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Found 74 with Last Name = 'jeske' and Initial = 'm'
TargetProteinase-activated receptor 1(Homo sapiens (Human))
Bayer Intellectual Property

US Patent
LigandPNGBDBM150313(US8987248, 106)
Affinity DataIC50:  7.05nMpH: 7.5 T: 2°CAssay Description:Platelet membranes are incubated with 12 nM [3H]haTRAP and test substance in different concentrations in a buffer (50 mM Tris pH 7.5, 10 mM magnesium...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetProteinase-activated receptor 1(Homo sapiens (Human))
Bayer Intellectual Property

US Patent
LigandPNGBDBM150314(US8987248, 115)
Affinity DataIC50:  11.1nMpH: 7.5 T: 2°CAssay Description:Platelet membranes are incubated with 12 nM [3H]haTRAP and test substance in different concentrations in a buffer (50 mM Tris pH 7.5, 10 mM magnesium...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProteinase-activated receptor 1(Homo sapiens (Human))
Bayer Intellectual Property

US Patent
LigandPNGBDBM150322(US8987248, 156)
Affinity DataIC50:  11.1nMpH: 7.5 T: 2°CAssay Description:Platelet membranes are incubated with 12 nM [3H]haTRAP and test substance in different concentrations in a buffer (50 mM Tris pH 7.5, 10 mM magnesium...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetProteinase-activated receptor 1(Homo sapiens (Human))
Bayer Intellectual Property

US Patent
LigandPNGBDBM150319(US8987248, 133)
Affinity DataIC50:  14.6nMpH: 7.5 T: 2°CAssay Description:Platelet membranes are incubated with 12 nM [3H]haTRAP and test substance in different concentrations in a buffer (50 mM Tris pH 7.5, 10 mM magnesium...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetProteinase-activated receptor 1(Homo sapiens (Human))
Bayer Intellectual Property

US Patent
LigandPNGBDBM150320(US8987248, 134)
Affinity DataIC50:  15.4nMpH: 7.5 T: 2°CAssay Description:Platelet membranes are incubated with 12 nM [3H]haTRAP and test substance in different concentrations in a buffer (50 mM Tris pH 7.5, 10 mM magnesium...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProteinase-activated receptor 1(Homo sapiens (Human))
Bayer Intellectual Property

US Patent
LigandPNGBDBM150315(US8987248, 119)
Affinity DataIC50:  15.7nMpH: 7.5 T: 2°CAssay Description:Platelet membranes are incubated with 12 nM [3H]haTRAP and test substance in different concentrations in a buffer (50 mM Tris pH 7.5, 10 mM magnesium...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProteinase-activated receptor 1(Homo sapiens (Human))
Bayer Intellectual Property

US Patent
LigandPNGBDBM150317(US8987248, 128)
Affinity DataIC50:  17.0nMpH: 7.5 T: 2°CAssay Description:Platelet membranes are incubated with 12 nM [3H]haTRAP and test substance in different concentrations in a buffer (50 mM Tris pH 7.5, 10 mM magnesium...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetProteinase-activated receptor 1(Homo sapiens (Human))
Bayer Intellectual Property

US Patent
LigandPNGBDBM150307(US8987248, 91)
Affinity DataIC50:  17.4nMpH: 7.5 T: 2°CAssay Description:Platelet membranes are incubated with 12 nM [3H]haTRAP and test substance in different concentrations in a buffer (50 mM Tris pH 7.5, 10 mM magnesium...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetProteinase-activated receptor 1(Homo sapiens (Human))
Bayer Intellectual Property

US Patent
LigandPNGBDBM150312(US8987248, 105)
Affinity DataIC50:  18.4nMpH: 7.5 T: 2°CAssay Description:Platelet membranes are incubated with 12 nM [3H]haTRAP and test substance in different concentrations in a buffer (50 mM Tris pH 7.5, 10 mM magnesium...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProteinase-activated receptor 1(Homo sapiens (Human))
Bayer Intellectual Property

US Patent
LigandPNGBDBM150305(US8987248, 83)
Affinity DataIC50:  19.7nMpH: 7.5 T: 2°CAssay Description:Platelet membranes are incubated with 12 nM [3H]haTRAP and test substance in different concentrations in a buffer (50 mM Tris pH 7.5, 10 mM magnesium...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProteinase-activated receptor 1(Homo sapiens (Human))
Bayer Intellectual Property

US Patent
LigandPNGBDBM150324(BDBM150325 | US8987248, 170)
Affinity DataIC50:  21.3nMpH: 7.5 T: 2°CAssay Description:Platelet membranes are incubated with 12 nM [3H]haTRAP and test substance in different concentrations in a buffer (50 mM Tris pH 7.5, 10 mM magnesium...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetProteinase-activated receptor 1(Homo sapiens (Human))
Bayer Intellectual Property

US Patent
LigandPNGBDBM150323(US8987248, 162)
Affinity DataIC50:  25nMpH: 7.5 T: 2°CAssay Description:Platelet membranes are incubated with 12 nM [3H]haTRAP and test substance in different concentrations in a buffer (50 mM Tris pH 7.5, 10 mM magnesium...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProteinase-activated receptor 1(Homo sapiens (Human))
Bayer Intellectual Property

US Patent
LigandPNGBDBM150301(US8987248, 7)
Affinity DataIC50:  29nMpH: 7.5 T: 2°CAssay Description:Platelet membranes are incubated with 12 nM [3H]haTRAP and test substance in different concentrations in a buffer (50 mM Tris pH 7.5, 10 mM magnesium...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetProteinase-activated receptor 1(Homo sapiens (Human))
Bayer Intellectual Property

US Patent
LigandPNGBDBM150318(US8987248, 129)
Affinity DataIC50:  33.6nMpH: 7.5 T: 2°CAssay Description:Platelet membranes are incubated with 12 nM [3H]haTRAP and test substance in different concentrations in a buffer (50 mM Tris pH 7.5, 10 mM magnesium...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetProlyl hydroxylase EGLN2(Homo sapiens (Human))
Bayer Intellectual Property

US Patent
LigandPNGBDBM118338(US8653111, 62)
Affinity DataIC50:  50nMAssay Description:Hydroxylated HIF bonds specifically to the von Hippel-Lindau protein-elongin B-elongin C complex (VBC complex). This interaction occurs only if HIF i...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetProteinase-activated receptor 1(Homo sapiens (Human))
Bayer Intellectual Property

US Patent
LigandPNGBDBM150321(US8987248, 141)
Affinity DataIC50:  53.7nMpH: 7.5 T: 2°CAssay Description:Platelet membranes are incubated with 12 nM [3H]haTRAP and test substance in different concentrations in a buffer (50 mM Tris pH 7.5, 10 mM magnesium...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetProteinase-activated receptor 1(Homo sapiens (Human))
Bayer Intellectual Property

US Patent
LigandPNGBDBM150326(US8987248, 178)
Affinity DataIC50:  63nMpH: 7.5 T: 2°CAssay Description:Platelet membranes are incubated with 12 nM [3H]haTRAP and test substance in different concentrations in a buffer (50 mM Tris pH 7.5, 10 mM magnesium...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTransmembrane prolyl 4-hydroxylase(Homo sapiens (Human))
Bayer Intellectual Property

US Patent
LigandPNGBDBM105221(US8580778, 21)
Affinity DataIC50:  70nMAssay Description:In vitro tests for determination of the activity and selectivity of HIF prolyl 4-hydroxylase inhibitors. Hydroxylated HIF bonds specifically to the ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetProteinase-activated receptor 1(Homo sapiens (Human))
Bayer Intellectual Property

US Patent
LigandPNGBDBM150316(US8987248, 121)
Affinity DataIC50:  79.9nMpH: 7.5 T: 2°CAssay Description:Platelet membranes are incubated with 12 nM [3H]haTRAP and test substance in different concentrations in a buffer (50 mM Tris pH 7.5, 10 mM magnesium...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetProteinase-activated receptor 1(Homo sapiens (Human))
Bayer Intellectual Property

US Patent
LigandPNGBDBM150324(BDBM150325 | US8987248, 170)
Affinity DataIC50:  81nMpH: 7.5 T: 2°CAssay Description:Platelet membranes are incubated with 12 nM [3H]haTRAP and test substance in different concentrations in a buffer (50 mM Tris pH 7.5, 10 mM magnesium...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTransmembrane prolyl 4-hydroxylase(Homo sapiens (Human))
Bayer Intellectual Property

US Patent
LigandPNGBDBM105220(US8580778, 20)
Affinity DataIC50:  90nMAssay Description:In vitro tests for determination of the activity and selectivity of HIF prolyl 4-hydroxylase inhibitors. Hydroxylated HIF bonds specifically to the ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetProteinase-activated receptor 1(Homo sapiens (Human))
Bayer Intellectual Property

US Patent
LigandPNGBDBM150304(US8987248, 36)
Affinity DataIC50:  98.2nMpH: 7.5 T: 2°CAssay Description:Platelet membranes are incubated with 12 nM [3H]haTRAP and test substance in different concentrations in a buffer (50 mM Tris pH 7.5, 10 mM magnesium...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProteinase-activated receptor 1(Homo sapiens (Human))
Bayer Intellectual Property

US Patent
LigandPNGBDBM150302(US8987248, 8)
Affinity DataIC50:  109nMpH: 7.5 T: 2°CAssay Description:Platelet membranes are incubated with 12 nM [3H]haTRAP and test substance in different concentrations in a buffer (50 mM Tris pH 7.5, 10 mM magnesium...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetProteinase-activated receptor 1(Homo sapiens (Human))
Bayer Intellectual Property

US Patent
LigandPNGBDBM150309(US8987248, 97)
Affinity DataIC50:  109nMpH: 7.5 T: 2°CAssay Description:Platelet membranes are incubated with 12 nM [3H]haTRAP and test substance in different concentrations in a buffer (50 mM Tris pH 7.5, 10 mM magnesium...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTransmembrane prolyl 4-hydroxylase(Homo sapiens (Human))
Bayer Intellectual Property

US Patent
LigandPNGBDBM105219(US8580778, 17)
Affinity DataIC50:  130nMAssay Description:In vitro tests for determination of the activity and selectivity of HIF prolyl 4-hydroxylase inhibitors. Hydroxylated HIF bonds specifically to the ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetProteinase-activated receptor 1(Homo sapiens (Human))
Bayer Intellectual Property

US Patent
LigandPNGBDBM150310(US8987248, 102)
Affinity DataIC50:  165nMpH: 7.5 T: 2°CAssay Description:Platelet membranes are incubated with 12 nM [3H]haTRAP and test substance in different concentrations in a buffer (50 mM Tris pH 7.5, 10 mM magnesium...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTransmembrane prolyl 4-hydroxylase(Homo sapiens (Human))
Bayer Intellectual Property

US Patent
LigandPNGBDBM105224(US8580778, 29)
Affinity DataIC50:  170nMAssay Description:In vitro tests for determination of the activity and selectivity of HIF prolyl 4-hydroxylase inhibitors. Hydroxylated HIF bonds specifically to the ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTransmembrane prolyl 4-hydroxylase(Homo sapiens (Human))
Bayer Intellectual Property

US Patent
LigandPNGBDBM105222(US8580778, 25)
Affinity DataIC50:  180nMAssay Description:In vitro tests for determination of the activity and selectivity of HIF prolyl 4-hydroxylase inhibitors. Hydroxylated HIF bonds specifically to the ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTransmembrane prolyl 4-hydroxylase(Homo sapiens (Human))
Bayer Intellectual Property

US Patent
LigandPNGBDBM3527(US8524699, 18)
Affinity DataIC50:  180nMpH: 7.5 T: 2°CAssay Description:In Vitro assay determination of the activity and selectivity of HIF Prolyl 4-hydroxylase inhibitors.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetProlyl hydroxylase EGLN2(Homo sapiens (Human))
Bayer Intellectual Property

US Patent
LigandPNGBDBM118341(US8653111, 85)
Affinity DataIC50:  190nMAssay Description:Hydroxylated HIF bonds specifically to the von Hippel-Lindau protein-elongin B-elongin C complex (VBC complex). This interaction occurs only if HIF i...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProteinase-activated receptor 1(Homo sapiens (Human))
Bayer Intellectual Property

US Patent
LigandPNGBDBM150308(US8987248, 95)
Affinity DataIC50:  237nMpH: 7.5 T: 2°CAssay Description:Platelet membranes are incubated with 12 nM [3H]haTRAP and test substance in different concentrations in a buffer (50 mM Tris pH 7.5, 10 mM magnesium...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProteinase-activated receptor 1(Homo sapiens (Human))
Bayer Intellectual Property

US Patent
LigandPNGBDBM150311(US8987248, 104)
Affinity DataIC50:  248nMpH: 7.5 T: 2°CAssay Description:Platelet membranes are incubated with 12 nM [3H]haTRAP and test substance in different concentrations in a buffer (50 mM Tris pH 7.5, 10 mM magnesium...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTransmembrane prolyl 4-hydroxylase(Homo sapiens (Human))
Bayer Intellectual Property

US Patent
LigandPNGBDBM109268(US8609698, 10)
Affinity DataIC50:  260nMAssay Description:Inhibition of the Activity of HIF Prolyl Hydroxylase is carried out as described [Oehme F., Jonghaus W., Narouz-Ott L., Huetter J., Flamme I., Anal. ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetProlyl hydroxylase EGLN2(Homo sapiens (Human))
Bayer Intellectual Property

US Patent
LigandPNGBDBM118328(US8653111, 7)
Affinity DataIC50:  340nMAssay Description:Hydroxylated HIF bonds specifically to the von Hippel-Lindau protein-elongin B-elongin C complex (VBC complex). This interaction occurs only if HIF i...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetProlyl hydroxylase EGLN2(Homo sapiens (Human))
Bayer Intellectual Property

US Patent
LigandPNGBDBM118344(US8653111, 103)
Affinity DataIC50:  350nMAssay Description:Hydroxylated HIF bonds specifically to the von Hippel-Lindau protein-elongin B-elongin C complex (VBC complex). This interaction occurs only if HIF i...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProteinase-activated receptor 1(Homo sapiens (Human))
Bayer Intellectual Property

US Patent
LigandPNGBDBM150306(US8987248, 90)
Affinity DataIC50:  359nMpH: 7.5 T: 2°CAssay Description:Platelet membranes are incubated with 12 nM [3H]haTRAP and test substance in different concentrations in a buffer (50 mM Tris pH 7.5, 10 mM magnesium...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetProlyl hydroxylase EGLN2(Homo sapiens (Human))
Bayer Intellectual Property

US Patent
LigandPNGBDBM118346(US8653111, 129)
Affinity DataIC50:  360nMAssay Description:Hydroxylated HIF bonds specifically to the von Hippel-Lindau protein-elongin B-elongin C complex (VBC complex). This interaction occurs only if HIF i...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTransmembrane prolyl 4-hydroxylase(Homo sapiens (Human))
Bayer Intellectual Property

US Patent
LigandPNGBDBM105223(US8580778, 26)
Affinity DataIC50:  380nMAssay Description:In vitro tests for determination of the activity and selectivity of HIF prolyl 4-hydroxylase inhibitors. Hydroxylated HIF bonds specifically to the ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTransmembrane prolyl 4-hydroxylase(Homo sapiens (Human))
Bayer Intellectual Property

US Patent
LigandPNGBDBM3543(US8524699, 16)
Affinity DataIC50:  480nMpH: 7.5 T: 2°CAssay Description:In Vitro assay determination of the activity and selectivity of HIF Prolyl 4-hydroxylase inhibitors.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetProteinase-activated receptor 1(Homo sapiens (Human))
Bayer Intellectual Property

US Patent
LigandPNGBDBM150303(US8987248, 18)
Affinity DataIC50:  483nMpH: 7.5 T: 2°CAssay Description:Platelet membranes are incubated with 12 nM [3H]haTRAP and test substance in different concentrations in a buffer (50 mM Tris pH 7.5, 10 mM magnesium...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetProlyl hydroxylase EGLN2(Homo sapiens (Human))
Bayer Intellectual Property

US Patent
LigandPNGBDBM118339(US8653111, 72)
Affinity DataIC50:  490nMAssay Description:Hydroxylated HIF bonds specifically to the von Hippel-Lindau protein-elongin B-elongin C complex (VBC complex). This interaction occurs only if HIF i...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetProlyl hydroxylase EGLN2(Homo sapiens (Human))
Bayer Intellectual Property

US Patent
LigandPNGBDBM118329(US8653111, 10)
Affinity DataIC50:  500nMAssay Description:Hydroxylated HIF bonds specifically to the von Hippel-Lindau protein-elongin B-elongin C complex (VBC complex). This interaction occurs only if HIF i...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTransmembrane prolyl 4-hydroxylase(Homo sapiens (Human))
Bayer Intellectual Property

US Patent
LigandPNGBDBM105217(US8580778, 5)
Affinity DataIC50:  540nMAssay Description:In vitro tests for determination of the activity and selectivity of HIF prolyl 4-hydroxylase inhibitors. Hydroxylated HIF bonds specifically to the ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetProlyl hydroxylase EGLN2(Homo sapiens (Human))
Bayer Intellectual Property

US Patent
LigandPNGBDBM118331(US8653111, 17)
Affinity DataIC50:  560nMAssay Description:Hydroxylated HIF bonds specifically to the von Hippel-Lindau protein-elongin B-elongin C complex (VBC complex). This interaction occurs only if HIF i...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProlyl hydroxylase EGLN2(Homo sapiens (Human))
Bayer Intellectual Property

US Patent
LigandPNGBDBM118347(US8653111, 166)
Affinity DataIC50:  690nMAssay Description:Hydroxylated HIF bonds specifically to the von Hippel-Lindau protein-elongin B-elongin C complex (VBC complex). This interaction occurs only if HIF i...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTransmembrane prolyl 4-hydroxylase(Homo sapiens (Human))
Bayer Intellectual Property

US Patent
LigandPNGBDBM3555(US8524699, 3)
Affinity DataIC50:  700nMpH: 7.5 T: 2°CAssay Description:In Vitro assay determination of the activity and selectivity of HIF Prolyl 4-hydroxylase inhibitors.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProlyl hydroxylase EGLN2(Homo sapiens (Human))
Bayer Intellectual Property

US Patent
LigandPNGBDBM118345(US8653111, 113)
Affinity DataIC50:  740nMAssay Description:Hydroxylated HIF bonds specifically to the von Hippel-Lindau protein-elongin B-elongin C complex (VBC complex). This interaction occurs only if HIF i...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetProlyl hydroxylase EGLN2(Homo sapiens (Human))
Bayer Intellectual Property

US Patent
LigandPNGBDBM118330(US8653111, 12)
Affinity DataIC50:  750nMAssay Description:Hydroxylated HIF bonds specifically to the von Hippel-Lindau protein-elongin B-elongin C complex (VBC complex). This interaction occurs only if HIF i...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTransmembrane prolyl 4-hydroxylase(Homo sapiens (Human))
Bayer Intellectual Property

US Patent
LigandPNGBDBM105218(US8580778, 9)
Affinity DataIC50:  760nMAssay Description:In vitro tests for determination of the activity and selectivity of HIF prolyl 4-hydroxylase inhibitors. Hydroxylated HIF bonds specifically to the ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetProlyl hydroxylase EGLN2(Homo sapiens (Human))
Bayer Intellectual Property

US Patent
LigandPNGBDBM118333(US8653111, 45)
Affinity DataIC50:  780nMAssay Description:Hydroxylated HIF bonds specifically to the von Hippel-Lindau protein-elongin B-elongin C complex (VBC complex). This interaction occurs only if HIF i...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
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