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Found 1819 with Last Name = 'klaus' and Initial = 'c'
TargetProtein kinase C alpha type(Bos taurus (bovine))
National Cancer Institute-Frederick

Curated by ChEMBL
LigandPNGBDBM50057512((1aR,1bS,4aR,7aS,7bS,8R,9R,9aS)-4a,7b-dihydroxy-3-...)
Affinity DataKi:  0.200nMAssay Description:Ability to displace bound [20-3H]-PDBU from a recombinant single isozyme (PKCalpha) in the presence of phosphatidylserineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C alpha type(Homo sapiens (Human))
National Cancer Institute-Bethesda

Curated by ChEMBL
LigandPNGBDBM50041389(Butyric acid (1aR,4aR,7aS,7bS,8R,9R,9aS)-9-butyryl...)
Affinity DataKi:  0.780nMAssay Description:Binding affinity (Ki) towards Protein kinase CMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Rattus norvegicus (rat))
Clinical Research Institute Of Montreal

Curated by ChEMBL
LigandPNGBDBM50041142((S)-2-Amino-N-((5S,8S,16aR)-5-benzyl-4,7,13,16-tet...)
Affinity DataKi:  0.880nMAssay Description:Binding affinity for mu opioid receptors by displacement of [3H]-DAMGO from rat brain membrane binding siteMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C delta type(Homo sapiens (Human))
National Cancer Institute-Frederick

Curated by ChEMBL
LigandPNGBDBM50107120((E) 2,2-Dimethyl-propionic acid 2-hydroxymethyl-4-...)
Affinity DataKi:  0.900nMAssay Description:Inhibition of [3H]PDBu binding to C1b domain of protein kinase C delta with phosphatidylserineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C delta type(Homo sapiens (Human))
National Cancer Institute-Frederick

Curated by ChEMBL
LigandPNGBDBM50107120((E) 2,2-Dimethyl-propionic acid 2-hydroxymethyl-4-...)
Affinity DataKi:  0.900nMAssay Description:Binding affinity for isolated C1b domain of protein kinase C-deltaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone-lysine N-methyltransferase SMYD3(Homo sapiens (Human))
Epizyme

Curated by ChEMBL
LigandPNGBDBM378462(6-chloro-2-oxo-N-((1R,3r,5S)-8-(((1-(4,4,4-trifluo...)
Affinity DataKi:  1.10nMAssay Description:Non-competitive inhibition of full length N-terminal His-tagged SMYD3 (1 to 428 residues) (unknown origin) expressed in Escherichia coli using varyin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C delta type(Homo sapiens (Human))
National Cancer Institute-Frederick

Curated by ChEMBL
LigandPNGBDBM50107112((Z) 2,2-Dimethyl-propionic acid 2-hydroxymethyl-4-...)
Affinity DataKi:  1.20nMAssay Description:Binding affinity for isolated C1b domain of protein kinase C-deltaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C delta type(Homo sapiens (Human))
National Cancer Institute-Frederick

Curated by ChEMBL
LigandPNGBDBM50107112((Z) 2,2-Dimethyl-propionic acid 2-hydroxymethyl-4-...)
Affinity DataKi:  1.20nMAssay Description:Inhibition of [3H]-PDBu binding to C1b domain of protein kinase C deltaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone-lysine N-methyltransferase SMYD3(Homo sapiens (Human))
Epizyme

Curated by ChEMBL
LigandPNGBDBM378462(6-chloro-2-oxo-N-((1R,3r,5S)-8-(((1-(4,4,4-trifluo...)
Affinity DataKi:  1.20nMAssay Description:Non-competitive inhibition of full length N-terminal His-tagged SMYD3 (1 to 428 residues) (unknown origin) expressed in Escherichia coli using fixed ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone-lysine N-methyltransferase SMYD3(Homo sapiens (Human))
Epizyme

Curated by ChEMBL
LigandPNGBDBM378459(N-((1R,3r,5S)-8-((4-(benzylamino)piperidin-1-yl)su...)
Affinity DataKi:  1.30nMAssay Description:Non-competitive inhibition of full length N-terminal His-tagged SMYD3 (1 to 428 residues) (unknown origin) expressed in Escherichia coli using varyin...More data for this Ligand-Target Pair
TargetMu-type opioid receptor(Rattus norvegicus (rat))
Clinical Research Institute Of Montreal

Curated by ChEMBL
LigandPNGBDBM50041146((S)-2-Amino-3-(4-hydroxy-phenyl)-N-[(5S,8R,16aR)-5...)
Affinity DataKi:  2.10nMAssay Description:Binding affinity for mu opioid receptors by displacement of [3H]-DAMGO from rat brain membrane binding siteMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Rattus norvegicus (rat))
Clinical Research Institute Of Montreal

Curated by ChEMBL
LigandPNGBDBM50001465((S)-2-[(S)-2-(2-{2-[(S)-2-Amino-3-(4-hydroxy-pheny...)
Affinity DataKi:  2.5nMAssay Description:Binding affinity for delta opioid receptors was determined by displacement of [3H]DSLET from rat brain membrane binding siteMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C alpha type(Homo sapiens (Human))
National Cancer Institute-Bethesda

Curated by ChEMBL
LigandPNGBDBM50085880(3-Isopropyl-4-methyl-pentanoic acid 2-hydroxymethy...)
Affinity DataKi:  2.70nMAssay Description:Displacement of [20-3H]-PDBU ligand from recombinant protein kinase C (baculovirus)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Rattus norvegicus (rat))
Clinical Research Institute Of Montreal

Curated by ChEMBL
LigandPNGBDBM50041148((S)-2-Amino-3-(4-hydroxy-phenyl)-N-((5S,8S,13aR)-5...)
Affinity DataKi:  2.70nMAssay Description:Binding affinity for mu opioid receptors by displacement of [3H]-DAMGO from rat brain membrane binding siteMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C alpha type(Homo sapiens (Human))
National Cancer Institute-Bethesda

Curated by ChEMBL
LigandPNGBDBM50085904(3-Isopropyl-4-methyl-pentanoic acid 2-hydroxymethy...)
Affinity DataKi:  2.90nMAssay Description:Displacement of [20-3H]phorbol-12,13-dibutyrate (PDBu) from recombinant Protein kinase C alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C alpha type(Homo sapiens (Human))
National Cancer Institute-Bethesda

Curated by ChEMBL
LigandPNGBDBM50107112((Z) 2,2-Dimethyl-propionic acid 2-hydroxymethyl-4-...)
Affinity DataKi:  2.90nMAssay Description:Displacement of [20-3H]-PDBU ligand from recombinant protein kinase C (baculovirus)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C alpha type(Homo sapiens (Human))
National Cancer Institute-Bethesda

Curated by ChEMBL
LigandPNGBDBM50085904(3-Isopropyl-4-methyl-pentanoic acid 2-hydroxymethy...)
Affinity DataKi:  2.90nMAssay Description:Displacement of [20-3H]-PDBU ligand from recombinant protein kinase C (baculovirus)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C alpha type(Homo sapiens (Human))
National Cancer Institute-Bethesda

Curated by ChEMBL
LigandPNGBDBM50107112((Z) 2,2-Dimethyl-propionic acid 2-hydroxymethyl-4-...)
Affinity DataKi:  2.90nMpH: 7.4Assay Description:Inhibition of [3H]PDBu binding to recombinant protein kinase C alpha was determined at pH 7.4, 37 degree C for 5 minMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Rattus norvegicus (rat))
Clinical Research Institute Of Montreal

Curated by ChEMBL
LigandPNGBDBM50041144((S)-2-Amino-N-((5S,8S)-5-benzyl-4,7,13,16-tetraoxo...)
Affinity DataKi:  3nMAssay Description:Binding affinity for delta opioid receptors was determined by displacement of [3H]DSLET from rat brain membrane binding siteMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Rattus norvegicus (rat))
Clinical Research Institute Of Montreal

Curated by ChEMBL
LigandPNGBDBM50041144((S)-2-Amino-N-((5S,8S)-5-benzyl-4,7,13,16-tetraoxo...)
Affinity DataKi:  3nMAssay Description:Binding affinity for mu opioid receptors by displacement of [3H]-DAMGO from rat brain membrane binding siteMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C delta type(Homo sapiens (Human))
National Cancer Institute-Frederick

Curated by ChEMBL
LigandPNGBDBM50172488(2,2-Dimethyl-propionic acid 2-hydroxymethyl-4-[3-i...)
Affinity DataKi:  3.10nMAssay Description:Inhibition of [3H]PDBu binding to C1b domain of protein kinase C delta with phosphatidylserineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C alpha type(Homo sapiens (Human))
National Cancer Institute-Bethesda

Curated by ChEMBL
LigandPNGBDBM50107120((E) 2,2-Dimethyl-propionic acid 2-hydroxymethyl-4-...)
Affinity DataKi:  3.30nMpH: 7.4Assay Description:Inhibition of [3H]PDBu binding to recombinant protein kinase C alpha was determined at pH 7.4, 37 degree C for 5 minMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Rattus norvegicus (rat))
Clinical Research Institute Of Montreal

Curated by ChEMBL
LigandPNGBDBM50041141((S)-2-Amino-3-(4-hydroxy-phenyl)-N-((5S,8R,16aR)-5...)
Affinity DataKi:  3.40nMAssay Description:Binding affinity for mu opioid receptors by displacement of [3H]-DAMGO from rat brain membrane binding siteMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Rattus norvegicus (rat))
Clinical Research Institute Of Montreal

Curated by ChEMBL
LigandPNGBDBM50041145((S)-2-Amino-3-(4-hydroxy-phenyl)-N-((5S,8S)-5-naph...)
Affinity DataKi:  3.99nMAssay Description:Binding affinity for mu opioid receptors by displacement of [3H]-DAMGO from rat brain membrane binding siteMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Rattus norvegicus (rat))
Clinical Research Institute Of Montreal

Curated by ChEMBL
LigandPNGBDBM50041145((S)-2-Amino-3-(4-hydroxy-phenyl)-N-((5S,8S)-5-naph...)
Affinity DataKi:  3.99nMAssay Description:Binding affinity for delta opioid receptors was determined by displacement of [3H]DSLET from rat brain membrane binding siteMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C alpha type(Homo sapiens (Human))
National Cancer Institute-Bethesda

Curated by ChEMBL
LigandPNGBDBM50107118(3-Isopropyl-4-methyl-pentanoic acid 2-hydroxymethy...)
Affinity DataKi:  4.5nMAssay Description:Displacement of [20-3H]-PDBU ligand from recombinant protein kinase C (baculovirus)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C alpha type(Homo sapiens (Human))
National Cancer Institute-Bethesda

Curated by ChEMBL
LigandPNGBDBM50107120((E) 2,2-Dimethyl-propionic acid 2-hydroxymethyl-4-...)
Affinity DataKi:  4.5nMAssay Description:Displacement of [20-3H]-PDBU ligand from recombinant protein kinase C (baculovirus)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone-lysine N-methyltransferase SMYD3(Homo sapiens (Human))
Epizyme

Curated by ChEMBL
LigandPNGBDBM378459(N-((1R,3r,5S)-8-((4-(benzylamino)piperidin-1-yl)su...)
Affinity DataKi:  4.70nMAssay Description:Mixed type inhibition of full length N-terminal His-tagged SMYD3 (1 to 428 residues) (unknown origin) expressed in Escherichia coli using fixed N-ter...More data for this Ligand-Target Pair
TargetProtein kinase C alpha type(Bos taurus (bovine))
National Cancer Institute-Frederick

Curated by ChEMBL
LigandPNGBDBM50368315(PROSTRATIN)
Affinity DataKi:  4.80nMAssay Description:Ability to displace bound [20-3H]-PDBU from a recombinant single isozyme (PKCalpha) in the presence of phosphatidylserineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C alpha type(Homo sapiens (Human))
National Cancer Institute-Bethesda

Curated by ChEMBL
LigandPNGBDBM50107121(CHEMBL135779 | N-Hydroxy-N-[2-hydroxymethyl-4-(3-i...)
Affinity DataKi:  4.80nMAssay Description:Displacement of [20-3H]-PDBU ligand from recombinant protein kinase C (baculovirus)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C alpha type(Homo sapiens (Human))
National Cancer Institute-Bethesda

Curated by ChEMBL
LigandPNGBDBM50107115(CHEMBL94505 | N-Hydroxy-N-[2-hydroxymethyl-4-(3-is...)
Affinity DataKi:  5.40nMAssay Description:Displacement of [20-3H]-PDBU ligand from recombinant protein kinase C (baculovirus)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Rattus norvegicus (rat))
Clinical Research Institute Of Montreal

Curated by ChEMBL
LigandPNGBDBM50041143((S)-2-Amino-3-(4-hydroxy-phenyl)-N-((5S,8S,16aR)-5...)
Affinity DataKi:  5.90nMAssay Description:Binding affinity for mu opioid receptors by displacement of [3H]-DAMGO from rat brain membrane binding siteMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Rattus norvegicus (rat))
Clinical Research Institute Of Montreal

Curated by ChEMBL
LigandPNGBDBM50041149((S)-2-Amino-3-(4-hydroxy-phenyl)-N-((5R,8R,15aS)-5...)
Affinity DataKi:  6.40nMAssay Description:Binding affinity for mu opioid receptors by displacement of [3H]-DAMGO from rat brain membrane binding siteMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C alpha type(Homo sapiens (Human))
National Cancer Institute-Bethesda

Curated by ChEMBL
LigandPNGBDBM50107116(3-Isopropyl-4-methyl-pentanoic acid 2-hydroxymethy...)
Affinity DataKi:  6.90nMAssay Description:Displacement of [20-3H]-PDBU ligand from recombinant protein kinase C (baculovirus)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C alpha type(Homo sapiens (Human))
National Cancer Institute-Bethesda

Curated by ChEMBL
LigandPNGBDBM50107119((Z) 2,2-Dimethyl-propionic acid 2-hydroxymethyl-4-...)
Affinity DataKi:  8.30nMAssay Description:Displacement of [20-3H]-PDBU ligand from recombinant protein kinase C (baculovirus)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Rattus norvegicus (rat))
Clinical Research Institute Of Montreal

Curated by ChEMBL
LigandPNGBDBM50001465((S)-2-[(S)-2-(2-{2-[(S)-2-Amino-3-(4-hydroxy-pheny...)
Affinity DataKi:  9.40nMAssay Description:Binding affinity for mu opioid receptors by displacement of [3H]-DAMGO from rat brain membrane binding siteMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Rattus norvegicus (rat))
Clinical Research Institute Of Montreal

Curated by ChEMBL
LigandPNGBDBM50041146((S)-2-Amino-3-(4-hydroxy-phenyl)-N-[(5S,8R,16aR)-5...)
Affinity DataKi:  10nMAssay Description:Binding affinity for delta opioid receptors was determined by displacement of [3H]DSLET from rat brain membrane binding siteMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C alpha type(Homo sapiens (Human))
National Cancer Institute-Bethesda

Curated by ChEMBL
LigandPNGBDBM50107111((E) 2,2-Dimethyl-propionic acid 2-hydroxymethyl-4-...)
Affinity DataKi:  11nMAssay Description:Displacement of [20-3H]-PDBU ligand from recombinant protein kinase C (baculovirus)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C alpha type(Homo sapiens (Human))
National Cancer Institute-Bethesda

Curated by ChEMBL
LigandPNGBDBM50127016(3-Methyl-butyric acid 3-hydroxymethyl-4-(3-isoprop...)
Affinity DataKi:  11nMAssay Description:Displacement of [20-3H]phorbol-12,13-dibutyrate (PDBu) from recombinant Protein kinase C alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Rattus norvegicus (rat))
Clinical Research Institute Of Montreal

Curated by ChEMBL
LigandPNGBDBM50041142((S)-2-Amino-N-((5S,8S,16aR)-5-benzyl-4,7,13,16-tet...)
Affinity DataKi:  13nMAssay Description:Binding affinity for delta opioid receptors was determined by displacement of [3H]DSLET from rat brain membrane binding siteMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C alpha type(Homo sapiens (Human))
National Cancer Institute-Bethesda

Curated by ChEMBL
LigandPNGBDBM50127018(3-Isopropyl-4-methyl-pentanoic acid 3-hydroxymethy...)
Affinity DataKi:  15nMAssay Description:Displacement of [20-3H]phorbol-12,13-dibutyrate (PDBu) from recombinant Protein kinase C alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C alpha type(Homo sapiens (Human))
National Cancer Institute-Bethesda

Curated by ChEMBL
LigandPNGBDBM50127015(3-Isopropyl-4-methyl-pentanoic acid 3-hydroxymethy...)
Affinity DataKi:  15nMAssay Description:Displacement of [20-3H]phorbol-12,13-dibutyrate (PDBu) from recombinant Protein kinase C alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Rattus norvegicus (rat))
Clinical Research Institute Of Montreal

Curated by ChEMBL
LigandPNGBDBM50041147((S)-2-Amino-3-(4-hydroxy-phenyl)-N-((5S,8S,17aR)-5...)
Affinity DataKi:  17nMAssay Description:Binding affinity for mu opioid receptors by displacement of [3H]-DAMGO from rat brain membrane binding siteMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Rattus norvegicus (rat))
Clinical Research Institute Of Montreal

Curated by ChEMBL
LigandPNGBDBM50041143((S)-2-Amino-3-(4-hydroxy-phenyl)-N-((5S,8S,16aR)-5...)
Affinity DataKi:  17nMAssay Description:Binding affinity for delta opioid receptors was determined by displacement of [3H]DSLET from rat brain membrane binding siteMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C alpha type(Homo sapiens (Human))
National Cancer Institute-Bethesda

Curated by ChEMBL
LigandPNGBDBM50041401((1S,3R,4S,9R,13S,14R)-13-Hydroxy-9-((R)-1-hydroxy-...)
Affinity DataKi:  20nMAssay Description:Binding affinity (Ki) towards Protein kinase CMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C delta type(Homo sapiens (Human))
National Cancer Institute-Frederick

Curated by ChEMBL
LigandPNGBDBM50172487(2,2-Dimethyl-thiopropionic acid O-{2-hydroxymethyl...)
Affinity DataKi:  21nMAssay Description:Inhibition of [3H]PDBu binding to C1b domain of protein kinase C delta with phosphatidylserineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C alpha type(Homo sapiens (Human))
National Cancer Institute-Bethesda

Curated by ChEMBL
LigandPNGBDBM50172488(2,2-Dimethyl-propionic acid 2-hydroxymethyl-4-[3-i...)
Affinity DataKi:  24nMpH: 7.4Assay Description:Inhibition of [3H]PDBu binding to recombinant protein kinase C alpha was determined at pH 7.4, 37 degree C for 5 minMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Rattus norvegicus (rat))
Clinical Research Institute Of Montreal

Curated by ChEMBL
LigandPNGBDBM50041141((S)-2-Amino-3-(4-hydroxy-phenyl)-N-((5S,8R,16aR)-5...)
Affinity DataKi:  24nMAssay Description:Binding affinity for delta opioid receptors was determined by displacement of [3H]DSLET from rat brain membrane binding siteMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C alpha type(Bos taurus (bovine))
National Cancer Institute-Frederick

Curated by ChEMBL
LigandPNGBDBM50100125(3-Isopropyl-4-methyl-pent-2-enoic acid 3-hydroxy-2...)
Affinity DataKi:  24.6nMAssay Description:Ability to displace bound [20-3H]-PDBU from a recombinant single isozyme (PKCalpha) in the presence of phosphatidylserineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Rattus norvegicus (rat))
Clinical Research Institute Of Montreal

Curated by ChEMBL
LigandPNGBDBM50041148((S)-2-Amino-3-(4-hydroxy-phenyl)-N-((5S,8S,13aR)-5...)
Affinity DataKi:  28nMAssay Description:Binding affinity for delta opioid receptors was determined by displacement of [3H]DSLET from rat brain membrane binding siteMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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