Compile Data Set for Download or QSAR
maximum 50k data
Found 1289 with Last Name = 'huber' and Initial = 'w'
TargetNeutrophil elastase(Homo sapiens (Human))
Marion Merrell Dow Research Institute

Curated by ChEMBL
LigandPNGBDBM50035500((S)-1-{(S)-2-[4-(4-Chloro-benzenesulfonylaminocarb...)
Affinity DataKi:  0.5nMAssay Description:Binding affinity of the compound for purified Human neutrophil elastase was determined in vitro.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Marion Merrell Dow Research Institute

Curated by ChEMBL
LigandPNGBDBM50035489((S)-1-{(S)-3-Methyl-2-[4-(morpholine-4-sulfonyl)-b...)
Affinity DataKi:  2nMAssay Description:In vitro inhibition of human neutrophil elastaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Marion Merrell Dow Research Institute

Curated by ChEMBL
LigandPNGBDBM50035528(Acetic acid (E)-2-[((S)-1-{(S)-2-[4-(4-chloro-benz...)
Affinity DataKi:  3nMAssay Description:Binding affinity of the compound for purified Human neutrophil elastase was determined in the presence of pig liver esterase, in vitro.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Marion Merrell Dow Research Institute

Curated by ChEMBL
LigandPNGBDBM50035500((S)-1-{(S)-2-[4-(4-Chloro-benzenesulfonylaminocarb...)
Affinity DataKi:  3nMAssay Description:In vitro inhibition of human neutrophil elastaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Oryctolagus cuniculus)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50324743((3R,4R)-1-(2,2-DIFLUORO-ETHYL)-PYRROLIDINE-3,4-DIC...)
Affinity DataKi:  3.30nMAssay Description:Binding affinity to rabbit factor 10aMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Marion Merrell Dow Research Institute

Curated by ChEMBL
LigandPNGBDBM50037811(CHEMBL123016 | {(S)-1-[(S)-3-Benzylcarbamoyl-1-(4-...)
Affinity DataKi:  5nMAssay Description:Compound was evaluated in vitro for the ability to inhibit HIV-protease.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Marion Merrell Dow Research Institute

Curated by ChEMBL
LigandPNGBDBM50035488((S)-1-{(S)-2-[4-(4-Chloro-benzenesulfonylaminocarb...)
Affinity DataKi:  7nMAssay Description:In vitro inhibitory activity against human neutrophil elastase was determined at a dose of 100 mg/kgMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50324771((3R,4R)-N3-(5-chloropyridin-2-yl)-N4-(2-fluoro-4-(...)
Affinity DataKi:  8nMAssay Description:Binding affinity to factor 10aMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50324757((3R,4R)-N3-(4-chlorophenyl)-1-(N,N-dimethylsulfamo...)
Affinity DataKi:  8nMAssay Description:Binding affinity to factor 10aMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50324755((3R,4R)-N-(4-CHLOROPHENYL)-N'-[2-FLUORO-4-(2-OXOPY...)
Affinity DataKi:  9nMAssay Description:Binding affinity to factor 10aMore data for this Ligand-Target Pair
TargetAngiotensin-converting enzyme(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50279944((R)-2-(2-Carboxymethyl-3-oxo-2,3,4,5-tetrahydro-1H...)
Affinity DataKi:  10nMAssay Description:Inhibitory constant of the compound was tested angiotensin converting enzymeMore data for this Ligand-Target Pair
In DepthDetails Article
TargetCoagulation factor X(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50324758((3R,4R)-N3-(4-chlorophenyl)-N4-(2-fluoro-4-(2-oxop...)
Affinity DataKi:  10nMAssay Description:Binding affinity to factor 10aMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50324752((3R,4R)-N3-(4-chlorophenyl)-1-(2,2-difluoroethyl)-...)
Affinity DataKi:  10nMAssay Description:Binding affinity to factor 10aMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50324754((3R,4R)-1-SULFAMOYL-PYRROLIDINE-3,4-DICARBOXYLIC A...)
Affinity DataKi:  10nMAssay Description:Binding affinity to factor 10aMore data for this Ligand-Target Pair
TargetCoagulation factor X(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50324767((3R,4R)-N3-(4-chlorophenyl)-N4-(2-fluoro-4-(2-oxop...)
Affinity DataKi:  11nMAssay Description:Binding affinity to factor 10aMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50324749((3R,4R)-N3-(4-chlorophenyl)-1-(ethylsulfonyl)-N4-(...)
Affinity DataKi:  11nMAssay Description:Binding affinity to factor 10aMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Marion Merrell Dow Research Institute

Curated by ChEMBL
LigandPNGBDBM50035498((S)-1-{(S)-3-Methyl-2-[4-(morpholine-4-carbonyl)-b...)
Affinity DataKi:  12nMAssay Description:Binding affinity of the compound for purified Human neutrophil elastase was determined in vitro.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Marion Merrell Dow Research Institute

Curated by ChEMBL
LigandPNGBDBM50035498((S)-1-{(S)-3-Methyl-2-[4-(morpholine-4-carbonyl)-b...)
Affinity DataKi:  12nMAssay Description:In vitro inhibition of human neutrophil elastaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50324787((3R,4R)-N3-(4-chlorophenyl)-1-(methylsulfonyl)-N4-...)
Affinity DataKi:  14nMAssay Description:Binding affinity to factor 10aMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50324744((3R,4R)-N3-(5-chloropyridin-2-yl)-N4-(2-fluoro-4-(...)
Affinity DataKi:  15nMAssay Description:Binding affinity to factor 10aMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50324746((3R,4R)-1-METHANESULFONYL-PYRROLIDINE-3,4-DICARBOX...)
Affinity DataKi:  15nMAssay Description:Binding affinity to factor 10aMore data for this Ligand-Target Pair
TargetCoagulation factor X(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50324789((3R,4R)-N3-(4-chlorophenyl)-N4-(2-fluoro-4-(3-meth...)
Affinity DataKi:  15nMAssay Description:Binding affinity to factor 10aMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Marion Merrell Dow Research Institute

Curated by ChEMBL
LigandPNGBDBM50035535(Acetic acid (E)-3-methyl-2-[((S)-1-{(S)-3-methyl-2...)
Affinity DataKi:  16nMAssay Description:Binding affinity of the compound for purified Human neutrophil elastase was determined in the presence of pig liver esterase, in vitro.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50324753((3R,4R)-N3-(4-chlorophenyl)-N4-(2-fluoro-4-(2-oxop...)
Affinity DataKi:  17nMAssay Description:Binding affinity to factor 10aMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Oryctolagus cuniculus)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50324745((3R,4R)-methyl 3-(5-chloropyridin-2-ylcarbamoyl)-4...)
Affinity DataKi:  17nMAssay Description:Binding affinity to rabbit factor 10aMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50324756((3R,4R)-N3-(4-chlorophenyl)-N4-(2-fluoro-4-(2-oxop...)
Affinity DataKi:  17nMAssay Description:Binding affinity to factor 10aMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50324762((3R,4R)-N3-(4-chlorophenyl)-N4-(2-fluoro-4-(2-oxop...)
Affinity DataKi:  18nMAssay Description:Binding affinity to factor 10aMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Marion Merrell Dow Research Institute

Curated by ChEMBL
LigandPNGBDBM50035492((S)-1-{(S)-3-Methyl-2-[4-(2-methyl-4-morpholin-4-y...)
Affinity DataKi:  19nMAssay Description:In vitro inhibition of human neutrophil elastaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50324769((3R,4R)-N3-(5-chloropyridin-2-yl)-N4-(2-fluoro-4-(...)
Affinity DataKi:  20nMAssay Description:Binding affinity to factor 10aMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Marion Merrell Dow Research Institute

Curated by ChEMBL
LigandPNGBDBM50037812(CHEMBL331994 | MDL-104168 | N-Benzyl-2,2-difluoro-...)
Affinity DataKi:  20nMAssay Description:Compound was evaluated in vitro for the ability to inhibit HIV-protease.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50324764((3R,4R)-N3-(4-chlorophenyl)-N4-(2-fluoro-4-(2-oxop...)
Affinity DataKi:  21nMAssay Description:Binding affinity to factor 10aMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Marion Merrell Dow Research Institute

Curated by ChEMBL
LigandPNGBDBM50035494(CHEMBL429359 | N-{(S)-2-Methyl-1-[(S)-2-(3,3,4,4,4...)
Affinity DataKi:  21nMAssay Description:In vitro inhibition of human neutrophil elastaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50324751((3R,4R)-methyl 3-(4-chlorophenylcarbamoyl)-4-(2-fl...)
Affinity DataKi:  22nMAssay Description:Binding affinity to factor 10aMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50324792((3R,4R)-N3-(4-chlorophenyl)-N4-(2-methyl-4-(2-oxop...)
Affinity DataKi:  22nMAssay Description:Binding affinity to factor 10aMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50324795((3R,4R)-N3-(4-chlorophenyl)-1-(methylsulfonyl)-N4-...)
Affinity DataKi:  24nMAssay Description:Binding affinity to factor 10aMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Marion Merrell Dow Research Institute

Curated by ChEMBL
LigandPNGBDBM50035485((S)-1-((S)-3-Methyl-2-{4-[4-(morpholine-4-carbonyl...)
Affinity DataKi:  24nMAssay Description:In vitro inhibition of human neutrophil elastaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50324750((3R,4R)-N3-(4-chlorophenyl)-N4-(2-fluoro-4-(2-oxop...)
Affinity DataKi:  24nMAssay Description:Binding affinity to factor 10aMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50324742((3R,4R)-N3-(5-chloropyridin-2-yl)-1-(ethylsulfonyl...)
Affinity DataKi:  24nMAssay Description:Binding affinity to factor 10aMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Marion Merrell Dow Research Institute

Curated by ChEMBL
LigandPNGBDBM50035495((S)-1-{(S)-3-Methyl-2-[4-(morpholine-4-carbonyl)-b...)
Affinity DataKi:  25nMAssay Description:In vitro inhibitory activity against human neutrophil elastase was determined at a dose of 50 mg/kgMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Marion Merrell Dow Research Institute

Curated by ChEMBL
LigandPNGBDBM50035532(Acetic acid (E)-3-methyl-2-[((S)-1-{(S)-3-methyl-2...)
Affinity DataKi:  25nMAssay Description:Binding affinity of the compound for purified Human neutrophil elastase was determined in the presence of pig liver esterase, in vitro.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Marion Merrell Dow Research Institute

Curated by ChEMBL
LigandPNGBDBM50035495((S)-1-{(S)-3-Methyl-2-[4-(morpholine-4-carbonyl)-b...)
Affinity DataKi:  25nMAssay Description:Binding affinity of the compound for purified Human neutrophil elastase was determined in vitro.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Marion Merrell Dow Research Institute

Curated by ChEMBL
LigandPNGBDBM50035531(CHEMBL74332 | Isobutyric acid (E)-3-methyl-2-[((S)...)
Affinity DataKi:  25nMAssay Description:Binding affinity of the compound for purified Human neutrophil elastase was determined in the presence of pig liver esterase, in vitro.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Marion Merrell Dow Research Institute

Curated by ChEMBL
LigandPNGBDBM50035530(CHEMBL74651 | Propionic acid (E)-3-methyl-2-[((S)-...)
Affinity DataKi:  25nMAssay Description:Binding affinity of the compound for purified Human neutrophil elastase was determined in the presence of pig liver esterase, in vitro.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50324745((3R,4R)-methyl 3-(5-chloropyridin-2-ylcarbamoyl)-4...)
Affinity DataKi:  27nMAssay Description:Binding affinity to factor 10aMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50324745((3R,4R)-methyl 3-(5-chloropyridin-2-ylcarbamoyl)-4...)
Affinity DataKi:  27nMAssay Description:Binding affinity to factor 10aMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Marion Merrell Dow Research Institute

Curated by ChEMBL
LigandPNGBDBM50035487(CHEMBL140639 | N-{(S)-2-Methyl-1-[(S)-2-(3,3,4,4,4...)
Affinity DataKi:  28nMAssay Description:In vitro inhibition of human neutrophil elastaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50324748((3R,4R)-1-acetyl-N3-(4-chlorophenyl)-N4-(2-fluoro-...)
Affinity DataKi:  28nMAssay Description:Binding affinity to factor 10aMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Marion Merrell Dow Research Institute

Curated by ChEMBL
LigandPNGBDBM50035502((S)-1-[(S)-3-Methyl-2-(3-pyridin-3-yl-propionylami...)
Affinity DataKi:  29nMAssay Description:In vitro inhibition of human neutrophil elastaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50324784((3R,4R)-N3-(4-chlorophenyl)-N4-(2,6-difluoro-4-(2-...)
Affinity DataKi:  31nMAssay Description:Binding affinity to factor 10aMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50324765((3R,4R)-N3-(4-chlorophenyl)-N4-(2-fluoro-4-(2-oxop...)
Affinity DataKi:  34nMAssay Description:Binding affinity to factor 10aMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Displayed 1 to 50 (of 1289 total ) | Next | Last >>
Jump to: