Found 763 with Last Name = 'hughes' and Initial = 'sh' TargetGag-Pol polyprotein [600-1029,C879S]/[600-1159,C879S](Human immunodeficiency virus type 1)
Nci-Fcrdc
Nci-Fcrdc
Affinity DataIC50: 7.30nMpH: 8.0 T: 2°CAssay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
Affinity DataIC50: 8.20nMAssay Description:Inhibition of strand transfer activity of HIV-1 integrase using [gamma-32P]-labeled DNA as substrateMore data for this Ligand-Target Pair
Affinity DataIC50: 8.40nMAssay Description:Inhibition of strand transfer activity of HIV-1 integrase using [gamma-32P]-labeled DNA as substrateMore data for this Ligand-Target Pair
Affinity DataIC50: 10nMAssay Description:Inhibition of strand transfer activity of HIV-1 integrase using [gamma-32P]-labeled DNA as substrateMore data for this Ligand-Target Pair
Affinity DataIC50: 10nMAssay Description:Inhibition of strand transfer activity of HIV-1 integrase using [gamma-32P]-labeled DNA as substrateMore data for this Ligand-Target Pair
Affinity DataIC50: 13nMAssay Description:Inhibition of strand transfer activity of HIV-1 integrase using [gamma-32P]-labeled DNA as substrateMore data for this Ligand-Target Pair
Affinity DataIC50: 14nMAssay Description:Inhibition of HIV-1 integrase-mediated strand transfer activity using [32P]-labeled oligonucleotide as substrate after 2 hrs by densitometric analysi...More data for this Ligand-Target Pair
Affinity DataIC50: 16nMAssay Description:Inhibition of strand transfer activity of HIV-1 integrase using [gamma-32P]-labeled DNA as substrateMore data for this Ligand-Target Pair
Affinity DataIC50: 17nMAssay Description:Inhibition of strand transfer activity of HIV-1 integrase using [gamma-32P]-labeled DNA as substrateMore data for this Ligand-Target Pair
Affinity DataIC50: 17nMAssay Description:Inhibition of HIV-1 integrase-mediated strand transfer activity using [32P]-labeled oligonucleotide as substrate after 2 hrs by densitometric analysi...More data for this Ligand-Target Pair
Affinity DataIC50: 18nMAssay Description:Inhibition of strand transfer activity of HIV-1 integrase using [gamma-32P]-labeled DNA as substrateMore data for this Ligand-Target Pair
Affinity DataIC50: 19nMAssay Description:Inhibition of strand transfer activity of HIV-1 integrase using [gamma-32P]-labeled DNA as substrateMore data for this Ligand-Target Pair
Affinity DataIC50: 21nMAssay Description:Inhibition of strand transfer activity of HIV-1 integrase using [gamma-32P]-labeled DNA as substrateMore data for this Ligand-Target Pair
Affinity DataIC50: 24nMAssay Description:Inhibition of strand transfer activity of HIV-1 integrase using [gamma-32P]-labeled DNA as substrateMore data for this Ligand-Target Pair
Affinity DataIC50: 27nMAssay Description:Inhibition of strand transfer activity of HIV-1 integrase using [gamma-32P]-labeled DNA as substrateMore data for this Ligand-Target Pair
Affinity DataIC50: 27nMAssay Description:Inhibition of HIV-1 integrase-mediated strand transfer activity using [32P]-labeled oligonucleotide as substrate after 2 hrs by densitometric analysi...More data for this Ligand-Target Pair
Affinity DataIC50: 27nMAssay Description:Inhibition of strand transfer activity of HIV-1 integrase using [gamma-32P]-labeled DNA as substrateMore data for this Ligand-Target Pair
Affinity DataIC50: 27nMAssay Description:Inhibition of strand transfer activity of HIV-1 integrase using [gamma-32P]-labeled DNA as substrateMore data for this Ligand-Target Pair
Affinity DataIC50: 39nMAssay Description:Inhibition of strand transfer activity of HIV-1 integrase using [gamma-32P]-labeled DNA as substrateMore data for this Ligand-Target Pair
Affinity DataIC50: 40nMAssay Description:Inhibition of HIV-1 integrase-mediated strand transfer activity using [32P]-labeled oligonucleotide as substrate after 2 hrs by densitometric analysi...More data for this Ligand-Target Pair
Affinity DataIC50: 41nMAssay Description:Inhibition of HIV-1 integrase-mediated strand transfer activity using [32P]-labeled oligonucleotide as substrate after 2 hrs by densitometric analysi...More data for this Ligand-Target Pair
Affinity DataIC50: 47nMAssay Description:Inhibition of HIV1 recombinant integrase strand transfer activity using [32P]-labeled oligonucleotide a substrate after 30 mins by electrophoretic an...More data for this Ligand-Target Pair
Affinity DataIC50: 50nMAssay Description:Inhibition of strand transfer activity of HIV-1 integrase using [gamma-32P]-labeled DNA as substrateMore data for this Ligand-Target Pair
Affinity DataIC50: 54nMAssay Description:Inhibition of HIV1 recombinant integrase strand transfer activity using [32P]-labeled oligonucleotide a substrate after 30 mins by electrophoretic an...More data for this Ligand-Target Pair
Affinity DataIC50: 55nMAssay Description:Inhibition of HIV-1 integrase-mediated strand transfer activity using [32P]-labeled oligonucleotide as substrate after 2 hrs by densitometric analysi...More data for this Ligand-Target Pair
Affinity DataIC50: 58nMAssay Description:Inhibition of HIV1 recombinant integrase strand transfer activity using [32P]-labeled oligonucleotide a substrate after 30 mins by electrophoretic an...More data for this Ligand-Target Pair
Affinity DataIC50: 67nMAssay Description:Inhibition of HIV1 recombinant integrase strand transfer activity expressed in Escherichia coli after 60 mins using [32P]-labeled oligonucleotide as ...More data for this Ligand-Target Pair
Affinity DataIC50: 67nMAssay Description:Inhibition of HIV1 recombinant integrase strand transfer activity expressed in Escherichia coli after 30 mins using [32P]-labeled oligonucleotide as ...More data for this Ligand-Target Pair
TargetGag-Pol polyprotein [1148-1435](Human immunodeficiency virus type 1)
National Institutes of Health
National Institutes of Health
Affinity DataIC50: 67nMAssay Description:The compound were evaluated in biochemical IN (integrase) assay that measure inhibitory potency (IC50 values)against both the 3'-processing(3'...More data for this Ligand-Target Pair
Affinity DataIC50: 74nMAssay Description:Inhibition of HIV1 recombinant integrase strand transfer activity expressed in Escherichia coli after 60 mins using [32P]-labeled oligonucleotide as ...More data for this Ligand-Target Pair
Affinity DataIC50: 79nMAssay Description:Inhibition of strand transfer activity of HIV-1 integrase using [gamma-32P]-labeled DNA as substrateMore data for this Ligand-Target Pair
Affinity DataIC50: 80nMAssay Description:Inhibition of HIV1 recombinant integrase strand transfer activity using [32P]-labeled oligonucleotide a substrate after 30 mins by electrophoretic an...More data for this Ligand-Target Pair
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus 1)
National Cancer Institute-Frederick
Curated by ChEMBL
National Cancer Institute-Frederick
Curated by ChEMBL
Affinity DataIC50: 80nMAssay Description:Inhibitory concentration required against Reverse transcriptase (RT)More data for this Ligand-Target Pair
Affinity DataIC50: 87nMAssay Description:Inhibition of strand transfer activity of HIV-1 integrase using [gamma-32P]-labeled DNA as substrateMore data for this Ligand-Target Pair
Affinity DataIC50: 100nMAssay Description:Inhibition of HIV1 integrase strand transfer activity in presence of magnesiumMore data for this Ligand-Target Pair
Affinity DataIC50: 100nMAssay Description:Inhibition of HIV1 integrase strand transfer activity in presence of magnesiumMore data for this Ligand-Target Pair
TargetGag-Pol polyprotein [600-1029,C879S]/[600-1159,C879S](Human immunodeficiency virus type 1)
Nci-Fcrdc
Nci-Fcrdc
Affinity DataIC50: 110nMpH: 8.0 T: 2°CAssay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
Affinity DataIC50: 110nMAssay Description:Inhibition of HIV1 recombinant integrase strand transfer activity using [32P]-labeled oligonucleotide a substrate after 30 mins by electrophoretic an...More data for this Ligand-Target Pair
Affinity DataIC50: 120nMAssay Description:Inhibition of HIV1 integrase strand transfer activity in presence of magnesiumMore data for this Ligand-Target Pair
Affinity DataIC50: 120nMAssay Description:Inhibition of HIV1 wild type reverse transcriptase-mediated viral DNA synthesis in human HOS-313 cells expressing HSV thymidine kinase assessed as lu...More data for this Ligand-Target Pair
Affinity DataIC50: 120nMAssay Description:Inhibition of HIV1 recombinant integrase strand transfer activity using [32P]-labeled oligonucleotide a substrate after 30 mins by electrophoretic an...More data for this Ligand-Target Pair
Affinity DataIC50: 130nMAssay Description:Inhibition of strand transfer activity of HIV-1 integrase using [gamma-32P]-labeled DNA as substrateMore data for this Ligand-Target Pair
Affinity DataIC50: 130nMAssay Description:Inhibition of strand transfer activity of HIV-1 integrase using [gamma-32P]-labeled DNA as substrateMore data for this Ligand-Target Pair
Affinity DataIC50: 140nMAssay Description:Inhibition of HIV1 recombinant integrase strand transfer activity expressed in Escherichia coli after 30 mins using [32P]-labeled oligonucleotide as ...More data for this Ligand-Target Pair
Affinity DataIC50: 160nMAssay Description:Inhibition of recombinant HIV1 integrase strand transfer activity in presence of magnesiumMore data for this Ligand-Target Pair
Affinity DataIC50: 170nMAssay Description:Inhibition of HIV1 recombinant integrase strand transfer activity expressed in Escherichia coli after 30 mins using [32P]-labeled oligonucleotide as ...More data for this Ligand-Target Pair
Affinity DataIC50: 170nMAssay Description:Inhibition of HIV1 integrase strand transfer activity in presence of magnesiumMore data for this Ligand-Target Pair
Affinity DataIC50: 190nMAssay Description:Inhibition of HIV1 reverse transcriptase M184V mutant-mediated viral DNA synthesis in human HOS-313 cells expressing HSV thymidine kinase assessed as...More data for this Ligand-Target Pair
Affinity DataIC50: 190nMAssay Description:Inhibition of HIV1 recombinant integrase strand transfer activity using [32P]-labeled oligonucleotide a substrate after 30 mins by electrophoretic an...More data for this Ligand-Target Pair
Affinity DataIC50: 190nMAssay Description:Inhibition of HIV1 recombinant integrase strand transfer activity using [32P]-labeled oligonucleotide a substrate after 30 mins by electrophoretic an...More data for this Ligand-Target Pair
