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Target
Potassium-transporting ATPase alpha chain 1
Ligand
BDBM50001247
Substrate
n/a
Meas. Tech.
ChEMBL_76081 (CHEMBL879774)
Ki
290±n/a nM
Citation
 Brown, TH; Ife, RJ; Keeling, DJ; Laing, SM; Leach, CA; Parsons, ME; Price, CA; Reavill, DR; Wiggall, KJ Reversible inhibitors of the gastric (H+/K+)-ATPase. 1. 1-Aryl-4-methylpyrrolo[3,2-c]quinolines as conformationally restrained analogues of 4-(arylamino)quinolines. J Med Chem 33:527-33 (1990) [PubMed]  Article 
Target
Name:
Potassium-transporting ATPase alpha chain 1
Synonyms:
ATP4A | ATP4A_PIG | Gastric H(+)/K(+) ATPase subunit alpha | H+/K+-ATPase | Na/K-ATPase | Potassium-transporting ATPase | Potassium-transporting ATPase alpha chain 1 | Proton pump
Type:
Enzyme
Mol. Mass.:
114279.23
Organism:
Sus scrofa (Pig)
Description:
P19156
Residue:
1034
Sequence:
MGKAENYELYQVELGPGPSGDMAAKMSKKKAGRGGGKRKEKLENMKKEMEINDHQLSVAELEQKYQTSATKGLSASLAAELLLRDGPNALRPPRGTPEYVKFARQLAGGLQCLMWVAAAICLIAFAIQASEGDLTTDDNLYLALALIAVVVVTGCFGYYQEFKSTNIIASFKNLVPQQATVIRDGDKFQINADQLVVGDLVEMKGGDRVPADIRILQAQGRKVDNSSLTGESEPQTRSPECTHESPLETRNIAFFSTMCLEGTAQGLVVNTGDRTIIGRIASLASGVENEKTPIAIEIEHFVDIIAGLAILFGATFFIVAMCIGYTFLRAMVFFMAIVVAYVPEGLLATVTVCLSLTAKRLASKNCVVKNLEAVETLGSTSVICSDKTGTLTQNRMTVSHLWFDNHIHSADTTEDQSGQTFDQSSETWRALCRVLTLCNRAAFKSGQDAVPVPKRIVIGDASETALLKFSELTLGNAMGYRERFPKVCEIPFNSTNKFQLSIHTLEDPRDPRHVLVMKGAPERVLERCSSILIKGQELPLDEQWREAFQTAYLSLGGLGERVLGFCQLYLSEKDYPPGYAFDVEAMNFPTSGLSFAGLVSMIDPPRATVPDAVLKCRTAGIRVIMVTGDHPITAKAIAASVGIISEGSETVEDIAARLRVPVDQVNRKDARACVINGMQLKDMDPSELVEALRTHPEMVFARTSPQQKLVIVESCQRLGAIVAVTGDGVNDSPALKKADIGVAMGIAGSDAAKNAADMILLDDNFASIVTGVEQGRLIFDNLKKSIAYTLTKNIPELTPYLIYITVSVPLPLGCITILFIELCTDIFPSVSLAYEKAESDIMHLRPRNPKRDRLVNEPLAAYSYFQIGAIQSFAGFTDYFTAMAQEGWFPLLCVGLRPQWENHHLQDLQDSYGQEWTFGQRLYQQYTCYTVFFISIEMCQIADVLIRKTRRLSAFQQGFFRNRILVIAIVFQVCIGCFLCYCPGMPNIFNFMPIRFQWWLVPMPFGLLIFVYDEIRKLGVRCCPGSWWDQELYY
  
Inhibitor
Name:
BDBM50001247
Synonyms:
8-Methoxy-4-o-tolylamino-quinoline-3-carboxylic acid ethyl ester | 8-Methoxy-4-o-tolylamino-quinoline-3-carboxylic acid ethyl ester; hydrochloride(0.2H2O) | CHEMBL552895 | CHEMBL95108
Type:
Small organic molecule
Emp. Form.:
C20H20N2O3
Mol. Mass.:
336.3844
SMILES:
CCOC(=O)c1cnc2c(OC)cccc2c1Nc1ccccc1C
Structure:
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