Affinity DataIC50: 10nMAssay Description:Inhibition of DGAT1 in human adipose tissue assessed as reduction in triacylglycerol synthesisMore data for this Ligand-Target Pair
Affinity DataIC50: 10nMAssay Description:Inhibition of DGAT1 in human HuTu80 cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 30nMAssay Description:Inhibition of human recombinant DGAT1 expressed in Sf9 cells by liquid scintillographyMore data for this Ligand-Target Pair
Affinity DataIC50: 30nMAssay Description:Inhibition of human recombinant DGAT1 expressed in Sf9 cells by liquid scintillographyMore data for this Ligand-Target Pair
Affinity DataIC50: 30nMAssay Description:Inhibition of human recombinant DGAT1 expressed in Sf9 cells by liquid scintillographyMore data for this Ligand-Target Pair
Affinity DataIC50: 40nMAssay Description:Inhibition of human recombinant DGAT1 expressed in Sf9 cells by liquid scintillographyMore data for this Ligand-Target Pair
TargetAcetyl-CoA carboxylase 2(Homo sapiens (Human))
Astrazeneca Research And Development
Curated by ChEMBL
Astrazeneca Research And Development
Curated by ChEMBL
Affinity DataIC50: 52nMAssay Description:Inhibition of human recombinant his-tagged ACC2 expressed in baculovirus/Sf9 cell assessed as inorganic phosphate formation preincubated for 15 mins ...More data for this Ligand-Target Pair
Affinity DataIC50: 60nMAssay Description:Inhibition of DGAT1 in dog liver microsomesMore data for this Ligand-Target Pair
Affinity DataIC50: 60nMAssay Description:Inhibition of human recombinant DGAT1 expressed in Sf9 cells by liquid scintillographyMore data for this Ligand-Target Pair
Affinity DataIC50: 60nMAssay Description:Inhibition of human recombinant DGAT1 expressed in Sf9 cells by liquid scintillographyMore data for this Ligand-Target Pair
Affinity DataIC50: 70nMAssay Description:Inhibition of human recombinant DGAT1 expressed in Sf9 cells by liquid scintillographyMore data for this Ligand-Target Pair
Affinity DataIC50: 70nMAssay Description:Inhibition of DGAT1 in human liver microsomesMore data for this Ligand-Target Pair
Affinity DataIC50: 80nMAssay Description:Inhibition of human recombinant DGAT1 expressed in Sf9 cells by liquid scintillographyMore data for this Ligand-Target Pair
Affinity DataIC50: 80nMAssay Description:Inhibition of human recombinant DGAT1 expressed in Sf9 cells by liquid scintillographyMore data for this Ligand-Target Pair
Affinity DataIC50: 83nMAssay Description:Antagonist activity at human recombinant P2Y12 receptor expressed in platelet cell membrane by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
TargetAcetyl-CoA carboxylase 2(Homo sapiens (Human))
Astrazeneca Research And Development
Curated by ChEMBL
Astrazeneca Research And Development
Curated by ChEMBL
Affinity DataIC50: 89nMAssay Description:Inhibition of human recombinant his-tagged ACC2 expressed in baculovirus/Sf9 cell assessed as inorganic phosphate formation preincubated for 15 mins ...More data for this Ligand-Target Pair
Affinity DataIC50: 90nMAssay Description:Inhibition of DGAT1 in rat adipose tissue assessed as reduction in triacylglycerol synthesisMore data for this Ligand-Target Pair
TargetAcetyl-CoA carboxylase 2(Homo sapiens (Human))
Astrazeneca Research And Development
Curated by ChEMBL
Astrazeneca Research And Development
Curated by ChEMBL
Affinity DataIC50: 99nMAssay Description:Inhibition of human recombinant his-tagged ACC2 expressed in baculovirus/Sf9 cell assessed as inorganic phosphate formation preincubated for 15 mins ...More data for this Ligand-Target Pair
Affinity DataIC50: 100nMAssay Description:Inhibition of DGAT1 in mouse liver microsomesMore data for this Ligand-Target Pair
Affinity DataIC50: 100nMAssay Description:Inhibition of human recombinant DGAT1 expressed in Sf9 cells by liquid scintillographyMore data for this Ligand-Target Pair
Affinity DataIC50: 100nMAssay Description:Antagonist activity at human recombinant P2Y12 receptor expressed in platelet cell membrane by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
Affinity DataIC50: 110nMAssay Description:Displacement of [125I]-AZ11931285 from human recombinant P2Y12 receptor expressed in platelet cell membrane after 1 hr by scintillation countingMore data for this Ligand-Target Pair
Affinity DataIC50: 110nMAssay Description:Inhibition of human recombinant DGAT1 expressed in Sf9 cells by liquid scintillographyMore data for this Ligand-Target Pair
Affinity DataIC50: 110nMAssay Description:Inhibition of human recombinant DGAT1 expressed in Sf9 cells by liquid scintillographyMore data for this Ligand-Target Pair
TargetAcetyl-CoA carboxylase 2(Homo sapiens (Human))
Astrazeneca Research And Development
Curated by ChEMBL
Astrazeneca Research And Development
Curated by ChEMBL
Affinity DataIC50: 110nMAssay Description:Inhibition of human recombinant his-tagged ACC2 expressed in baculovirus/Sf9 cell assessed as inorganic phosphate formation preincubated for 15 mins ...More data for this Ligand-Target Pair
Affinity DataIC50: 110nMAssay Description:Antagonist activity at human recombinant P2Y12 receptor expressed in platelet cell membrane by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
Affinity DataIC50: 120nMAssay Description:Inhibition of human recombinant DGAT1 expressed in Sf9 cells by liquid scintillographyMore data for this Ligand-Target Pair
Affinity DataIC50: 120nMAssay Description:Inhibition of human recombinant DGAT1 expressed in Sf9 cells by liquid scintillographyMore data for this Ligand-Target Pair
Affinity DataIC50: 120nMAssay Description:Inhibition of human recombinant DGAT1 expressed in Sf9 cells by liquid scintillographyMore data for this Ligand-Target Pair
TargetAcetyl-CoA carboxylase 2(Homo sapiens (Human))
Astrazeneca Research And Development
Curated by ChEMBL
Astrazeneca Research And Development
Curated by ChEMBL
Affinity DataIC50: 130nMAssay Description:Inhibition of human recombinant his-tagged ACC2 expressed in baculovirus/Sf9 cell assessed as inorganic phosphate formation preincubated for 15 mins ...More data for this Ligand-Target Pair
TargetAcetyl-CoA carboxylase(Rattus norvegicus (Rat))
Astrazeneca Research And Development
Curated by ChEMBL
Astrazeneca Research And Development
Curated by ChEMBL
Affinity DataIC50: 150nMAssay Description:Inhibition of ACC2 in obese Zucker rat assessed as reduction in hepatic malonyl-coA level preincubated for 15 mins measured after 1.5 hrs using Malac...More data for this Ligand-Target Pair
Affinity DataIC50: 150nMAssay Description:Inhibition of DGAT1 in rat liver microsomesMore data for this Ligand-Target Pair
Affinity DataIC50: 170nMAssay Description:Displacement of [125I]-AZ11931285 from human recombinant P2Y12 receptor expressed in platelet cell membrane after 1 hr by scintillation countingMore data for this Ligand-Target Pair
Affinity DataIC50: 170nMAssay Description:Inhibition of human recombinant DGAT1 expressed in Sf9 cells by liquid scintillographyMore data for this Ligand-Target Pair
TargetAcetyl-CoA carboxylase(Rattus norvegicus (Rat))
Astrazeneca Research And Development
Curated by ChEMBL
Astrazeneca Research And Development
Curated by ChEMBL
Affinity DataIC50: 170nMAssay Description:Inhibition of ACC2 in obese Zucker rat assessed as reduction in hepatic malonyl-coA level preincubated for 15 mins measured after 1.5 hrs using Malac...More data for this Ligand-Target Pair
Affinity DataIC50: 180nMAssay Description:Antagonist activity at human recombinant P2Y12 receptor expressed in platelet cell membrane by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
Affinity DataIC50: 180nMAssay Description:Antagonist activity at human recombinant P2Y12 receptor expressed in platelet cell membrane by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
Affinity DataIC50: 190nMAssay Description:Displacement of [125I]-AZ11931285 from human recombinant P2Y12 receptor expressed in platelet cell membrane after 1 hr by scintillation countingMore data for this Ligand-Target Pair
Affinity DataIC50: 190nMAssay Description:Antagonist activity at human recombinant P2Y12 receptor expressed in platelet cell membrane by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
Affinity DataIC50: 190nMAssay Description:Displacement of [125I]-AZ11931285 from human recombinant P2Y12 receptor expressed in platelet cell membrane after 1 hr by scintillation countingMore data for this Ligand-Target Pair
TargetAcetyl-CoA carboxylase(Rattus norvegicus (Rat))
Astrazeneca Research And Development
Curated by ChEMBL
Astrazeneca Research And Development
Curated by ChEMBL
Affinity DataIC50: 190nMAssay Description:Inhibition of ACC2 in obese Zucker rat assessed as reduction in hepatic malonyl-coA level preincubated for 15 mins measured after 1.5 hrs using Malac...More data for this Ligand-Target Pair
Affinity DataIC50: 200nMAssay Description:Inhibition of human recombinant DGAT1 expressed in Sf9 cells by liquid scintillographyMore data for this Ligand-Target Pair
TargetAcetyl-CoA carboxylase 2(Homo sapiens (Human))
Astrazeneca Research And Development
Curated by ChEMBL
Astrazeneca Research And Development
Curated by ChEMBL
Affinity DataIC50: 210nMAssay Description:Inhibition of human recombinant his-tagged ACC2 expressed in baculovirus/Sf9 cell assessed as inorganic phosphate formation preincubated for 15 mins ...More data for this Ligand-Target Pair
Affinity DataIC50: 210nMAssay Description:Displacement of [125I]-AZ11931285 from human recombinant P2Y12 receptor expressed in platelet cell membrane after 1 hr by scintillation countingMore data for this Ligand-Target Pair
Affinity DataIC50: 210nMAssay Description:Antagonist activity at human recombinant P2Y12 receptor expressed in platelet cell membrane by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
TargetAcetyl-CoA carboxylase 2(Homo sapiens (Human))
Astrazeneca Research And Development
Curated by ChEMBL
Astrazeneca Research And Development
Curated by ChEMBL
Affinity DataIC50: 210nMAssay Description:Inhibition of human recombinant his-tagged ACC2 expressed in baculovirus/Sf9 cell assessed as inorganic phosphate formation preincubated for 15 mins ...More data for this Ligand-Target Pair
Affinity DataIC50: 230nMAssay Description:Antagonist activity at human recombinant P2Y12 receptor expressed in platelet cell membrane by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
TargetAcetyl-CoA carboxylase 2(Homo sapiens (Human))
Astrazeneca Research And Development
Curated by ChEMBL
Astrazeneca Research And Development
Curated by ChEMBL
Affinity DataIC50: 230nMAssay Description:Inhibition of human recombinant his-tagged ACC2 expressed in baculovirus/Sf9 cell assessed as inorganic phosphate formation preincubated for 15 mins ...More data for this Ligand-Target Pair
TargetAcetyl-CoA carboxylase 1(Rattus norvegicus (Rat))
Astrazeneca Research And Development
Curated by ChEMBL
Astrazeneca Research And Development
Curated by ChEMBL
Affinity DataIC50: 230nMAssay Description:Inhibition of obese Zucker rat ACC1 assessed as reduction in hepatic malonyl-coA level preincubated for 15 mins measured after 1.5 hrs using Malachit...More data for this Ligand-Target Pair
Affinity DataIC50: 240nMAssay Description:Inhibition of human recombinant DGAT1 expressed in Sf9 cells by liquid scintillographyMore data for this Ligand-Target Pair