Compile Data Set for Download or QSAR
maximum 50k data
Found 204 with Last Name = 'lampe' and Initial = 't'
TargetCoagulation factor X(Homo sapiens (Human))
Bayer Healthcare

LigandPNGBDBM7842(BAY 59-7939 Analog 17 | US8822458, 46)
Affinity DataIC50:  0.400nMpH: 8.3 T: 2°CAssay Description:The enzymatic activity was measured using chromogenic or fluorogenic substrates in 96-well microtiter plates.Color change was monitored continuously ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Bayer

Curated by ChEMBL
LigandPNGBDBM50111902(2-(2-ethoxy-5-(4-methylpiperazin-1-ylsulfonyl)phen...)
Affinity DataIC50:  0.600nMAssay Description:Inhibition of Phosphodiesterase 5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Bayer

Curated by ChEMBL
LigandPNGBDBM50111900(4-[4-Ethoxy-3-(5-methyl-4-oxo-7-propyl-3,4-dihydro...)
Affinity DataIC50:  0.700nMAssay Description:Inhibition of Phosphodiesterase 5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Bayer Healthcare

LigandPNGBDBM7840(RIVAROXABAN | US8822458, 44 | US8822458, 97)
Affinity DataIC50:  0.700nMpH: 8.3 T: 2°CAssay Description:The enzymatic activity was measured using chromogenic or fluorogenic substrates in 96-well microtiter plates.Color change was monitored continuously ...More data for this Ligand-Target Pair
TargetCoagulation factor X(Homo sapiens (Human))
Bayer Healthcare

LigandPNGBDBM130530(US8822458, 127)
Affinity DataIC50:  0.700nMT: 2°CAssay Description:The enzymatic activity of human factor Xa (FXa) was measured using the conversion of a chromogenic substrate specific for FXa. Factor Xa cleaves p-ni...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCoagulation factor X(Homo sapiens (Human))
Bayer Healthcare

LigandPNGBDBM12998(5-Chloro-N-({(5S)-2-oxo-3-[4-(3-oxomorpholin-4-yl)...)
Affinity DataIC50:  1nMpH: 8.3 T: 2°CAssay Description:The enzymatic activity was measured using chromogenic or fluorogenic substrates in 96-well microtiter plates.Color change was monitored continuously ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Bayer

Curated by ChEMBL
LigandPNGBDBM50169652(6-(2-Ethoxy-phenyl)-3-methyl-1-propyl-1,5-dihydro-...)
Affinity DataIC50:  1nMAssay Description:Inhibition of phosphodiesterase 5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Bayer Healthcare

LigandPNGBDBM130532(US8822458, 129)
Affinity DataIC50:  1nMT: 2°CAssay Description:The enzymatic activity of human factor Xa (FXa) was measured using the conversion of a chromogenic substrate specific for FXa. Factor Xa cleaves p-ni...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Bayer

Curated by ChEMBL
LigandPNGBDBM50169633(7-Cyclopentyl-2-[2-ethoxy-5-(4-methyl-piperazine-1...)
Affinity DataIC50:  1nMAssay Description:Inhibition of phosphodiesterase 5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Bayer

Curated by ChEMBL
LigandPNGBDBM50169627(7-Cyclopentyl-2-{2-ethoxy-5-[4-(2-hydroxy-ethyl)-p...)
Affinity DataIC50:  1nMAssay Description:Inhibition of phosphodiesterase 5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Bayer Healthcare

LigandPNGBDBM12997(5-Chloro-N-({(5S)-3-[3-fluoro-4-(3-oxomorpholin-4-...)
Affinity DataIC50:  1.40nMpH: 8.3 T: 2°CAssay Description:The enzymatic activity was measured using chromogenic or fluorogenic substrates in 96-well microtiter plates.Color change was monitored continuously ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Bayer Healthcare

LigandPNGBDBM7840(RIVAROXABAN | US8822458, 44 | US8822458, 97)
Affinity DataIC50:  1.40nMT: 2°CAssay Description:The enzymatic activity of human factor Xa (FXa) was measured using the conversion of a chromogenic substrate specific for FXa. Factor Xa cleaves p-ni...More data for this Ligand-Target Pair
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Bayer

Curated by ChEMBL
LigandPNGBDBM50111902(2-(2-ethoxy-5-(4-methylpiperazin-1-ylsulfonyl)phen...)
Affinity DataIC50:  2nMAssay Description:Inhibition of phosphodiesterase 5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Bayer Healthcare

LigandPNGBDBM130531(US8822458, 128)
Affinity DataIC50:  2nMT: 2°CAssay Description:The enzymatic activity of human factor Xa (FXa) was measured using the conversion of a chromogenic substrate specific for FXa. Factor Xa cleaves p-ni...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCoagulation factor X(Homo sapiens (Human))
Bayer Healthcare

LigandPNGBDBM12999(BAY 59-7939 Analog 14 | N-({(5S)-3-[3-Amino-4-(3-o...)
Affinity DataIC50:  2.5nMpH: 8.3 T: 2°CAssay Description:The enzymatic activity was measured using chromogenic or fluorogenic substrates in 96-well microtiter plates.Color change was monitored continuously ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Bayer Healthcare

LigandPNGBDBM8299(US8822458, 162)
Affinity DataIC50:  2.80nMT: 2°CAssay Description:The enzymatic activity of human factor Xa (FXa) was measured using the conversion of a chromogenic substrate specific for FXa. Factor Xa cleaves p-ni...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCoagulation factor X(Homo sapiens (Human))
Bayer Healthcare

LigandPNGBDBM130533(US8822458, 130)
Affinity DataIC50:  3.30nMT: 2°CAssay Description:The enzymatic activity of human factor Xa (FXa) was measured using the conversion of a chromogenic substrate specific for FXa. Factor Xa cleaves p-ni...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCoagulation factor X(Homo sapiens (Human))
Bayer Healthcare

LigandPNGBDBM130527(US8822458, 56)
Affinity DataIC50:  4nMT: 2°CAssay Description:The enzymatic activity of human factor Xa (FXa) was measured using the conversion of a chromogenic substrate specific for FXa. Factor Xa cleaves p-ni...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCoagulation factor X(Homo sapiens (Human))
Bayer Healthcare

LigandPNGBDBM7552(BAY 59-7939 Analog 11 | US8822458, 17)
Affinity DataIC50:  4nMT: 2°CAssay Description:The enzymatic activity of human factor Xa (FXa) was measured using the conversion of a chromogenic substrate specific for FXa. Factor Xa cleaves p-ni...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCoagulation factor X(Homo sapiens (Human))
Bayer Healthcare

LigandPNGBDBM7552(BAY 59-7939 Analog 11 | US8822458, 17)
Affinity DataIC50:  4nMpH: 8.3 T: 2°CAssay Description:The enzymatic activity was measured using chromogenic or fluorogenic substrates in 96-well microtiter plates.Color change was monitored continuously ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Bayer Healthcare

LigandPNGBDBM7841(BAY 59-7939 Analog 18 | US8822458, 45 | US9359341,...)
Affinity DataIC50:  4.20nMAssay Description:The enzymatic activity was measured using chromogenic or fluorogenic substrates in 96-well microtiter plates.Color change was monitored continuously ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Bayer Healthcare

LigandPNGBDBM7841(BAY 59-7939 Analog 18 | US8822458, 45 | US9359341,...)
Affinity DataIC50:  4.20nMT: 2°CAssay Description:The enzymatic activity of human factor Xa (FXa) was measured using the conversion of a chromogenic substrate specific for FXa. Factor Xa cleaves p-ni...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Bayer

Curated by ChEMBL
LigandPNGBDBM50111897(2-(2-Ethoxy-phenyl)-3,5-dimethyl-7-propyl-3H-imida...)
Affinity DataIC50:  5nMAssay Description:Inhibition of phosphodiesterase 5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Bayer

Curated by ChEMBL
LigandPNGBDBM50111897(2-(2-Ethoxy-phenyl)-3,5-dimethyl-7-propyl-3H-imida...)
Affinity DataIC50:  5nMAssay Description:Inhibition of Phosphodiesterase 5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Bayer

Curated by ChEMBL
LigandPNGBDBM50169641(2-{2-Ethoxy-5-[4-(2-hydroxy-ethyl)-piperazine-1-su...)
Affinity DataIC50:  5nMAssay Description:Inhibition of phosphodiesterase 5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Bayer

Curated by ChEMBL
LigandPNGBDBM50169635(7-Cyclopentyl-2-(2-ethoxy-phenyl)-5-methyl-3H-imid...)
Affinity DataIC50:  5nMAssay Description:Inhibition of phosphodiesterase 5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Bayer

Curated by ChEMBL
LigandPNGBDBM50169634(3-Cyclopentyl-5-{2-ethoxy-5-[4-(2-hydroxy-ethyl)-p...)
Affinity DataIC50:  5nMAssay Description:Inhibition of phosphodiesterase 5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Bayer

Curated by ChEMBL
LigandPNGBDBM14390(5-[2-ethoxy-5-(4-methyl-1-piperazinylsulfonyl)phen...)
Affinity DataIC50:  6.60nMAssay Description:Inhibition of phosphodiesterase 5More data for this Ligand-Target Pair
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Bayer

Curated by ChEMBL
LigandPNGBDBM14390(5-[2-ethoxy-5-(4-methyl-1-piperazinylsulfonyl)phen...)
Affinity DataIC50:  6.60nMAssay Description:Inhibition of Phosphodiesterase 5More data for this Ligand-Target Pair
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Bayer

Curated by ChEMBL
LigandPNGBDBM50169647(7-Cyclopentyl-2-[2-ethoxy-5-(4-methyl-piperazine-1...)
Affinity DataIC50:  7nMAssay Description:Inhibition of phosphodiesterase 5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Bayer

Curated by ChEMBL
LigandPNGBDBM50169639(2-[2-Ethoxy-5-(4-methyl-piperazine-1-sulfonyl)-phe...)
Affinity DataIC50:  8nMAssay Description:Inhibition of phosphodiesterase 5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Bayer

Curated by ChEMBL
LigandPNGBDBM50169630(6-[2-Ethoxy-5-(4-methyl-piperazine-1-sulfonyl)-phe...)
Affinity DataIC50:  8nMAssay Description:Inhibition of phosphodiesterase 5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Bayer Healthcare

LigandPNGBDBM13008(4-Amino-5-chloro-N-({(5S)-2-oxo-3-[4-(3-oxomorphol...)
Affinity DataIC50:  8.5nMAssay Description:The enzymatic activity was measured using chromogenic or fluorogenic substrates in 96-well microtiter plates.Color change was monitored continuously ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Bayer

Curated by ChEMBL
LigandPNGBDBM50111901(2-(5-(4-methylpiperazin-1-ylsulfonyl)-2-propoxyphe...)
Affinity DataIC50:  10nMAssay Description:Inhibition of Phosphodiesterase 5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Bayer

Curated by ChEMBL
LigandPNGBDBM50111898(2-(2-Propoxy-phenyl)-9-propyl-1,9-dihydro-purin-6-...)
Affinity DataIC50:  10nMAssay Description:Inhibition of Phosphodiesterase 5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Bayer

Curated by ChEMBL
LigandPNGBDBM50169643(8-Cyclopentyl-2-{2-ethoxy-5-[4-(2-hydroxy-ethyl)-p...)
Affinity DataIC50:  10nMAssay Description:Inhibition of phosphodiesterase 5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50024352(CHEMBL183857)
Affinity DataIC50:  10nMAssay Description:Inhibition of phosphodiesterase 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50169634(3-Cyclopentyl-5-{2-ethoxy-5-[4-(2-hydroxy-ethyl)-p...)
Affinity DataIC50:  10nMAssay Description:Inhibition of phosphodiesterase 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Bayer

Curated by ChEMBL
LigandPNGBDBM50169637(2-[2-Ethoxy-5-(4-methyl-piperazine-1-sulfonyl)-phe...)
Affinity DataIC50:  10nMAssay Description:Inhibition of phosphodiesterase 5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Bayer

Curated by ChEMBL
LigandPNGBDBM50169626(2-[2-Ethoxy-5-(4-methyl-piperazine-1-sulfonyl)-phe...)
Affinity DataIC50:  10nMAssay Description:Inhibition of phosphodiesterase 5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Bayer

Curated by ChEMBL
LigandPNGBDBM50169625(2-{2-Ethoxy-5-[4-(2-hydroxy-ethyl)-piperazine-1-su...)
Affinity DataIC50:  10nMAssay Description:Inhibition of phosphodiesterase 5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Bayer

Curated by ChEMBL
LigandPNGBDBM50169648(3-Cyclopentyl-5-{2-ethoxy-5-[4-(2-hydroxy-ethyl)-p...)
Affinity DataIC50:  10nMAssay Description:Inhibition of phosphodiesterase 5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50169627(7-Cyclopentyl-2-{2-ethoxy-5-[4-(2-hydroxy-ethyl)-p...)
Affinity DataIC50:  10nMAssay Description:Inhibition of phosphodiesterase 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50169633(7-Cyclopentyl-2-[2-ethoxy-5-(4-methyl-piperazine-1...)
Affinity DataIC50:  10nMAssay Description:Inhibition of phosphodiesterase 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Bayer Healthcare

LigandPNGBDBM130529(US8822458, 126)
Affinity DataIC50:  13nMT: 2°CAssay Description:The enzymatic activity of human factor Xa (FXa) was measured using the conversion of a chromogenic substrate specific for FXa. Factor Xa cleaves p-ni...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCoagulation factor X(Homo sapiens (Human))
Bayer Healthcare

LigandPNGBDBM7839(US8822458, 43)
Affinity DataIC50:  14nMT: 2°CAssay Description:The enzymatic activity of human factor Xa (FXa) was measured using the conversion of a chromogenic substrate specific for FXa. Factor Xa cleaves p-ni...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Bayer

Curated by ChEMBL
LigandPNGBDBM50169651(8-Cyclopentyl-2-(2-ethoxy-phenyl)-6-methyl-3H-imid...)
Affinity DataIC50:  20nMAssay Description:Inhibition of phosphodiesterase 5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Bayer

Curated by ChEMBL
LigandPNGBDBM50169646(6-[2-Ethoxy-5-(4-methyl-piperazine-1-sulfonyl)-phe...)
Affinity DataIC50:  20nMAssay Description:Inhibition of phosphodiesterase 5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Bayer Healthcare

LigandPNGBDBM13005(4-chloro-N-{[(5S)-2-oxo-3-[4-(3-oxomorpholin-4-yl)...)
Affinity DataIC50:  20nMAssay Description:The enzymatic activity was measured using chromogenic or fluorogenic substrates in 96-well microtiter plates.Color change was monitored continuously ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50169641(2-{2-Ethoxy-5-[4-(2-hydroxy-ethyl)-piperazine-1-su...)
Affinity DataIC50:  20nMAssay Description:Inhibition of phosphodiesterase 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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