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Found 231 with Last Name = 'kobayashi' and Initial = 'm'
TargetEnoyl-[acyl-carrier-protein] reductase [NADH](Mycobacterium tuberculosis (strain ATCC 25618 / H3...)
Kyushu Institute Of Technology

Curated by ChEMBL
LigandPNGBDBM50425950(CHEMBL2311561 | Isoniazid-NAD)
Affinity DataKi:  0.75nMAssay Description:Inhibition of Mycobacterium tuberculosis InhAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-2 adrenergic receptor(Homo sapiens (Human))
Kissei Pharmaceutical

Curated by PDSP Ki Database
LigandPNGBDBM85786(KUR-1246)
Affinity DataKi:  25.7nMMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetDioxygenase(Pseudomonas paucimobilis)
Riken

Curated by ChEMBL
LigandPNGBDBM50111620(4-((Z)-1-Fluoro-2-phenyl-vinyl)-phenol | CHEMBL147...)
Affinity DataKi:  980nMAssay Description:Tested for the inhibition of Lignostilbene-alpha, beta-dioxygenase (LSD)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-3 adrenergic receptor(Homo sapiens (Human))
Kissei Pharmaceutical

Curated by PDSP Ki Database
LigandPNGBDBM85786(KUR-1246)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetThymidylate kinase(Mycobacterium tuberculosis)
Kyushu Institute Of Technology

Curated by ChEMBL
LigandPNGBDBM50131916(Phosphoric acid mono-[3-azidomethyl-5-(5-methyl-2,...)
Affinity DataKi:  1.00E+4nMAssay Description:Inhibition of Mycobacterium tuberculosis thymidine monophosphate kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidylate kinase(Mycobacterium tuberculosis)
Kyushu Institute Of Technology

Curated by ChEMBL
LigandPNGBDBM50131914(Phosphoric acid mono-[3-aminomethyl-5-(5-methyl-2,...)
Affinity DataKi:  1.05E+4nMAssay Description:Inhibition of Mycobacterium tuberculosis thymidine monophosphate kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 1/2(RAT)
Shionogi

Curated by ChEMBL
LigandPNGBDBM50472624(CHEMBL62439)
Affinity DataIC50: <1nMAssay Description:In vitro inhibitory effect on production of prostaglandin E2 (PGE2) in rat synovial cells.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 1/2(RAT)
Shionogi

Curated by ChEMBL
LigandPNGBDBM50472616(CHEMBL65325)
Affinity DataIC50: <1nMAssay Description:In vitro inhibitory effect on production of prostaglandin E2 (PGE2) in rat synovial cells.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 1/2(RAT)
Shionogi

Curated by ChEMBL
LigandPNGBDBM50472627(CHEMBL304489)
Affinity DataIC50: <1nMAssay Description:In vitro inhibitory effect on production of prostaglandin E2 (PGE2) in rat synovial cells.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 1/2(RAT)
Shionogi

Curated by ChEMBL
LigandPNGBDBM50472632(CHEMBL65140)
Affinity DataIC50: <1nMAssay Description:In vitro inhibitory effect on production of prostaglandin E2 (PGE2) in rat synovial cells.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 1/2(RAT)
Shionogi

Curated by ChEMBL
LigandPNGBDBM50472618(CHEMBL303092)
Affinity DataIC50: <1nMAssay Description:In vitro inhibitory effect on production of prostaglandin E2 (PGE2) in rat synovial cells.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 1/2(RAT)
Shionogi

Curated by ChEMBL
LigandPNGBDBM50472623(CHEMBL294100)
Affinity DataIC50: <1nMAssay Description:In vitro inhibitory effect on production of prostaglandin E2 (PGE2) in rat synovial cells.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 1/2(RAT)
Shionogi

Curated by ChEMBL
LigandPNGBDBM50472613(CHEMBL305076)
Affinity DataIC50:  2.10nMAssay Description:In vitro inhibitory effect on production of prostaglandin E2 (PGE2) in rat synovial cells.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 1/2(RAT)
Shionogi

Curated by ChEMBL
LigandPNGBDBM50472612(CHEMBL60496)
Affinity DataIC50:  2.5nMAssay Description:In vitro inhibitory effect on production of prostaglandin E2 (PGE2) in rat synovial cells.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 1/2(RAT)
Shionogi

Curated by ChEMBL
LigandPNGBDBM50472605(CHEMBL64507)
Affinity DataIC50:  2.5nMAssay Description:In vitro inhibitory effect on production of prostaglandin E2 (PGE2) in rat synovial cells.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
Shionogi

Curated by ChEMBL
LigandPNGBDBM50483553(CHEBI:76007 | Dolutegravir Sodium | GSK1349572 | G...)
Affinity DataIC50:  2.70nMAssay Description:Inhibition of strand transfer activity of Human immunodeficiency virus 1 Integrase using [3H]labeled target DNA as substrate after 45 mins by scintil...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
Shionogi

Curated by ChEMBL
LigandPNGBDBM50062551(CHEBI:76010 | Dolutegravir | GSK1349572 | S-349572)
Affinity DataIC50:  2.70nMAssay Description:Inhibition of HIV-1 integrase strand transfer activity using [3H]-DNA as substrate preincubated for 60 mins prior to substrate addition measured afte...More data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 1/2(RAT)
Shionogi

Curated by ChEMBL
LigandPNGBDBM17638(2-{1-[(4-chlorophenyl)carbonyl]-5-methoxy-2-methyl...)
Affinity DataIC50:  2.90nMAssay Description:In vitro inhibitory effect on production of prostaglandin E2 (PGE2) in rat synovial cells.More data for this Ligand-Target Pair
TargetIntegrase(Human immunodeficiency virus 1)
Shionogi

Curated by ChEMBL
LigandPNGBDBM50492496(Cabotegravir | GSK-1265744A | GSK1265744 | GSK1265...)
Affinity DataIC50:  3nMAssay Description:Inhibition of HIV-1 integrase strand transfer activity using [3H]-DNA as substrate preincubated for 60 mins prior to substrate addition measured afte...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein arginine N-methyltransferase 5(Homo sapiens (Human))
Mirati Therapeutics

Curated by ChEMBL
LigandPNGBDBM579099(& 16-2 | US11479551, Example 16-1)
Affinity DataIC50:  3nMAssay Description:Inhibition of PRMT5 methyltransferase activity in MTAP knockout human HCT-116 cells assessed as inhibition of PRMT5- mediated SDMA modification level...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein arginine N-methyltransferase 5(Homo sapiens (Human))
Mirati Therapeutics

Curated by ChEMBL
LigandPNGBDBM579099(& 16-2 | US11479551, Example 16-1)
Affinity DataIC50:  3nMAssay Description:Inhibition of PRMT5 methyltransferase activity in MTAP knockout human HCT-116 cells assessed as inhibition of PRMT5- mediated SDMA modification level...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
Shionogi

Curated by ChEMBL
LigandPNGBDBM25351(N-[2-(4-{[(4-fluorophenyl)methyl]carbamoyl}-5-hydr...)
Affinity DataIC50:  3.30nMAssay Description:Inhibition of Human immunodeficiency virus 1 integrase by strand transfer scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
Shionogi

Curated by ChEMBL
LigandPNGBDBM50480673(Isentress | Isentress hd | MK-0518 | MK-0518 POTAS...)
Affinity DataIC50:  3.30nMAssay Description:Inhibition of strand transfer activity of Human immunodeficiency virus 1 Integrase using [3H]labeled target DNA as substrate after 45 mins by scintil...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein arginine N-methyltransferase 5(Homo sapiens (Human))
Mirati Therapeutics

Curated by ChEMBL
LigandPNGBDBM50585596(CHEMBL5076766)
Affinity DataIC50:  4nMAssay Description:Inhibition of PRMT5 methyltransferase activity in MTAP knockout human HCT-116 cells assessed as inhibition of PRMT5- mediated SDMA modification level...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
Shionogi

Curated by ChEMBL
LigandPNGBDBM50492497(CHEMBL2403118)
Affinity DataIC50:  5nMAssay Description:Inhibition of HIV-1 integrase strand transfer activity using [3H]-DNA as substrate preincubated for 60 mins prior to substrate addition measured afte...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProtein arginine N-methyltransferase 5(Homo sapiens (Human))
Mirati Therapeutics

Curated by ChEMBL
LigandPNGBDBM579030(2-(4-(4-(aminomethyl)-1-oxo-1,2- dihydrophthalazin...)
Affinity DataIC50:  5nMAssay Description:Inhibition of PRMT5 methyltransferase activity in MTAP knockout human HCT-116 cells assessed as inhibition of PRMT5- mediated SDMA modification level...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetProstaglandin D2 receptor 2(Homo sapiens (Human))
Astellas Pharma

Curated by ChEMBL
LigandPNGBDBM50362167(CHEMBL1941129)
Affinity DataIC50:  5.5nMAssay Description:Displacement of [3H]PGD2 from human CRTH2 receptor expressed in HEK293 cells after 2 hrs by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin D2 receptor 2(Homo sapiens (Human))
Astellas Pharma

Curated by ChEMBL
LigandPNGBDBM50362160(CHEMBL1941121)
Affinity DataIC50:  5.80nMAssay Description:Displacement of [3H]PGD2 from human CRTH2 receptor expressed in HEK293 cells after 2 hrs by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein arginine N-methyltransferase 5(Homo sapiens (Human))
Mirati Therapeutics

Curated by ChEMBL
LigandPNGBDBM579105(US11479551, Example 16-7 | US11479551, Example 16-...)
Affinity DataIC50:  6nMAssay Description:Inhibition of PRMT5 methyltransferase activity in MTAP knockout human HCT-116 cells assessed as inhibition of PRMT5- mediated SDMA modification level...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein arginine N-methyltransferase 5(Homo sapiens (Human))
Mirati Therapeutics

Curated by ChEMBL
LigandPNGBDBM579105(US11479551, Example 16-7 | US11479551, Example 16-...)
Affinity DataIC50:  6nMAssay Description:Inhibition of PRMT5 methyltransferase activity in MTAP knockout human HCT-116 cells assessed as inhibition of PRMT5- mediated SDMA modification level...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
Shionogi

Curated by ChEMBL
LigandPNGBDBM50183273((S)-6-(3-chloro-2-fluorobenzyl)-1-(1-hydroxy-3-met...)
Affinity DataIC50:  6nMAssay Description:Inhibition of strand transfer activity of Human immunodeficiency virus 1 Integrase using [3H]labeled target DNA as substrate after 45 mins by scintil...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
Shionogi

Curated by ChEMBL
LigandPNGBDBM50183273((S)-6-(3-chloro-2-fluorobenzyl)-1-(1-hydroxy-3-met...)
Affinity DataIC50:  6nMAssay Description:Inhibition of Human immunodeficiency virus 1 integrase by strand transfer scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 1/2(RAT)
Shionogi

Curated by ChEMBL
LigandPNGBDBM50472615(CHEMBL64813)
Affinity DataIC50:  6.20nMAssay Description:In vitro inhibitory effect on production of prostaglandin E2 (PGE2) in rat synovial cells.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProstaglandin D2 receptor 2(Homo sapiens (Human))
Astellas Pharma

Curated by ChEMBL
LigandPNGBDBM50362159(CHEMBL1941120)
Affinity DataIC50:  6.20nMAssay Description:Displacement of [3H]PGD2 from human CRTH2 receptor expressed in HEK293 cells after 2 hrs by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
Shionogi

Curated by ChEMBL
LigandPNGBDBM50045107(CHEMBL1256978 | GSK364735)
Affinity DataIC50:  7.80nMAssay Description:Inhibition of Human immunodeficiency virus 1 integrase by strand transfer scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein arginine N-methyltransferase 5(Homo sapiens (Human))
Mirati Therapeutics

Curated by ChEMBL
LigandPNGBDBM579105(US11479551, Example 16-7 | US11479551, Example 16-...)
Affinity DataIC50:  8nMAssay Description:Inhibition of PRMT5 methyltransferase activity in MTAP knockout human HCT-116 cells assessed as inhibition of PRMT5- mediated SDMA modification level...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein arginine N-methyltransferase 5(Homo sapiens (Human))
Mirati Therapeutics

Curated by ChEMBL
LigandPNGBDBM578996(2-(4-(4-(aminomethyl)-1-oxo-1,2- dihydrophthalazin...)
Affinity DataIC50:  8nMAssay Description:Inhibition of PRMT5 methyltransferase activity in MTAP knockout human HCT-116 cells assessed as inhibition of PRMT5- mediated SDMA modification level...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProtein arginine N-methyltransferase 5(Homo sapiens (Human))
Mirati Therapeutics

Curated by ChEMBL
LigandPNGBDBM50585595(CHEMBL5076613)
Affinity DataIC50:  9nMAssay Description:Inhibition of PRMT5 methyltransferase activity in MTAP knockout human HCT-116 cells assessed as inhibition of PRMT5- mediated SDMA modification level...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 1/2(RAT)
Shionogi

Curated by ChEMBL
LigandPNGBDBM50472610(CHEMBL60725)
Affinity DataIC50:  9.10nMAssay Description:In vitro inhibitory effect on production of prostaglandin E2 (PGE2) in rat synovial cells.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProstaglandin D2 receptor 2(Homo sapiens (Human))
Astellas Pharma

Curated by ChEMBL
LigandPNGBDBM50362158(CHEMBL1941119)
Affinity DataIC50:  9.20nMAssay Description:Displacement of [3H]PGD2 from human CRTH2 receptor expressed in HEK293 cells after 2 hrs by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 1/2(RAT)
Shionogi

Curated by ChEMBL
LigandPNGBDBM50472622(CHEMBL291543)
Affinity DataIC50:  9.5nMAssay Description:In vitro inhibitory effect on production of prostaglandin E2 (PGE2) in rat synovial cells.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin D2 receptor 2(Homo sapiens (Human))
Astellas Pharma

Curated by ChEMBL
LigandPNGBDBM50362166(CHEMBL1941128)
Affinity DataIC50:  9.70nMAssay Description:Displacement of [3H]PGD2 from human CRTH2 receptor expressed in HEK293 cells after 2 hrs by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
Shionogi

Curated by ChEMBL
LigandPNGBDBM50021581(CHEMBL414850 | L-870810)
Affinity DataIC50:  9.90nMAssay Description:Inhibition of Human immunodeficiency virus 1 integrase by strand transfer scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 1/2(RAT)
Shionogi

Curated by ChEMBL
LigandPNGBDBM50472631(CHEMBL60738)
Affinity DataIC50:  10nMAssay Description:In vitro inhibitory effect on production of prostaglandin E2 (PGE2) in rat synovial cells.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
Shionogi

Curated by ChEMBL
LigandPNGBDBM50485874(CHEMBL2171671)
Affinity DataIC50:  10nMAssay Description:Inhibition of HIV1 integrase strand transfer activity using pre-incubation and wash with Mg2+ cofactor by ELISA based microtiter plate integration as...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
Shionogi

Curated by ChEMBL
LigandPNGBDBM50183273((S)-6-(3-chloro-2-fluorobenzyl)-1-(1-hydroxy-3-met...)
Affinity DataIC50:  11nMAssay Description:Displacement of 20 nM [3H]GSK304649 from Human immunodeficiency virus 1 integrase by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin D2 receptor 2(Homo sapiens (Human))
Astellas Pharma

Curated by ChEMBL
LigandPNGBDBM50362157(CHEMBL1941118)
Affinity DataIC50:  11nMAssay Description:Displacement of [3H]PGD2 from human CRTH2 receptor expressed in HEK293 cells after 2 hrs by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein arginine N-methyltransferase 5(Homo sapiens (Human))
Mirati Therapeutics

Curated by ChEMBL
LigandPNGBDBM579047(2-(4-(4-(aminomethyl)-1-oxo-1,2- dihydrophthalazin...)
Affinity DataIC50:  11nMAssay Description:Inhibition of PRMT5 methyltransferase activity in MTAP knockout human HCT-116 cells assessed as inhibition of PRMT5- mediated SDMA modification level...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetProstaglandin D2 receptor 2(Homo sapiens (Human))
Astellas Pharma

Curated by ChEMBL
LigandPNGBDBM50362164(CHEMBL1941126)
Affinity DataIC50:  11nMAssay Description:Displacement of [3H]PGD2 from human CRTH2 receptor expressed in HEK293 cells after 2 hrs by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein arginine N-methyltransferase 5(Homo sapiens (Human))
Mirati Therapeutics

Curated by ChEMBL
LigandPNGBDBM50585597(CHEMBL5083379)
Affinity DataIC50:  11nMAssay Description:Inhibition of PRMT5 methyltransferase activity in MTAP knockout human HCT-116 cells assessed as inhibition of PRMT5- mediated SDMA modification level...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
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