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Target
Histamine H3 receptor
Ligand
BDBM50327232
Substrate
n/a
Meas. Tech.
ChEMBL_664249 (CHEMBL1261756)
Ki
11.2±n/a nM
Citation
 Walter, M; Isensee, K; Kottke, T; Ligneau, X; Camelin, JC; Schwartz, JC; Stark, H Azole derivatives as histamine H3 receptor antagonists, part 2: C-C and C-S coupled heterocycles. Bioorg Med Chem Lett 20:5883-6 (2010) [PubMed]  Article 
Target
Name:
Histamine H3 receptor
Synonyms:
G-protein coupled receptor 97 | GPCR97 | HH3R | HISTAMINE H3 | HRH3 | HRH3_HUMAN | Histamine H3 receptor (H3) | Histamine H3L | Histamine receptor (H3 and H4)
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
48691.47
Organism:
Homo sapiens (Human)
Description:
Binding assays were using CHO cells stably expressing hH3R receptors.
Residue:
445
Sequence:
MERAPPDGPLNASGALAGEAAAAGGARGFSAAWTAVLAALMALLIVATVLGNALVMLAFVADSSLRTQNNFFLLNLAISDFLVGAFCIPLYVPYVLTGRWTFGRGLCKLWLVVDYLLCTSSAFNIVLISYDRFLSVTRAVSYRAQQGDTRRAVRKMLLVWVLAFLLYGPAILSWEYLSGGSSIPEGHCYAEFFYNWYFLITASTLEFFTPFLSVTFFNLSIYLNIQRRTRLRLDGAREAAGPEPPPEAQPSPPPPPGCWGCWQKGHGEAMPLHRYGVGEAAVGAEAGEATLGGGGGGGSVASPTSSSGSSSRGTERPRSLKRGSKPSASSASLEKRMKMVSQSFTQRFRLSRDRKVAKSLAVIVSIFGLCWAPYTLLMIIRAACHGHCVPDYWYETSFWLLWANSAVNPVLYPLCHHSFRRAFTKLLCPQKLKIQPHSSLEHCWK
  
Inhibitor
Name:
BDBM50327232
Synonyms:
4,5-diphenyl-2-(3-(piperidin-1-yl)propoxy)thiazole | CHEMBL1257584 | ST-1025
Type:
Small organic molecule
Emp. Form.:
C23H26N2OS
Mol. Mass.:
378.53
SMILES:
C(COc1nc(c(s1)-c1ccccc1)-c1ccccc1)CN1CCCCC1
Structure:
Search PDB for entries with ligand similarity: