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Found 44 with Last Name = 'laing' and Initial = 'sm'
TargetPotassium-transporting ATPase alpha chain 1(Sus scrofa (Pig))
Smith Kline & French Research

Curated by ChEMBL
LigandPNGBDBM50001247(8-Methoxy-4-o-tolylamino-quinoline-3-carboxylic ac...)
Affinity DataKi:  290nMAssay Description:Binding affinity of compound towards H+/K+ ATPase for activation was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium-transporting ATPase alpha chain 1(Sus scrofa (Pig))
Smith Kline & French Research

Curated by ChEMBL
LigandPNGBDBM50013228(6-Methoxy-4-methyl-1-o-tolyl-2,3-dihydro-1H-pyrrol...)
Affinity DataKi:  290nMAssay Description:In vitro inhibition of H+/K+ ATPase activity was determined in gastric vesicles of pig using ATPase assay with pH 7More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium-transporting ATPase alpha chain 1/subunit beta(Rattus norvegicus)
Smithkline Beecham Pharmaceuticals R&D

Curated by ChEMBL
LigandPNGBDBM50000672(6-Methoxy-4-methyl-1-o-tolyl-1H-pyrrolo[3,2-c]quin...)
Affinity DataIC50:  64nMAssay Description:Inhibition of rat isolated gastric(H+/K+)-ATPase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium-transporting ATPase alpha chain 1(Sus scrofa (Pig))
Smith Kline & French Research

Curated by ChEMBL
LigandPNGBDBM50008977((8-Benzyloxy-2-methyl-imidazo[1,2-a]pyridin-3-yl)-...)
Affinity DataIC50:  101nMAssay Description:In vitro inhibition of H+/K+ ATPase activity was determined in gastric vesicles of pig using ATPase assay with pH 7More data for this Ligand-Target Pair
TargetPotassium-transporting ATPase alpha chain 1/subunit beta(Rattus norvegicus)
Smithkline Beecham Pharmaceuticals R&D

Curated by ChEMBL
LigandPNGBDBM50000668(2-(6-Methyl-1-o-tolyl-1H-pyrrolo[3,2-c]quinolin-4-...)
Affinity DataIC50:  170nMAssay Description:Inhibition of rat isolated gastric(H+/K+)-ATPase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium-transporting ATPase alpha chain 1(Sus scrofa (Pig))
Smith Kline & French Research

Curated by ChEMBL
LigandPNGBDBM50013237(3-Methyl-4-(4-methyl-2,3-dihydro-pyrrolo[3,2-c]qui...)
Affinity DataIC50:  170nMAssay Description:In vitro inhibition of H+/K+ ATPase activity was determined in gastric vesicles of pig using ATPase assay with pH 7More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium-transporting ATPase alpha chain 1/subunit beta(Rattus norvegicus)
Smithkline Beecham Pharmaceuticals R&D

Curated by ChEMBL
LigandPNGBDBM50000675(CHEMBL54511 | Methyl-(6-methyl-1-o-tolyl-2,3-dihyd...)
Affinity DataIC50:  180nMAssay Description:Inhibition of rat isolated gastric(H+/K+)-ATPase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium-transporting ATPase alpha chain 1/subunit beta(Rattus norvegicus)
Smithkline Beecham Pharmaceuticals R&D

Curated by ChEMBL
LigandPNGBDBM50000673(6-Methyl-1-o-tolyl-2,3-dihydro-1H-pyrrolo[3,2-c]qu...)
Affinity DataIC50:  220nMAssay Description:Inhibition of rat isolated gastric(H+/K+)-ATPase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium-transporting ATPase alpha chain 1/subunit beta(Rattus norvegicus)
Smithkline Beecham Pharmaceuticals R&D

Curated by ChEMBL
LigandPNGBDBM50000677(4-(6-Methyl-1-o-tolyl-1H-pyrrolo[3,2-c]quinolin-4-...)
Affinity DataIC50:  220nMAssay Description:Inhibition of rat isolated gastric(H+/K+)-ATPase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium-transporting ATPase alpha chain 1/subunit beta(Rattus norvegicus)
Smithkline Beecham Pharmaceuticals R&D

Curated by ChEMBL
LigandPNGBDBM50000684((6-Methoxy-1-o-tolyl-2,3-dihydro-1H-pyrrolo[3,2-c]...)
Affinity DataIC50:  250nMAssay Description:Inhibition of rat isolated gastric(H+/K+)-ATPase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium-transporting ATPase alpha chain 1/subunit beta(Rattus norvegicus)
Smithkline Beecham Pharmaceuticals R&D

Curated by ChEMBL
LigandPNGBDBM50000666(2-(6-Methoxy-1-o-tolyl-2,3-dihydro-1H-pyrrolo[3,2-...)
Affinity DataIC50:  280nMAssay Description:Inhibition of rat isolated gastric(H+/K+)-ATPase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium-transporting ATPase alpha chain 1/subunit beta(Rattus norvegicus)
Smithkline Beecham Pharmaceuticals R&D

Curated by ChEMBL
LigandPNGBDBM50000682(CHEMBL292179 | [1-(4-Methoxy-2-methyl-phenyl)-6-me...)
Affinity DataIC50:  280nMAssay Description:Inhibition of rat isolated gastric(H+/K+)-ATPase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium-transporting ATPase alpha chain 1/subunit beta(Rattus norvegicus)
Smithkline Beecham Pharmaceuticals R&D

Curated by ChEMBL
LigandPNGBDBM50000680(CHEMBL52811 | Methyl-(6-methyl-1-o-tolyl-1H-pyrrol...)
Affinity DataIC50:  290nMAssay Description:Inhibition of rat isolated gastric(H+/K+)-ATPase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium-transporting ATPase alpha chain 1/subunit beta(Rattus norvegicus)
Smithkline Beecham Pharmaceuticals R&D

Curated by ChEMBL
LigandPNGBDBM50000667(3-(6-Methyl-1-o-tolyl-1H-pyrrolo[3,2-c]quinolin-4-...)
Affinity DataIC50:  410nMAssay Description:Inhibition of rat isolated gastric(H+/K+)-ATPase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium-transporting ATPase alpha chain 1(Sus scrofa (Pig))
Smith Kline & French Research

Curated by ChEMBL
LigandPNGBDBM50013243(4-Methyl-1-o-tolyl-2,3-dihydro-1H-pyrrolo[3,2-c]qu...)
Affinity DataIC50:  410nMAssay Description:In vitro inhibition of H+/K+ ATPase activity was determined in gastric vesicles of pig using ATPase assay with pH 7More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium-transporting ATPase alpha chain 1(Sus scrofa (Pig))
Smith Kline & French Research

Curated by ChEMBL
LigandPNGBDBM50013240(4,6-Dimethyl-1-o-tolyl-2,3-dihydro-1H-pyrrolo[3,2-...)
Affinity DataIC50:  420nMAssay Description:In vitro inhibition of H+/K+ ATPase activity was determined in gastric vesicles of pig using ATPase assay with pH 7More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium-transporting ATPase alpha chain 1/subunit beta(Rattus norvegicus)
Smithkline Beecham Pharmaceuticals R&D

Curated by ChEMBL
LigandPNGBDBM50000679(6-Methoxy-1-(2-methoxy-phenyl)-2,3-dihydro-1H-pyrr...)
Affinity DataIC50:  440nMAssay Description:Inhibition of rat isolated gastric(H+/K+)-ATPase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium-transporting ATPase alpha chain 1(Sus scrofa (Pig))
Smith Kline & French Research

Curated by ChEMBL
LigandPNGBDBM50013236(1-(4-Methoxy-2-methyl-phenyl)-4-methyl-2,3-dihydro...)
Affinity DataIC50:  530nMAssay Description:In vitro inhibition of H+/K+ ATPase activity was determined in gastric vesicles of pig using ATPase assay with pH 7More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium-transporting ATPase alpha chain 1(Sus scrofa (Pig))
Smith Kline & French Research

Curated by ChEMBL
LigandPNGBDBM50000672(6-Methoxy-4-methyl-1-o-tolyl-1H-pyrrolo[3,2-c]quin...)
Affinity DataIC50:  640nMAssay Description:In vitro inhibition of H+/K+ ATPase activity was determined in gastric vesicles of pig using ATPase assay with pH 7More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium-transporting ATPase alpha chain 1(Sus scrofa (Pig))
Smith Kline & French Research

Curated by ChEMBL
LigandPNGBDBM50013228(6-Methoxy-4-methyl-1-o-tolyl-2,3-dihydro-1H-pyrrol...)
Affinity DataIC50:  660nMAssay Description:In vitro inhibition of H+/K+ ATPase activity was determined in gastric vesicles of pig using ATPase assay with pH 7More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium-transporting ATPase alpha chain 1(Sus scrofa (Pig))
Smith Kline & French Research

Curated by ChEMBL
LigandPNGBDBM50013231(6-Fluoro-4-methyl-1-o-tolyl-2,3-dihydro-1H-pyrrolo...)
Affinity DataIC50:  750nMAssay Description:In vitro inhibition of H+/K+ ATPase activity was determined in gastric vesicles of pig using ATPase assay with pH 7More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium-transporting ATPase alpha chain 1/subunit beta(Rattus norvegicus)
Smithkline Beecham Pharmaceuticals R&D

Curated by ChEMBL
LigandPNGBDBM50000670(8-Methoxy-4-o-tolylamino-quinoline-2-carboxylic ac...)
Affinity DataIC50:  850nMAssay Description:Inhibition of rat isolated gastric(H+/K+)-ATPase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium-transporting ATPase alpha chain 1(Sus scrofa (Pig))
Smith Kline & French Research

Curated by ChEMBL
LigandPNGBDBM50001247(8-Methoxy-4-o-tolylamino-quinoline-3-carboxylic ac...)
Affinity DataIC50:  850nMpH: 7.0Assay Description:Binding affinity of compound towards H+/K+ ATPase for activation was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium-transporting ATPase alpha chain 1/subunit beta(Rattus norvegicus)
Smithkline Beecham Pharmaceuticals R&D

Curated by ChEMBL
LigandPNGBDBM50000685(6-Methyl-1-o-tolyl-2,3-dihydro-1H-pyrrolo[3,2-c]qu...)
Affinity DataIC50:  980nMAssay Description:Inhibition of rat isolated gastric(H+/K+)-ATPase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium-transporting ATPase alpha chain 1(Sus scrofa (Pig))
Smith Kline & French Research

Curated by ChEMBL
LigandPNGBDBM50013230(6-Methoxy-1-(4-methoxy-2-methyl-phenyl)-4-methyl-2...)
Affinity DataIC50:  1.00E+3nMAssay Description:In vitro inhibition of H+/K+ ATPase activity was determined in gastric vesicles of pig using ATPase assay with pH 7More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium-transporting ATPase alpha chain 1/subunit beta(Rattus norvegicus)
Smithkline Beecham Pharmaceuticals R&D

Curated by ChEMBL
LigandPNGBDBM50000681(CHEMBL54813 | Dimethyl-(6-methyl-1-o-tolyl-2,3-dih...)
Affinity DataIC50:  1.03E+3nMAssay Description:Inhibition of rat isolated gastric(H+/K+)-ATPase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium-transporting ATPase alpha chain 1(Sus scrofa (Pig))
Smith Kline & French Research

Curated by ChEMBL
LigandPNGBDBM50013233(4-Methyl-1-o-tolyl-2,3-dihydro-1H-pyrrolo[3,2-c]qu...)
Affinity DataIC50:  1.10E+3nMAssay Description:In vitro inhibition of H+/K+ ATPase activity was determined in gastric vesicles of pig using ATPase assay with pH 7More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium-transporting ATPase alpha chain 1/subunit beta(Rattus norvegicus)
Smithkline Beecham Pharmaceuticals R&D

Curated by ChEMBL
LigandPNGBDBM50000686((8-Methyl-1-o-tolyl-2,3-dihydro-1H-pyrrolo[2,3-b]q...)
Affinity DataIC50:  1.10E+3nMAssay Description:Inhibition of rat isolated gastric(H+/K+)-ATPase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium-transporting ATPase alpha chain 1/subunit beta(Rattus norvegicus)
Smithkline Beecham Pharmaceuticals R&D

Curated by ChEMBL
LigandPNGBDBM50000671((1-o-Tolyl-2,3-dihydro-1H-pyrrolo[3,2-c]quinolin-4...)
Affinity DataIC50:  1.23E+3nMAssay Description:Inhibition of rat isolated gastric(H+/K+)-ATPase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium-transporting ATPase alpha chain 1/subunit beta(Rattus norvegicus)
Smithkline Beecham Pharmaceuticals R&D

Curated by ChEMBL
LigandPNGBDBM50000669(6-Methoxy-1-(2-methoxy-phenyl)-2,3-dihydro-1H-pyrr...)
Affinity DataIC50:  1.29E+3nMAssay Description:Inhibition of rat isolated gastric(H+/K+)-ATPase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium-transporting ATPase alpha chain 1(Sus scrofa (Pig))
Smith Kline & French Research

Curated by ChEMBL
LigandPNGBDBM50013229(6-Methoxy-4,5-dimethyl-1-o-tolyl-2,3-dihydro-1H-py...)
Affinity DataIC50:  1.30E+3nMAssay Description:In vitro inhibition of H+/K+ ATPase activity was determined in gastric vesicles of pig using ATPase assay with pH 7More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium-transporting ATPase alpha chain 1(Sus scrofa (Pig))
Smith Kline & French Research

Curated by ChEMBL
LigandPNGBDBM50013239(1-(2,6-Dimethyl-phenyl)-4-methyl-2,3-dihydro-1H-py...)
Affinity DataIC50:  1.50E+3nMAssay Description:In vitro inhibition of H+/K+ ATPase activity was determined in gastric vesicles of pig using ATPase assay with pH 7More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium-transporting ATPase alpha chain 1(Sus scrofa (Pig))
Smith Kline & French Research

Curated by ChEMBL
LigandPNGBDBM50013234(6-Methoxy-1-(2-methoxy-phenyl)-4-methyl-2,3-dihydr...)
Affinity DataIC50:  1.60E+3nMAssay Description:In vitro inhibition of H+/K+ ATPase activity was determined in gastric vesicles of pig using ATPase assay with pH 7More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium-transporting ATPase alpha chain 1(Sus scrofa (Pig))
Smith Kline & French Research

Curated by ChEMBL
LigandPNGBDBM50013226(6-Methoxy-4-methyl-1-phenyl-2,3-dihydro-1H-pyrrolo...)
Affinity DataIC50:  2.40E+3nMAssay Description:In vitro inhibition of H+/K+ ATPase activity was determined in gastric vesicles of pig using ATPase assay with pH 7More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium-transporting ATPase alpha chain 1(Sus scrofa (Pig))
Smith Kline & French Research

Curated by ChEMBL
LigandPNGBDBM50013242(4-Methyl-1-o-tolyl-2,3-dihydro-1H-pyrrolo[3,2-c]qu...)
Affinity DataIC50:  2.90E+3nMAssay Description:In vitro inhibition of H+/K+ ATPase activity was determined in gastric vesicles of pig using ATPase assay with pH 7More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium-transporting ATPase alpha chain 1(Sus scrofa (Pig))
Smith Kline & French Research

Curated by ChEMBL
LigandPNGBDBM50013227(7-Methoxy-1-o-tolyl-1,2,3,4-tetrahydro-benzo[h][1,...)
Affinity DataIC50:  3.10E+3nMAssay Description:In vitro inhibition of H+/K+ ATPase activity was determined in gastric vesicles of pig using ATPase assay with pH 7More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium-transporting ATPase alpha chain 1/subunit beta(Rattus norvegicus)
Smithkline Beecham Pharmaceuticals R&D

Curated by ChEMBL
LigandPNGBDBM50000676(1-Methyl-3-(6-methyl-1-o-tolyl-2,3-dihydro-1H-pyrr...)
Affinity DataIC50:  4.97E+3nMAssay Description:Inhibition of rat isolated gastric(H+/K+)-ATPase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium-transporting ATPase alpha chain 1/subunit beta(Rattus norvegicus)
Smithkline Beecham Pharmaceuticals R&D

Curated by ChEMBL
LigandPNGBDBM50000678((6-Methyl-1-o-tolyl-2,3-dihydro-1H-pyrrolo[3,2-c]q...)
Affinity DataIC50:  4.97E+3nMAssay Description:Inhibition of rat isolated gastric(H+/K+)-ATPase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium-transporting ATPase alpha chain 1(Sus scrofa (Pig))
Smith Kline & French Research

Curated by ChEMBL
LigandPNGBDBM50013235(1-o-Tolyl-1H-imidazo[4,5-c]quinoline | CHEMBL35727...)
Affinity DataIC50:  9.80E+3nMAssay Description:In vitro inhibition of H+/K+ ATPase activity was determined in gastric vesicles of pig using ATPase assay with pH 7More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium-transporting ATPase alpha chain 1/subunit beta(Rattus norvegicus)
Smithkline Beecham Pharmaceuticals R&D

Curated by ChEMBL
LigandPNGBDBM50000674(4-Chloro-6-methoxy-1-(2-methoxy-phenyl)-2,3-dihydr...)
Affinity DataIC50:  1.07E+4nMAssay Description:The compound was evaluated for the inhibition of gastric H+/K+ ATPaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium-transporting ATPase alpha chain 1(Sus scrofa (Pig))
Smith Kline & French Research

Curated by ChEMBL
LigandPNGBDBM50013225(1-Benzyl-6-methoxy-4-methyl-2,3-dihydro-1H-pyrrolo...)
Affinity DataIC50:  1.10E+4nMAssay Description:In vitro inhibition of H+/K+ ATPase activity was determined in gastric vesicles of pig using ATPase assay with pH 7More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium-transporting ATPase alpha chain 1(Sus scrofa (Pig))
Smith Kline & French Research

Curated by ChEMBL
LigandPNGBDBM50013238(1-o-Tolyl-1,3-dihydro-imidazo[4,5-c]quinoline-2-th...)
Affinity DataIC50:  2.20E+4nMAssay Description:In vitro inhibition of H+/K+ ATPase activity was determined in gastric vesicles of pig using ATPase assay with pH 7More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium-transporting ATPase alpha chain 1/subunit beta(Rattus norvegicus)
Smithkline Beecham Pharmaceuticals R&D

Curated by ChEMBL
LigandPNGBDBM50000683(6-Methoxy-1-(2-methoxy-phenyl)-2,3-dihydro-1H-pyrr...)
Affinity DataIC50:  3.34E+4nMAssay Description:Inhibition of rat isolated gastric(H+/K+)-ATPase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium-transporting ATPase alpha chain 1(Sus scrofa (Pig))
Smith Kline & French Research

Curated by ChEMBL
LigandPNGBDBM50013241(1-o-Tolyl-1H-[1,2,3]triazolo[4,5-c]quinoline | CHE...)
Affinity DataIC50:  6.90E+4nMAssay Description:In vitro inhibition of H+/K+ ATPase activity was determined in gastric vesicles of pig using ATPase assay with pH 7More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed