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Found 154 with Last Name = 'lastant' and Initial = 'j'
TargetFibroblast growth factor receptor 2(Homo sapiens (Human))
Principia Biopharma

Curated by ChEMBL
LigandPNGBDBM286984(8-(3-(4-acryloylpiperazin-1-yl)propyl)-6-(2,6-dich...)
Affinity DataKi:  1.30nMAssay Description:Irreversible inhibition of human FGFR2 preincubated with enzyme followed by peptide substrate addition by caliper capillary electrophoresis methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFibroblast growth factor receptor 1(Homo sapiens (Human))
Principia Biopharma

Curated by ChEMBL
LigandPNGBDBM286984(8-(3-(4-acryloylpiperazin-1-yl)propyl)-6-(2,6-dich...)
Affinity DataKi:  1.60nMAssay Description:Irreversible inhibition of human FGFR1 using 5-FAM-KKKKEEIYFFF-NH2 as substrate preincubated with enzyme followed by peptide substrate addition by ca...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFibroblast growth factor receptor 3(Homo sapiens (Human))
Principia Biopharma

Curated by ChEMBL
LigandPNGBDBM286984(8-(3-(4-acryloylpiperazin-1-yl)propyl)-6-(2,6-dich...)
Affinity DataKi:  2.20nMAssay Description:Irreversible inhibition of human FGFR3 preincubated with enzyme followed by peptide substrate addition by caliper capillary electrophoresis methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFibroblast growth factor receptor 4(Homo sapiens (Human))
Principia Biopharma

Curated by ChEMBL
LigandPNGBDBM286984(8-(3-(4-acryloylpiperazin-1-yl)propyl)-6-(2,6-dich...)
Affinity DataKi:  73nMAssay Description:Irreversible inhibition of human FGFR4 preincubated with enzyme followed by peptide substrate addition by caliper capillary electrophoresis methodMore data for this Ligand-Target Pair
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Principia Biopharma, A Sanofi

Curated by ChEMBL
LigandPNGBDBM50589205(CHEMBL5174021)
Affinity DataIC50:  0nMAssay Description:Inhibition of BTK (unknown origin) using peptide substrate in presence of ATP by caliper electrophoresis methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Principia Biopharma, A Sanofi

Curated by ChEMBL
LigandPNGBDBM50589186(CHEMBL5189379)
Affinity DataIC50:  0.300nMAssay Description:Inhibition of BTK (unknown origin) using peptide substrate in presence of ATP by caliper electrophoresis methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetFibroblast growth factor receptor 1(Homo sapiens (Human))
Principia Biopharma

Curated by ChEMBL
LigandPNGBDBM287008(8-(2-((1-acryloylazetidin-3-yl)oxy)ethyl)-6-(2,6-d...)
Affinity DataIC50:  0.400nMAssay Description:In vitro antagonist activity against rat prostatic androgen receptor (AR)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Principia Biopharma, A Sanofi

Curated by ChEMBL
LigandPNGBDBM50589207(CHEMBL5169419)
Affinity DataIC50:  0.400nMAssay Description:Inhibition of BTK (unknown origin) using peptide substrate in presence of ATP by caliper electrophoresis methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetTyrosine-protein kinase Tec(Homo sapiens (Human))
Principia Biopharma, A Sanofi

Curated by ChEMBL
LigandPNGBDBM50589186(CHEMBL5189379)
Affinity DataIC50:  0.5nMAssay Description:Inhibition of TEC (unknown origin) using peptide substrate in presence of ATP by caliper electrophoresis methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetTyrosine-protein kinase Blk(Homo sapiens (Human))
Principia Biopharma, A Sanofi

Curated by ChEMBL
LigandPNGBDBM50589186(CHEMBL5189379)
Affinity DataIC50:  0.5nMAssay Description:Inhibition of BLK (unknown origin) using peptide substrate in presence of ATP by caliper electrophoresis methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Principia Biopharma, A Sanofi

Curated by ChEMBL
LigandPNGBDBM50589202(CHEMBL5191633)
Affinity DataIC50:  0.600nMAssay Description:Inhibition of biotinylated-labeled BTK-selective probe binding to BTK in human Ramos assessed as target occupancy pretreated for 1 hr followed by pro...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetFibroblast growth factor receptor 1(Homo sapiens (Human))
Principia Biopharma

Curated by ChEMBL
LigandPNGBDBM286984(8-(3-(4-acryloylpiperazin-1-yl)propyl)-6-(2,6-dich...)
Affinity DataIC50:  0.600nMAssay Description:Inhibition of human FGFR1 using 5-FAM-KKKKEEIYFFF-NH2 as substrate preincubated for 15 mins followed by peptide substrate addition measured after 3 h...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFibroblast growth factor receptor 1(Homo sapiens (Human))
Principia Biopharma

Curated by ChEMBL
LigandPNGBDBM286984(8-(3-(4-acryloylpiperazin-1-yl)propyl)-6-(2,6-dich...)
Affinity DataIC50:  0.600nMAssay Description:Inhibition of FGFR1 in HUVEC assessed as reduction in FGF2-induced ERK phosphorylation preincubated for 60 mins followed by FGF2 stimulation for 10 m...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytoplasmic tyrosine-protein kinase BMX(Homo sapiens (Human))
Principia Biopharma, A Sanofi

Curated by ChEMBL
LigandPNGBDBM50589186(CHEMBL5189379)
Affinity DataIC50:  0.600nMAssay Description:Inhibition of BMX (unknown origin) using peptide substrate in presence of ATP by caliper electrophoresis methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetFibroblast growth factor receptor 1(Homo sapiens (Human))
Principia Biopharma

Curated by ChEMBL
LigandPNGBDBM286381(8-(2-((1-acryloylpiperidin-3-yl)oxy)ethyl)-6-(2,6-...)
Affinity DataIC50:  0.700nMAssay Description:Inhibition of FGFR1 in HUVEC assessed as reduction in FGF2-induced ERK phosphorylation preincubated for 60 mins followed by FGF2 stimulation for 10 m...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetFibroblast growth factor receptor 1(Homo sapiens (Human))
Principia Biopharma

Curated by ChEMBL
LigandPNGBDBM50238813(CHEMBL4083740)
Affinity DataIC50:  0.700nMAssay Description:In vitro antagonist activity against rat prostatic androgen receptor (AR)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFibroblast growth factor receptor 1(Homo sapiens (Human))
Principia Biopharma

Curated by ChEMBL
LigandPNGBDBM50238823(CHEMBL4086567)
Affinity DataIC50:  0.800nMAssay Description:Inhibition of human FGFR1 using 5-FAM-KKKKEEIYFFF-NH2 as substrate preincubated for 15 mins followed by peptide substrate addition measured after 3 h...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Tec(Homo sapiens (Human))
Principia Biopharma, A Sanofi

Curated by ChEMBL
LigandPNGBDBM50557485(Prn-1008 | Prn1008 | Rilzabrutinib)
Affinity DataIC50:  0.800nMAssay Description:Inhibition of TEC (unknown origin) using peptide substrate in presence of ATPMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetFibroblast growth factor receptor 1(Homo sapiens (Human))
Principia Biopharma

Curated by ChEMBL
LigandPNGBDBM50238811(CHEMBL4073347)
Affinity DataIC50:  0.800nMAssay Description:Inhibition of FGFR1 in HUVEC assessed as reduction in FGF2-induced ERK phosphorylation preincubated for 60 mins followed by FGF2 stimulation for 10 m...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Principia Biopharma, A Sanofi

Curated by ChEMBL
LigandPNGBDBM50589212(CHEMBL5195816)
Affinity DataIC50:  0.800nMAssay Description:Inhibition of BTK (unknown origin) using peptide substrate in presence of ATP by caliper electrophoresis methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Principia Biopharma, A Sanofi

Curated by ChEMBL
LigandPNGBDBM50589187(CHEMBL5178314)
Affinity DataIC50:  0.900nMAssay Description:Inhibition of BTK (unknown origin) using peptide substrate in presence of ATP by caliper electrophoresis methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetCytoplasmic tyrosine-protein kinase BMX(Homo sapiens (Human))
Principia Biopharma, A Sanofi

Curated by ChEMBL
LigandPNGBDBM50557485(Prn-1008 | Prn1008 | Rilzabrutinib)
Affinity DataIC50:  1nMAssay Description:Inhibition of BMX (unknown origin) using peptide substrate in presence of ATPMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Principia Biopharma, A Sanofi

Curated by ChEMBL
LigandPNGBDBM50589213(CHEMBL3702850)
Affinity DataIC50:  1nMAssay Description:Inhibition of BTK (unknown origin) using peptide substrate in presence of ATP by caliper electrophoresis methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetFibroblast growth factor receptor 1(Homo sapiens (Human))
Principia Biopharma

Curated by ChEMBL
LigandPNGBDBM287067(8-(2-((1-acryloylazetidin-3-yl)(methyl)amino)ethyl...)
Affinity DataIC50:  1nMAssay Description:Inhibition of FGFR1 in HUVEC assessed as reduction in FGF2-induced ERK phosphorylation preincubated for 60 mins followed by FGF2 stimulation for 10 m...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetFibroblast growth factor receptor 1(Homo sapiens (Human))
Principia Biopharma

Curated by ChEMBL
LigandPNGBDBM50238809(CHEMBL4084708)
Affinity DataIC50:  1.10nMAssay Description:Inhibition of human FGFR1 using 5-FAM-KKKKEEIYFFF-NH2 as substrate preincubated for 15 mins followed by peptide substrate addition measured after 3 h...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Principia Biopharma, A Sanofi

Curated by ChEMBL
LigandPNGBDBM50589200(CHEMBL5207901)
Affinity DataIC50:  1.10nMAssay Description:Inhibition of BTK (unknown origin) using peptide substrate in presence of ATP by caliper electrophoresis methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetTyrosine-protein kinase TXK(Homo sapiens (Human))
Principia Biopharma, A Sanofi

Curated by ChEMBL
LigandPNGBDBM50557485(Prn-1008 | Prn1008 | Rilzabrutinib)
Affinity DataIC50:  1.20nMAssay Description:Inhibition of RLK (unknown origin) using peptide substrate in presence of ATPMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetFibroblast growth factor receptor 1(Homo sapiens (Human))
Principia Biopharma

Curated by ChEMBL
LigandPNGBDBM287008(8-(2-((1-acryloylazetidin-3-yl)oxy)ethyl)-6-(2,6-d...)
Affinity DataIC50:  1.20nMAssay Description:Inhibition of FGFR1 in HUVEC assessed as reduction in FGF2-induced ERK phosphorylation preincubated for 60 mins followed by FGF2 stimulation for 10 m...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase TXK(Homo sapiens (Human))
Principia Biopharma, A Sanofi

Curated by ChEMBL
LigandPNGBDBM50589186(CHEMBL5189379)
Affinity DataIC50:  1.20nMAssay Description:Inhibition of RLK (unknown origin) using peptide substrate in presence of ATP by caliper electrophoresis methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Principia Biopharma, A Sanofi

Curated by ChEMBL
LigandPNGBDBM50589208(CHEMBL3702851)
Affinity DataIC50:  1.20nMAssay Description:Inhibition of BTK (unknown origin) using peptide substrate in presence of ATP by caliper electrophoresis methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetFibroblast growth factor receptor 1(Homo sapiens (Human))
Principia Biopharma

Curated by ChEMBL
LigandPNGBDBM50238805(CHEMBL4061286)
Affinity DataIC50:  1.30nMAssay Description:Inhibition of FGFR1 in HUVEC assessed as reduction in FGF2-induced ERK phosphorylation preincubated for 60 mins followed by FGF2 stimulation for 10 m...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Principia Biopharma, A Sanofi

Curated by ChEMBL
LigandPNGBDBM50557485(Prn-1008 | Prn1008 | Rilzabrutinib)
Affinity DataIC50:  1.30nMAssay Description:Inhibition of BTK (unknown origin) using peptide substrate in presence of ATPMore data for this Ligand-Target Pair
TargetFibroblast growth factor receptor 1(Homo sapiens (Human))
Principia Biopharma

Curated by ChEMBL
LigandPNGBDBM50238804(CHEMBL4099578)
Affinity DataIC50:  1.30nMAssay Description:Inhibition of FGFR1 in HUVEC assessed as reduction in FGF2-induced ERK phosphorylation preincubated for 60 mins followed by FGF2 stimulation for 10 m...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFibroblast growth factor receptor 1(Homo sapiens (Human))
Principia Biopharma

Curated by ChEMBL
LigandPNGBDBM287067(8-(2-((1-acryloylazetidin-3-yl)(methyl)amino)ethyl...)
Affinity DataIC50:  1.30nMAssay Description:Inhibition of FGFR1 in HUVEC assessed as reduction in FGF2-induced ERK phosphorylation preincubated for 60 mins followed by FGF2 stimulation for 10 m...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetFibroblast growth factor receptor 1(Homo sapiens (Human))
Principia Biopharma

Curated by ChEMBL
LigandPNGBDBM50238805(CHEMBL4061286)
Affinity DataIC50:  1.30nMAssay Description:In vitro antagonist activity against rat prostatic androgen receptor (AR)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFibroblast growth factor receptor 1(Homo sapiens (Human))
Principia Biopharma

Curated by ChEMBL
LigandPNGBDBM50238806(CHEMBL4083151)
Affinity DataIC50:  1.30nMAssay Description:Inhibition of human FGFR1 using 5-FAM-KKKKEEIYFFF-NH2 as substrate preincubated for 15 mins followed by peptide substrate addition measured after 3 h...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Principia Biopharma, A Sanofi

Curated by ChEMBL
LigandPNGBDBM50589209(CHEMBL3702858)
Affinity DataIC50:  1.30nMAssay Description:Inhibition of BTK (unknown origin) using peptide substrate in presence of ATP by caliper electrophoresis methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Principia Biopharma, A Sanofi

Curated by ChEMBL
LigandPNGBDBM50557485(Prn-1008 | Prn1008 | Rilzabrutinib)
Affinity DataIC50:  1.30nMAssay Description:Inhibition of BTK (unknown origin) using peptide substrate in presence of ATP by caliper electrophoresis methodMore data for this Ligand-Target Pair
TargetFibroblast growth factor receptor 2(Homo sapiens (Human))
Principia Biopharma

Curated by ChEMBL
LigandPNGBDBM286984(8-(3-(4-acryloylpiperazin-1-yl)propyl)-6-(2,6-dich...)
Affinity DataIC50:  1.30nMAssay Description:Inhibition of human FGFR2 preincubated for 15 mins followed by peptide substrate addition measured after 3 hrs by caliper capillary electrophoresis m...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFibroblast growth factor receptor 1(Homo sapiens (Human))
Principia Biopharma

Curated by ChEMBL
LigandPNGBDBM50238818(CHEMBL4064081)
Affinity DataIC50:  1.40nMAssay Description:Inhibition of human FGFR1 using 5-FAM-KKKKEEIYFFF-NH2 as substrate preincubated for 15 mins followed by peptide substrate addition measured after 3 h...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFibroblast growth factor receptor 1(Homo sapiens (Human))
Principia Biopharma

Curated by ChEMBL
LigandPNGBDBM50238818(CHEMBL4064081)
Affinity DataIC50:  1.40nMAssay Description:Inhibition of FGFR1 in HUVEC assessed as reduction in FGF2-induced ERK phosphorylation preincubated for 60 mins followed by FGF2 stimulation for 10 m...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFibroblast growth factor receptor 1(Homo sapiens (Human))
Principia Biopharma

Curated by ChEMBL
LigandPNGBDBM50238824(CHEMBL4064756)
Affinity DataIC50:  1.5nMAssay Description:Inhibition of human FGFR1 using 5-FAM-KKKKEEIYFFF-NH2 as substrate preincubated for 15 mins followed by peptide substrate addition measured after 3 h...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFibroblast growth factor receptor 1(Homo sapiens (Human))
Principia Biopharma

Curated by ChEMBL
LigandPNGBDBM50238803(CHEMBL4066763)
Affinity DataIC50:  1.60nMAssay Description:Inhibition of FGFR1 in HUVEC assessed as reduction in FGF2-induced ERK phosphorylation preincubated for 60 mins followed by FGF2 stimulation for 10 m...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFibroblast growth factor receptor 1(Homo sapiens (Human))
Principia Biopharma

Curated by ChEMBL
LigandPNGBDBM50238803(CHEMBL4066763)
Affinity DataIC50:  1.70nMAssay Description:Inhibition of FGFR1 in HUVEC assessed as reduction in FGF2-induced ERK phosphorylation preincubated for 60 mins followed by FGF2 stimulation for 10 m...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFibroblast growth factor receptor 1(Homo sapiens (Human))
Principia Biopharma

Curated by ChEMBL
LigandPNGBDBM286523(8-(2-((1-acryloylpyrrolidin-3-yl)oxy)ethyl)-6-(2,6...)
Affinity DataIC50:  1.80nMAssay Description:Inhibition of FGFR1 in HUVEC assessed as reduction in FGF2-induced ERK phosphorylation preincubated for 60 mins followed by FGF2 stimulation for 10 m...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Principia Biopharma, A Sanofi

Curated by ChEMBL
LigandPNGBDBM50589191(CHEMBL4114766)
Affinity DataIC50:  1.80nMAssay Description:Inhibition of BTK (unknown origin) using peptide substrate in presence of ATP by caliper electrophoresis methodMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetCytoplasmic tyrosine-protein kinase BMX(Homo sapiens (Human))
Principia Biopharma, A Sanofi

Curated by ChEMBL
LigandPNGBDBM50589191(CHEMBL4114766)
Affinity DataIC50:  1.80nMAssay Description:Inhibition of BMX (unknown origin) using peptide substrate in presence of ATP by caliper electrophoresis methodMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetTyrosine-protein kinase Tec(Homo sapiens (Human))
Principia Biopharma, A Sanofi

Curated by ChEMBL
LigandPNGBDBM50589191(CHEMBL4114766)
Affinity DataIC50:  1.90nMAssay Description:Inhibition of TEC (unknown origin) using peptide substrate in presence of ATP by caliper electrophoresis methodMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Principia Biopharma, A Sanofi

Curated by ChEMBL
LigandPNGBDBM50589211(CHEMBL3702855)
Affinity DataIC50:  1.90nMAssay Description:Inhibition of BTK (unknown origin) using peptide substrate in presence of ATP by caliper electrophoresis methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Principia Biopharma, A Sanofi

Curated by ChEMBL
LigandPNGBDBM50589201(CHEMBL5170583)
Affinity DataIC50:  1.90nMAssay Description:Inhibition of BTK (unknown origin) using peptide substrate in presence of ATP by caliper electrophoresis methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
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