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Found 441 with Last Name = 'kanter' and Initial = 'j'
TargetCoagulation factor X(Homo sapiens (Human))
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM12751(1-(3-carbamimidoylphenyl)-3-methyl-N-[4-(2-sulfamo...)
Affinity DataKi:  0.0130nMAssay Description:Inhibitory activity of the compound against Coagulation factor Xa (serine protease) was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50193861(5-chloro-N-(5-chloro-pyridin-2-yl)-2-[4-(N,N-dimet...)
Affinity DataKi:  0.0440nMAssay Description:Inhibition of Factor 10a (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50249120(CHEMBL472967 | N-(4-chloro-2-(5-chloropyridin-2-yl...)
Affinity DataKi:  0.0600nMAssay Description:Inhibition of Factor 10a (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM19023(1-(4-methoxyphenyl)-7-oxo-6-[4-(2-oxopiperidin-1-y...)
Affinity DataKi:  0.0800nMAssay Description:Inhibition of Factor 10a (unknown origin)More data for this Ligand-Target Pair
TargetCoagulation factor X(Homo sapiens (Human))
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50249423(CHEMBL515919 | N-(2-(5-chloropyridin-2-ylcarbamoyl...)
Affinity DataKi:  0.105nMAssay Description:Inhibition of Factor 10a (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50249298(BEVYXXA | CHEMBL512351 | N-(5-chloropyridin-2-yl)-...)
Affinity DataKi:  0.117nMAssay Description:Inhibition of Factor 10a (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50113598((Z)-3-(3-Carbamimidoyl-4-fluoro-phenyl)-2-fluoro-b...)
Affinity DataKi:  0.180nMAssay Description:Inhibitory activity of the compound against factor Xa,activity expressed as Ki nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM7840(RIVAROXABAN | US8822458, 44 | US8822458, 97)
Affinity DataKi:  0.400nMAssay Description:Inhibition of Factor 10a (unknown origin)More data for this Ligand-Target Pair
TargetCoagulation factor X(Homo sapiens (Human))
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50249295(CHEMBL471725 | N-(5-chloropyridin-2-yl)-2-(4-(N,N-...)
Affinity DataKi:  1.40nMAssay Description:Inhibition of Factor 10a (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H4 receptor(Rattus norvegicus (rat))
Griffin Discoveries

Curated by ChEMBL
LigandPNGBDBM50361015(CHEMBL592379)
Affinity DataKi:  1.55nMAssay Description:Binding affinity to rat histamine H4 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSoluble acetylcholine receptor(Aplysia Californica)
Vu University Amsterdam

Curated by ChEMBL
LigandPNGBDBM50080818((-)-lobeline | 2-(6-(2-Hydroxy-2-phenylethyl)-1-me...)
Affinity DataKi:  2.51nMAssay Description:Displacement of [3H]epibatidine from Aplysia californica acetylcholine binding protein expressed using baculoviral system after 1.5 hrs by scintillat...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-dependent protein kinase(Oryctolagus cuniculus (Rabbit))
University of California San Diego

LigandPNGBDBM36603(4'',6''-Dideoxybalanol, 6)
Affinity DataKi:  3.40nM ΔG°:  -49.1kJ/mole IC50:  5.5nMpH: 7.5 T: 2°CAssay Description:Cyclic AMP-dependent protein kinase (PKA) enzyme inhibition assay using purified recombinant C subunit of PKA (catalytic (C) subunit (cPKA)) with hol...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-dependent protein kinase(Oryctolagus cuniculus (Rabbit))
University of California San Diego

LigandPNGBDBM36604(5'-Deoxybalanol, 7)
Affinity DataKi:  3.5nM ΔG°:  -49.1kJ/mole IC50:  5.70nMpH: 7.5 T: 2°CAssay Description:Cyclic AMP-dependent protein kinase (PKA) enzyme inhibition assay using purified recombinant C subunit of PKA (catalytic (C) subunit (cPKA)) with hol...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-dependent protein kinase(Oryctolagus cuniculus (Rabbit))
University of California San Diego

LigandPNGBDBM3207(10''-Deoxybalanol, 4 | 2-{[2,6-dihydroxy-4-({[(3R,...)
Affinity DataKi:  3.90nM ΔG°:  -48.8kJ/mole IC50:  6.30nMpH: 7.5 T: 2°CAssay Description:Cyclic AMP-dependent protein kinase (PKA) enzyme inhibition assay using purified recombinant C subunit of PKA (catalytic (C) subunit (cPKA)) with hol...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H4 receptor(Homo sapiens (Human))
Griffin Discoveries

Curated by ChEMBL
LigandPNGBDBM50415482(CHEMBL591011)
Affinity DataKi:  4.27nMAssay Description:Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H4 receptor(Homo sapiens (Human))
Griffin Discoveries

Curated by ChEMBL
LigandPNGBDBM50415489(CHEMBL591969)
Affinity DataKi:  4.47nMAssay Description:Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-dependent protein kinase(Oryctolagus cuniculus (Rabbit))
University of California San Diego

LigandPNGBDBM3149(2-{[2,6-dihydroxy-4-({[(3R,4R)-3-[(4-hydroxybenzen...)
Affinity DataKi:  4.70nM ΔG°:  -48.3kJ/molepH: 7.5 T: 2°CAssay Description:Cyclic AMP-dependent protein kinase (PKA) enzyme inhibition assay using purified recombinant C subunit of PKA (catalytic (C) subunit (cPKA)) with hol...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H4 receptor(Homo sapiens (Human))
Griffin Discoveries

Curated by ChEMBL
LigandPNGBDBM50361015(CHEMBL592379)
Affinity DataKi:  4.90nMAssay Description:Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Homo sapiens (Human))
Vu University Amsterdam

Curated by ChEMBL
LigandPNGBDBM50080818((-)-lobeline | 2-(6-(2-Hydroxy-2-phenylethyl)-1-me...)
Affinity DataKi:  5.01nMAssay Description:Displacement of [3H]epibatidine from human nAChR alpha4beta2 receptor expressed in human HEK293T cells by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C beta type(Rattus norvegicus (rat))
University of California San Diego

LigandPNGBDBM3149(2-{[2,6-dihydroxy-4-({[(3R,4R)-3-[(4-hydroxybenzen...)
Affinity DataKi:  5.30nM ΔG°:  -48.0kJ/moleT: 2°CAssay Description:Protein kinase C (PKC) enzyme inhibition assay using purified rat brain protein kinase C from Calbiochem #539494.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H4 receptor(Homo sapiens (Human))
Griffin Discoveries

Curated by ChEMBL
LigandPNGBDBM50415486(CHEMBL592663)
Affinity DataKi:  5.37nMAssay Description:Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H4 receptor(Homo sapiens (Human))
Griffin Discoveries

Curated by ChEMBL
LigandPNGBDBM50415494(CHEMBL592434)
Affinity DataKi:  5.75nMAssay Description:Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H4 receptor(Homo sapiens (Human))
Griffin Discoveries

Curated by ChEMBL
LigandPNGBDBM50412494(CHEMBL452847 | VUF-10497)
Affinity DataKi:  7.59nMAssay Description:Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H4 receptor(Homo sapiens (Human))
Griffin Discoveries

Curated by ChEMBL
LigandPNGBDBM50415480(CHEMBL591500)
Affinity DataKi:  7.59nMAssay Description:Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H4 receptor(Homo sapiens (Human))
Griffin Discoveries

Curated by ChEMBL
LigandPNGBDBM50415500(CHEMBL591496)
Affinity DataKi:  8.13nMAssay Description:Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H4 receptor(Homo sapiens (Human))
Griffin Discoveries

Curated by ChEMBL
LigandPNGBDBM50415485(CHEMBL591250)
Affinity DataKi:  9.33nMAssay Description:Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-X-C chemokine receptor type 3(Homo sapiens (Human))
Vu University Amsterdam

Curated by ChEMBL
LigandPNGBDBM50310502((R)-N-(1-(3-(4-ethoxyphenyl)-4-oxo-3,4-dihydropyri...)
Affinity DataKi:  10nMAssay Description:Displacement of [125I]CXCL10 from CXCR3 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H4 receptor(Homo sapiens (Human))
Griffin Discoveries

Curated by ChEMBL
LigandPNGBDBM50415484(CHEMBL591249)
Affinity DataKi:  10nMAssay Description:Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-dependent protein kinase(Oryctolagus cuniculus (Rabbit))
University of California San Diego

LigandPNGBDBM36602(14''-Decarboxybalanol hydrochloride, 5)
Affinity DataKi:  11nM ΔG°:  -46.2kJ/mole IC50:  18nMpH: 7.5 T: 2°CAssay Description:Cyclic AMP-dependent protein kinase (PKA) enzyme inhibition assay using purified recombinant C subunit of PKA (catalytic (C) subunit (cPKA)) with hol...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H4 receptor(Homo sapiens (Human))
Griffin Discoveries

Curated by ChEMBL
LigandPNGBDBM50415499(CHEMBL589746)
Affinity DataKi:  11.2nMAssay Description:Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H4 receptor(Homo sapiens (Human))
Griffin Discoveries

Curated by ChEMBL
LigandPNGBDBM7966(2-(1H-imidazol-4-yl)ethan-1-amine | CHEMBL544208 |...)
Affinity DataKi:  12.0nMAssay Description:Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetHistamine H4 receptor(Homo sapiens (Human))
Griffin Discoveries

Curated by ChEMBL
LigandPNGBDBM50415481(CHEMBL592188)
Affinity DataKi:  12.6nMAssay Description:Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Homo sapiens (Human))
Vu University Amsterdam

Curated by ChEMBL
LigandPNGBDBM82070(CAS_29790-52-1 | NICOTINE-L (BASE) | Nicotine-D sa...)
Affinity DataKi:  12.6nMAssay Description:Displacement of [3H]epibatidine from human nAChR alpha4beta2 receptor expressed in human HEK293T cells by scintillation countingMore data for this Ligand-Target Pair
TargetHistamine H4 receptor(Homo sapiens (Human))
Griffin Discoveries

Curated by ChEMBL
LigandPNGBDBM50415498(CHEMBL589782)
Affinity DataKi:  15.5nMAssay Description:Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H4 receptor(Homo sapiens (Human))
Griffin Discoveries

Curated by ChEMBL
LigandPNGBDBM50415483(CHEMBL591248)
Affinity DataKi:  17.8nMAssay Description:Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C beta type(Rattus norvegicus (rat))
University of California San Diego

LigandPNGBDBM2579((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)
Affinity DataKi:  19nM ΔG°:  -44.8kJ/moleT: 2°CAssay Description:Protein kinase C (PKC) enzyme inhibition assay using purified rat brain protein kinase C from Calbiochem #539494.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H4 receptor(Homo sapiens (Human))
Griffin Discoveries

Curated by ChEMBL
LigandPNGBDBM50415497(CHEMBL590995)
Affinity DataKi:  19.1nMAssay Description:Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H4 receptor(Homo sapiens (Human))
Griffin Discoveries

Curated by ChEMBL
LigandPNGBDBM50415488(CHEMBL601946)
Affinity DataKi:  26.9nMAssay Description:Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSoluble acetylcholine receptor(Aplysia Californica)
Vu University Amsterdam

Curated by ChEMBL
LigandPNGBDBM50419732(CHEMBL1947053)
Affinity DataKi:  31.6nMAssay Description:Displacement of [3H]epibatidine from Aplysia californica acetylcholine binding protein expressed using baculoviral system after 1.5 hrs by scintillat...More data for this Ligand-Target Pair
TargetAcetylcholine-binding protein(Lymnaea stagnalis)
Vu University Amsterdam

Curated by ChEMBL
LigandPNGBDBM50419742(CHEMBL1947055)
Affinity DataKi:  31.6nMAssay Description:Displacement of [3H]epibatidine from Lymnaea stagnalis acetylcholine binding protein expressed using baculoviral system after 1.5 hrs by scintillatio...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H4 receptor(Homo sapiens (Human))
Griffin Discoveries

Curated by ChEMBL
LigandPNGBDBM50415501(CHEMBL591711)
Affinity DataKi:  33.1nMAssay Description:Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H4 receptor(Homo sapiens (Human))
Griffin Discoveries

Curated by ChEMBL
LigandPNGBDBM50412516(CHEMBL509852 | VUF-10515)
Affinity DataKi:  33.9nMAssay Description:Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-dependent protein kinase(Oryctolagus cuniculus (Rabbit))
University of California San Diego

LigandPNGBDBM2579((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)
Affinity DataKi:  35nMpH: 7.5Assay Description:Cyclic AMP-dependent protein kinase (PKA) enzyme inhibition assay using purified recombinant C subunit of PKA (catalytic (C) subunit (cPKA)) with hol...More data for this Ligand-Target Pair
TargetHistamine H4 receptor(Homo sapiens (Human))
Griffin Discoveries

Curated by ChEMBL
LigandPNGBDBM50412512(CHEMBL509142 | VUF-10507)
Affinity DataKi:  35.5nMAssay Description:Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H4 receptor(Homo sapiens (Human))
Griffin Discoveries

Curated by ChEMBL
LigandPNGBDBM50412515(CHEMBL452869 | VUF-10516)
Affinity DataKi:  38.9nMAssay Description:Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholine-binding protein(Lymnaea stagnalis)
Vu University Amsterdam

Curated by ChEMBL
LigandPNGBDBM50419740(CHEMBL1946189)
Affinity DataKi:  39.8nMAssay Description:Displacement of [3H]epibatidine from Lymnaea stagnalis acetylcholine binding protein expressed using baculoviral system after 1.5 hrs by scintillatio...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-X-C chemokine receptor type 3(Homo sapiens (Human))
Vu University Amsterdam

Curated by ChEMBL
LigandPNGBDBM50399980(CHEMBL2181467)
Affinity DataKi:  39.8nMAssay Description:Displacement of [125I]CXCL10 from CXCR3 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-dependent protein kinase(Oryctolagus cuniculus (Rabbit))
University of California San Diego

LigandPNGBDBM36606(H-89, 10)
Affinity DataKi:  48nMpH: 7.5Assay Description:Cyclic AMP-dependent protein kinase (PKA) enzyme inhibition assay using purified recombinant C subunit of PKA (catalytic (C) subunit (cPKA)) with hol...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistamine H4 receptor(Homo sapiens (Human))
Griffin Discoveries

Curated by ChEMBL
LigandPNGBDBM50415493(CHEMBL589800)
Affinity DataKi:  50.1nMAssay Description:Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-X-C chemokine receptor type 3(Homo sapiens (Human))
Vu University Amsterdam

Curated by ChEMBL
LigandPNGBDBM50399981(CHEMBL2181450)
Affinity DataKi:  50.1nMAssay Description:Displacement of [125I]CXCL10 from CXCR3 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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