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Found 299 with Last Name = 'kottke' and Initial = 't'
TargetHistamine H3 receptor(Homo sapiens (Human))
Johann Wolfgang Goethe Universit£T

Curated by ChEMBL
LigandPNGBDBM50277100(4-(3-Piperidin-1-yl-propoxy)-benzoic acid 2-{4-[3-...)
Affinity DataKi:  0.0420nMAssay Description:Displacement of [125I]iodoproxyfan from human histamine H3 receptor expressed in CHO/HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Johann Wolfgang Goethe Universit£T

Curated by ChEMBL
LigandPNGBDBM50277045(CHEMBL459350 | [3-(10,11-Dihydro-dibenzo[a,d]cyclo...)
Affinity DataKi:  0.25nMAssay Description:Displacement of [125I]iodoproxyfan from human histamine H3 receptor expressed in CHO/HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Johann Wolfgang Goethe Universit£T

Curated by ChEMBL
LigandPNGBDBM50247053(1-(3-(3-(4-chlorophenyl)propoxy)propyl)piperidine ...)
Affinity DataKi:  0.300nMAssay Description:Binding affinity to human histamine H3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Johann Wolfgang Goethe Universit£T

Curated by ChEMBL
LigandPNGBDBM50277046(CHEMBL517244 | methyl({4-[3-(piperidin-1-yl)propox...)
Affinity DataKi:  0.358nMAssay Description:Displacement of [125I]iodoproxyfan from human histamine H3 receptor expressed in CHO/HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Johann Wolfgang Goethe Universit£T

Curated by ChEMBL
LigandPNGBDBM22911(2-(3H-imidazol-4-yl)ethylsulfanylmethanimidamide |...)
Affinity DataKi:  0.700nMAssay Description:Displacement of [125I]iodoproxyfan from human full-length histamine H3 receptor expressed in HEK293 cells after 60 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H1 receptor(Homo sapiens (Human))
Johann Wolfgang Goethe Universit£T

Curated by ChEMBL
LigandPNGBDBM50020712(10,11-dihydro-5-(gamma-dimethylaminopropylidene)-5...)
Affinity DataKi:  1.12nMAssay Description:Displacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetHistamine H3 receptor(Homo sapiens (Human))
Johann Wolfgang Goethe Universit£T

Curated by ChEMBL
LigandPNGBDBM50277076(CHEMBL459373 | [3-(2-Chloro-phenothiazin-10-yl)-pr...)
Affinity DataKi:  1.21nMAssay Description:Displacement of [125I]iodoproxyfan from human histamine H3 receptor expressed in CHO/HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
Johann Wolfgang Goethe Universit£T

Curated by ChEMBL
LigandPNGBDBM78433(2-[4-[3-[2-(trifluoromethyl)-10-phenothiazinyl]pro...)
Affinity DataKi:  1.44nMAssay Description:Displacement of [3H]spiperone from human dopamine D2 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetHistamine H3 receptor(Homo sapiens (Human))
Johann Wolfgang Goethe Universit£T

Curated by ChEMBL
LigandPNGBDBM50277077(CHEMBL517407 | {3-[2-Chloro-thioxanthenylidene]-pr...)
Affinity DataKi:  1.54nMAssay Description:Displacement of [125I]iodoproxyfan from human histamine H3 receptor expressed in CHO/HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H4 receptor(Homo sapiens (Human))
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM22911(2-(3H-imidazol-4-yl)ethylsulfanylmethanimidamide |...)
Affinity DataKi:  1.60nMAssay Description:Displacement of [3H]histamine from human full-length histamine H4 receptor expressed in HEK293 cells after 60 minsMore data for this Ligand-Target Pair
TargetHistamine H1 receptor(Homo sapiens (Human))
Johann Wolfgang Goethe Universit£T

Curated by ChEMBL
LigandPNGBDBM35228(CHEMBL21731 | Dibencycladine | Ludiomil | maprotil...)
Affinity DataKi:  1.67nMAssay Description:Displacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H1 receptor(Homo sapiens (Human))
Johann Wolfgang Goethe Universit£T

Curated by ChEMBL
LigandPNGBDBM50001884(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
Affinity DataKi:  2.38nMAssay Description:Displacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetHistamine H3 receptor(Homo sapiens (Human))
Johann Wolfgang Goethe Universit£T

Curated by ChEMBL
LigandPNGBDBM22541(Clobenpropit | N''-[(4-chlorophenyl)methyl]{[3-(1H...)
Affinity DataKi:  2.40nMAssay Description:Displacement of [3H]iodoproxyfan from human histamine H3 receptor expressed in CHO-K1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Johann Wolfgang Goethe Universit£T

Curated by ChEMBL
LigandPNGBDBM22541(Clobenpropit | N''-[(4-chlorophenyl)methyl]{[3-(1H...)
Affinity DataKi:  2.40nMAssay Description:Displacement of [125I]iodoproxyfan from human full-length histamine H3 receptor expressed in HEK293 cells after 60 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Johann Wolfgang Goethe Universit£T

Curated by ChEMBL
LigandPNGBDBM50247053(1-(3-(3-(4-chlorophenyl)propoxy)propyl)piperidine ...)
Affinity DataKi:  2.70nMAssay Description:Displacement of [125I]Iodoproxyfan from human histamine H3 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
Johann Wolfgang Goethe Universit£T

Curated by ChEMBL
LigandPNGBDBM50240514((3Z)-3-(2-chloro-9H-thioxanthen-9-ylidene)-N,N-dim...)
Affinity DataKi:  2.96nMAssay Description:Displacement of [3H]spiperone from human dopamine D2 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(3) dopamine receptor(Homo sapiens (Human))
Johann Wolfgang Goethe Universit£T

Curated by ChEMBL
LigandPNGBDBM78433(2-[4-[3-[2-(trifluoromethyl)-10-phenothiazinyl]pro...)
Affinity DataKi:  3.21nMAssay Description:Displacement of [3H]spiperone from human dopamine D3 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Johann Wolfgang Goethe Universit£T

Curated by ChEMBL
LigandPNGBDBM50277099(8-Chloro-11-{4-[4-(3-piperidin-1-yl-propoxy)-benzy...)
Affinity DataKi:  3.27nMAssay Description:Displacement of [125I]iodoproxyfan from human histamine H3 receptor expressed in CHO/HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Johann Wolfgang Goethe Universit£T

Curated by ChEMBL
LigandPNGBDBM50277044(CHEMBL460402 | N-[3-(10,11-Dihydro-dibenzo[a,d]cyc...)
Affinity DataKi:  3.5nMAssay Description:Displacement of [125I]iodoproxyfan from human histamine H3 receptor expressed in CHO/HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H1 receptor(Homo sapiens (Human))
Johann Wolfgang Goethe Universit£T

Curated by ChEMBL
LigandPNGBDBM50240514((3Z)-3-(2-chloro-9H-thioxanthen-9-ylidene)-N,N-dim...)
Affinity DataKi:  3.75nMAssay Description:Displacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
Johann Wolfgang Goethe Universit£T

Curated by ChEMBL
LigandPNGBDBM50001888((chloropromazine) [3-(2-Chloro-phenothiazin-10-yl)...)
Affinity DataKi:  4.06nMAssay Description:Displacement of [3H]spiperone from human dopamine D2 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetHistamine H1 receptor(Homo sapiens (Human))
Johann Wolfgang Goethe Universit£T

Curated by ChEMBL
LigandPNGBDBM50001888((chloropromazine) [3-(2-Chloro-phenothiazin-10-yl)...)
Affinity DataKi:  4.25nMAssay Description:Displacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetHistamine H4 receptor(Homo sapiens (Human))
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM22541(Clobenpropit | N''-[(4-chlorophenyl)methyl]{[3-(1H...)
Affinity DataKi:  4.30nMAssay Description:Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H4 receptor(Homo sapiens (Human))
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM22541(Clobenpropit | N''-[(4-chlorophenyl)methyl]{[3-(1H...)
Affinity DataKi:  4.30nMAssay Description:Displacement of [3H]histamine from human full-length histamine H4 receptor expressed in HEK293 cells after 60 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(3) dopamine receptor(Homo sapiens (Human))
Johann Wolfgang Goethe Universit£T

Curated by ChEMBL
LigandPNGBDBM50240514((3Z)-3-(2-chloro-9H-thioxanthen-9-ylidene)-N,N-dim...)
Affinity DataKi:  4.56nMAssay Description:Displacement of [3H]spiperone from human dopamine D3 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Johann Wolfgang Goethe Universit£T

Curated by ChEMBL
LigandPNGBDBM50311769((S)-3-(1H-imidazol-4-yl)propyl 2-methylbutylcarbam...)
Affinity DataKi:  4.70nMAssay Description:Displacement of [3H]iodoproxyfan from human histamine H3 receptor expressed in CHO-K1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Johann Wolfgang Goethe Universit£T

Curated by ChEMBL
LigandPNGBDBM50276977(CHEMBL457957 | N-[3-(10,11-Dihydro-dibenzo[a,d]cyc...)
Affinity DataKi:  4.90nMAssay Description:Displacement of [125I]iodoproxyfan from human histamine H3 receptor expressed in CHO/HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Rattus norvegicus (rat))
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50074076((3-Methyl-pentyl)-carbamic acid 3-(1H-imidazol-4-y...)
Affinity DataKi:  5.10nMAssay Description:Displacement of [3H]histamine from histamine H3 receptor in rat cerebral cortexMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(3) dopamine receptor(Homo sapiens (Human))
Johann Wolfgang Goethe Universit£T

Curated by ChEMBL
LigandPNGBDBM50001888((chloropromazine) [3-(2-Chloro-phenothiazin-10-yl)...)
Affinity DataKi:  6.90nMAssay Description:Displacement of [3H]spiperone from human dopamine D3 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Johann Wolfgang Goethe Universit£T

Curated by ChEMBL
LigandPNGBDBM50327227(4,5-diphenyl-2-(3-(piperidin-1-yl)propylthio)thiaz...)
Affinity DataKi:  7.40nMAssay Description:Displacement of [125I]Iodoproxyfan from human histamine H3 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Johann Wolfgang Goethe Universit£T

Curated by ChEMBL
LigandPNGBDBM50074088((2-Methyl-pentyl)-carbamic acid 3-(1H-imidazol-4-y...)
Affinity DataKi:  8.30nMAssay Description:Displacement of [3H]iodoproxyfan from human histamine H3 receptor expressed in CHO-K1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Rattus norvegicus (rat))
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50074072((1-Methyl-pentyl)-carbamic acid 3-(1H-imidazol-4-y...)
Affinity DataKi:  8.70nMAssay Description:Displacement of [3H]histamine from histamine H3 receptor in rat cerebral cortexMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Johann Wolfgang Goethe Universit£T

Curated by ChEMBL
LigandPNGBDBM50459836(CHEMBL4227989)
Affinity DataKi:  8.80nMAssay Description:Displacement of [125I]Iodoproxyfan from recombinant human histamine H3 receptor expressed in CHOK1 cell membranes after 90 minsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetD(1B) dopamine receptor(Homo sapiens (Human))
Johann Wolfgang Goethe Universit£T

Curated by ChEMBL
LigandPNGBDBM50240514((3Z)-3-(2-chloro-9H-thioxanthen-9-ylidene)-N,N-dim...)
Affinity DataKi:  9nMAssay Description:Displacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H4 receptor(Homo sapiens (Human))
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50021553(CHEMBL3290570)
Affinity DataKi:  10nMAssay Description:Displacement of [3H]-histamine from human histamine H4 receptor after 45 mins by scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Johann Wolfgang Goethe Universit£T

Curated by ChEMBL
LigandPNGBDBM50327232(4,5-diphenyl-2-(3-(piperidin-1-yl)propoxy)thiazole...)
Affinity DataKi:  11.2nMAssay Description:Displacement of [125I]Iodoproxyfan from human histamine H3 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H4 receptor(Homo sapiens (Human))
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50304523(CHEMBL595180 | N4-(2,6-Dichlorobenzyl)-6-(4-methyl...)
Affinity DataKi:  12nMAssay Description:Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Johann Wolfgang Goethe Universit£T

Curated by ChEMBL
LigandPNGBDBM50311765((R)-3-(1H-imidazol-4-yl)propyl sec-butylcarbamate ...)
Affinity DataKi:  12nMAssay Description:Displacement of [3H]iodoproxyfan from human histamine H3 receptor expressed in CHO-K1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Rattus norvegicus (rat))
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50311772((S)-3-(1H-imidazol-4-yl)propyl hexan-2-ylcarbamate...)
Affinity DataKi:  12nMAssay Description:Displacement of [3H]histamine from histamine H3 receptor in rat cerebral cortexMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Rattus norvegicus (rat))
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50311768((R)-3-(1H-imidazol-4-yl)propyl pentan-2-ylcarbamat...)
Affinity DataKi:  12nMAssay Description:Displacement of [3H]histamine from histamine H3 receptor in rat cerebral cortexMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Johann Wolfgang Goethe Universit£T

Curated by ChEMBL
LigandPNGBDBM50311780(3-(1H-imidazol-4-yl)propyl 4-methylpentylcarbamate...)
Affinity DataKi:  13nMAssay Description:Displacement of [3H]iodoproxyfan from human histamine H3 receptor expressed in CHO-K1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Johann Wolfgang Goethe Universit£T

Curated by ChEMBL
LigandPNGBDBM50074076((3-Methyl-pentyl)-carbamic acid 3-(1H-imidazol-4-y...)
Affinity DataKi:  13nMAssay Description:Displacement of [3H]iodoproxyfan from human histamine H3 receptor expressed in CHO-K1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Johann Wolfgang Goethe Universit£T

Curated by ChEMBL
LigandPNGBDBM50459827(CHEMBL4225644)
Affinity DataKi:  14nMAssay Description:Displacement of [125I]Iodoproxyfan from recombinant human histamine H3 receptor expressed in CHOK1 cell membranes after 90 minsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Johann Wolfgang Goethe Universit£T

Curated by ChEMBL
LigandPNGBDBM50343837(3-(1H-imidazol-4-yl)propyl pent-4-enylcarbamate hy...)
Affinity DataKi:  14nMAssay Description:Displacement of [125I]iodoproxyfan from human histamine H3 receptor expressed in CHO-K1 cells after 60 mins by gamma countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H4 receptor(Homo sapiens (Human))
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM22566(5-chloro-2-[(4-methylpiperazin-1-yl)carbonyl]-1H-i...)
Affinity DataKi:  14nMAssay Description:Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(3) dopamine receptor(Homo sapiens (Human))
Johann Wolfgang Goethe Universit£T

Curated by ChEMBL
LigandPNGBDBM50277100(4-(3-Piperidin-1-yl-propoxy)-benzoic acid 2-{4-[3-...)
Affinity DataKi:  15nMAssay Description:Displacement of [3H]spiperone from human dopamine D3 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Johann Wolfgang Goethe Universit£T

Curated by ChEMBL
LigandPNGBDBM50311768((R)-3-(1H-imidazol-4-yl)propyl pentan-2-ylcarbamat...)
Affinity DataKi:  15nMAssay Description:Displacement of [3H]iodoproxyfan from human histamine H3 receptor expressed in CHO-K1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Rattus norvegicus (rat))
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50074088((2-Methyl-pentyl)-carbamic acid 3-(1H-imidazol-4-y...)
Affinity DataKi:  15nMAssay Description:Displacement of [3H]histamine from histamine H3 receptor in rat cerebral cortexMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Johann Wolfgang Goethe Universit£T

Curated by ChEMBL
LigandPNGBDBM50343838(3-(1H-imidazol-4-yl)propyl 2-cyclopropylethylcarba...)
Affinity DataKi:  17nMAssay Description:Displacement of [125I]iodoproxyfan from human histamine H3 receptor expressed in CHO-K1 cells after 60 mins by gamma countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Rattus norvegicus (rat))
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50247053(1-(3-(3-(4-chlorophenyl)propoxy)propyl)piperidine ...)
Affinity DataKi:  17nMAssay Description:Binding affinity to rat histamine H3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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