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Found 171 with Last Name = 'kuntz' and Initial = 'da'
TargetAlpha-mannosidase 2(Drosophila melanogaster (Fruit fly))
University of Toronto

LigandPNGBDBM84868(Swainsonine derivative, 3)
Affinity DataKi:  2.70nM ΔG°:  -48.9kJ/mole IC50:  29nMpH: 5.75 T: 2°CAssay Description:Inhibition of dGMII was measured at pH 5.75. Determination of the IC50 values (concentrations of inhibitor at which 50% of activity remains) was car...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-mannosidase 2(Drosophila melanogaster (Fruit fly))
University of Toronto

LigandPNGBDBM84869(Swainsonine derivative, 4)
Affinity DataKi:  2.70nM ΔG°:  -48.9kJ/mole IC50:  29nMpH: 5.75 T: 2°CAssay Description:Inhibition of dGMII was measured at pH 5.75. Determination of the IC50 values (concentrations of inhibitor at which 50% of activity remains) was car...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-mannosidase 2(Drosophila melanogaster (Fruit fly))
University of Toronto

LigandPNGBDBM84867(Swainsonine derivative, 2)
Affinity DataKi:  2.80nM ΔG°:  -48.8kJ/mole IC50:  30nMpH: 5.75 T: 2°CAssay Description:Inhibition of dGMII was measured at pH 5.75. Determination of the IC50 values (concentrations of inhibitor at which 50% of activity remains) was car...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-mannosidase 2(Drosophila melanogaster (Fruit fly))
University of Toronto

LigandPNGBDBM50168995((-)-swainsonine | (1S,2R,8R,8aR)-Octahydro-indoliz...)
Affinity DataKi:  3nM ΔG°:  -48.6kJ/mole IC50:  37nMpH: 5.75 T: 2°CAssay Description:Inhibition of dGMII was measured at pH 5.75. Determination of the IC50 values (concentrations of inhibitor at which 50% of activity remains) was car...More data for this Ligand-Target Pair
TargetAlpha-mannosidase 2(Drosophila melanogaster (Fruit fly))
University of Toronto

LigandPNGBDBM50078117((1R,2R,3R,4S,5R)-4-AMINO-5-(METHYLTHIO)CYCLOPENTAN...)
Affinity DataKi:  36nMAssay Description:The rate of hydrolysis catalyzed by drosophila golgi alpha-mannosidase II (dGMII)and in the presence of different concentration of inhibitor was meas...More data for this Ligand-Target Pair
TargetAlpha-mannosidase 2(Drosophila melanogaster (Fruit fly))
University of Toronto

LigandPNGBDBM50088625((1R,2R,3R,4S,5R)-4-Amino-5-methoxy-cyclopentane-1,...)
Affinity DataKi:  76nMAssay Description:The rate of hydrolysis catalyzed by drosophila golgi alpha-mannosidase II (dGMII)and in the presence of different concentration of inhibitor was meas...More data for this Ligand-Target Pair
TargetMaltase-glucoamylase(Homo sapiens (Human))
Simon Fraser University

Curated by ChEMBL
LigandPNGBDBM50316180((1S,2R,3S,4S)-1-{(1S)-2-[(2R,3S,4S)-3,4-dihydroxy-...)
Affinity DataKi:  100nMAssay Description:Inhibition of recombinant human maltase glucoamylase N-terminal catalytic domainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMaltase-glucoamylase(Homo sapiens (Human))
Simon Fraser University

Curated by ChEMBL
LigandPNGBDBM50316181((1S,2R,3S,4R)-1-{(1S)-2-[(2R,3S,4S)-3,4-dihydroxy-...)
Affinity DataKi:  130nMAssay Description:Inhibition of recombinant human maltase glucoamylase N-terminal catalytic domainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-mannosidase 2(Drosophila melanogaster (Fruit fly))
University of Toronto

LigandPNGBDBM84614(Mannostatin B, 2)
Affinity DataKi:  150nMAssay Description:The rate of hydrolysis catalyzed by drosophila golgi alpha-mannosidase II (dGMII)and in the presence of different concentration of inhibitor was meas...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMaltase-glucoamylase(Homo sapiens (Human))
Simon Fraser University

Curated by ChEMBL
LigandPNGBDBM50316179((1S,2R,3R,4S)-1-{(1S)-2-[(2R,3S,4S)-3,4-dihydroxy-...)
Affinity DataKi:  190nMAssay Description:Inhibition of recombinant human maltase glucoamylase N-terminal catalytic domainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMaltase-glucoamylase(Homo sapiens (Human))
Simon Fraser University

Curated by ChEMBL
LigandPNGBDBM50316178(1,4-Dideoxy-1,4-[[2S,3S,4R,5R,6R-2,4,5,6,7-pentahy...)
Affinity DataKi:  200nMAssay Description:Inhibition of recombinant human maltase glucoamylase N-terminal catalytic domainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-mannosidase 2(Drosophila melanogaster (Fruit fly))
University of Toronto

LigandPNGBDBM84615(Mannostatin analogue, 4a)
Affinity DataKi:  300nMAssay Description:The rate of hydrolysis catalyzed by drosophila golgi alpha-mannosidase II (dGMII)and in the presence of different concentration of inhibitor was meas...More data for this Ligand-Target Pair
TargetLysosomal alpha-mannosidase(Homo sapiens (Human))
Ecole Polytechnique FéDéRale De Lausanne

Curated by ChEMBL
LigandPNGBDBM50263049((3R,4R,5R)-3,4-dihydroxy-5-(((R)-2-hydroxy-1-pheny...)
Affinity DataKi:  550nMAssay Description:Inhibition of alpha-mannosidase in human LNZ308 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysosomal alpha-mannosidase(Homo sapiens (Human))
Ecole Polytechnique FéDéRale De Lausanne

Curated by ChEMBL
LigandPNGBDBM50263049((3R,4R,5R)-3,4-dihydroxy-5-(((R)-2-hydroxy-1-pheny...)
Affinity DataKi:  670nMAssay Description:Inhibition of alpha-mannosidase in human HCECMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysosomal alpha-mannosidase(Homo sapiens (Human))
Ecole Polytechnique FéDéRale De Lausanne

Curated by ChEMBL
LigandPNGBDBM50263049((3R,4R,5R)-3,4-dihydroxy-5-(((R)-2-hydroxy-1-pheny...)
Affinity DataKi:  3.20E+3nMAssay Description:Inhibition of alpha-mannosidase in human LN18 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysosomal alpha-mannosidase(Homo sapiens (Human))
Ecole Polytechnique FéDéRale De Lausanne

Curated by ChEMBL
LigandPNGBDBM50168988((2R,3R,4S)-2-({[(1R)-2-HYDROXY-1-PHENYLETHYL]AMINO...)
Affinity DataKi:  2.33E+4nMAssay Description:Inhibition of alpha-mannosidase in human HCECMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysosomal alpha-mannosidase(Homo sapiens (Human))
Ecole Polytechnique FéDéRale De Lausanne

Curated by ChEMBL
LigandPNGBDBM50168988((2R,3R,4S)-2-({[(1R)-2-HYDROXY-1-PHENYLETHYL]AMINO...)
Affinity DataKi:  3.25E+4nMAssay Description:Inhibition of alpha-mannosidase in human LN18 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysosomal alpha-mannosidase(Homo sapiens (Human))
Ecole Polytechnique FéDéRale De Lausanne

Curated by ChEMBL
LigandPNGBDBM50168988((2R,3R,4S)-2-({[(1R)-2-HYDROXY-1-PHENYLETHYL]AMINO...)
Affinity DataKi:  4.15E+4nMAssay Description:Inhibition of alpha-mannosidase in human LNZ308 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-mannosidase 2(Drosophila melanogaster (Fruit fly))
University of Toronto

LigandPNGBDBM50088627((1S,2S,3R,4R)-4-Amino-cyclopentane-1,2,3-triol | (...)
Affinity DataKi:  2.65E+5nMAssay Description:The rate of hydrolysis catalyzed by drosophila golgi alpha-mannosidase II (dGMII)and in the presence of different concentration of inhibitor was meas...More data for this Ligand-Target Pair
TargetLysosomal alpha-mannosidase(Homo sapiens (Human))
Ecole Polytechnique FéDéRale De Lausanne

Curated by ChEMBL
LigandPNGBDBM50168995((-)-swainsonine | (1S,2R,8R,8aR)-Octahydro-indoliz...)
Affinity DataIC50:  10nMAssay Description:Inhibition of alpha-mannosidase in human HCECMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-mannosidase 2(Drosophila melanogaster (Fruit fly))
University of Toronto

LigandPNGBDBM84871(Swainsonine derivative, 6)
Affinity DataIC50:  44nMpH: 5.75 T: 2°CAssay Description:Inhibition of dGMII was measured at pH 5.75. Determination of the IC50 values (concentrations of inhibitor at which 50% of activity remains) was car...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysosomal alpha-mannosidase(Homo sapiens (Human))
Ecole Polytechnique FéDéRale De Lausanne

Curated by ChEMBL
LigandPNGBDBM50168995((-)-swainsonine | (1S,2R,8R,8aR)-Octahydro-indoliz...)
Affinity DataIC50:  50nMAssay Description:Inhibition of alpha-mannosidase in human LN18 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-mannosidase 2(Drosophila melanogaster (Fruit fly))
University of Toronto

LigandPNGBDBM84872(Swainsonine derivative, 7)
Affinity DataIC50:  250nMpH: 5.75 T: 2°CAssay Description:Inhibition of dGMII was measured at pH 5.75. Determination of the IC50 values (concentrations of inhibitor at which 50% of activity remains) was car...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-mannosidase 2(Drosophila melanogaster (Fruit fly))
University of Toronto

LigandPNGBDBM84870(Swainsonine derivative, 5)
Affinity DataIC50:  250nMpH: 5.75 T: 2°CAssay Description:Inhibition of dGMII was measured at pH 5.75. Determination of the IC50 values (concentrations of inhibitor at which 50% of activity remains) was car...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysosomal alpha-mannosidase(Homo sapiens (Human))
Ecole Polytechnique FéDéRale De Lausanne

Curated by ChEMBL
LigandPNGBDBM50263049((3R,4R,5R)-3,4-dihydroxy-5-(((R)-2-hydroxy-1-pheny...)
Affinity DataIC50:  500nMAssay Description:Inhibition of alpha-mannosidase in human HCECMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysosomal alpha-mannosidase(Homo sapiens (Human))
Ecole Polytechnique FéDéRale De Lausanne

Curated by ChEMBL
LigandPNGBDBM50263049((3R,4R,5R)-3,4-dihydroxy-5-(((R)-2-hydroxy-1-pheny...)
Affinity DataIC50:  500nMAssay Description:Inhibition of alpha-mannosidase in human LNZ308 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysosomal alpha-mannosidase(Homo sapiens (Human))
Ecole Polytechnique FéDéRale De Lausanne

Curated by ChEMBL
LigandPNGBDBM50263091((R)-2-(((2R,3R,4R)-3,4-dihydroxy-1-methyl-5-oxopyr...)
Affinity DataIC50:  750nMAssay Description:Inhibition of alpha-mannosidase in human HCECMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetB-cell lymphoma 6 protein [5-128](Homo sapiens (Human))
Ontario Institute for Cancer Research

LigandPNGBDBM648377(acsmedchemlett.2c00502 OICR 9483A, 30)
Affinity DataIC50:  980nMAssay Description:To identify small molecule BCL6 inhibitors, we developed a Fluorescence Polarization (FP) assay to assess the ability of ligands to compete with a fl...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetB-cell lymphoma 6 protein [5-128](Homo sapiens (Human))
Ontario Institute for Cancer Research

LigandPNGBDBM648376(acsmedchemlett.2c00502 OICR 10525D, 29)
Affinity DataIC50:  980nMAssay Description:To identify small molecule BCL6 inhibitors, we developed a Fluorescence Polarization (FP) assay to assess the ability of ligands to compete with a fl...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetB-cell lymphoma 6 protein [5-128](Homo sapiens (Human))
Ontario Institute for Cancer Research

LigandPNGBDBM648372(acsmedchemlett.2c00502 OICR 9451A, 25)
Affinity DataIC50:  1.00E+3nMAssay Description:To identify small molecule BCL6 inhibitors, we developed a Fluorescence Polarization (FP) assay to assess the ability of ligands to compete with a fl...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetB-cell lymphoma 6 protein [5-128](Homo sapiens (Human))
Ontario Institute for Cancer Research

LigandPNGBDBM648373(acsmedchemlett.2c00502 OICR 9453A, 26)
Affinity DataIC50:  1.10E+3nMAssay Description:To identify small molecule BCL6 inhibitors, we developed a Fluorescence Polarization (FP) assay to assess the ability of ligands to compete with a fl...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetB-cell lymphoma 6 protein [5-128](Homo sapiens (Human))
Ontario Institute for Cancer Research

LigandPNGBDBM648371(acsmedchemlett.2c00502 OICR 9320D, 24)
Affinity DataIC50:  1.10E+3nMAssay Description:To identify small molecule BCL6 inhibitors, we developed a Fluorescence Polarization (FP) assay to assess the ability of ligands to compete with a fl...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails PubMed
TargetB-cell lymphoma 6 protein [5-128](Homo sapiens (Human))
Ontario Institute for Cancer Research

LigandPNGBDBM648374(acsmedchemlett.2c00502 OICR 9452A, 27)
Affinity DataIC50:  1.50E+3nMAssay Description:To identify small molecule BCL6 inhibitors, we developed a Fluorescence Polarization (FP) assay to assess the ability of ligands to compete with a fl...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetLysosomal alpha-mannosidase(Homo sapiens (Human))
Ecole Polytechnique FéDéRale De Lausanne

Curated by ChEMBL
LigandPNGBDBM50263049((3R,4R,5R)-3,4-dihydroxy-5-(((R)-2-hydroxy-1-pheny...)
Affinity DataIC50:  2.00E+3nMAssay Description:Inhibition of alpha-mannosidase in human LN18 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetB-cell lymphoma 6 protein [5-128](Homo sapiens (Human))
Ontario Institute for Cancer Research

LigandPNGBDBM648375(acsmedchemlett.2c00502 Compound 28)
Affinity DataIC50:  3.20E+3nMAssay Description:To identify small molecule BCL6 inhibitors, we developed a Fluorescence Polarization (FP) assay to assess the ability of ligands to compete with a fl...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetLysosomal alpha-mannosidase(Homo sapiens (Human))
Ecole Polytechnique FéDéRale De Lausanne

Curated by ChEMBL
LigandPNGBDBM50263091((R)-2-(((2R,3R,4R)-3,4-dihydroxy-1-methyl-5-oxopyr...)
Affinity DataIC50:  7.50E+3nMAssay Description:Inhibition of alpha-mannosidase in human LNZ308 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetB-cell lymphoma 6 protein [5-128](Homo sapiens (Human))
Ontario Institute for Cancer Research

LigandPNGBDBM648369(acsmedchemlett.2c00502 OICR 9058A, 22)
Affinity DataIC50:  1.20E+4nMAssay Description:To identify small molecule BCL6 inhibitors, we developed a Fluorescence Polarization (FP) assay to assess the ability of ligands to compete with a fl...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetB-cell lymphoma 6 protein [5-128](Homo sapiens (Human))
Ontario Institute for Cancer Research

LigandPNGBDBM648368(acsmedchemlett.2c00502 OICR 7859A, 21)
Affinity DataIC50:  1.60E+4nMAssay Description:To identify small molecule BCL6 inhibitors, we developed a Fluorescence Polarization (FP) assay to assess the ability of ligands to compete with a fl...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails PubMed
TargetB-cell lymphoma 6 protein [5-128](Homo sapiens (Human))
Ontario Institute for Cancer Research

LigandPNGBDBM648364(acsmedchemlett.2c00502 OICR 7629A, 17)
Affinity DataIC50:  2.00E+4nMAssay Description:To identify small molecule BCL6 inhibitors, we developed a Fluorescence Polarization (FP) assay to assess the ability of ligands to compete with a fl...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails PubMed
TargetLysosomal alpha-mannosidase(Homo sapiens (Human))
Ecole Polytechnique FéDéRale De Lausanne

Curated by ChEMBL
LigandPNGBDBM50168995((-)-swainsonine | (1S,2R,8R,8aR)-Octahydro-indoliz...)
Affinity DataIC50:  2.00E+4nMAssay Description:Inhibition of alpha-mannosidase in human LNZ308 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetB-cell lymphoma 6 protein [5-128](Homo sapiens (Human))
Ontario Institute for Cancer Research

LigandPNGBDBM648370(acsmedchemlett.2c00502 OICR 9398A, 23)
Affinity DataIC50:  2.30E+4nMAssay Description:To identify small molecule BCL6 inhibitors, we developed a Fluorescence Polarization (FP) assay to assess the ability of ligands to compete with a fl...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetLysosomal alpha-mannosidase(Homo sapiens (Human))
Ecole Polytechnique FéDéRale De Lausanne

Curated by ChEMBL
LigandPNGBDBM50168988((2R,3R,4S)-2-({[(1R)-2-HYDROXY-1-PHENYLETHYL]AMINO...)
Affinity DataIC50:  2.50E+4nMAssay Description:Inhibition of alpha-mannosidase in human HCECMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysosomal alpha-mannosidase(Homo sapiens (Human))
Ecole Polytechnique FéDéRale De Lausanne

Curated by ChEMBL
LigandPNGBDBM50168988((2R,3R,4S)-2-({[(1R)-2-HYDROXY-1-PHENYLETHYL]AMINO...)
Affinity DataIC50:  5.00E+4nMAssay Description:Inhibition of alpha-mannosidase in human LN18 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysosomal alpha-mannosidase(Homo sapiens (Human))
Ecole Polytechnique FéDéRale De Lausanne

Curated by ChEMBL
LigandPNGBDBM50263048((3R,4R,5R)-3,4-dihydroxy-5-(((R)-2-hydroxy-1-pheny...)
Affinity DataIC50:  5.00E+4nMAssay Description:Inhibition of alpha-mannosidase in human LNZ308 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysosomal alpha-mannosidase(Homo sapiens (Human))
Ecole Polytechnique FéDéRale De Lausanne

Curated by ChEMBL
LigandPNGBDBM50168988((2R,3R,4S)-2-({[(1R)-2-HYDROXY-1-PHENYLETHYL]AMINO...)
Affinity DataIC50:  5.00E+4nMAssay Description:Inhibition of alpha-mannosidase in human LNZ308 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysosomal alpha-mannosidase(Homo sapiens (Human))
Ecole Polytechnique FéDéRale De Lausanne

Curated by ChEMBL
LigandPNGBDBM50263047((R)-2-(((2R,3R,4S)-3,4-dihydroxypyrrolidin-2-yl)me...)
Affinity DataIC50:  7.50E+4nMAssay Description:Inhibition of alpha-mannosidase in human LNZ308 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysosomal alpha-mannosidase(Homo sapiens (Human))
Ecole Polytechnique FéDéRale De Lausanne

Curated by ChEMBL
LigandPNGBDBM50263091((R)-2-(((2R,3R,4R)-3,4-dihydroxy-1-methyl-5-oxopyr...)
Affinity DataIC50:  7.50E+4nMAssay Description:Inhibition of alpha-mannosidase in human LN18 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysosomal alpha-mannosidase(Homo sapiens (Human))
Ecole Polytechnique FéDéRale De Lausanne

Curated by ChEMBL
LigandPNGBDBM50263047((R)-2-(((2R,3R,4S)-3,4-dihydroxypyrrolidin-2-yl)me...)
Affinity DataIC50:  7.50E+4nMAssay Description:Inhibition of alpha-mannosidase in human HCECMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysosomal alpha-mannosidase(Homo sapiens (Human))
Ecole Polytechnique FéDéRale De Lausanne

Curated by ChEMBL
LigandPNGBDBM50263048((3R,4R,5R)-3,4-dihydroxy-5-(((R)-2-hydroxy-1-pheny...)
Affinity DataIC50:  7.50E+4nMAssay Description:Inhibition of alpha-mannosidase in human HCECMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysosomal alpha-mannosidase(Homo sapiens (Human))
Ecole Polytechnique FéDéRale De Lausanne

Curated by ChEMBL
LigandPNGBDBM50263050((R)-2-(((2R,3R,4R)-3,4-dihydroxy-5-oxopyrrolidin-2...)
Affinity DataIC50:  7.50E+4nMAssay Description:Inhibition of alpha-mannosidase in human HCECMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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