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Found 29 with Last Name = 'kurohara' and Initial = 't'
TargetNAD-dependent protein deacetylase sirtuin-2(Homo sapiens (Human))
Kyoto Prefectural University Of Medicine

Curated by ChEMBL
LigandPNGBDBM50513317(CHEMBL4465620)
Affinity DataKi:  68nMAssay Description:Inhibition of human N-terminal His-tagged SIRT2 expressed in Escherichia coli using p53 (Gln-Pro-Lys-Lys(Ac)) (317 to 320 residues) as substrate incu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNAD-dependent protein deacetylase sirtuin-2(Homo sapiens (Human))
Kyoto Prefectural University Of Medicine

Curated by ChEMBL
LigandPNGBDBM50513318(CHEMBL4516553)
Affinity DataKi:  470nMAssay Description:Inhibition of human N-terminal His-tagged SIRT2 expressed in Escherichia coli using p53 (Gln-Pro-Lys-Lys(Ac)) (317 to 320 residues) as substrate incu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetLysine-specific demethylase 6B(Homo sapiens (Human))
Kyoto Prefectural University Of Medicine

Curated by ChEMBL
LigandPNGBDBM60875(3-((6-(4,5-Dihydro-1H-benzo[d]azepin-3(2H)-yl)-2-(...)
Affinity DataIC50:  16nMAssay Description:Inhibition of C-terminal FLAG-tagged human KDM6B expressed in expressed in Sf9 cells pre-incubated for 4 hrs before substrate addition and measured a...More data for this Ligand-Target Pair
TargetHematopoietic prostaglandin D synthase(Homo sapiens (Human))
National Institute Of Health Sciences

Curated by ChEMBL
LigandPNGBDBM50591607(CHEMBL5193611)
Affinity DataIC50:  78nMAssay Description:Binding affinity to recombinant human H-PGDS incubated for 1 hrs by competitive fluorescence polarization assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetLysine-specific demethylase 5A(Homo sapiens (Human))
Kyoto Prefectural University Of Medicine

Curated by ChEMBL
LigandPNGBDBM50095446(CHEMBL3590426)
Affinity DataIC50:  79nMAssay Description:Inhibition of C-terminal FLAG-tagged human KDM5A expressed in Sf9 cells pre-incubated for 4 hrs before substrate addition and measured after 1 hr by ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHematopoietic prostaglandin D synthase(Homo sapiens (Human))
National Institute Of Health Sciences

Curated by ChEMBL
LigandPNGBDBM50587270(CHEMBL5076100)
Affinity DataIC50:  117nMAssay Description:Binding affinity to recombinant human H-PGDS incubated for 1 hrs by competitive fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetHematopoietic prostaglandin D synthase(Homo sapiens (Human))
National Institute Of Health Sciences

Curated by ChEMBL
LigandPNGBDBM50591608(CHEMBL5207946)
Affinity DataIC50:  124nMAssay Description:Binding affinity to recombinant human H-PGDS incubated for 1 hrs by competitive fluorescence polarization assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
Kyoto Prefectural University Of Medicine

Curated by ChEMBL
LigandPNGBDBM50595758(CHEMBL5207682)
Affinity DataIC50:  126nMAssay Description:Inhibition of LSD1 (unknown origin) using H3K4me2 peptide as substrate preincubated for 15 mins followed by substrate addition and measured after 30 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetHematopoietic prostaglandin D synthase(Homo sapiens (Human))
National Institute Of Health Sciences

Curated by ChEMBL
LigandPNGBDBM136516(US8865714, 3)
Affinity DataIC50:  134nMAssay Description:Binding affinity to recombinant human H-PGDS incubated for 1 hrs by competitive fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetHematopoietic prostaglandin D synthase(Homo sapiens (Human))
National Institute Of Health Sciences

Curated by ChEMBL
LigandPNGBDBM50591606(CHEMBL5200341)
Affinity DataIC50:  196nMAssay Description:Binding affinity to recombinant human H-PGDS incubated for 1 hrs by competitive fluorescence polarization assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetHematopoietic prostaglandin D synthase(Homo sapiens (Human))
National Institute Of Health Sciences

Curated by ChEMBL
LigandPNGBDBM50463722(CHEMBL4238186)
Affinity DataIC50:  211nMAssay Description:Binding affinity to recombinant human H-PGDS incubated for 1 hrs by competitive fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetNAD-dependent protein deacetylase sirtuin-2(Homo sapiens (Human))
Kyoto Prefectural University Of Medicine

Curated by ChEMBL
LigandPNGBDBM50148781(CHEMBL3770903)
Affinity DataIC50:  300nMAssay Description:Inhibition of human N-terminal His-tagged SIRT2 expressed in Escherichia coli using p53 (Gln-Pro-Lys-Lys(Ac)) (317 to 320 residues) as substrate incu...More data for this Ligand-Target Pair
TargetNAD-dependent protein deacetylase sirtuin-2(Homo sapiens (Human))
Kyoto Prefectural University Of Medicine

Curated by ChEMBL
LigandPNGBDBM50513317(CHEMBL4465620)
Affinity DataIC50:  310nMAssay Description:Inhibition of human N-terminal His-tagged SIRT2 expressed in Escherichia coli using p53 (Gln-Pro-Lys-Lys(Ac)) (317 to 320 residues) as substrate incu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNAD-dependent protein deacetylase sirtuin-2(Homo sapiens (Human))
Kyoto Prefectural University Of Medicine

Curated by ChEMBL
LigandPNGBDBM50513320(CHEMBL4471909)
Affinity DataIC50:  370nMAssay Description:Inhibition of human N-terminal His-tagged SIRT2 expressed in Escherichia coli using p53 (Gln-Pro-Lys-Lys(Ac)) (317 to 320 residues) as substrate incu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
Kyoto Prefectural University Of Medicine

Curated by ChEMBL
LigandPNGBDBM50595759(CHEMBL5175995)
Affinity DataIC50:  444nMAssay Description:Inhibition of LSD1 (unknown origin) using H3K4me2 peptide as substrate preincubated for 15 mins followed by substrate addition and measured after 30 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
Kyoto Prefectural University Of Medicine

Curated by ChEMBL
LigandPNGBDBM50595760(CHEMBL5177373)
Affinity DataIC50:  457nMAssay Description:Inhibition of LSD1 (unknown origin) using H3K4me2 peptide as substrate preincubated for 15 mins followed by substrate addition and measured after 30 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetNAD-dependent protein deacetylase sirtuin-2(Homo sapiens (Human))
Kyoto Prefectural University Of Medicine

Curated by ChEMBL
LigandPNGBDBM50513318(CHEMBL4516553)
Affinity DataIC50:  600nMAssay Description:Inhibition of human N-terminal His-tagged SIRT2 expressed in Escherichia coli using p53 (Gln-Pro-Lys-Lys(Ac)) (317 to 320 residues) as substrate incu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNAD-dependent protein deacetylase sirtuin-2(Homo sapiens (Human))
Kyoto Prefectural University Of Medicine

Curated by ChEMBL
LigandPNGBDBM50513319(CHEMBL4589851)
Affinity DataIC50:  1.18E+3nMAssay Description:Inhibition of human N-terminal His-tagged SIRT2 expressed in Escherichia coli using p53 (Gln-Pro-Lys-Lys(Ac)) (317 to 320 residues) as substrate incu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
Kyoto Prefectural University Of Medicine

Curated by ChEMBL
LigandPNGBDBM50595757(CHEMBL5174314)
Affinity DataIC50:  1.29E+3nMAssay Description:Inhibition of LSD1 (unknown origin) using H3K4me2 peptide as substrate preincubated for 15 mins followed by substrate addition and measured after 30 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetNAD-dependent protein deacetylase sirtuin-2(Homo sapiens (Human))
Kyoto Prefectural University Of Medicine

Curated by ChEMBL
LigandPNGBDBM50392111(CHEMBL2152613)
Affinity DataIC50:  1.74E+3nMAssay Description:Inhibition of human N-terminal His-tagged SIRT2 expressed in Escherichia coli using p53 (Gln-Pro-Lys-Lys(Ac)) (317 to 320 residues) as substrate incu...More data for this Ligand-Target Pair
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
Kyoto Prefectural University Of Medicine

Curated by ChEMBL
LigandPNGBDBM50113851((+/-)-Tranylcypromine | 2-PCPA | 2-Phenyl-cyclopro...)
Affinity DataIC50:  2.48E+4nMAssay Description:Inhibition of LSD1 (unknown origin) using H3K4me2 peptide as substrate preincubated for 15 mins followed by substrate addition and measured after 30 ...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetLysine-specific demethylase 5A(Homo sapiens (Human))
Kyoto Prefectural University Of Medicine

Curated by ChEMBL
LigandPNGBDBM50523909(CHEMBL4456295)
Affinity DataIC50:  4.60E+4nMAssay Description:Inhibition of C-terminal FLAG-tagged human KDM5A expressed in Sf9 cells pre-incubated for 4 hrs before substrate addition and measured after 1 hr by ...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails ArticlePubMed
TargetLysine-specific demethylase 5A(Homo sapiens (Human))
Kyoto Prefectural University Of Medicine

Curated by ChEMBL
LigandPNGBDBM50523910(CHEMBL4451372)
Affinity DataIC50:  4.80E+4nMAssay Description:Inhibition of C-terminal FLAG-tagged human KDM5A expressed in Sf9 cells pre-incubated for 4 hrs before substrate addition and measured after 1 hr by ...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails ArticlePubMed
TargetNAD-dependent protein deacetylase sirtuin-3, mitochondrial(Homo sapiens (Human))
Kyoto Prefectural University Of Medicine

Curated by ChEMBL
LigandPNGBDBM50513317(CHEMBL4465620)
Affinity DataIC50:  6.92E+4nMAssay Description:Inhibition of human N-terminal His-tagged SIRT3 (102 to 399 residues) expressed in Escherichia coli using p53 (Gln-Pro-Lys-Lys(Ac)) (317 to 320 resid...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNAD-dependent protein deacetylase sirtuin-1(Homo sapiens (Human))
Kyoto Prefectural University Of Medicine

Curated by ChEMBL
LigandPNGBDBM50513317(CHEMBL4465620)
Affinity DataIC50:  7.74E+4nMAssay Description:Inhibition of human N-terminal His-tagged SIRT1 expressed in Escherichia coli using p53 (Arg-His-Lys-Lys(Ac)) (379 to 382 residues) as substrate incu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetLysine-specific demethylase 4A(Homo sapiens (Human))
Kyoto Prefectural University Of Medicine

Curated by ChEMBL
LigandPNGBDBM26106(CHEMBL90852 | N-oxalyl glycine, 1a | NOG | Oxalylg...)
Affinity DataIC50:  8.50E+4nMAssay Description:Inhibition of C-terminal FLAG-tagged human KDM4A expressed in Escherichia coli pre-incubated for 4 hrs before substrate addition and measured after 1...More data for this Ligand-Target Pair
TargetProgesterone receptor(Homo sapiens (Human))
National Institute Of Health Sciences

Curated by ChEMBL
LigandPNGBDBM8903((1S,2R,10S,11S,14S,15S)-14-acetyl-2,15-dimethyltet...)
Affinity DataEC50:  0.180nMAssay Description:Agonist activity at PR in human T47D cells using p-nitrophenyl phosphate as substrate assessed as induction of alkaline phosphatase activity incubate...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetProgesterone receptor(Homo sapiens (Human))
National Institute Of Health Sciences

Curated by ChEMBL
LigandPNGBDBM50587264(CHEMBL5077912)
Affinity DataEC50: >125nMAssay Description:Agonist activity at PR in human T47D cells using p-nitrophenyl phosphate as substrate assessed as induction of alkaline phosphatase activity incubate...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProgesterone receptor(Homo sapiens (Human))
National Institute Of Health Sciences

Curated by ChEMBL
LigandPNGBDBM50587263(NORGESTOMET | Norgestomet | SC-21009)
Affinity DataEC50:  4.5nMAssay Description:Agonist activity at PR in human T47D cells using p-nitrophenyl phosphate as substrate assessed as induction of alkaline phosphatase activity incubate...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed