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Found 2583 with Last Name = 'jones' and Initial = 'l'
TargetDihydrofolate reductase(Candida albicans)
Wellcome Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50049912(7-(1,1-Dimethyl-propyl)-8-methyl-7H-pyrrolo[3,2-f]...)
Affinity DataKi:  0.00710nMAssay Description:Inhibition of Dihydrofolate reductase enzyme from Candida albicansMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Homo sapiens (Human))
Wellcome Research Laboratories

Curated by ChEMBL
LigandPNGBDBM18224(6-[(2,5-dimethoxyphenyl)methyl]-5-methylpyrido[2,3...)
Affinity DataKi:  0.0250nMAssay Description:Inhibition of human recombinant Dihydrofolate reductase enzymeMore data for this Ligand-Target Pair
TargetTyrosine-protein kinase ITK/TSK(Homo sapiens (Human))
Pfizer

LigandPNGBDBM209866(PF-06651600 | US11111242, Example 5 | US2023034848...)
Affinity DataKi:  0.0269nMpH: 7.5Assay Description:Assay buffer was 20 mM HEPES, pH 7.5, 10 mM MgCl2, 0.01% BSA, 1 mM DTT, 0.0005% Tween 20, and 2% DMSO. Inactivation kinetic reactions were performed ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Candida albicans)
Wellcome Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50049905(7-(1-Ethyl-propyl)-8-methyl-7H-pyrrolo[3,2-f]quina...)
Affinity DataKi:  0.0300nMAssay Description:Inhibition of Dihydrofolate reductase enzyme from Candida albicansMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVesicular acetylcholine transporter(Homo sapiens (Human))
Washington University

Curated by ChEMBL
LigandPNGBDBM50039613((2R,3R)-3-(4-Phenyl-piperidin-1-yl)-1,2,3,4-tetrah...)
Affinity DataKi:  0.0550nMAssay Description:Displacement of [3H]vesamicol from human vesicular acetylcholine transporter expressed in rat PC12 cells by liquid scintillation spectrometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50343152(CHEMBL1773196 | N-(3-(3-((R)-3-(diisopropylamino)-...)
Affinity DataKi:  0.0910nMAssay Description:Displacement of [3H]N-methyl Scopolamine from human muscarinic M3 receptor expressed in CHO cells by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Homo sapiens (Human))
Wellcome Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50049906(7-tert-Butyl-8-ethyl-7H-pyrrolo[3,2-f]quinazoline-...)
Affinity DataKi:  0.100nMAssay Description:Inhibition of human recombinant Dihydrofolate reductase enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Homo sapiens (Human))
Wellcome Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50049901(7-sec-Butyl-8-ethyl-7H-pyrrolo[3,2-f]quinazoline-1...)
Affinity DataKi:  0.100nMAssay Description:Inhibition of human recombinant Dihydrofolate reductase enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Homo sapiens (Human))
Wellcome Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50049907(7-(1-Ethyl-propyl)-8-isopropyl-7H-pyrrolo[3,2-f]qu...)
Affinity DataKi:  0.100nMAssay Description:Inhibition of human recombinant Dihydrofolate reductase enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Candida albicans)
Wellcome Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50049911(8-tert-Butyl-7H-pyrrolo[3,2-f]quinazoline-1,3-diam...)
Affinity DataKi:  0.120nMAssay Description:Inhibition of Dihydrofolate reductase enzyme from Candida albicansMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase TXK(Homo sapiens (Human))
Pfizer

LigandPNGBDBM209866(PF-06651600 | US11111242, Example 5 | US2023034848...)
Affinity DataKi:  0.131nMpH: 7.5Assay Description:Assay buffer was 20 mM HEPES, pH 7.5, 10 mM MgCl2, 0.01% BSA, 1 mM DTT, 0.0005% Tween 20, and 2% DMSO. Inactivation kinetic reactions were performed ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50128835(CHEMBL3629360)
Affinity DataKi:  0.140nMAssay Description:Antagonist activity at muscarinic M2 receptor (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Candida albicans)
Wellcome Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50049898(8-Isopropyl-7H-pyrrolo[3,2-f]quinazoline-1,3-diami...)
Affinity DataKi:  0.160nMAssay Description:Inhibition of Dihydrofolate reductase enzyme from Candida albicansMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50128835(CHEMBL3629360)
Affinity DataKi:  0.160nMAssay Description:Antagonist activity at muscarinic M1 receptor (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Homo sapiens (Human))
Wellcome Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50049909(8-tert-Butyl-7-isopropyl-7H-pyrrolo[3,2-f]quinazol...)
Affinity DataKi:  0.200nMAssay Description:Inhibition of human recombinant Dihydrofolate reductase enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Homo sapiens (Human))
Wellcome Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50049897(8-Ethyl-7-(1-ethyl-propyl)-7H-pyrrolo[3,2-f]quinaz...)
Affinity DataKi:  0.200nMAssay Description:Inhibition of human recombinant Dihydrofolate reductase enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Candida albicans)
Wellcome Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50049899(7-Isopropyl-8-methyl-7H-pyrrolo[3,2-f]quinazoline-...)
Affinity DataKi:  0.220nMAssay Description:Inhibition of Dihydrofolate reductase enzyme from Candida albicansMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Candida albicans)
Wellcome Research Laboratories

Curated by ChEMBL
LigandPNGBDBM18043(1,3-DIAMINO-7-(1-ETHYEPROPYE)-7H-PYRRALO-[3,2-F]QU...)
Affinity DataKi:  0.220nMAssay Description:Inhibition of Dihydrofolate reductase enzyme from Candida albicansMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedMMDB

TargetVesicular acetylcholine transporter(Homo sapiens (Human))
Washington University

Curated by ChEMBL
LigandPNGBDBM50046952((3'R,4'R)-1'-(4-Fluoro-benzyl)-4-phenyl-[1,3']bipi...)
Affinity DataKi:  0.220nMAssay Description:Displacement of [3H]vesamicol from human vesicular acetylcholine transporter expressed in rat PC12 cells by liquid scintillation spectrometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Candida albicans)
Wellcome Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50049914(7-(3,4,5-Trimethoxy-benzyl)-7H-pyrrolo[3,2-f]quina...)
Affinity DataKi:  0.230nMAssay Description:Inhibition of Dihydrofolate reductase enzyme from Candida albicansMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVesicular acetylcholine transporter(Homo sapiens (Human))
Washington University

Curated by ChEMBL
LigandPNGBDBM50292908((+/-)-trans-2-Hydroxy-3-(4-(4-bromobenzoyl)piperid...)
Affinity DataKi:  0.25nMAssay Description:Displacement of [3H]vesamicol from human vesicular acetylcholine transporter expressed in rat PC12 cells by liquid scintillation spectrometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50343153(CHEMBL1773197 | N-(3-(3-((R)-3-(diisopropylamino)-...)
Affinity DataKi:  0.276nMAssay Description:Displacement of [3H]N-methyl Scopolamine from human muscarinic M3 receptor expressed in CHO cells by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50128835(CHEMBL3629360)
Affinity DataKi:  0.290nMAssay Description:Displacement of [3H]N-methyl scopolamine from human cloned muscarinic M3 receptor by dilution methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Homo sapiens (Human))
Wellcome Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50049905(7-(1-Ethyl-propyl)-8-methyl-7H-pyrrolo[3,2-f]quina...)
Affinity DataKi:  0.300nMAssay Description:Inhibition of human recombinant Dihydrofolate reductase enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50343161(5-((R)-2-(4-(4-(3-((R)-3-(diisopropylamino)-1-phen...)
Affinity DataKi:  0.305nMAssay Description:Displacement of [3H]N-methyl Scopolamine from human muscarinic M3 receptor expressed in CHO cells by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50343161(5-((R)-2-(4-(4-(3-((R)-3-(diisopropylamino)-1-phen...)
Affinity DataKi:  0.310nMAssay Description:Displacement of [3H]N-methyl scopolamine from human cloned muscarinic M3 receptor by dilution methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Candida albicans)
Wellcome Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50049913(7-Ethyl-8-isopropyl-7H-pyrrolo[3,2-f]quinazoline-1...)
Affinity DataKi:  0.330nMAssay Description:Inhibition of Dihydrofolate reductase enzyme from Candida albicansMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Candida albicans)
Wellcome Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50049902(7,8-Diethyl-7H-pyrrolo[3,2-f]quinazoline-1,3-diami...)
Affinity DataKi:  0.330nMAssay Description:Inhibition of Dihydrofolate reductase enzyme from Candida albicansMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50128837(CHEMBL3629354)
Affinity DataKi:  0.340nMAssay Description:Displacement of [3H]N-methyl scopolamine from human cloned muscarinic M3 receptor by dilution methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M4(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50128835(CHEMBL3629360)
Affinity DataKi:  0.350nMAssay Description:Antagonist activity at muscarinic M4 receptor (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Candida albicans)
Wellcome Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50049896(8-Butyl-7-tert-butyl-7H-pyrrolo[3,2-f]quinazoline-...)
Affinity DataKi:  0.380nMAssay Description:Inhibition of Dihydrofolate reductase enzyme from Candida albicansMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50343154(2-(3-((R)-2-((R)-2-(3,5-dihydroxyphenyl)-2-hydroxy...)
Affinity DataKi:  0.397nMAssay Description:Displacement of [3H]N-methyl Scopolamine from human muscarinic M3 receptor expressed in CHO cells by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Homo sapiens (Human))
Wellcome Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50049903(7-(1-Ethyl-propyl)-8-propyl-7H-pyrrolo[3,2-f]quina...)
Affinity DataKi:  0.400nMAssay Description:Inhibition of human recombinant Dihydrofolate reductase enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Homo sapiens (Human))
Wellcome Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50049912(7-(1,1-Dimethyl-propyl)-8-methyl-7H-pyrrolo[3,2-f]...)
Affinity DataKi:  0.400nMAssay Description:Inhibition of human recombinant Dihydrofolate reductase enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVesicular acetylcholine transporter(Homo sapiens (Human))
Washington University

Curated by ChEMBL
LigandPNGBDBM50292905((2R,3R)-5-(3-iodoallyloxy)-3-(4-phenylpiperidin-1-...)
Affinity DataKi:  0.450nMAssay Description:Displacement of [3H]vesamicol from human vesicular acetylcholine transporter expressed in rat PC12 cells by liquid scintillation spectrometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVesicular acetylcholine transporter(Homo sapiens (Human))
Washington University

Curated by ChEMBL
LigandPNGBDBM50292910((+/-)-trans-2-Hydroxy-3-(4-(4-nitrobenzoyl)piperid...)
Affinity DataKi:  0.480nMAssay Description:Displacement of [3H]vesamicol from human vesicular acetylcholine transporter expressed in rat PC12 cells by liquid scintillation spectrometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytoplasmic tyrosine-protein kinase BMX(Homo sapiens (Human))
Pfizer

LigandPNGBDBM209866(PF-06651600 | US11111242, Example 5 | US2023034848...)
Affinity DataKi:  0.545nMpH: 7.5Assay Description:Assay buffer was 20 mM HEPES, pH 7.5, 10 mM MgCl2, 0.01% BSA, 1 mM DTT, 0.0005% Tween 20, and 2% DMSO. Inactivation kinetic reactions were performed ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50263211(2-Cyclobutylamino-N-[4'-(cyclopropylmethyl-carbamo...)
Affinity DataKi:  0.600nMAssay Description:Displacement of rhodamine-green labeled (2-(6-amino-3-imino-3H-xanthen-9-yl)-5-{[({4-[4-(4-Cl-3-hydroxyphenyl)-5-(4-pyridinyl)-1H-imidazol-2yl]phenyl...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50343157(CHEMBL1773264 | N-(5-((R)-2-(4-(4-(3-((R)-3-(diiso...)
Affinity DataKi:  0.634nMAssay Description:Displacement of [3H]N-methyl Scopolamine from human muscarinic M3 receptor expressed in CHO cells by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Candida albicans)
Wellcome Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50049910(7-Ethyl-8-propyl-7H-pyrrolo[3,2-f]quinazoline-1,3-...)
Affinity DataKi:  0.650nMAssay Description:Inhibition of Dihydrofolate reductase enzyme from Candida albicansMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Tec(Homo sapiens (Human))
Pfizer

LigandPNGBDBM209866(PF-06651600 | US11111242, Example 5 | US2023034848...)
Affinity DataKi:  0.679nMpH: 7.5Assay Description:Assay buffer was 20 mM HEPES, pH 7.5, 10 mM MgCl2, 0.01% BSA, 1 mM DTT, 0.0005% Tween 20, and 2% DMSO. Inactivation kinetic reactions were performed ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50128830(CHEMBL3629353)
Affinity DataKi:  0.730nMAssay Description:Displacement of [3H]N-methyl scopolamine from human cloned muscarinic M3 receptor by dilution methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50343158(2-((R)-3-(diisopropylamino)-1-phenylpropyl)-4-(4-(...)
Affinity DataKi:  0.765nMAssay Description:Displacement of [3H]N-methyl Scopolamine from human muscarinic M3 receptor expressed in CHO cells by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVesicular acetylcholine transporter(Homo sapiens (Human))
Washington University

Curated by ChEMBL
LigandPNGBDBM50292906((2R,3R)-5-(3-fluoropropoxy)-3-(4-phenylpiperidin-1...)
Affinity DataKi:  0.770nMAssay Description:Displacement of [3H]vesamicol from human vesicular acetylcholine transporter expressed in rat PC12 cells by liquid scintillation spectrometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50343160(CHEMBL1773266 | N-(5-((R)-2-(6-(4-(3-((R)-3-(diiso...)
Affinity DataKi:  0.990nMAssay Description:Displacement of [3H]N-methyl Scopolamine from human muscarinic M3 receptor expressed in CHO cells by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 3A(Homo sapiens (Human))
Washington University

Curated by ChEMBL
LigandPNGBDBM50007872(3-Ethyl-2-oxo-2,3-dihydro-benzoimidazole-1-carboxy...)
Affinity DataKi:  1nMAssay Description:Binding affinity to 5HT3 receptor (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M5(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50128835(CHEMBL3629360)
Affinity DataKi:  1.10nMAssay Description:Antagonist activity at muscarinic M5 receptor (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50128836(CHEMBL143228)
Affinity DataKi:  1.10nMAssay Description:Displacement of [3H]N-methyl scopolamine from human cloned muscarinic M3 receptor by dilution methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50128838(CHEMBL3629355)
Affinity DataKi:  1.10nMAssay Description:Displacement of [3H]N-methyl scopolamine from human cloned muscarinic M3 receptor by dilution methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone acetyltransferase KAT2B(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50234923(CHEMBL4069412)
Affinity DataKi:  1.26nMAssay Description:Binding affinity to human partial length PCAF bromodomain expressed in mammalian expression system by BROMOscan methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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