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Found 1320 with Last Name = 'kobayashi' and Initial = 'n'
TargetProlyl endopeptidase(Homo sapiens (Human))
Zeria Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50038898((S)-1-((S)-1-(2-(2,3-dihydro-1H-inden-2-yl)acetyl)...)
Affinity DataIC50:  0.420nMAssay Description:In vitro inhibitory activity against purified prolyl endopeptidase (PEP) from canine brain.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProlyl endopeptidase(Homo sapiens (Human))
Zeria Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50038897((S)-1-[(S)-1-((S)-2-1,2,3,4-Tetrahydro-naphthalen-...)
Affinity DataIC50:  0.450nMAssay Description:In vitro inhibitory activity against purified prolyl endopeptidase (PEP) from canine brain.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProlyl endopeptidase(Homo sapiens (Human))
Zeria Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50038899((S)-1-[(R)-3-((S)-2-1,2,3,4-Tetrahydro-naphthalen-...)
Affinity DataIC50:  0.460nMAssay Description:In vitro inhibitory activity against purified prolyl endopeptidase (PEP) from canine brain.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProlyl endopeptidase(Homo sapiens (Human))
Zeria Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50038891((S)-1-[(S)-1-((S)-2-1,2,3,4-Tetrahydro-naphthalen-...)
Affinity DataIC50:  0.520nMAssay Description:In vitro inhibitory activity against purified prolyl endopeptidase (PEP) from canine brain.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProlyl endopeptidase(Homo sapiens (Human))
Zeria Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50038893((S)-1-[(R)-3-((S)-2-1,2,3,4-Tetrahydro-naphthalen-...)
Affinity DataIC50:  0.550nMAssay Description:In vitro inhibitory activity against purified prolyl endopeptidase (PEP) from canine brain.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProlyl endopeptidase(Homo sapiens (Human))
Zeria Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50038868((R)-3-[(R)-3-((S)-2-1,2,3,4-Tetrahydro-naphthalen-...)
Affinity DataIC50:  0.850nMAssay Description:In vitro inhibitory activity against purified prolyl endopeptidase (PEP) from canine brain.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProlyl endopeptidase(Homo sapiens (Human))
Zeria Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50038876((S)-1-[(R)-3-(2-Indan-2-yl-acetyl)-thiazolidine-4-...)
Affinity DataIC50:  1nMAssay Description:In vitro inhibitory activity against purified prolyl endopeptidase (PEP) from canine brain.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProlyl endopeptidase(Homo sapiens (Human))
Zeria Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50038879((S)-2-(2-Formyl-pyrrolidine-1-carbonyl)-pyrrolidin...)
Affinity DataIC50:  1.10nMAssay Description:In vitro inhibitory activity against purified prolyl endopeptidase (PEP) from canine brain.More data for this Ligand-Target Pair
TargetProlyl endopeptidase(Homo sapiens (Human))
Zeria Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50038885((S)-1-[(R)-3-(2-Indan-2-yl-acetyl)-thiazolidine-4-...)
Affinity DataIC50:  1.10nMAssay Description:In vitro inhibitory activity against purified prolyl endopeptidase (PEP) from canine brain.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProlyl endopeptidase(Homo sapiens (Human))
Zeria Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50038889((S)-1-((S)-1-(2-(2,3-dihydro-1H-inden-2-yl)acetyl)...)
Affinity DataIC50:  1.20nMAssay Description:In vitro inhibitory activity against purified prolyl endopeptidase (PEP) from canine brain.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
Shionogi

US Patent
LigandPNGBDBM505120(US11066409, Compound I-0003)
Affinity DataIC50:  1.80nMAssay Description:Evaluation of a human P2X7 receptor inhibitory activity Stably expressing cell line (1321N1 cell transfected with the human P2X7 receptor gene (GenBa...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAcetyl-CoA carboxylase 2(Homo sapiens (Human))
Shionogi

Curated by ChEMBL
LigandPNGBDBM50462049(CHEMBL4225405)
Affinity DataIC50:  1.90nMAssay Description:Inhibition of recombinant human ACC2 assessed as reduction in conversion of acetyl-CoA to malonyl-CoA incubated for 1 to 3 hrs with substrate by MALD...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAcetyl-CoA carboxylase 2(Homo sapiens (Human))
Shionogi

Curated by ChEMBL
LigandPNGBDBM307410(US10150728, Example I-639)
Affinity DataIC50:  2nMAssay Description:Recombinant human ACC1 and recombinant human ACC2, which were prepared by the method mentioned above, were preincubated with assay buffer solution (5...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetThromboxane-A synthase(Rattus norvegicus)
Eisai

Curated by ChEMBL
LigandPNGBDBM50037039(2-Amino-5,7-dimethyl-4-pyridin-3-ylmethyl-benzothi...)
Affinity DataIC50:  2nMAssay Description:Inhibitory activity against the production of thromboxane B2 (TXB2) in glycogen-induced peritoneal cells of ratMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetyl-CoA carboxylase 2(Homo sapiens (Human))
Shionogi

Curated by ChEMBL
LigandPNGBDBM307424(US10150728, Example I-655)
Affinity DataIC50:  2nMAssay Description:Recombinant human ACC1 and recombinant human ACC2, which were prepared by the method mentioned above, were preincubated with assay buffer solution (5...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAcetyl-CoA carboxylase 2(Homo sapiens (Human))
Shionogi

Curated by ChEMBL
LigandPNGBDBM50462060(CHEMBL4229067)
Affinity DataIC50:  2.10nMAssay Description:Inhibition of recombinant human ACC2 assessed as reduction in conversion of acetyl-CoA to malonyl-CoA incubated for 1 to 3 hrs with substrate by MALD...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProlyl endopeptidase(Homo sapiens (Human))
Zeria Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50038864(2-(S)-1,2,3,4-Tetrahydro-naphthalen-2-yl-1-[(R)-4-...)
Affinity DataIC50:  2.30nMAssay Description:In vitro inhibitory activity against purified prolyl endopeptidase (PEP) from canine brain.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetyl-CoA carboxylase 2(Homo sapiens (Human))
Shionogi

Curated by ChEMBL
LigandPNGBDBM307449(US10150728, Example I-683)
Affinity DataIC50:  3nMAssay Description:Recombinant human ACC1 and recombinant human ACC2, which were prepared by the method mentioned above, were preincubated with assay buffer solution (5...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAcetyl-CoA carboxylase 2(Homo sapiens (Human))
Shionogi

Curated by ChEMBL
LigandPNGBDBM307463(US10150728, Example I-698)
Affinity DataIC50:  3nMAssay Description:Recombinant human ACC1 and recombinant human ACC2, which were prepared by the method mentioned above, were preincubated with assay buffer solution (5...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAcetyl-CoA carboxylase 2(Homo sapiens (Human))
Shionogi

Curated by ChEMBL
LigandPNGBDBM307475(US10150728, Example I-713)
Affinity DataIC50:  3nMAssay Description:Recombinant human ACC1 and recombinant human ACC2, which were prepared by the method mentioned above, were preincubated with assay buffer solution (5...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAcetyl-CoA carboxylase 2(Homo sapiens (Human))
Shionogi

Curated by ChEMBL
LigandPNGBDBM307497(US10150728, Example I-740)
Affinity DataIC50:  3nMAssay Description:Recombinant human ACC1 and recombinant human ACC2, which were prepared by the method mentioned above, were preincubated with assay buffer solution (5...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAcetyl-CoA carboxylase 2(Homo sapiens (Human))
Shionogi

Curated by ChEMBL
LigandPNGBDBM307385(US10150728, Example I-611)
Affinity DataIC50:  3nMAssay Description:Recombinant human ACC1 and recombinant human ACC2, which were prepared by the method mentioned above, were preincubated with assay buffer solution (5...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAcetyl-CoA carboxylase 2(Homo sapiens (Human))
Shionogi

Curated by ChEMBL
LigandPNGBDBM306965(US10150728, Example I-178)
Affinity DataIC50:  3nMAssay Description:Recombinant human ACC1 and recombinant human ACC2, which were prepared by the method mentioned above, were preincubated with assay buffer solution (5...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAcetyl-CoA carboxylase 2(Homo sapiens (Human))
Shionogi

Curated by ChEMBL
LigandPNGBDBM306944(US10150728, Example I-157)
Affinity DataIC50:  3nMAssay Description:Recombinant human ACC1 and recombinant human ACC2, which were prepared by the method mentioned above, were preincubated with assay buffer solution (5...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProlyl endopeptidase(Homo sapiens (Human))
Zeria Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50038887(2-(S)-1,2,3,4-Tetrahydro-naphthalen-2-yl-1-[(R)-2-...)
Affinity DataIC50:  3.40nMAssay Description:In vitro inhibitory activity against purified prolyl endopeptidase (PEP) from canine brain.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetyl-CoA carboxylase 2(Homo sapiens (Human))
Shionogi

Curated by ChEMBL
LigandPNGBDBM307421(US10150728, Example I-651)
Affinity DataIC50:  4nMAssay Description:Recombinant human ACC1 and recombinant human ACC2, which were prepared by the method mentioned above, were preincubated with assay buffer solution (5...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProlyl endopeptidase(Homo sapiens (Human))
Zeria Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50038895(1-[(R)-4-(Pyrrolidine-1-carbonyl)-thiazolidin-3-yl...)
Affinity DataIC50:  4nMAssay Description:In vitro inhibitory activity against purified prolyl endopeptidase (PEP) from canine brain.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetyl-CoA carboxylase 2(Homo sapiens (Human))
Shionogi

Curated by ChEMBL
LigandPNGBDBM307427(US10150728, Example I-658)
Affinity DataIC50:  4nMAssay Description:Recombinant human ACC1 and recombinant human ACC2, which were prepared by the method mentioned above, were preincubated with assay buffer solution (5...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAcetyl-CoA carboxylase 2(Homo sapiens (Human))
Shionogi

Curated by ChEMBL
LigandPNGBDBM307433(US10150728, Example I-665)
Affinity DataIC50:  4nMAssay Description:Recombinant human ACC1 and recombinant human ACC2, which were prepared by the method mentioned above, were preincubated with assay buffer solution (5...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAcetyl-CoA carboxylase 2(Homo sapiens (Human))
Shionogi

Curated by ChEMBL
LigandPNGBDBM307454(US10150728, Example I-688)
Affinity DataIC50:  4nMAssay Description:Recombinant human ACC1 and recombinant human ACC2, which were prepared by the method mentioned above, were preincubated with assay buffer solution (5...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAcetyl-CoA carboxylase 2(Homo sapiens (Human))
Shionogi

Curated by ChEMBL
LigandPNGBDBM307462(US10150728, Example I-697)
Affinity DataIC50:  4nMAssay Description:Recombinant human ACC1 and recombinant human ACC2, which were prepared by the method mentioned above, were preincubated with assay buffer solution (5...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAcetyl-CoA carboxylase 2(Homo sapiens (Human))
Shionogi

Curated by ChEMBL
LigandPNGBDBM307487(US10150728, Example I-729)
Affinity DataIC50:  4nMAssay Description:Recombinant human ACC1 and recombinant human ACC2, which were prepared by the method mentioned above, were preincubated with assay buffer solution (5...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAcetyl-CoA carboxylase 2(Homo sapiens (Human))
Shionogi

Curated by ChEMBL
LigandPNGBDBM307491(US10150728, Example I-734)
Affinity DataIC50:  4nMAssay Description:Recombinant human ACC1 and recombinant human ACC2, which were prepared by the method mentioned above, were preincubated with assay buffer solution (5...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAcetyl-CoA carboxylase 2(Homo sapiens (Human))
Shionogi

Curated by ChEMBL
LigandPNGBDBM307330(US10150728, Example I-544)
Affinity DataIC50:  4nMAssay Description:Recombinant human ACC1 and recombinant human ACC2, which were prepared by the method mentioned above, were preincubated with assay buffer solution (5...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAcetyl-CoA carboxylase 2(Homo sapiens (Human))
Shionogi

Curated by ChEMBL
LigandPNGBDBM307407(US10150728, Example I-636)
Affinity DataIC50:  4nMAssay Description:Recombinant human ACC1 and recombinant human ACC2, which were prepared by the method mentioned above, were preincubated with assay buffer solution (5...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAcetyl-CoA carboxylase 2(Homo sapiens (Human))
Shionogi

Curated by ChEMBL
LigandPNGBDBM307408(US10150728, Example I-637)
Affinity DataIC50:  4nMAssay Description:Recombinant human ACC1 and recombinant human ACC2, which were prepared by the method mentioned above, were preincubated with assay buffer solution (5...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAcetyl-CoA carboxylase 2(Homo sapiens (Human))
Shionogi

Curated by ChEMBL
LigandPNGBDBM307223(US10150728, Example I-436)
Affinity DataIC50:  4nMAssay Description:Recombinant human ACC1 and recombinant human ACC2, which were prepared by the method mentioned above, were preincubated with assay buffer solution (5...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAcetyl-CoA carboxylase 2(Homo sapiens (Human))
Shionogi

Curated by ChEMBL
LigandPNGBDBM307226(US10150728, Example I-439)
Affinity DataIC50:  4nMAssay Description:Recombinant human ACC1 and recombinant human ACC2, which were prepared by the method mentioned above, were preincubated with assay buffer solution (5...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAcetyl-CoA carboxylase 2(Homo sapiens (Human))
Shionogi

Curated by ChEMBL
LigandPNGBDBM307247(US10150728, Example I-460)
Affinity DataIC50:  4nMAssay Description:Recombinant human ACC1 and recombinant human ACC2, which were prepared by the method mentioned above, were preincubated with assay buffer solution (5...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAcetyl-CoA carboxylase 2(Homo sapiens (Human))
Shionogi

Curated by ChEMBL
LigandPNGBDBM307248(US10150728, Example I-461)
Affinity DataIC50:  4nMAssay Description:Recombinant human ACC1 and recombinant human ACC2, which were prepared by the method mentioned above, were preincubated with assay buffer solution (5...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAcetyl-CoA carboxylase 2(Homo sapiens (Human))
Shionogi

Curated by ChEMBL
LigandPNGBDBM307172(US10150728, Example I-385)
Affinity DataIC50:  4nMAssay Description:Recombinant human ACC1 and recombinant human ACC2, which were prepared by the method mentioned above, were preincubated with assay buffer solution (5...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAcetyl-CoA carboxylase 2(Homo sapiens (Human))
Shionogi

Curated by ChEMBL
LigandPNGBDBM307025(US10150728, Example I-238)
Affinity DataIC50:  4nMAssay Description:Recombinant human ACC1 and recombinant human ACC2, which were prepared by the method mentioned above, were preincubated with assay buffer solution (5...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAcetyl-CoA carboxylase 2(Homo sapiens (Human))
Shionogi

Curated by ChEMBL
LigandPNGBDBM307032(US10150728, Example I-245)
Affinity DataIC50:  4nMAssay Description:Recombinant human ACC1 and recombinant human ACC2, which were prepared by the method mentioned above, were preincubated with assay buffer solution (5...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAcetyl-CoA carboxylase 2(Homo sapiens (Human))
Shionogi

Curated by ChEMBL
LigandPNGBDBM307006(US10150728, Example I-219)
Affinity DataIC50:  4nMAssay Description:Recombinant human ACC1 and recombinant human ACC2, which were prepared by the method mentioned above, were preincubated with assay buffer solution (5...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAcetyl-CoA carboxylase 2(Homo sapiens (Human))
Shionogi

Curated by ChEMBL
LigandPNGBDBM306906(US10150728, Example I-119)
Affinity DataIC50:  4nMAssay Description:Recombinant human ACC1 and recombinant human ACC2, which were prepared by the method mentioned above, were preincubated with assay buffer solution (5...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAcetyl-CoA carboxylase 2(Homo sapiens (Human))
Shionogi

Curated by ChEMBL
LigandPNGBDBM50462062(CHEMBL4225659)
Affinity DataIC50:  4.30nMAssay Description:Inhibition of recombinant human ACC2 assessed as reduction in conversion of acetyl-CoA to malonyl-CoA incubated for 1 to 3 hrs with substrate by MALD...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAcetyl-CoA carboxylase 2(Homo sapiens (Human))
Shionogi

Curated by ChEMBL
LigandPNGBDBM307430(US10150728, Example I-662)
Affinity DataIC50:  5nMAssay Description:Recombinant human ACC1 and recombinant human ACC2, which were prepared by the method mentioned above, were preincubated with assay buffer solution (5...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAcetyl-CoA carboxylase 2(Homo sapiens (Human))
Shionogi

Curated by ChEMBL
LigandPNGBDBM307448(US10150728, Example I-682)
Affinity DataIC50:  5nMAssay Description:Recombinant human ACC1 and recombinant human ACC2, which were prepared by the method mentioned above, were preincubated with assay buffer solution (5...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAcetyl-CoA carboxylase 2(Homo sapiens (Human))
Shionogi

Curated by ChEMBL
LigandPNGBDBM307452(US10150728, Example I-686)
Affinity DataIC50:  5nMAssay Description:Recombinant human ACC1 and recombinant human ACC2, which were prepared by the method mentioned above, were preincubated with assay buffer solution (5...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAcetyl-CoA carboxylase 2(Homo sapiens (Human))
Shionogi

Curated by ChEMBL
LigandPNGBDBM307471(US10150728, Example I-708)
Affinity DataIC50:  5nMAssay Description:Recombinant human ACC1 and recombinant human ACC2, which were prepared by the method mentioned above, were preincubated with assay buffer solution (5...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
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