus norvegicus (Rat))
The Johns Hopkins University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50049757(()-2-(6-Chloro-pyridin-3-yl)-7-aza-bicyclo[2.2.1]h...)
Affinity DataKi:  0.0610nMAssay Description:Displacement of [3H]epibatidine from rat alpha4beta2 nicotinic receptor expressed in human HEK293 cells by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-4(Rattus norvegicus (Rat))
The Johns Hopkins University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50295958((S)-2-chloro-2'-fluoro-5-((1-methylpyrrolidin-2-yl...)
Affinity DataKi:  0.0620nMAssay Description:Displacement of [3H]epibatidine from rat alpha4beta2 nicotinic receptor expressed in human HEK293 cells by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-4(Rattus norvegicus (Rat))
The Johns Hopkins University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50295954(2-Chloro-3-(2-fluoro-4-(pyridinyl)methoxy)-5-((1-m...)
Affinity DataKi:  0.0620nMAssay Description:Displacement of [3H]epibatidine from rat alpha4beta2 nicotinic receptor expressed in human HEK293 cells by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-2(Rattus norvegicus (Rat))
The Johns Hopkins University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50049757(()-2-(6-Chloro-pyridin-3-yl)-7-aza-bicyclo[2.2.1]h...)
Affinity DataKi:  0.0950nMAssay Description:Displacement of [3H]epibatidine from rat alpha2beta4 nicotinic receptor expressed in human HEK293 cells by liquid scintillation countingMore data for this Ligand-Target Pair
TargetNeuronal acetylcholine receptor subunit alpha-4(Rattus norvegicus (Rat))
The Johns Hopkins University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50295953(2-Chloro-3-(2-fluoro-4-(pyridinyl)methoxy)-5-(2-(S...)
Affinity DataKi:  0.130nMAssay Description:Displacement of [3H]epibatidine from rat alpha4beta2 nicotinic receptor expressed in human HEK293 cells by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-4(Rattus norvegicus (Rat))
The Johns Hopkins University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50049757(()-2-(6-Chloro-pyridin-3-yl)-7-aza-bicyclo[2.2.1]h...)
Affinity DataKi:  0.160nMAssay Description:Displacement of [3H]epibatidine from rat alpha4beta4 nicotinic receptor expressed in human HEK293 cells by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-3(Rattus norvegicus (Rat))
The Johns Hopkins University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50295953(2-Chloro-3-(2-fluoro-4-(pyridinyl)methoxy)-5-(2-(S...)
Affinity DataKi:  0.25nMAssay Description:Displacement of [3H]epibatidine from rat alpha3beta2 nicotinic receptor expressed in human HEK293 cells by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-3(Rattus norvegicus (Rat))
The Johns Hopkins University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50295956(2-Chloro-3-(2-chloro-5-(pyridinyl)methoxy)-5-((1-m...)
Affinity DataKi:  0.260nMAssay Description:Displacement of [3H]epibatidine from rat alpha3beta2 nicotinic receptor expressed in human HEK293 cells by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-3(Rattus norvegicus (Rat))
The Johns Hopkins University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50295954(2-Chloro-3-(2-fluoro-4-(pyridinyl)methoxy)-5-((1-m...)
Affinity DataKi:  0.330nMAssay Description:Displacement of [3H]epibatidine from rat alpha3beta2 nicotinic receptor expressed in human HEK293 cells by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-4(Rattus norvegicus (Rat))
The Johns Hopkins University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50295955(5-(((S)-Pyrrolidin-2-yl)methoxy)-3-((6-chloropyrid...)
Affinity DataKi:  0.490nMAssay Description:Displacement of [3H]epibatidine from rat alpha4beta4 nicotinic receptor expressed in human HEK293 cells by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-3(Rattus norvegicus (Rat))
The Johns Hopkins University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50049757(()-2-(6-Chloro-pyridin-3-yl)-7-aza-bicyclo[2.2.1]h...)
Affinity DataKi:  0.570nMAssay Description:Displacement of [3H]epibatidine from rat alpha3beta4 nicotinic receptor expressed in human HEK293 cells by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-3(Rattus norvegicus (Rat))
The Johns Hopkins University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50295958((S)-2-chloro-2'-fluoro-5-((1-methylpyrrolidin-2-yl...)
Affinity DataKi:  0.710nMAssay Description:Displacement of [3H]epibatidine from rat alpha3beta2 nicotinic receptor expressed in human HEK293 cells by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-3(Rattus norvegicus (Rat))
The Johns Hopkins University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50295957(2-Chloro-3-(2-chloro-5-(pyridinyl)methoxy)-5-((1-m...)
Affinity DataKi:  0.850nMAssay Description:Displacement of [3H]epibatidine from rat alpha3beta2 nicotinic receptor expressed in human HEK293 cells by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-4(Rattus norvegicus (Rat))
The Johns Hopkins University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50295957(2-Chloro-3-(2-chloro-5-(pyridinyl)methoxy)-5-((1-m...)
Affinity DataKi:  1.10nMAssay Description:Displacement of [3H]epibatidine from rat alpha4beta2 nicotinic receptor expressed in human HEK293 cells by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-4(Rattus norvegicus (Rat))
The Johns Hopkins University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50295953(2-Chloro-3-(2-fluoro-4-(pyridinyl)methoxy)-5-(2-(S...)
Affinity DataKi:  1.10nMAssay Description:Displacement of [3H]epibatidine from rat alpha4beta4 nicotinic receptor expressed in human HEK293 cells by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-4(Rattus norvegicus (Rat))
The Johns Hopkins University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50066788((S)-3-(azetidin-2-ylmethoxy)-2-fluoropyridine | 3-...)
Affinity DataKi:  1.30nMAssay Description:Displacement of [3H]epibatidine from rat alpha4beta2 nicotinic receptor expressed in human HEK293 cells by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-2(Rattus norvegicus (Rat))
The Johns Hopkins University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50066788((S)-3-(azetidin-2-ylmethoxy)-2-fluoropyridine | 3-...)
Affinity DataKi:  1.40nMAssay Description:Displacement of [3H]epibatidine from rat alpha2beta2 nicotinic receptor expressed in human HEK293 cells by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-2(Rattus norvegicus (Rat))
The Johns Hopkins University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50295957(2-Chloro-3-(2-chloro-5-(pyridinyl)methoxy)-5-((1-m...)
Affinity DataKi:  1.5nMAssay Description:Displacement of [3H]epibatidine from rat alpha2beta2 nicotinic receptor expressed in human HEK293 cells by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-4(Rattus norvegicus (Rat))
The Johns Hopkins University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50295954(2-Chloro-3-(2-fluoro-4-(pyridinyl)methoxy)-5-((1-m...)
Affinity DataKi:  1.60nMAssay Description:Displacement of [3H]epibatidine from rat alpha4beta4 nicotinic receptor expressed in human HEK293 cells by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmyloid-beta precursor protein(Homo sapiens (Human))
University Of Pittsburgh

Curated by ChEMBL
LigandPNGBDBM50129794(CHEMBL328660 | [4-(6-Bromo-benzothiazol-2-yl)-phen...)
Affinity DataKi:  1.70nMAssay Description:Binding affinity for Amyloid beta 1-40 aggregates in competition with [N-methyl-3H] BTA-1.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmyloid-beta precursor protein(Homo sapiens (Human))
University Of Pittsburgh

Curated by ChEMBL
LigandPNGBDBM50129784(4-(6-Methoxybenzo[d]thiazol-2-yl)-N,N-dimethylanil...)
Affinity DataKi:  1.90nMAssay Description:Binding affinity for Amyloid beta 1-40 aggregates in competition with [N-methyl-3H] BTA-1.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmyloid-beta precursor protein(Homo sapiens (Human))
University Of Pittsburgh

Curated by ChEMBL
LigandPNGBDBM50100133(CHEMBL55401 | [4-(6-Bromo-benzothiazol-2-yl)-pheny...)
Affinity DataKi:  2.90nMAssay Description:Binding affinity for Amyloid beta 1-40 aggregates in competition with [N-methyl-3H] BTA-1.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-3(Rattus norvegicus (Rat))
The Johns Hopkins University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50066788((S)-3-(azetidin-2-ylmethoxy)-2-fluoropyridine | 3-...)
Affinity DataKi:  3nMAssay Description:Displacement of [3H]epibatidine from rat alpha3beta2 nicotinic receptor expressed in human HEK293 cells by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmyloid-beta precursor protein(Homo sapiens (Human))
University Of Pittsburgh

Curated by ChEMBL
LigandPNGBDBM50129791((4-Benzothiazol-2-yl-phenyl)-dimethyl-amine | 4-(B...)
Affinity DataKi:  4nMAssay Description:Binding affinity for Amyloid beta 1-40 aggregates in competition with [N-methyl-3H] BTA-1.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-2(Rattus norvegicus (Rat))
The Johns Hopkins University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50295955(5-(((S)-Pyrrolidin-2-yl)methoxy)-3-((6-chloropyrid...)
Affinity DataKi:  4.10nMAssay Description:Displacement of [3H]epibatidine from rat alpha2beta4 nicotinic receptor expressed in human HEK293 cells by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmyloid-beta precursor protein(Homo sapiens (Human))
University Of Pittsburgh

Curated by ChEMBL
LigandPNGBDBM50129793(2-(4''-methylaminophenyl)-6-hydroxybenzothiazole |...)
Affinity DataKi:  4.30nMAssay Description:Binding affinity for Amyloid beta 1-40 aggregates in competition with [N-methyl-3H] BTA-1.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmyloid-beta precursor protein(Homo sapiens (Human))
University Of Pittsburgh

Curated by ChEMBL
LigandPNGBDBM50129792(2-(4-Dimethylamino-phenyl)-benzothiazol-6-ol | CHE...)
Affinity DataKi:  4.40nMAssay Description:Binding affinity for Amyloid beta 1-40 aggregates in competition with [N-methyl-3H] BTA-1.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmyloid-beta precursor protein(Homo sapiens (Human))
University Of Pittsburgh

Curated by ChEMBL
LigandPNGBDBM50129786(CHEMBL94230 | [4-(6-Methoxy-benzothiazol-2-yl)-phe...)
Affinity DataKi:  4.90nMAssay Description:Binding affinity for Amyloid beta 1-40 aggregates in competition with [N-methyl-3H] BTA-1.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-4(Rattus norvegicus (Rat))
The Johns Hopkins University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50295956(2-Chloro-3-(2-chloro-5-(pyridinyl)methoxy)-5-((1-m...)
Affinity DataKi:  6.60nMAssay Description:Displacement of [3H]epibatidine from rat alpha4beta4 nicotinic receptor expressed in human HEK293 cells by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmyloid-beta precursor protein(Homo sapiens (Human))
University Of Pittsburgh

Curated by ChEMBL
LigandPNGBDBM50052701(2-(4-Aminophenyl)-6-methoxybenzothiazole | 4-(6-Me...)
Affinity DataKi:  7nMAssay Description:Binding affinity for Amyloid beta 1-40 aggregates in competition with [N-methyl-3H] BTA-1.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmyloid-beta precursor protein(Homo sapiens (Human))
University Of Pittsburgh

Curated by ChEMBL
LigandPNGBDBM50129783(4-(6-Bromo-benzothiazol-2-yl)-phenylamine | CHEMBL...)
Affinity DataKi:  7.20nMAssay Description:Binding affinity for Amyloid beta 1-40 aggregates in competition with [N-methyl-3H] BTA-1.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-4(Rattus norvegicus (Rat))
The Johns Hopkins University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50295957(2-Chloro-3-(2-chloro-5-(pyridinyl)methoxy)-5-((1-m...)
Affinity DataKi:  7.60nMAssay Description:Displacement of [3H]epibatidine from rat alpha4beta4 nicotinic receptor expressed in human HEK293 cells by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-2(Rattus norvegicus (Rat))
The Johns Hopkins University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50295953(2-Chloro-3-(2-fluoro-4-(pyridinyl)methoxy)-5-(2-(S...)
Affinity DataKi:  8.20nMAssay Description:Displacement of [3H]epibatidine from rat alpha2beta4 nicotinic receptor expressed in human HEK293 cells by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmyloid-beta precursor protein(Homo sapiens (Human))
University Of Pittsburgh

Curated by ChEMBL
LigandPNGBDBM50129787(2-(4-Methylamino-phenyl)-benzothiazole-6-carbonitr...)
Affinity DataKi:  8.60nMAssay Description:Binding affinity for Amyloid beta 1-40 aggregates in competition with [N-methyl-3H] BTA-1.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmyloid-beta precursor protein(Homo sapiens (Human))
University Of Pittsburgh

Curated by ChEMBL
LigandPNGBDBM50129788(2-(4-Aminophenyl)-6-methylbenzothiazole | 4-(6-Met...)
Affinity DataKi:  9.5nMAssay Description:Binding affinity for Amyloid beta 1-40 aggregates in competition with [N-methyl-3H] BTA-1.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmyloid-beta precursor protein(Homo sapiens (Human))
University Of Pittsburgh

Curated by ChEMBL
LigandPNGBDBM50109051(CHEMBL330529 | Methyl-[4-(6-methyl-benzothiazol-2-...)
Affinity DataKi:  10nMAssay Description:Binding affinity for Amyloid beta 1-40 aggregates in competition with [N-methyl-3H] BTA-1.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-4(Rattus norvegicus (Rat))
The Johns Hopkins University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM82070(CAS_29790-52-1 | NICOTINE-L (BASE) | Nicotine-D sa...)
Affinity DataKi:  10nMAssay Description:Displacement of [3H]epibatidine from rat alpha4beta2 nicotinic receptor expressed in human HEK293 cells by liquid scintillation countingMore data for this Ligand-Target Pair
TargetNeuronal acetylcholine receptor subunit alpha-2(Rattus norvegicus (Rat))
The Johns Hopkins University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50295954(2-Chloro-3-(2-fluoro-4-(pyridinyl)methoxy)-5-((1-m...)
Affinity DataKi:  11nMAssay Description:Displacement of [3H]epibatidine from rat alpha2beta4 nicotinic receptor expressed in human HEK293 cells by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmyloid-beta precursor protein(Homo sapiens (Human))
University Of Pittsburgh

Curated by ChEMBL
LigandPNGBDBM50129785(2-(4-Dimethylamino-phenyl)-benzothiazole-6-carboni...)
Affinity DataKi:  11nMAssay Description:Binding affinity for Amyloid beta 1-40 aggregates in competition with [N-methyl-3H] BTA-1.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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