BindingDB PrimarySearch

Found 510 with Last Name = 'knoepfel' and Initial = 't'

Toll-like receptor 8(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL

IC50: 0.0500nMAssay Description:Antagonist activity at human TLR8 expressed in human PBMC cells assessed as inhibition of ssRNA stimulated TNF level preincubated for 30 mins followe...More data for this Ligand-Target Pair

PDB Reactome pathway
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Toll-like receptor 8(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL

BDBM50586262(CHEMBL5091113)

IC50: 0.0800nMAssay Description:Antagonist activity at human TLR8 expressed in human PBMC cells assessed as inhibition of ssRNA stimulated TNF level preincubated for 30 mins followe...More data for this Ligand-Target Pair

PDB Reactome pathway
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3D Structure (crystal)

Toll-like receptor 8(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL

BDBM50586259(CHEMBL5090067)

PDB Reactome pathway
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Toll-like receptor 7(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL

BDBM50586260(CHEMBL5079910)

IC50: 0.100nMAssay Description:Antagonist activity at human TLR7 expressed in human PBMC cells assessed as inhibition of ssRNA stimulated IFNalpha level preincubated for 30 mins fo...More data for this Ligand-Target Pair

PDB Reactome pathway
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Toll-like receptor 8(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL

BDBM50586260(CHEMBL5079910)

IC50: 0.200nMAssay Description:Antagonist activity at human TLR8 expressed in human PBMC cells assessed as inhibition of ssRNA stimulated TNF level preincubated for 30 mins followe...More data for this Ligand-Target Pair

PDB Reactome pathway
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Fibroblast growth factor receptor 4(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL

BDBM50559106(CHEMBL4786195)

IC50: 0.200nMAssay Description:Inhibition of recombinant non-phosphorylated FGFR4 kinase domain (442 to 753) (unknown origin) expressed in Sf9 insect cells using 5-Fluo-Ahx-KKKKEEI...More data for this Ligand-Target Pair

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Fibroblast growth factor receptor 4(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL

BDBM209349(US9266883, 148)

IC50: 0.300nMAssay Description:Inhibition of recombinant non-phosphorylated FGFR4 kinase domain (442 to 753) (unknown origin) expressed in Sf9 insect cells using 5-Fluo-Ahx-KKKKEEI...More data for this Ligand-Target Pair

PDB Reactome pathway KEGG
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Toll-like receptor 7(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL

BDBM50586259(CHEMBL5090067)

IC50: 0.390nMAssay Description:Antagonist activity at human TLR7 expressed in human PBMC cells assessed as inhibition of ssRNA stimulated IFNalpha level preincubated for 30 mins fo...More data for this Ligand-Target Pair

PDB Reactome pathway
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Fibroblast growth factor receptor 4(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL

BDBM209334(US9266883, 98)

IC50: 0.400nMAssay Description:Inhibition of recombinant non-phosphorylated FGFR4 kinase domain (442 to 753) (unknown origin) expressed in Sf9 insect cells using 5-Fluo-Ahx-KKKKEEI...More data for this Ligand-Target Pair

PDB Reactome pathway KEGG
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Fibroblast growth factor receptor 4(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL

BDBM50559126(CHEMBL4796410)

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Toll-like receptor 8(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL

BDBM50543142(CHEMBL4641633)

IC50: 0.430nMAssay Description:Antagonist activity at TLR8 in human whole blood assessed as inhibition of DOTAP-ssRNA40 induced TNFalpha production preincubated for 30 mins followe...More data for this Ligand-Target Pair

PDB Reactome pathway
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Toll-like receptor 8(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL

BDBM50586262(CHEMBL5091113)

IC50: 0.600nMAssay Description:Antagonist activity at human TLR8 expressed in human whole blood assessed as inhibition of ssRNA stimulated TNF level preincubated for 30 mins follow...More data for this Ligand-Target Pair

PDB Reactome pathway
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3D Structure (crystal)

Fibroblast growth factor receptor 4(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL

BDBM50559105(CHEMBL4754106)

IC50: 0.600nMAssay Description:Inhibition of recombinant non-phosphorylated FGFR4 kinase domain (442 to 753) (unknown origin) expressed in Sf9 insect cells using 5-Fluo-Ahx-KKKKEEI...More data for this Ligand-Target Pair

PDB Reactome pathway KEGG
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Toll-like receptor 7(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL

BDBM50543142(CHEMBL4641633)

IC50: 0.620nMAssay Description:Antagonist activity at TLR7 in human PBMC assessed as inhibition of DOTAP-ssRNA40 induced IFNalpha production preincubated for 30 mins followed by ss...More data for this Ligand-Target Pair

PDB Reactome pathway
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Toll-like receptor 7(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL

BDBM50586256(CHEMBL5085458)

IC50: 0.670nMAssay Description:Antagonist activity at human TLR7 expressed in human PBMC cells assessed as inhibition of ssRNA stimulated IFNalpha level preincubated for 30 mins fo...More data for this Ligand-Target Pair

PDB Reactome pathway
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Fibroblast growth factor receptor 4(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL

BDBM209275(US9266883, 33)

IC50: 0.700nMAssay Description:Inhibition of FGFR4 (388 to 802 residues) (unknown origin) using 5-Fluo-Ahx-KKKKEEIYFFFG-NH2 as substrate after 60 mins by microfluidic mobility shif...More data for this Ligand-Target Pair

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Fibroblast growth factor receptor 4(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL

BDBM209275(US9266883, 33)

IC50: 0.700nMAssay Description:Inhibition of recombinant non-phosphorylated FGFR4 kinase domain (442 to 753) (unknown origin) expressed in Sf9 insect cells using 5-Fluo-Ahx-KKKKEEI...More data for this Ligand-Target Pair

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Fibroblast growth factor receptor 4(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL

BDBM50559116(CHEMBL4764394)

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Fibroblast growth factor receptor 4(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL

BDBM50559121(CHEMBL4758832)

IC50: 0.800nMAssay Description:Inhibition of recombinant non-phosphorylated FGFR4 kinase domain (442 to 753) (unknown origin) expressed in Sf9 insect cells using 5-Fluo-Ahx-KKKKEEI...More data for this Ligand-Target Pair

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Fibroblast growth factor receptor 4(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL

BDBM50559128(CHEMBL4742811)

IC50: 0.900nMAssay Description:Inhibition of recombinant non-phosphorylated FGFR4 kinase domain (442 to 753) (unknown origin) expressed in Sf9 insect cells using 5-Fluo-Ahx-KKKKEEI...More data for this Ligand-Target Pair

PDB Reactome pathway KEGG
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Fibroblast growth factor receptor 4(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL

BDBM50559108(CHEMBL4745615)

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Fibroblast growth factor receptor 4(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL

BDBM209336(US9266883, 101)

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Fibroblast growth factor receptor 4(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL

BDBM50559111(CHEMBL4791610)

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Fibroblast growth factor receptor 4(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL

BDBM50559123(CHEMBL4745780)

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Toll-like receptor 8(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL

BDBM50560358(CHEMBL4790219)

IC50: 1nMAssay Description:Antagonist activity at TLR8 in human THP-1 cells assessed as inhibition of resiquimod-induced TNFalpha productionMore data for this Ligand-Target Pair

PDB Reactome pathway
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Toll-like receptor 8(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL

BDBM50543137(CHEMBL4634860)

IC50: <1nMAssay Description:Antagonist activity at TLR8 in human THP-1 cells assessed as inhibition of resiquimod-induced TNFalpha productionMore data for this Ligand-Target Pair

PDB Reactome pathway
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Toll-like receptor 8(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL

BDBM50560355(CHEMBL4740968)

IC50: <1nMAssay Description:Antagonist activity at TLR8 in human THP-1 cells assessed as inhibition of resiquimod-induced TNFalpha productionMore data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
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Toll-like receptor 7(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL

BDBM50560359(CHEMBL4762866)

IC50: <1nMAssay Description:Antagonist activity at TLR7 in human PBMC assessed as inhibition of ssRNA40-induced IFNalpha productionMore data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
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Toll-like receptor 7(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL

BDBM50543137(CHEMBL4634860)

IC50: <1nMAssay Description:Antagonist activity at TLR7 in human PBMC assessed as inhibition of ssRNA40-induced IFNalpha productionMore data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
antibodypedia GoogleScholar

PC cid PC sid

Details Article PubMed

Toll-like receptor 7(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL

BDBM50560358(CHEMBL4790219)

IC50: <1nMAssay Description:Antagonist activity at TLR7 in human PBMC assessed as inhibition of ssRNA40-induced IFNalpha productionMore data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
antibodypedia GoogleScholar

PC cid PC sid

Details Article PubMed

Toll-like receptor 7(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL

BDBM50586258(CHEMBL5085289)

IC50: 1nMAssay Description:Antagonist activity at human TLR7 expressed in human PBMC cells assessed as inhibition of ssRNA stimulated IFNalpha level preincubated for 30 mins fo...More data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
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Toll-like receptor 7(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL

BDBM50586253(CHEMBL5077018)

IC50: 1.10nMAssay Description:Antagonist activity at human TLR7 expressed in human PBMC cells assessed as inhibition of ssRNA stimulated IFNalpha level preincubated for 30 mins fo...More data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
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Fibroblast growth factor receptor 4(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL

BDBM50559122(CHEMBL4756889)

IC50: 1.10nMAssay Description:Inhibition of recombinant non-phosphorylated FGFR4 kinase domain (442 to 753) (unknown origin) expressed in Sf9 insect cells using 5-Fluo-Ahx-KKKKEEI...More data for this Ligand-Target Pair

PDB Reactome pathway KEGG
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Fibroblast growth factor receptor 4(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL

BDBM209370(US9266883, 234)

IC50: 1.10nMAssay Description:Inhibition of FGFR4 (388 to 802 residues) (unknown origin) using 5-Fluo-Ahx-KKKKEEIYFFFG-NH2 as substrate after 60 mins by microfluidic mobility shif...More data for this Ligand-Target Pair

PDB Reactome pathway KEGG
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Toll-like receptor 8(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL

BDBM50543163(CHEMBL4642652)

IC50: 1.10nMAssay Description:Antagonist activity at TLR8 in human PBMC assessed as inhibition of DOTAP-ssRNA40 induced TNFalpha production preincubated for 30 mins followed by ss...More data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
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Fibroblast growth factor receptor 4(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL

BDBM209268(US9266883, 26)

IC50: 1.20nMAssay Description:Inhibition of FGFR4 (388 to 802 residues) (unknown origin) using 5-Fluo-Ahx-KKKKEEIYFFFG-NH2 as substrate after 60 mins by microfluidic mobility shif...More data for this Ligand-Target Pair

PDB Reactome pathway KEGG
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Fibroblast growth factor receptor 4(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL

BDBM50559112(CHEMBL4764678)

IC50: 1.20nMAssay Description:Inhibition of recombinant non-phosphorylated FGFR4 kinase domain (442 to 753) (unknown origin) expressed in Sf9 insect cells using 5-Fluo-Ahx-KKKKEEI...More data for this Ligand-Target Pair

PDB Reactome pathway KEGG
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Fibroblast growth factor receptor 4(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL

BDBM50559124(CHEMBL4784921)

PDB Reactome pathway KEGG
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Toll-like receptor 8(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL

BDBM50586255(CHEMBL5077828)

IC50: 1.20nMAssay Description:Antagonist activity at human TLR8 expressed in human PBMC cells assessed as inhibition of ssRNA stimulated TNF level preincubated for 30 mins followe...More data for this Ligand-Target Pair

PDB Reactome pathway
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Toll-like receptor 8(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL

BDBM50586256(CHEMBL5085458)

PDB Reactome pathway
UniProtKB/SwissProt
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Fibroblast growth factor receptor 4(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL

BDBM209268(US9266883, 26)

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Fibroblast growth factor receptor 4(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL

BDBM50559104(CHEMBL4778828)

IC50: 1.30nMAssay Description:Inhibition of recombinant non-phosphorylated FGFR4 kinase domain (442 to 753) (unknown origin) expressed in Sf9 insect cells using 5-Fluo-Ahx-KKKKEEI...More data for this Ligand-Target Pair

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Fibroblast growth factor receptor 4(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL

BDBM50559125(CHEMBL4759211)

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Fibroblast growth factor receptor 4(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL

BDBM209265(US9266883, 23)

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Fibroblast growth factor receptor 4(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL

BDBM209265(US9266883, 23)

IC50: 1.30nMAssay Description:Inhibition of FGFR4 (388 to 802 residues) (unknown origin) using 5-Fluo-Ahx-KKKKEEIYFFFG-NH2 as substrate after 60 mins by microfluidic mobility shif...More data for this Ligand-Target Pair

PDB Reactome pathway KEGG
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Fibroblast growth factor receptor 4(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL

BDBM50559101(CHEMBL4789692)

IC50: 1.40nMAssay Description:Inhibition of recombinant non-phosphorylated FGFR4 kinase domain (442 to 753) (unknown origin) expressed in Sf9 insect cells using 5-Fluo-Ahx-KKKKEEI...More data for this Ligand-Target Pair

PDB Reactome pathway KEGG
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Fibroblast growth factor receptor 4(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL

BDBM50559099(CHEMBL4758510)

IC50: 1.5nMAssay Description:Inhibition of recombinant non-phosphorylated FGFR4 kinase domain (442 to 753) (unknown origin) expressed in Sf9 insect cells using 5-Fluo-Ahx-KKKKEEI...More data for this Ligand-Target Pair

PDB Reactome pathway KEGG
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Toll-like receptor 8(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL

BDBM50543142(CHEMBL4641633)

IC50: 1.5nMAssay Description:Antagonist activity at TLR8 in human PBMC assessed as inhibition of DOTAP-ssRNA40 induced TNFalpha production preincubated for 30 mins followed by ss...More data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
antibodypedia GoogleScholar

PC cid PC sid

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Fibroblast growth factor receptor 4(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL

BDBM50559118(CHEMBL4284069)

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Toll-like receptor 8(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL

BDBM50586258(CHEMBL5085289)

IC50: 1.5nMAssay Description:Antagonist activity at human TLR8 expressed in human PBMC cells assessed as inhibition of ssRNA stimulated TNF level preincubated for 30 mins followe...More data for this Ligand-Target Pair

PDB Reactome pathway
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Displayed 1 to 50 (of 510 total ) | Next | Last >>

Filter my 510 hits

Targets 16▿
- Fibroblast growth factor receptor 4 275
- Toll-like receptor 8 98
- Toll-like receptor 7 51
- Toll-like receptor 9 38
- Potassium voltage-gated channel subfamily H member 2 24
- Toll-like receptor 4 10
- Cytochrome P450 3A4 5
- Toll-like receptor 1 1
- Toll-like receptor 2 1
- MAP kinase-activated protein kinase 2 1
- Toll-like receptor 5 1
- Fibroblast growth factor receptor 1 1
- Aurora kinase A 1
- Fibroblast growth factor receptor 2 1
- Interleukin-1 receptor type 1 1
- Fibroblast growth factor receptor 3 1
- ...
Publications 5▿
- J Med Chem 63: 12542-12573 (2020) 244
- J Med Chem 63: 8276-8295 (2020) 87
- Bioorg Med Chem Lett 30: (2020) 68
- ACS Med Chem Lett 9: 215-220 (2018) 57
- ACS Med Chem Lett 13: 658-664 (2022) 54
Institutions 2▿
- Novartis Institutes For Biomedical Research 355
- Genomics Institute Of The Novartis Research Foundation 155
Affinity: 0.050 to 4.9E+4 nM▿
- IC50 495
- Kd 12
- Affinity ≤ nM
Xtal structures: 7
Docked structures: 0
Catalog Cmpds: 7