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Found 998 with Last Name = 'kohl' and Initial = 'c'
TargetMitogen-activated protein kinase 1/3(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM28123(3-cyanoquinoline, 8 | 4-({3-chloro-4-[(1-methyl-1H...)
Affinity DataIC50:  0.0100nMAssay Description:Inhibition of MEK1 phosphorylation in LoVo cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeprilysin(Rattus norvegicus (Rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50197517((S)-2-{1-[3-(4-chloro-phenyl)-propylcarbamoyl]-cyc...)
Affinity DataIC50:  0.600nMAssay Description:Inhibition of rat NEPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeprilysin(Oryctolagus cuniculus (rabbit))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50197517((S)-2-{1-[3-(4-chloro-phenyl)-propylcarbamoyl]-cyc...)
Affinity DataIC50:  0.800nMAssay Description:Inhibition of rabbit NEPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50132262(4-[3-Chloro-4-(1,5-dimethyl-1H-imidazol-2-ylsulfan...)
Affinity DataIC50:  1nMAssay Description:Inhibitory concentration of the compound against Mitogen activated protein kinase kinase kinase 1 was determined using Raf/MEK1 coupled assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM28124(3-cyanoquinoline, 9 | 6-methoxy-7-[3-(morpholin-4-...)
Affinity DataIC50:  1.10nMAssay Description:Inhibitory activity against Dual specificity mitogen-activated protein kinase kinase using coupled MEK assay (which uses activated Raf to activate an...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM6477(4-Anilino-7,8-dialkoxybenzo[g]quinoline-3-carbonit...)
Affinity DataIC50:  1.40nMAssay Description:Inhibition of Src protein tryrosine kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM28123(3-cyanoquinoline, 8 | 4-({3-chloro-4-[(1-methyl-1H...)
Affinity DataIC50:  2nMAssay Description:Inhibitory concentration against Mitogen activated protein kinase kinase kinase 1 was determined using Raf/MEK1 coupled assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50132261(4-[3-Chloro-4-(1-methyl-1H-imidazol-2-ylsulfanyl)-...)
Affinity DataIC50:  2nMAssay Description:Inhibitory concentration of the compound against Mitogen activated protein kinase kinase kinase 1 was determined using Raf/MEK1 coupled assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM28123(3-cyanoquinoline, 8 | 4-({3-chloro-4-[(1-methyl-1H...)
Affinity DataIC50:  2nMAssay Description:Inhibitory concentration of the compound against Mitogen activated protein kinase kinase kinase 1 was determined using Raf/MEK1 coupled assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50132260(2-(2-Chloro-4-iodo-phenylamino)-N-cyclopropylmetho...)
Affinity DataIC50:  2nMAssay Description:Inhibitory concentration of the compound against Mitogen activated protein kinase kinase kinase 1 was determined using Raf/MEK1 coupled assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50132266(4-[3-Bromo-4-(1-methyl-1H-imidazol-2-ylsulfanyl)-p...)
Affinity DataIC50:  2nMAssay Description:Inhibitory concentration of the compound against Mitogen activated protein kinase kinase kinase 1 was determined using Raf/MEK1 coupled assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50132264(4-[3-Chloro-4-(1,4,5-trimethyl-1H-imidazol-2-ylsul...)
Affinity DataIC50:  2nMAssay Description:Inhibitory concentration of the compound against Mitogen activated protein kinase kinase kinase 1 was determined using Raf/MEK1 coupled assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeprilysin(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50197517((S)-2-{1-[3-(4-chloro-phenyl)-propylcarbamoyl]-cyc...)
Affinity DataIC50:  2.30nMpH: 7.0Assay Description:Inhibition of human kidney NEP at pH 7More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50095232(6-Methoxy-7-(3-morpholin-4-yl-propoxy)-4-(4-phenox...)
Affinity DataIC50:  2.40nMAssay Description:Inhibition of ERK-phosphorylation by Raf-MEK-ERK in coupled ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50099987(4-(4-Benzyl-phenylamino)-6-methoxy-7-(3-morpholin-...)
Affinity DataIC50:  2.70nMAssay Description:Inhibitory activity against Dual specificity mitogen-activated protein kinase kinase using coupled MEK assay (which uses activated Raf to activate an...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine 1-phosphate receptor 4(Homo sapiens (Human))
Actelion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50158348((2S,3R,4E)-2-amino-3-hydroxyoctadec-4-en-1-yl dihy...)
Affinity DataIC50:  2.90nMAssay Description:Displacement of [33P]S1P from human recombinant S1P4 receptor expressed in CHO cells by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM28118(3-cyanoquinoline, 3 | 4-({3-chloro-4-[(1-methyl-1H...)
Affinity DataIC50:  3nMAssay Description:Inhibitory concentration of the compound against Mitogen activated protein kinase kinase kinase 1 was determined using Raf/MEK1 coupled assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50099990(4-(4-Benzyl-phenylamino)-6,7-dimethoxy-quinoline-3...)
Affinity DataIC50:  3.60nMAssay Description:Inhibitory activity against Dual specificity mitogen-activated protein kinase kinase using coupled MEK assay (which uses activated Raf to activate an...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeprilysin(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50197513((S)-2-((1-((2-(hydroxymethyl)-2,3-dihydro-1H-inden...)
Affinity DataIC50:  3.70nMpH: 7.0Assay Description:Inhibition of human kidney NEP at pH 7More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM4531(4-Phenylamino-3-quinolinecarbonitrile deriv. 1i | ...)
Affinity DataIC50:  4nMAssay Description:Inhibition of Src protein tryrosine kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50095232(6-Methoxy-7-(3-morpholin-4-yl-propoxy)-4-(4-phenox...)
Affinity DataIC50:  4nMAssay Description:Inhibitory concentration of the compound against Mitogen activated protein kinase kinase kinase 1 was determined using Raf/MEK1 coupled assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM28119(3-cyanoquinoline, 4 | 4-({3-chloro-4-[(1-methyl-1H...)
Affinity DataIC50:  4nMAssay Description:Inhibitory concentration of the compound against Mitogen activated protein kinase kinase kinase 1 was determined using Raf/MEK1 coupled assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50099983(6-Methoxy-7-(3-morpholin-4-yl-propoxy)-4-(4-thioph...)
Affinity DataIC50:  4.20nMAssay Description:Inhibitory activity against Dual specificity mitogen-activated protein kinase kinase using coupled MEK assay (which uses activated Raf to activate an...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50099981(6-Methoxy-7-(3-morpholin-4-yl-propoxy)-4-(4-thioph...)
Affinity DataIC50:  4.40nMAssay Description:Inhibitory activity against Dual specificity mitogen-activated protein kinase kinase using coupled MEK assay (which uses activated Raf to activate an...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeprilysin(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50197519((S)-2-{1-[3-(4-fluoro-phenyl)-propylcarbamoyl]-cyc...)
Affinity DataIC50:  4.60nMpH: 7.0Assay Description:Inhibition of human kidney NEP at pH 7More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM28122(3-cyanoquinoline, 7 | 6-methoxy-4-({4-[(1-methyl-1...)
Affinity DataIC50:  5nMAssay Description:Inhibitory concentration of the compound against Mitogen activated protein kinase kinase kinase 1 was determined using Raf/MEK1 coupled assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeprilysin(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50197517((S)-2-{1-[3-(4-chloro-phenyl)-propylcarbamoyl]-cyc...)
Affinity DataIC50:  5.40nMAssay Description:Inhibition of human recombinant NEPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM28124(3-cyanoquinoline, 9 | 6-methoxy-7-[3-(morpholin-4-...)
Affinity DataIC50:  5.70nMAssay Description:Inhibitory activity against Dual specificity mitogen-activated protein kinase kinase using direct MEK assay (which by-passes the need for activated R...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine 1-phosphate receptor 1(Homo sapiens (Human))
Actelion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50316769((Z,Z)-5-[3-Chloro-4-((2R)-2,3-dihydroxy-propoxy)-b...)
Affinity DataIC50:  6nMAssay Description:Displacement of [33P]S1P from human recombinant S1P1 receptor expressed in HEK cells by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeprilysin(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50197507((S)-4-methoxy-2-{1-[(1R,2S)-2-(4-methoxy-phenyl)-c...)
Affinity DataIC50:  6.10nMpH: 7.0Assay Description:Inhibition of human kidney NEP at pH 7More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50095226(6,7-Dimethoxy-4-(4-phenoxy-phenylamino)-quinoline-...)
Affinity DataIC50:  6.20nMAssay Description:Inhibitory activity against Dual specificity mitogen-activated protein kinase kinase using coupled MEK assay (which uses activated Raf to activate an...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50095232(6-Methoxy-7-(3-morpholin-4-yl-propoxy)-4-(4-phenox...)
Affinity DataIC50:  7nMAssay Description:Inhibition of ERK-phosphorylation by MEK-ERK in direct ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50095232(6-Methoxy-7-(3-morpholin-4-yl-propoxy)-4-(4-phenox...)
Affinity DataIC50:  7nMAssay Description:Inhibitory activity against Dual specificity mitogen-activated protein kinase kinase using direct MEK assay (which by-passes the need for activated R...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50095232(6-Methoxy-7-(3-morpholin-4-yl-propoxy)-4-(4-phenox...)
Affinity DataIC50:  7nMAssay Description:Inhibitory activity against Dual specificity mitogen-activated protein kinase kinase using direct MEK assay (which by-passes the need for activated R...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM28125(3-cyanoquinoline, 10 | 4-{[3-chloro-4-(pyridin-2-y...)
Affinity DataIC50:  8nMAssay Description:Inhibitory concentration of the compound against Mitogen activated protein kinase kinase kinase 1 was determined using Raf/MEK1 coupled assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase kinase kinase 1(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM28123(3-cyanoquinoline, 8 | 4-({3-chloro-4-[(1-methyl-1H...)
Affinity DataIC50:  8nMAssay Description:Inhibition of MEK-1 Kinase phosphorylation in LoVo cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50095235(6-Methoxy-7-(2-morpholin-4-yl-ethoxy)-4-(4-phenoxy...)
Affinity DataIC50:  8nMAssay Description:Inhibition of ERK-phosphorylation by Raf-MEK-ERK in coupled ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50132263(4-[3-Chloro-4-(thiazol-2-ylsulfanyl)-phenylamino]-...)
Affinity DataIC50:  9nMAssay Description:Inhibitory concentration of the compound against Mitogen activated protein kinase kinase kinase 1 was determined using Raf/MEK1 coupled assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50095226(6,7-Dimethoxy-4-(4-phenoxy-phenylamino)-quinoline-...)
Affinity DataIC50:  9nMAssay Description:Inhibition of Dual specificity mitogen-activated protein kinase kinase (MEK-1)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50095226(6,7-Dimethoxy-4-(4-phenoxy-phenylamino)-quinoline-...)
Affinity DataIC50:  9nMAssay Description:Inhibition of ERK-phosphorylation by Raf-MEK-ERK in coupled ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50132265(4-[3-Chloro-4-(1-methyl-1H-imidazol-2-ylsulfanyl)-...)
Affinity DataIC50:  10nMAssay Description:Inhibitory concentration of the compound against Mitogen activated protein kinase kinase kinase 1 was determined using Raf/MEK1 coupled assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50109282(7,8-Dimethoxy-4-(4-phenoxy-phenylamino)-benzo[g]qu...)
Affinity DataIC50:  10nMAssay Description:Inhibition of Dual specificity mitogen-activated protein kinase kinase (MEK-1)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeprilysin(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50197513((S)-2-((1-((2-(hydroxymethyl)-2,3-dihydro-1H-inden...)
Affinity DataIC50:  10nMpH: 7.4Assay Description:Inhibition of human kidney NEP at pH 7.4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeprilysin(Oryctolagus cuniculus (rabbit))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50190746((R)-2-((1-((5-ethyl-1,3,4-thiadiazol-2-yl)carbamoy...)
Affinity DataIC50:  10.2nMAssay Description:Inhibition of rabbit NEPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeprilysin(Oryctolagus cuniculus (rabbit))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50190746((R)-2-((1-((5-ethyl-1,3,4-thiadiazol-2-yl)carbamoy...)
Affinity DataIC50:  10.2nMAssay Description:Inhibition of rabbit NEPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeprilysin(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50197517((S)-2-{1-[3-(4-chloro-phenyl)-propylcarbamoyl]-cyc...)
Affinity DataIC50:  10.5nMpH: 7.4Assay Description:Inhibition of human kidney NEP at pH 7.4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeprilysin(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50190771((R)-2-((1-((2-(hydroxymethyl)-2,3-dihydro-1H-inden...)
Affinity DataIC50:  11nMAssay Description:Inhibition of dog NEPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeprilysin(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50197519((S)-2-{1-[3-(4-fluoro-phenyl)-propylcarbamoyl]-cyc...)
Affinity DataIC50:  12.6nMpH: 7.4Assay Description:Inhibition of human kidney NEP at pH 7.4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeprilysin(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50197507((S)-4-methoxy-2-{1-[(1R,2S)-2-(4-methoxy-phenyl)-c...)
Affinity DataIC50:  13.8nMpH: 7.4Assay Description:Inhibition of human kidney NEP at pH 7.4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50099987(4-(4-Benzyl-phenylamino)-6-methoxy-7-(3-morpholin-...)
Affinity DataIC50:  14nMAssay Description:Inhibitory activity against Dual specificity mitogen-activated protein kinase kinase using direct MEK assay (which by-passes the need for activated R...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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