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Found 70 with Last Name = 'kador' and Initial = 'pf'
TargetAldo-keto reductase family 1 member B1(Rattus norvegicus)
National Eye Institute

Curated by ChEMBL
LigandPNGBDBM16496(2-{3-[(4-bromo-2-fluorophenyl)methyl]-7-chloro-2,4...)
Affinity DataIC50:  4.40nMAssay Description:Inhibitory activity against purified rat lens aldose reductase (RLAR)More data for this Ligand-Target Pair
TargetAldo-keto reductase family 1 member B1(Rattus norvegicus)
National Eye Institute

Curated by ChEMBL
LigandPNGBDBM50009777((ponalrestat)[3-(4-Bromo-2-fluoro-benzyl)-4-oxo-3,...)
Affinity DataIC50:  16nMAssay Description:Inhibitory activity against purified rat lens aldose reductase (RLAR)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Rattus norvegicus)
National Eye Institute

Curated by ChEMBL
LigandPNGBDBM50049730(2-(5-(2-methyl-3-phenylallylidene)-4-oxo-2-thioxot...)
Affinity DataIC50:  23nMAssay Description:Inhibitory activity against purified rat lens aldose reductase (RLAR)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Rattus norvegicus)
National Eye Institute

Curated by ChEMBL
LigandPNGBDBM50040782((2,8-Diisopropyl-3-thioxo-2,3-dihydro-benzo[1,4]ox...)
Affinity DataIC50:  130nMAssay Description:Inhibitory activity against purified rat lens aldose reductase (RLAR)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Rattus norvegicus)
National Eye Institute

Curated by ChEMBL
LigandPNGBDBM50022275((5-Isothiocyanato-1,3-dioxo-1H,3H-benzo[de]isoquin...)
Affinity DataIC50:  300nMAssay Description:Compound was tested for 50% inhibitory concentration that was required for irreversible inhibition of aldose reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Rattus norvegicus)
National Eye Institute

Curated by ChEMBL
LigandPNGBDBM50005527(CHEMBL13803 | [5-(2-Iodo-acetyl)-1,3-dioxo-1H,3H-b...)
Affinity DataIC50:  400nMAssay Description:Compound was evaluated for the inhibition of Rat kidney Aldehyde reductase (RKALR)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Rattus norvegicus)
National Eye Institute

Curated by ChEMBL
LigandPNGBDBM50040781((2,7-Difluoro-9H-fluoren-9-yl)-acetic acid | CHEMB...)
Affinity DataIC50:  430nMAssay Description:Inhibitory activity against purified rat lens aldose reductase (RLAR)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Rattus norvegicus)
National Eye Institute

Curated by ChEMBL
LigandPNGBDBM50005525(CHEMBL13997 | [5-(2-Chloro-acetyl)-1,3-dioxo-1H,3H...)
Affinity DataIC50:  550nMAssay Description:Compound was evaluated for the inhibition of Rat Lens Aldose reductase (RLAR)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Rattus norvegicus)
National Eye Institute

Curated by ChEMBL
LigandPNGBDBM50005524(CHEMBL273484 | [5-(2-Bromo-acetyl)-1,3-dioxo-1H,3H...)
Affinity DataIC50:  600nMAssay Description:Compound was evaluated for the inhibition of Rat Lens Aldose reductase (RLAR)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Rattus norvegicus)
National Eye Institute

Curated by ChEMBL
LigandPNGBDBM50005526((5-Acetyl-1,3-dioxo-1H,3H-benzo[de]isoquinolin-2-y...)
Affinity DataIC50:  640nMAssay Description:Compound was evaluated for the inhibition of Rat Lens Aldose reductase (RLAR)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM16312((4S)-6-fluoro-2,3-dihydrospiro[1-benzopyran-4,4'-i...)
Affinity DataIC50:  700nMAssay Description:Inhibitory activity of the compound against human placental aldose reductase in Orange A column at day 8More data for this Ligand-Target Pair
TargetAldo-keto reductase family 1 member B1(Rattus norvegicus)
National Eye Institute

Curated by ChEMBL
LigandPNGBDBM50040779((2-Fluoro-9H-fluoren-9-yl)-acetic acid | CHEMBL349...)
Affinity DataIC50:  850nMAssay Description:Inhibitory activity against purified rat lens aldose reductase (RLAR)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Rattus norvegicus)
National Eye Institute

Curated by ChEMBL
LigandPNGBDBM16415((1,3-dioxo-1H-benzo[de]isoquinolin-2(3H)-yl)acetic...)
Affinity DataIC50:  1.50E+3nMAssay Description:Inhibitory activity against purified rat lens aldose reductase (RLAR)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedMMDB

TargetAldo-keto reductase family 1 member B1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50025972(7-Hydroxy-4-oxo-4a,8a-dihydro-4H-chromene-2-carbox...)
Affinity DataIC50:  1.80E+3nMAssay Description:Inhibitory activity of the compound against human placental aldose reductase in Sepharose 4B column at day 7More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50025978(7-Hydroxy-4-oxo-4H-chromene-2-carboxylic acid | CH...)
Affinity DataIC50:  1.80E+3nMAssay Description:Inhibitory activity of the compound against human placental aldose reductase (HPAR).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Rattus norvegicus)
National Eye Institute

Curated by ChEMBL
LigandPNGBDBM50025978(7-Hydroxy-4-oxo-4H-chromene-2-carboxylic acid | CH...)
Affinity DataIC50:  2.20E+3nMAssay Description:Inhibitory activity of the compound against rat lens aldose reductase (RLAR).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Rattus norvegicus)
National Eye Institute

Curated by ChEMBL
LigandPNGBDBM50025973(7-Hydroxy-4-oxo-4H-chromene-2-carboxylic acid ethy...)
Affinity DataIC50:  2.30E+3nMAssay Description:Inhibitory activity of the compound against rat lens aldose reductase (RLAR).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Rattus norvegicus)
National Eye Institute

Curated by ChEMBL
LigandPNGBDBM50025980(7-Hydroxy-4-oxo-4H-chromene-2-carboxylic acid benz...)
Affinity DataIC50:  2.50E+3nMAssay Description:Inhibitory activity of the compound against rat lens aldose reductase (RLAR).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50025972(7-Hydroxy-4-oxo-4a,8a-dihydro-4H-chromene-2-carbox...)
Affinity DataIC50:  3.10E+3nMAssay Description:Inhibitory activity of the compound against human placental aldose reductase in Orange A column at day 8More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Rattus norvegicus)
National Eye Institute

Curated by ChEMBL
LigandPNGBDBM50025977(7-Hydroxy-4-oxo-4H-chromene-2-carboxylic acid isop...)
Affinity DataIC50:  3.10E+3nMAssay Description:Inhibitory activity of the compound against rat lens aldose reductase (RLAR).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50025980(7-Hydroxy-4-oxo-4H-chromene-2-carboxylic acid benz...)
Affinity DataIC50:  3.20E+3nMAssay Description:Inhibitory activity of the compound against human placental aldose reductase (HPAR)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50025979(3-(Ethoxyoxalyl-amino)-2-hydroxy-5-nitro-benzoic a...)
Affinity DataIC50:  3.20E+3nMAssay Description:Inhibitory activity of the compound against human placental aldose reductase in Orange A column at time 2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Rattus norvegicus)
National Eye Institute

Curated by ChEMBL
LigandPNGBDBM50040780(CHEMBL163958 | cid_234512 | spiro[9H-fluorene-9,4'...)
Affinity DataIC50:  3.50E+3nMAssay Description:Inhibitory activity against purified rat lens aldose reductase (RLAR)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Rattus norvegicus)
National Eye Institute

Curated by ChEMBL
LigandPNGBDBM50022277((5-Azido-1,3-dioxo-1H,3H-benzo[de]isoquinolin-2-yl...)
Affinity DataIC50:  3.60E+3nMAssay Description:Compound was tested for 50% inhibitory concentration that was required for irreversible inhibition of aldose reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50025972(7-Hydroxy-4-oxo-4a,8a-dihydro-4H-chromene-2-carbox...)
Affinity DataIC50:  3.90E+3nMAssay Description:Inhibitory activity of the compound against human placental aldose reductase in 30 -70% (NH4)2SO4.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50025979(3-(Ethoxyoxalyl-amino)-2-hydroxy-5-nitro-benzoic a...)
Affinity DataIC50:  4.00E+3nMAssay Description:Inhibitory activity of the compound against human placental aldose reductase in Orange A column at at time 2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50025976(3-Chloro-2-(1H-tetrazol-5-yl)-chromen-4-one | CHEM...)
Affinity DataIC50:  4.10E+3nMAssay Description:Inhibitory activity of the compound against human placental aldose reductase in Sepharose 4B column at day 7More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50025977(7-Hydroxy-4-oxo-4H-chromene-2-carboxylic acid isop...)
Affinity DataIC50:  4.30E+3nMAssay Description:Inhibitory activity of the compound against human placental aldose reductase (HPAR)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50025975(3-Hydroxy-11-oxo-11H-pyrido[2,1-b]quinazoline-8-ca...)
Affinity DataIC50:  4.50E+3nMAssay Description:Inhibitory activity of the compound against human placental aldose reductase in 30 -70% (NH4)2SO4.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50025979(3-(Ethoxyoxalyl-amino)-2-hydroxy-5-nitro-benzoic a...)
Affinity DataIC50:  4.50E+3nMAssay Description:Inhibitory activity of the compound against human placental aldose reductase in Sepharose 4B column at day 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM16312((4S)-6-fluoro-2,3-dihydrospiro[1-benzopyran-4,4'-i...)
Affinity DataIC50:  4.70E+3nMAssay Description:Inhibitory activity of the compound against human placental aldose reductase in Orange A column at day 8More data for this Ligand-Target Pair
TargetAldo-keto reductase family 1 member B1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50025972(7-Hydroxy-4-oxo-4a,8a-dihydro-4H-chromene-2-carbox...)
Affinity DataIC50:  4.70E+3nMAssay Description:Inhibitory activity of the compound against human placental aldose reductase in Sepharose 4B column at day 7More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50025973(7-Hydroxy-4-oxo-4H-chromene-2-carboxylic acid ethy...)
Affinity DataIC50:  5.00E+3nMAssay Description:Inhibitory activity of the compound against human placental aldose reductase (HPAR)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50025975(3-Hydroxy-11-oxo-11H-pyrido[2,1-b]quinazoline-8-ca...)
Affinity DataIC50:  5.00E+3nMAssay Description:Inhibitory activity of the compound against human placental aldose reductase in Sepharose 4B column at day 7More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50025972(7-Hydroxy-4-oxo-4a,8a-dihydro-4H-chromene-2-carbox...)
Affinity DataIC50:  5.90E+3nMAssay Description:Inhibitory activity of the compound against human placental aldose reductase in 30 -70% (NH4)2SO4.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Rattus norvegicus)
National Eye Institute

Curated by ChEMBL
LigandPNGBDBM50005526((5-Acetyl-1,3-dioxo-1H,3H-benzo[de]isoquinolin-2-y...)
Affinity DataIC50:  6.40E+3nMAssay Description:Compound was evaluated for the inhibition of Rat kidney Aldehyde reductase (RKALR)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM16415((1,3-dioxo-1H-benzo[de]isoquinolin-2(3H)-yl)acetic...)
Affinity DataIC50:  6.50E+3nMAssay Description:Inhibitory activity of the compound against human placental aldose reductase in Sepharose 4B column at time 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Rattus norvegicus)
National Eye Institute

Curated by ChEMBL
LigandPNGBDBM50005527(CHEMBL13803 | [5-(2-Iodo-acetyl)-1,3-dioxo-1H,3H-b...)
Affinity DataIC50:  6.50E+3nMAssay Description:Compound was evaluated for the inhibition of Rat kidney Aldehyde reductase (RKALR)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50025974(2-(3,4-Dihydroxy-phenyl)-5,7-dihydroxy-3-(4,5,6-tr...)
Affinity DataIC50:  7.10E+3nMAssay Description:Inhibitory activity of the compound against human placental aldose reductase in Sepharose 4B column at day 7More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50025975(3-Hydroxy-11-oxo-11H-pyrido[2,1-b]quinazoline-8-ca...)
Affinity DataIC50:  7.20E+3nMAssay Description:Inhibitory activity of the compound against human placental aldose reductase in Orange A column at at time 2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM16312((4S)-6-fluoro-2,3-dihydrospiro[1-benzopyran-4,4'-i...)
Affinity DataIC50:  7.20E+3nMAssay Description:Inhibitory activity of the compound against human placental aldose reductase in Sepharose 4B column at day 7More data for this Ligand-Target Pair
TargetAldo-keto reductase family 1 member B1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50025975(3-Hydroxy-11-oxo-11H-pyrido[2,1-b]quinazoline-8-ca...)
Affinity DataIC50:  7.30E+3nMAssay Description:Inhibitory activity of the compound against human placental aldose reductase in Sepharose 4B column at day 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50025979(3-(Ethoxyoxalyl-amino)-2-hydroxy-5-nitro-benzoic a...)
Affinity DataIC50:  7.30E+3nMAssay Description:Inhibitory activity of the compound against human placental aldose reductase in Orange A column at day 8More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Rattus norvegicus)
National Eye Institute

Curated by ChEMBL
LigandPNGBDBM50005524(CHEMBL273484 | [5-(2-Bromo-acetyl)-1,3-dioxo-1H,3H...)
Affinity DataIC50:  8.00E+3nMAssay Description:Compound was evaluated for the inhibition of Rat kidney Aldehyde reductase (RKALR)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50025979(3-(Ethoxyoxalyl-amino)-2-hydroxy-5-nitro-benzoic a...)
Affinity DataIC50:  8.30E+3nMAssay Description:Inhibitory activity of the compound against human placental aldose reductase in Orange A column at day 2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Rattus norvegicus)
National Eye Institute

Curated by ChEMBL
LigandPNGBDBM50034798((9H-Fluoren-9-yl)-acetic acid | CHEMBL44381)
Affinity DataIC50:  8.90E+3nMAssay Description:Inhibitory activity against purified rat lens aldose reductase (RLAR)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50025974(2-(3,4-Dihydroxy-phenyl)-5,7-dihydroxy-3-(4,5,6-tr...)
Affinity DataIC50:  9.00E+3nMAssay Description:Inhibitory activity of the compound against human placental aldose reductase in Orange A column at day 8More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Rattus norvegicus)
National Eye Institute

Curated by ChEMBL
LigandPNGBDBM50005525(CHEMBL13997 | [5-(2-Chloro-acetyl)-1,3-dioxo-1H,3H...)
Affinity DataIC50:  1.04E+4nMAssay Description:Compound was evaluated for the inhibition of Rat Lens Aldose reductase (RLAR)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Rattus norvegicus)
National Eye Institute

Curated by ChEMBL
LigandPNGBDBM50040777(CHEMBL351278 | spiro[9H-fluorene-9,4'-(tetrahydro-...)
Affinity DataIC50:  1.17E+4nMAssay Description:Inhibitory activity against purified rat lens aldose reductase (RLAR)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Rattus norvegicus)
National Eye Institute

Curated by ChEMBL
LigandPNGBDBM50022276((5-Isothiocyanato-1,3-dioxo-1H,3H-benzo[de]isoquin...)
Affinity DataIC50:  1.40E+4nMAssay Description:Compound was tested for 50% inhibitory concentration that was required for irreversible inhibition of aldose reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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