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Found 78 with Last Name = 'hurley' and Initial = 'lh'
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
The University Of Arizona

Curated by ChEMBL
LigandPNGBDBM50323919(4-(4-(3-(3-tert-butyl-1-p-tolyl-1H-pyrazol-5-yl)ur...)
Affinity DataIC50:  1nMAssay Description:Inhibition of human recombinant full-length N-terminal GST-tagged p38alpha expressed in Escherichia coli by radiometric kinase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
The University Of Arizona

Curated by ChEMBL
LigandPNGBDBM50323917(1-(4-chloro-3-(trifluoromethyl)phenyl)-3-(4-(2-mor...)
Affinity DataIC50:  1nMAssay Description:Inhibition of human recombinant full-length N-terminal GST-tagged p38alpha expressed in Escherichia coli by radiometric kinase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
The University Of Arizona

Curated by ChEMBL
LigandPNGBDBM13533(1-[2-(4-methylphenyl)-5-tert-butyl-pyrazol-3-yl]-3...)
Affinity DataIC50:  4nMAssay Description:Inhibition of human recombinant full-length N-terminal GST-tagged p38alpha expressed in Escherichia coli by radiometric kinase assayMore data for this Ligand-Target Pair
TargetTyrosine-protein kinase ABL1(Mus musculus)
The University Of Arizona

Curated by ChEMBL
LigandPNGBDBM50323918(1-(3-tert-butyl-1-p-tolyl-1H-pyrazol-5-yl)-3-(4-me...)
Affinity DataIC50:  8.60nMAssay Description:Inhibition of mouse recombinant N-terminal His6-tagged Abl by radiometric kinase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ABL1(Mus musculus)
The University Of Arizona

Curated by ChEMBL
LigandPNGBDBM13530(4-[(4-methylpiperazin-1-yl)methyl]-N-[4-methyl-3-[...)
Affinity DataIC50:  10.8nMAssay Description:Inhibition of mouse recombinant N-terminal His6-tagged Abl by radiometric kinase assayMore data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
The University Of Arizona

Curated by ChEMBL
LigandPNGBDBM50308764(4-(3,4-Difluorophenyl)-N-(4-methyl-3-(3-methyl-4-o...)
Affinity DataIC50:  11nMAssay Description:Inhibition of human recombinant full length p38alpha assessed as MAPKAPK2 phosphorylation by [32P]ATP SDS-PAGE gel kinase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
The University Of Arizona

Curated by ChEMBL
LigandPNGBDBM50308757(5-(4-Fluorophenyl)-N-(4-methyl-3-(3-methyl-4-oxo-3...)
Affinity DataIC50:  16nMAssay Description:Inhibition of human recombinant full length p38alpha assessed as MAPKAPK2 phosphorylation by [32P]ATP SDS-PAGE gel kinase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
The University Of Arizona

Curated by ChEMBL
LigandPNGBDBM50323922(1-(4-chloro-3-(trifluoromethyl)phenyl)-3-(4-methyl...)
Affinity DataIC50:  18.4nMAssay Description:Inhibition of human recombinant full-length N-terminal GST-tagged p38alpha expressed in Escherichia coli by radiometric kinase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
The University Of Arizona

Curated by ChEMBL
LigandPNGBDBM16673(4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamo...)
Affinity DataIC50:  38nMAssay Description:Inhibition of p38alphaMore data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
The University Of Arizona

Curated by ChEMBL
LigandPNGBDBM50308758(5-(3-Chloro-4-fluorophenyl)-N-(4-methyl-3-(3-methy...)
Affinity DataIC50:  49nMAssay Description:Inhibition of human recombinant full length p38alpha assessed as MAPKAPK2 phosphorylation by [32P]ATP SDS-PAGE gel kinase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA polymerase I, thermostable(Thermus aquaticus)
The University Of Arizona

Curated by ChEMBL
LigandPNGBDBM50123623((R)-13-(3-aminopyrrolidin-1-yl)-12-fluoro-10-oxo-1...)
Affinity DataIC50:  60nMAssay Description:Inhibition of Taq DNA polymeraseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
The University Of Arizona

Curated by ChEMBL
LigandPNGBDBM50308759(5-(4-Fluoro-3-methylphenyl)-N-(4-methyl-3-(3-methy...)
Affinity DataIC50:  60nMAssay Description:Inhibition of human recombinant full length p38alpha assessed as MAPKAPK2 phosphorylation by [32P]ATP SDS-PAGE gel kinase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ABL1(Mus musculus)
The University Of Arizona

Curated by ChEMBL
LigandPNGBDBM50323919(4-(4-(3-(3-tert-butyl-1-p-tolyl-1H-pyrazol-5-yl)ur...)
Affinity DataIC50:  62.6nMAssay Description:Inhibition of mouse recombinant N-terminal His6-tagged Abl by radiometric kinase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
The University Of Arizona

Curated by ChEMBL
LigandPNGBDBM16673(4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamo...)
Affinity DataIC50:  76.2nMAssay Description:Inhibition of human recombinant full-length GST-tagged B-Raf by radiometric kinase assayMore data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
The University Of Arizona

Curated by ChEMBL
LigandPNGBDBM13533(1-[2-(4-methylphenyl)-5-tert-butyl-pyrazol-3-yl]-3...)
Affinity DataIC50:  83.4nMAssay Description:Inhibition of human recombinant full-length GST-tagged B-Raf by radiometric kinase assayMore data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
The University Of Arizona

Curated by ChEMBL
LigandPNGBDBM16673(4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamo...)
Affinity DataIC50:  84nMAssay Description:Inhibition of human recombinant full length p38alpha assessed as MAPKAPK2 phosphorylation by [32P]ATP SDS-PAGE gel kinase assayMore data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
The University Of Arizona

Curated by ChEMBL
LigandPNGBDBM16673(4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamo...)
Affinity DataIC50:  84.8nMAssay Description:Inhibition of human recombinant full-length N-terminal GST-tagged p38alpha expressed in Escherichia coli by radiometric kinase assayMore data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
The University Of Arizona

Curated by ChEMBL
LigandPNGBDBM50323921(1-(4-chloro-3-(trifluoromethyl)phenyl)-3-(4-(2-mor...)
Affinity DataIC50:  92.3nMAssay Description:Inhibition of human recombinant full-length GST-tagged B-Raf by radiometric kinase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
The University Of Arizona

Curated by ChEMBL
LigandPNGBDBM50308761(CHEMBL591673 | N-(4-Methyl-3-(3-methyl-4-oxo-3,4-d...)
Affinity DataIC50:  94nMAssay Description:Inhibition of human recombinant full length p38alpha assessed as MAPKAPK2 phosphorylation by [32P]ATP SDS-PAGE gel kinase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
The University Of Arizona

Curated by ChEMBL
LigandPNGBDBM50308765(2-tert-Butyl-N-(4-methyl-3-(3-methyl-4-oxo-3,4-dih...)
Affinity DataIC50:  96nMAssay Description:Inhibition of human recombinant full length p38alpha assessed as MAPKAPK2 phosphorylation by [32P]ATP SDS-PAGE gel kinase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
The University Of Arizona

Curated by ChEMBL
LigandPNGBDBM50308760(5-(3-Fluoro-4-methylphenyl)-N-(4-methyl-3-(3-methy...)
Affinity DataIC50:  100nMAssay Description:Inhibition of human recombinant full length p38alpha assessed as MAPKAPK2 phosphorylation by [32P]ATP SDS-PAGE gel kinase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
The University Of Arizona

Curated by ChEMBL
LigandPNGBDBM50308762(CHEMBL591526 | N-(4-Methyl-3-(3-methyl-4-oxo-3,4-d...)
Affinity DataIC50:  105nMAssay Description:Inhibition of human recombinant full length p38alpha assessed as MAPKAPK2 phosphorylation by [32P]ATP SDS-PAGE gel kinase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
The University Of Arizona

Curated by ChEMBL
LigandPNGBDBM50323921(1-(4-chloro-3-(trifluoromethyl)phenyl)-3-(4-(2-mor...)
Affinity DataIC50:  106nMAssay Description:Inhibition of human recombinant full-length N-terminal GST-tagged p38alpha expressed in Escherichia coli by radiometric kinase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
The University Of Arizona

Curated by ChEMBL
LigandPNGBDBM50308766(CHEMBL605404 | N-(4-Methyl-3-(3-methyl-4-oxo-3,4-d...)
Affinity DataIC50:  122nMAssay Description:Inhibition of human recombinant full length p38alpha assessed as MAPKAPK2 phosphorylation by [32P]ATP SDS-PAGE gel kinase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
The University Of Arizona

Curated by ChEMBL
LigandPNGBDBM50323922(1-(4-chloro-3-(trifluoromethyl)phenyl)-3-(4-methyl...)
Affinity DataIC50:  180nMAssay Description:Inhibition of human recombinant full-length GST-tagged B-Raf by radiometric kinase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
The University Of Arizona

Curated by ChEMBL
LigandPNGBDBM50323918(1-(3-tert-butyl-1-p-tolyl-1H-pyrazol-5-yl)-3-(4-me...)
Affinity DataIC50:  189nMAssay Description:Inhibition of human recombinant full-length N-terminal GST-tagged p38alpha expressed in Escherichia coli by radiometric kinase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ABL1(Mus musculus)
The University Of Arizona

Curated by ChEMBL
LigandPNGBDBM16673(4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamo...)
Affinity DataIC50:  226nMAssay Description:Inhibition of mouse recombinant N-terminal His6-tagged Abl by radiometric kinase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
The University Of Arizona

Curated by ChEMBL
LigandPNGBDBM50323919(4-(4-(3-(3-tert-butyl-1-p-tolyl-1H-pyrazol-5-yl)ur...)
Affinity DataIC50:  237nMAssay Description:Inhibition of human recombinant full-length GST-tagged B-Raf by radiometric kinase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 2-alpha/2-beta(Homo sapiens (Human))
The University Of Texas At Austin

Curated by ChEMBL
LigandPNGBDBM50471898(CHEMBL135778)
Affinity DataIC50:  240nMAssay Description:Inhibition of topoisomerase II as conversion of catenated to decatenated KDNAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ABL1(Mus musculus)
The University Of Arizona

Curated by ChEMBL
LigandPNGBDBM50323921(1-(4-chloro-3-(trifluoromethyl)phenyl)-3-(4-(2-mor...)
Affinity DataIC50:  244nMAssay Description:Inhibition of mouse recombinant N-terminal His6-tagged Abl by radiometric kinase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
The University Of Arizona

Curated by ChEMBL
LigandPNGBDBM50308755(CHEMBL589415 | N-(4-Methyl-3-(3-methyl-4-oxo-3,4-d...)
Affinity DataIC50:  405nMAssay Description:Inhibition of human recombinant full length p38alpha assessed as MAPKAPK2 phosphorylation by [32P]ATP SDS-PAGE gel kinase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
The University Of Arizona

Curated by ChEMBL
LigandPNGBDBM50323918(1-(3-tert-butyl-1-p-tolyl-1H-pyrazol-5-yl)-3-(4-me...)
Affinity DataIC50:  414nMAssay Description:Inhibition of human recombinant full-length GST-tagged B-Raf by radiometric kinase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 2-alpha/2-beta(Homo sapiens (Human))
The University Of Texas At Austin

Curated by ChEMBL
LigandPNGBDBM50471897(CHEMBL137098)
Affinity DataIC50:  420nMAssay Description:Inhibition of topoisomerase II as conversion of catenated to decatenated KDNAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 2-alpha/2-beta(Homo sapiens (Human))
The University Of Texas At Austin

Curated by ChEMBL
LigandPNGBDBM50471907(CHEMBL337526)
Affinity DataIC50:  440nMAssay Description:Inhibition of topoisomerase II as conversion of catenated to decatenated KDNAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
The University Of Arizona

Curated by ChEMBL
LigandPNGBDBM50308763(CHEMBL591661 | N-(4-Methyl-3-(3-methyl-4-oxo-3,4-d...)
Affinity DataIC50:  468nMAssay Description:Inhibition of human recombinant full length p38alpha assessed as MAPKAPK2 phosphorylation by [32P]ATP SDS-PAGE gel kinase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 2-alpha/2-beta(Homo sapiens (Human))
The University Of Texas At Austin

Curated by ChEMBL
LigandPNGBDBM50471900(CHEMBL335700)
Affinity DataIC50:  490nMAssay Description:Inhibition of topoisomerase II as conversion of catenated to decatenated KDNAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 2-alpha/2-beta(Homo sapiens (Human))
The University Of Texas At Austin

Curated by ChEMBL
LigandPNGBDBM50471895(A-62176 | CHEMBL101299)
Affinity DataIC50:  510nMAssay Description:Inhibition of topoisomerase II as conversion of catenated to decatenated KDNAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 2-alpha/2-beta(Homo sapiens (Human))
The University Of Texas At Austin

Curated by ChEMBL
LigandPNGBDBM50471905(CHEMBL334497)
Affinity DataIC50:  550nMAssay Description:Inhibition of topoisomerase II as conversion of catenated to decatenated KDNAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ABL1(Mus musculus)
The University Of Arizona

Curated by ChEMBL
LigandPNGBDBM50323920(CHEMBL1213975 | N-methyl-4-(4-(3-(4-((4-methylpipe...)
Affinity DataIC50:  572nMAssay Description:Inhibition of mouse recombinant N-terminal His6-tagged Abl by radiometric kinase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 2-alpha/2-beta(Homo sapiens (Human))
The University Of Texas At Austin

Curated by ChEMBL
LigandPNGBDBM50471906(CHEMBL337205)
Affinity DataIC50:  640nMAssay Description:Inhibition of topoisomerase II as conversion of catenated to decatenated KDNAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDNA polymerase I, thermostable(Thermus aquaticus)
The University Of Arizona

Curated by ChEMBL
LigandPNGBDBM50123624((S)-13-(3-aminopyrrolidin-1-yl)-12-fluoro-10-oxo-1...)
Affinity DataIC50:  670nMAssay Description:Inhibition of Taq DNA polymeraseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 2-alpha/2-beta(Homo sapiens (Human))
The University Of Texas At Austin

Curated by ChEMBL
LigandPNGBDBM50471903(CHEMBL335387)
Affinity DataIC50:  720nMAssay Description:Inhibition of topoisomerase II as conversion of catenated to decatenated KDNAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 2-alpha/2-beta(Homo sapiens (Human))
The University Of Texas At Austin

Curated by ChEMBL
LigandPNGBDBM50471896(CHEMBL423534)
Affinity DataIC50:  770nMAssay Description:Inhibition of topoisomerase II as conversion of catenated to decatenated KDNAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 2-alpha/2-beta(Homo sapiens (Human))
The University Of Texas At Austin

Curated by ChEMBL
LigandPNGBDBM50471902(CHEMBL335643)
Affinity DataIC50:  770nMAssay Description:Inhibition of topoisomerase II as conversion of catenated to decatenated KDNAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 2-alpha/2-beta(Homo sapiens (Human))
The University Of Texas At Austin

Curated by ChEMBL
LigandPNGBDBM50471901(CHEMBL422988)
Affinity DataIC50:  1.22E+3nMAssay Description:Inhibition of topoisomerase II as conversion of catenated to decatenated KDNAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
The University Of Arizona

Curated by ChEMBL
LigandPNGBDBM50308756(CHEMBL605198 | N-(4-Methyl-3-(3-methyl-4-oxo-3,4-d...)
Affinity DataIC50:  1.65E+3nMAssay Description:Inhibition of human recombinant full length p38alpha assessed as MAPKAPK2 phosphorylation by [32P]ATP SDS-PAGE gel kinase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 2-alpha/2-beta(Homo sapiens (Human))
The University Of Texas At Austin

Curated by ChEMBL
LigandPNGBDBM50471899(CHEMBL137263)
Affinity DataIC50:  1.84E+3nMAssay Description:Inhibition of topoisomerase II as conversion of catenated to decatenated KDNAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDNA polymerase I, thermostable(Thermus aquaticus)
The University Of Arizona

Curated by ChEMBL
LigandPNGBDBM50123624((S)-13-(3-aminopyrrolidin-1-yl)-12-fluoro-10-oxo-1...)
Affinity DataIC50:  2.10E+3nMAssay Description:Inhibition of Taq DNA polymerase by TRAP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA polymerase I, thermostable(Thermus aquaticus)
The University Of Arizona

Curated by ChEMBL
LigandPNGBDBM50123622(6-[3-amino-(3R)-tetrahydro-1H-1-pyrrolyl]-5-fluoro...)
Affinity DataIC50:  2.40E+3nMAssay Description:Inhibition of Taq DNA polymeraseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTelomerase reverse transcriptase(Homo sapiens (Human))
University Of Texas At Austin

Curated by ChEMBL
LigandPNGBDBM50107617(5-(1-Methyl-3-pyridyl)-10,15,20-tri(1-methyl-3-qui...)
Affinity DataIC50:  5.00E+3nMAssay Description:Apparent telomerase inhibition by mixed mechanismMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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