TargetNAD-dependent protein deacetylase sirtuin-2(Homo sapiens (Human))
Kyoto Prefectural University Of Medicine
Curated by ChEMBL
Kyoto Prefectural University Of Medicine
Curated by ChEMBL
Affinity DataKi: 68nMAssay Description:Inhibition of human N-terminal His-tagged SIRT2 expressed in Escherichia coli using p53 (Gln-Pro-Lys-Lys(Ac)) (317 to 320 residues) as substrate incu...More data for this Ligand-Target Pair
TargetNAD-dependent protein deacetylase sirtuin-2(Homo sapiens (Human))
Kyoto Prefectural University Of Medicine
Curated by ChEMBL
Kyoto Prefectural University Of Medicine
Curated by ChEMBL
Affinity DataKi: 470nMAssay Description:Inhibition of human N-terminal His-tagged SIRT2 expressed in Escherichia coli using p53 (Gln-Pro-Lys-Lys(Ac)) (317 to 320 residues) as substrate incu...More data for this Ligand-Target Pair
TargetLysine-specific demethylase 6B(Homo sapiens (Human))
Kyoto Prefectural University Of Medicine
Curated by ChEMBL
Kyoto Prefectural University Of Medicine
Curated by ChEMBL
Affinity DataIC50: 16nMAssay Description:Inhibition of C-terminal FLAG-tagged human KDM6B expressed in expressed in Sf9 cells pre-incubated for 4 hrs before substrate addition and measured a...More data for this Ligand-Target Pair
TargetHematopoietic prostaglandin D synthase(Homo sapiens (Human))
National Institute Of Health Sciences
Curated by ChEMBL
National Institute Of Health Sciences
Curated by ChEMBL
Affinity DataIC50: 78nMAssay Description:Binding affinity to recombinant human H-PGDS incubated for 1 hrs by competitive fluorescence polarization assayMore data for this Ligand-Target Pair
TargetLysine-specific demethylase 5A(Homo sapiens (Human))
Kyoto Prefectural University Of Medicine
Curated by ChEMBL
Kyoto Prefectural University Of Medicine
Curated by ChEMBL
Affinity DataIC50: 79nMAssay Description:Inhibition of C-terminal FLAG-tagged human KDM5A expressed in Sf9 cells pre-incubated for 4 hrs before substrate addition and measured after 1 hr by ...More data for this Ligand-Target Pair
TargetHematopoietic prostaglandin D synthase(Homo sapiens (Human))
National Institute Of Health Sciences
Curated by ChEMBL
National Institute Of Health Sciences
Curated by ChEMBL
Affinity DataIC50: 117nMAssay Description:Binding affinity to recombinant human H-PGDS incubated for 1 hrs by competitive fluorescence polarization assayMore data for this Ligand-Target Pair
TargetHematopoietic prostaglandin D synthase(Homo sapiens (Human))
National Institute Of Health Sciences
Curated by ChEMBL
National Institute Of Health Sciences
Curated by ChEMBL
Affinity DataIC50: 124nMAssay Description:Binding affinity to recombinant human H-PGDS incubated for 1 hrs by competitive fluorescence polarization assayMore data for this Ligand-Target Pair
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
Kyoto Prefectural University Of Medicine
Curated by ChEMBL
Kyoto Prefectural University Of Medicine
Curated by ChEMBL
Affinity DataIC50: 126nMAssay Description:Inhibition of LSD1 (unknown origin) using H3K4me2 peptide as substrate preincubated for 15 mins followed by substrate addition and measured after 30 ...More data for this Ligand-Target Pair
TargetHematopoietic prostaglandin D synthase(Homo sapiens (Human))
National Institute Of Health Sciences
Curated by ChEMBL
National Institute Of Health Sciences
Curated by ChEMBL
Affinity DataIC50: 134nMAssay Description:Binding affinity to recombinant human H-PGDS incubated for 1 hrs by competitive fluorescence polarization assayMore data for this Ligand-Target Pair
TargetHematopoietic prostaglandin D synthase(Homo sapiens (Human))
National Institute Of Health Sciences
Curated by ChEMBL
National Institute Of Health Sciences
Curated by ChEMBL
Affinity DataIC50: 196nMAssay Description:Binding affinity to recombinant human H-PGDS incubated for 1 hrs by competitive fluorescence polarization assayMore data for this Ligand-Target Pair
TargetHematopoietic prostaglandin D synthase(Homo sapiens (Human))
National Institute Of Health Sciences
Curated by ChEMBL
National Institute Of Health Sciences
Curated by ChEMBL
Affinity DataIC50: 211nMAssay Description:Binding affinity to recombinant human H-PGDS incubated for 1 hrs by competitive fluorescence polarization assayMore data for this Ligand-Target Pair
TargetNAD-dependent protein deacetylase sirtuin-2(Homo sapiens (Human))
Kyoto Prefectural University Of Medicine
Curated by ChEMBL
Kyoto Prefectural University Of Medicine
Curated by ChEMBL
Affinity DataIC50: 300nMAssay Description:Inhibition of human N-terminal His-tagged SIRT2 expressed in Escherichia coli using p53 (Gln-Pro-Lys-Lys(Ac)) (317 to 320 residues) as substrate incu...More data for this Ligand-Target Pair
TargetNAD-dependent protein deacetylase sirtuin-2(Homo sapiens (Human))
Kyoto Prefectural University Of Medicine
Curated by ChEMBL
Kyoto Prefectural University Of Medicine
Curated by ChEMBL
Affinity DataIC50: 310nMAssay Description:Inhibition of human N-terminal His-tagged SIRT2 expressed in Escherichia coli using p53 (Gln-Pro-Lys-Lys(Ac)) (317 to 320 residues) as substrate incu...More data for this Ligand-Target Pair
TargetNAD-dependent protein deacetylase sirtuin-2(Homo sapiens (Human))
Kyoto Prefectural University Of Medicine
Curated by ChEMBL
Kyoto Prefectural University Of Medicine
Curated by ChEMBL
Affinity DataIC50: 370nMAssay Description:Inhibition of human N-terminal His-tagged SIRT2 expressed in Escherichia coli using p53 (Gln-Pro-Lys-Lys(Ac)) (317 to 320 residues) as substrate incu...More data for this Ligand-Target Pair
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
Kyoto Prefectural University Of Medicine
Curated by ChEMBL
Kyoto Prefectural University Of Medicine
Curated by ChEMBL
Affinity DataIC50: 444nMAssay Description:Inhibition of LSD1 (unknown origin) using H3K4me2 peptide as substrate preincubated for 15 mins followed by substrate addition and measured after 30 ...More data for this Ligand-Target Pair
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
Kyoto Prefectural University Of Medicine
Curated by ChEMBL
Kyoto Prefectural University Of Medicine
Curated by ChEMBL
Affinity DataIC50: 457nMAssay Description:Inhibition of LSD1 (unknown origin) using H3K4me2 peptide as substrate preincubated for 15 mins followed by substrate addition and measured after 30 ...More data for this Ligand-Target Pair
TargetNAD-dependent protein deacetylase sirtuin-2(Homo sapiens (Human))
Kyoto Prefectural University Of Medicine
Curated by ChEMBL
Kyoto Prefectural University Of Medicine
Curated by ChEMBL
Affinity DataIC50: 600nMAssay Description:Inhibition of human N-terminal His-tagged SIRT2 expressed in Escherichia coli using p53 (Gln-Pro-Lys-Lys(Ac)) (317 to 320 residues) as substrate incu...More data for this Ligand-Target Pair
TargetNAD-dependent protein deacetylase sirtuin-2(Homo sapiens (Human))
Kyoto Prefectural University Of Medicine
Curated by ChEMBL
Kyoto Prefectural University Of Medicine
Curated by ChEMBL
Affinity DataIC50: 1.18E+3nMAssay Description:Inhibition of human N-terminal His-tagged SIRT2 expressed in Escherichia coli using p53 (Gln-Pro-Lys-Lys(Ac)) (317 to 320 residues) as substrate incu...More data for this Ligand-Target Pair
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
Kyoto Prefectural University Of Medicine
Curated by ChEMBL
Kyoto Prefectural University Of Medicine
Curated by ChEMBL
Affinity DataIC50: 1.29E+3nMAssay Description:Inhibition of LSD1 (unknown origin) using H3K4me2 peptide as substrate preincubated for 15 mins followed by substrate addition and measured after 30 ...More data for this Ligand-Target Pair
TargetNAD-dependent protein deacetylase sirtuin-2(Homo sapiens (Human))
Kyoto Prefectural University Of Medicine
Curated by ChEMBL
Kyoto Prefectural University Of Medicine
Curated by ChEMBL
Affinity DataIC50: 1.74E+3nMAssay Description:Inhibition of human N-terminal His-tagged SIRT2 expressed in Escherichia coli using p53 (Gln-Pro-Lys-Lys(Ac)) (317 to 320 residues) as substrate incu...More data for this Ligand-Target Pair
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
Kyoto Prefectural University Of Medicine
Curated by ChEMBL
Kyoto Prefectural University Of Medicine
Curated by ChEMBL
Affinity DataIC50: 2.48E+4nMAssay Description:Inhibition of LSD1 (unknown origin) using H3K4me2 peptide as substrate preincubated for 15 mins followed by substrate addition and measured after 30 ...More data for this Ligand-Target Pair
TargetLysine-specific demethylase 5A(Homo sapiens (Human))
Kyoto Prefectural University Of Medicine
Curated by ChEMBL
Kyoto Prefectural University Of Medicine
Curated by ChEMBL
Affinity DataIC50: 4.60E+4nMAssay Description:Inhibition of C-terminal FLAG-tagged human KDM5A expressed in Sf9 cells pre-incubated for 4 hrs before substrate addition and measured after 1 hr by ...More data for this Ligand-Target Pair
TargetLysine-specific demethylase 5A(Homo sapiens (Human))
Kyoto Prefectural University Of Medicine
Curated by ChEMBL
Kyoto Prefectural University Of Medicine
Curated by ChEMBL
Affinity DataIC50: 4.80E+4nMAssay Description:Inhibition of C-terminal FLAG-tagged human KDM5A expressed in Sf9 cells pre-incubated for 4 hrs before substrate addition and measured after 1 hr by ...More data for this Ligand-Target Pair
TargetNAD-dependent protein deacetylase sirtuin-3, mitochondrial(Homo sapiens (Human))
Kyoto Prefectural University Of Medicine
Curated by ChEMBL
Kyoto Prefectural University Of Medicine
Curated by ChEMBL
Affinity DataIC50: 6.92E+4nMAssay Description:Inhibition of human N-terminal His-tagged SIRT3 (102 to 399 residues) expressed in Escherichia coli using p53 (Gln-Pro-Lys-Lys(Ac)) (317 to 320 resid...More data for this Ligand-Target Pair
TargetNAD-dependent protein deacetylase sirtuin-1(Homo sapiens (Human))
Kyoto Prefectural University Of Medicine
Curated by ChEMBL
Kyoto Prefectural University Of Medicine
Curated by ChEMBL
Affinity DataIC50: 7.74E+4nMAssay Description:Inhibition of human N-terminal His-tagged SIRT1 expressed in Escherichia coli using p53 (Arg-His-Lys-Lys(Ac)) (379 to 382 residues) as substrate incu...More data for this Ligand-Target Pair
TargetLysine-specific demethylase 4A(Homo sapiens (Human))
Kyoto Prefectural University Of Medicine
Curated by ChEMBL
Kyoto Prefectural University Of Medicine
Curated by ChEMBL
Affinity DataIC50: 8.50E+4nMAssay Description:Inhibition of C-terminal FLAG-tagged human KDM4A expressed in Escherichia coli pre-incubated for 4 hrs before substrate addition and measured after 1...More data for this Ligand-Target Pair
TargetProgesterone receptor(Homo sapiens (Human))
National Institute Of Health Sciences
Curated by ChEMBL
National Institute Of Health Sciences
Curated by ChEMBL
Affinity DataEC50: 0.180nMAssay Description:Agonist activity at PR in human T47D cells using p-nitrophenyl phosphate as substrate assessed as induction of alkaline phosphatase activity incubate...More data for this Ligand-Target Pair
TargetProgesterone receptor(Homo sapiens (Human))
National Institute Of Health Sciences
Curated by ChEMBL
National Institute Of Health Sciences
Curated by ChEMBL
Affinity DataEC50: >125nMAssay Description:Agonist activity at PR in human T47D cells using p-nitrophenyl phosphate as substrate assessed as induction of alkaline phosphatase activity incubate...More data for this Ligand-Target Pair
TargetProgesterone receptor(Homo sapiens (Human))
National Institute Of Health Sciences
Curated by ChEMBL
National Institute Of Health Sciences
Curated by ChEMBL
Affinity DataEC50: 4.5nMAssay Description:Agonist activity at PR in human T47D cells using p-nitrophenyl phosphate as substrate assessed as induction of alkaline phosphatase activity incubate...More data for this Ligand-Target Pair