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Found 86 with Last Name = 'komeno' and Initial = 'm'
TargetSphingosine 1-phosphate receptor 5(Homo sapiens (Human))
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50250631(CHEMBL4093489)
Affinity DataKi:  0.574nMAssay Description:Displacement of [33P]-S1P from human S1P5 receptor expressed in CHO-K1 cells after 60 mins by scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine 1-phosphate receptor 1(Homo sapiens (Human))
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50250631(CHEMBL4093489)
Affinity DataKi:  0.626nMAssay Description:Agonist activity at human S1P5 receptor expressed in CHO-K1 cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 30 mins by E...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine 1-phosphate receptor 1(Rattus norvegicus)
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50250631(CHEMBL4093489)
Affinity DataKi:  0.772nMAssay Description:Displacement of [33P]-S1P from human S1P2 receptor expressed in CHO-K1 cells after 60 mins by scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine 1-phosphate receptor 4(Homo sapiens (Human))
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50250631(CHEMBL4093489)
Affinity DataKi:  29nMAssay Description:Displacement of [33P]-S1P from human S1P4 receptor expressed in CHO-K1 cells after 60 mins by scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine 1-phosphate receptor 2(Homo sapiens (Human))
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50250631(CHEMBL4093489)
Affinity DataKi: >5.45E+3nMAssay Description:Displacement of [33P]-S1P from rat S1P1 receptor after 60 mins by scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine 1-phosphate receptor 3(Homo sapiens (Human))
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50250631(CHEMBL4093489)
Affinity DataKi: >5.63E+3nMAssay Description:Displacement of [33P]-S1P from human S1P3 receptor expressed in CHO-K1 cells after 60 mins by scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, inducible(Mus musculus (mouse))
Fukui Research Institute

Curated by ChEMBL
LigandPNGBDBM50116666(4-Methyl-3,6-dihydro-1H-pyridin-(2Z)-ylideneamine ...)
Affinity DataIC50:  22nMAssay Description:The concentration required for inhibition of Inducible nitric oxide synthase in mouseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, inducible(Mus musculus (mouse))
Fukui Research Institute

Curated by ChEMBL
LigandPNGBDBM50116674(6-Allyl-4-methyl-5,6-dihydro-1H-pyridin-(2Z)-ylide...)
Affinity DataIC50:  25nMAssay Description:The concentration required for inhibition of Inducible nitric oxide synthase in mouseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, inducible(Homo sapiens (Human))
Fukui Research Institute

Curated by ChEMBL
LigandPNGBDBM50116674(6-Allyl-4-methyl-5,6-dihydro-1H-pyridin-(2Z)-ylide...)
Affinity DataIC50:  50nMAssay Description:Concentration required to inhibit human Inducible nitric oxide synthase over expressed in A549 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, inducible(Homo sapiens (Human))
Fukui Research Institute

Curated by ChEMBL
LigandPNGBDBM50116668(4-Methyl-6-propyl-5,6-dihydro-1H-pyridin-(2Z)-ylid...)
Affinity DataIC50:  60nMAssay Description:Concentration required to inhibit human Inducible nitric oxide synthase over expressed in A549 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, inducible(Mus musculus (mouse))
Fukui Research Institute

Curated by ChEMBL
LigandPNGBDBM50116667(4,5,5-Trimethyl-5,6-dihydro-1H-pyridin-(2Z)-yliden...)
Affinity DataIC50:  100nMAssay Description:The concentration required for inhibition of Inducible nitric oxide synthase in mouseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, inducible(Mus musculus (mouse))
Fukui Research Institute

Curated by ChEMBL
LigandPNGBDBM50116668(4-Methyl-6-propyl-5,6-dihydro-1H-pyridin-(2Z)-ylid...)
Affinity DataIC50:  100nMAssay Description:The concentration required for inhibition of Inducible nitric oxide synthase in mouseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, inducible(Homo sapiens (Human))
Fukui Research Institute

Curated by ChEMBL
LigandPNGBDBM50116670((4aR,7aR)-4-Methyl-1,4a,5,6,7,7a-hexahydro-[1]pyri...)
Affinity DataIC50:  170nMAssay Description:Concentration required to inhibit human Inducible nitric oxide synthase over expressed in A549 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, inducible(Homo sapiens (Human))
Fukui Research Institute

Curated by ChEMBL
LigandPNGBDBM50116676(4,6-Dimethyl-5,6-dihydro-1H-pyridin-(2Z)-ylideneam...)
Affinity DataIC50:  180nMAssay Description:Concentration required to inhibit Inducible nitric oxide synthase over expressed in A549 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, inducible(Homo sapiens (Human))
Fukui Research Institute

Curated by ChEMBL
LigandPNGBDBM50116666(4-Methyl-3,6-dihydro-1H-pyridin-(2Z)-ylideneamine ...)
Affinity DataIC50:  200nMAssay Description:Inhibition of human endothelial Nitric Oxide Synthase expressed in Sf-21 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, endothelial(Homo sapiens (Human))
Fukui Research Institute

Curated by ChEMBL
LigandPNGBDBM50116666(4-Methyl-3,6-dihydro-1H-pyridin-(2Z)-ylideneamine ...)
Affinity DataIC50:  230nMAssay Description:Concentration required to inhibit human Inducible nitric oxide synthase over expressed in A549 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, endothelial(Homo sapiens (Human))
Fukui Research Institute

Curated by ChEMBL
LigandPNGBDBM50116676(4,6-Dimethyl-5,6-dihydro-1H-pyridin-(2Z)-ylideneam...)
Affinity DataIC50:  240nMAssay Description:Inhibition of human endothelial Nitric Oxide Synthase expressed in Sf-21 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, inducible(Homo sapiens (Human))
Fukui Research Institute

Curated by ChEMBL
LigandPNGBDBM50116673(3,4-Dimethyl-5,6-dihydro-1H-pyridin-(2Z)-ylideneam...)
Affinity DataIC50:  310nMAssay Description:Concentration required to inhibit human Inducible nitric oxide synthase over expressed in A549 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, endothelial(Homo sapiens (Human))
Fukui Research Institute

Curated by ChEMBL
LigandPNGBDBM50116673(3,4-Dimethyl-5,6-dihydro-1H-pyridin-(2Z)-ylideneam...)
Affinity DataIC50:  320nMAssay Description:Inhibition of human endothelial Nitric Oxide Synthase expressed in Sf-21 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, endothelial(Homo sapiens (Human))
Fukui Research Institute

Curated by ChEMBL
LigandPNGBDBM50116674(6-Allyl-4-methyl-5,6-dihydro-1H-pyridin-(2Z)-ylide...)
Affinity DataIC50:  360nMAssay Description:Inhibition of human endothelial Nitric Oxide Synthase expressed in Sf-21 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, inducible(Homo sapiens (Human))
Fukui Research Institute

Curated by ChEMBL
LigandPNGBDBM50116667(4,5,5-Trimethyl-5,6-dihydro-1H-pyridin-(2Z)-yliden...)
Affinity DataIC50:  420nMAssay Description:Concentration required to inhibit human Inducible nitric oxide synthase over expressed in A549 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, endothelial(Homo sapiens (Human))
Fukui Research Institute

Curated by ChEMBL
LigandPNGBDBM50116666(4-Methyl-3,6-dihydro-1H-pyridin-(2Z)-ylideneamine ...)
Affinity DataIC50:  440nMAssay Description:Inhibition of human endothelial Nitric Oxide Synthase expressed in Sf-21 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, inducible(Homo sapiens (Human))
Fukui Research Institute

Curated by ChEMBL
LigandPNGBDBM50116675(4,5-Dimethyl-5,6-dihydro-1H-pyridin-(2Z)-ylideneam...)
Affinity DataIC50:  510nMAssay Description:Concentration required to inhibit Inducible nitric oxide synthase over expressed in A549 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, endothelial(Homo sapiens (Human))
Fukui Research Institute

Curated by ChEMBL
LigandPNGBDBM50116670((4aR,7aR)-4-Methyl-1,4a,5,6,7,7a-hexahydro-[1]pyri...)
Affinity DataIC50:  510nMAssay Description:Inhibition of human endothelial Nitric Oxide Synthase expressed in Sf-21 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, endothelial(Homo sapiens (Human))
Fukui Research Institute

Curated by ChEMBL
LigandPNGBDBM50116675(4,5-Dimethyl-5,6-dihydro-1H-pyridin-(2Z)-ylideneam...)
Affinity DataIC50:  520nMAssay Description:Inhibition of human endothelial Nitric Oxide Synthase expressed in Sf-21 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, endothelial(Homo sapiens (Human))
Fukui Research Institute

Curated by ChEMBL
LigandPNGBDBM50116668(4-Methyl-6-propyl-5,6-dihydro-1H-pyridin-(2Z)-ylid...)
Affinity DataIC50:  580nMAssay Description:Inhibition of human endothelial Nitric Oxide Synthase expressed in Sf-21 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, inducible(Homo sapiens (Human))
Fukui Research Institute

Curated by ChEMBL
LigandPNGBDBM50116666(4-Methyl-3,6-dihydro-1H-pyridin-(2Z)-ylideneamine ...)
Affinity DataIC50:  700nMAssay Description:Concentration required to inhibit human Inducible nitric oxide synthase over expressed in A549 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, inducible(Homo sapiens (Human))
Fukui Research Institute

Curated by ChEMBL
LigandPNGBDBM50237936(4-Ethyl-5,6-dihydro-1H-pyridin-(2Z)-ylideneamine |...)
Affinity DataIC50:  1.20E+3nMAssay Description:Concentration required to inhibit human Inducible nitric oxide synthase over expressed in A549 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, inducible(Homo sapiens (Human))
Fukui Research Institute

Curated by ChEMBL
LigandPNGBDBM50116677((4aR,8aR)-4-Methyl-4a,5,6,7,8,8a-hexahydro-1H-quin...)
Affinity DataIC50:  1.40E+3nMAssay Description:Concentration required to inhibit human Inducible nitric oxide synthase over expressed in A549 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, endothelial(Homo sapiens (Human))
Fukui Research Institute

Curated by ChEMBL
LigandPNGBDBM50237936(4-Ethyl-5,6-dihydro-1H-pyridin-(2Z)-ylideneamine |...)
Affinity DataIC50:  1.50E+3nMAssay Description:Inhibition of human endothelial Nitric Oxide Synthase expressed in Sf-21 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, endothelial(Homo sapiens (Human))
Fukui Research Institute

Curated by ChEMBL
LigandPNGBDBM50116667(4,5,5-Trimethyl-5,6-dihydro-1H-pyridin-(2Z)-yliden...)
Affinity DataIC50:  2.10E+3nMAssay Description:Inhibition of human endothelial Nitric Oxide Synthase expressed in Sf-21 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, inducible(Homo sapiens (Human))
Fukui Research Institute

Curated by ChEMBL
LigandPNGBDBM50116669(5,5-Dimethyl-5,6-dihydro-1H-pyridin-(2Z)-ylideneam...)
Affinity DataIC50:  2.80E+3nMAssay Description:Concentration required to inhibit human Inducible nitric oxide synthase over expressed in A549 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, endothelial(Homo sapiens (Human))
Fukui Research Institute

Curated by ChEMBL
LigandPNGBDBM50116677((4aR,8aR)-4-Methyl-4a,5,6,7,8,8a-hexahydro-1H-quin...)
Affinity DataIC50:  7.40E+3nMAssay Description:Inhibition of human endothelial Nitric Oxide Synthase expressed in Sf-21 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, endothelial(Homo sapiens (Human))
Fukui Research Institute

Curated by ChEMBL
LigandPNGBDBM50116669(5,5-Dimethyl-5,6-dihydro-1H-pyridin-(2Z)-ylideneam...)
Affinity DataIC50:  3.10E+4nMAssay Description:Inhibition of human endothelial Nitric Oxide Synthase expressed in Sf-21 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine 1-phosphate receptor 1(Homo sapiens (Human))
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50250632(CHEMBL4100785)
Affinity DataEC50:  7.90nMAssay Description:Agonist activity at human S1P1 receptor expressed in CHO-K1 cells assessed as increase in S1P-stimulated calcium influx preincubated for 5 mins follo...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine 1-phosphate receptor 1(Homo sapiens (Human))
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50250636(CHEMBL4085321)
Affinity DataEC50:  1nMAssay Description:Agonist activity at human S1P1 receptor expressed in CHO-K1 cells assessed as increase in S1P-stimulated calcium influx preincubated for 5 mins follo...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine 1-phosphate receptor 1(Homo sapiens (Human))
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50250623(CHEMBL4103252)
Affinity DataEC50:  5nMAssay Description:Agonist activity at human S1P1 receptor expressed in CHO-K1 cells assessed as increase in S1P-stimulated calcium influx preincubated for 5 mins follo...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine 1-phosphate receptor 3(Homo sapiens (Human))
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50250629(CHEMBL4074505)
Affinity DataEC50:  6.80E+3nMAssay Description:Agonist activity at human S1P3 receptor expressed in CHO-K1 cells assessed as increase in S1P-stimulated calcium influx preincubated for 5 mins follo...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine 1-phosphate receptor 5(Homo sapiens (Human))
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50250637(CHEMBL4087932)
Affinity DataEC50:  0.920nMAssay Description:Agonist activity at human S1P5 receptor expressed in CHO-K1 cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 30 mins by E...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine 1-phosphate receptor 1(Homo sapiens (Human))
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50250631(CHEMBL4093489)
Affinity DataEC50:  1nMAssay Description:Agonist activity at human S1P1 receptor expressed in CHO-K1 cells assessed as increase in S1P-stimulated calcium influx preincubated for 5 mins follo...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine 1-phosphate receptor 1(Homo sapiens (Human))
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50250615(CHEMBL4077888)
Affinity DataEC50:  57nMAssay Description:Agonist activity at human S1P1 receptor expressed in CHO-K1 cells assessed as increase in S1P-stimulated calcium influx preincubated for 5 mins follo...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine 1-phosphate receptor 3(Homo sapiens (Human))
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50250636(CHEMBL4085321)
Affinity DataEC50:  9.30E+3nMAssay Description:Agonist activity at human S1P3 receptor expressed in CHO-K1 cells assessed as increase in S1P-stimulated calcium influx preincubated for 5 mins follo...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine 1-phosphate receptor 1(Rattus norvegicus)
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50250631(CHEMBL4093489)
Affinity DataEC50:  0.0286nMAssay Description:Agonist activity at rat S1P1 receptor assessed as inhibition of forskolin-stimulated cAMP accumulation after 30 mins by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine 1-phosphate receptor 3(Homo sapiens (Human))
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50250632(CHEMBL4100785)
Affinity DataEC50: >3.00E+4nMAssay Description:Agonist activity at human S1P3 receptor expressed in CHO-K1 cells assessed as increase in S1P-stimulated calcium influx preincubated for 5 mins follo...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine 1-phosphate receptor 3(Homo sapiens (Human))
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50250637(CHEMBL4087932)
Affinity DataEC50: >3.00E+4nMAssay Description:Agonist activity at human S1P3 receptor expressed in CHO-K1 cells assessed as increase in S1P-stimulated calcium influx preincubated for 5 mins follo...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine 1-phosphate receptor 5(Homo sapiens (Human))
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50250614(CHEMBL4095920)
Affinity DataEC50:  0.980nMAssay Description:Agonist activity at human S1P5 receptor expressed in CHO-K1 cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 30 mins by E...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine 1-phosphate receptor 1(Homo sapiens (Human))
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50250628(CHEMBL4062652)
Affinity DataEC50:  54nMAssay Description:Agonist activity at human S1P1 receptor expressed in CHO-K1 cells assessed as increase in S1P-stimulated calcium influx preincubated for 5 mins follo...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine 1-phosphate receptor 1(Homo sapiens (Human))
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50250637(CHEMBL4087932)
Affinity DataEC50:  1.20nMAssay Description:Agonist activity at human S1P1 receptor expressed in CHO-K1 cells assessed as increase in S1P-stimulated calcium influx preincubated for 5 mins follo...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine 1-phosphate receptor 3(Homo sapiens (Human))
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50250631(CHEMBL4093489)
Affinity DataEC50: >3.00E+4nMAssay Description:Agonist activity at human S1P1 receptor expressed in CHO-K1 cells assessed as increase in S1P-stimulated calcium influx preincubated for 5 mins follo...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine 1-phosphate receptor 1(Homo sapiens (Human))
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50250631(CHEMBL4093489)
Affinity DataEC50:  0.0270nMAssay Description:Agonist activity at human S1P1 receptor expressed in CHO-K1 cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 30 mins by E...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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