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Found 28 with Last Name = 'landau' and Initial = 'sb'
TargetBromodomain-containing protein 4 [349-460](Homo sapiens (Human))
Tensha Therapeutics

US Patent
LigandPNGBDBM223491(US10407441, Compound JQ6 | US10925881, Name (S)-JQ...)
Affinity DataIC50:  0.240nMAssay Description:The binding activity of lead compounds with the BRD4 site 2 was determined by Alpha-assay with a 12-point dose response curveMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBromodomain-containing protein 4 [349-460](Homo sapiens (Human))
Tensha Therapeutics

US Patent
LigandPNGBDBM223492(US10407441, Compound JQ8 | US10925881, Name (S)-JQ...)
Affinity DataIC50:  0.427nMAssay Description:The binding activity of lead compounds with the BRD4 site 2 was determined by Alpha-assay with a 12-point dose response curveMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBromodomain-containing protein 4 [349-460](Homo sapiens (Human))
Tensha Therapeutics

US Patent
LigandPNGBDBM223493(US10407441, Compound JQ13 | US10925881, Name (S)-J...)
Affinity DataIC50:  0.584nMAssay Description:The binding activity of lead compounds with the BRD4 site 2 was determined by Alpha-assay with a 12-point dose response curveMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBromodomain-containing protein 4 [44-167](Homo sapiens (Human))
Tensha Therapeutics

US Patent
LigandPNGBDBM223492(US10407441, Compound JQ8 | US10925881, Name (S)-JQ...)
Affinity DataIC50:  2.19nMAssay Description:The binding activity of lead compounds with the BRD4 site 1 was determined by Alpha-assay with a 12-point dose response curveMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBromodomain-containing protein 4 [44-167](Homo sapiens (Human))
Tensha Therapeutics

US Patent
LigandPNGBDBM223493(US10407441, Compound JQ13 | US10925881, Name (S)-J...)
Affinity DataIC50:  2.49nMAssay Description:The binding activity of lead compounds with the BRD4 site 1 was determined by Alpha-assay with a 12-point dose response curveMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBromodomain-containing protein 4 [44-167](Homo sapiens (Human))
Tensha Therapeutics

US Patent
LigandPNGBDBM223491(US10407441, Compound JQ6 | US10925881, Name (S)-JQ...)
Affinity DataIC50:  3.48nMAssay Description:The binding activity of lead compounds with the BRD4 site 1 was determined by Alpha-assay with a 12-point dose response curveMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBromodomain-containing protein 4 [349-460](Homo sapiens (Human))
Tensha Therapeutics

US Patent
LigandPNGBDBM483491(US10925881, Name (S)-JQ35)
Affinity DataIC50:  6.13nMAssay Description:The binding activity of lead compounds with the BRD4 site 2 was determined by Alpha-assay with a 12-point dose response curveMore data for this Ligand-Target Pair
In DepthDetails US Patent
TargetBromodomain-containing protein 4 [349-460](Homo sapiens (Human))
Tensha Therapeutics

US Patent
LigandPNGBDBM50365262((+)-JQ1 | (S)-JQ1 (1) | CHEMBL1957266 | JQ1 | US10...)
Affinity DataIC50:  14nMAssay Description:The binding activity of lead compounds with the BRD4 site 2 was determined by Alpha-assay with a 12-point dose response curveMore data for this Ligand-Target Pair
In DepthDetails US Patent
TargetBromodomain-containing protein 4 [44-167](Homo sapiens (Human))
Tensha Therapeutics

US Patent
LigandPNGBDBM50365262((+)-JQ1 | (S)-JQ1 (1) | CHEMBL1957266 | JQ1 | US10...)
Affinity DataIC50:  18nMAssay Description:The binding activity of lead compounds with the BRD4 site 1 was determined by Alpha-assay with a 12-point dose response curveMore data for this Ligand-Target Pair
In DepthDetails US Patent
TargetBromodomain-containing protein 4 [44-167](Homo sapiens (Human))
Tensha Therapeutics

US Patent
LigandPNGBDBM483491(US10925881, Name (S)-JQ35)
Affinity DataIC50:  24.3nMAssay Description:The binding activity of lead compounds with the BRD4 site 1 was determined by Alpha-assay with a 12-point dose response curveMore data for this Ligand-Target Pair
In DepthDetails US Patent
TargetBromodomain-containing protein 4 [349-460](Homo sapiens (Human))
Tensha Therapeutics

US Patent
LigandPNGBDBM483490(US10925881, Name (S)-JQ33)
Affinity DataIC50:  29.5nMAssay Description:The binding activity of lead compounds with the BRD4 site 2 was determined by Alpha-assay with a 12-point dose response curveMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBromodomain-containing protein 4 [44-167](Homo sapiens (Human))
Tensha Therapeutics

US Patent
LigandPNGBDBM483490(US10925881, Name (S)-JQ33)
Affinity DataIC50:  85nMAssay Description:The binding activity of lead compounds with the BRD4 site 1 was determined by Alpha-assay with a 12-point dose response curveMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBromodomain-containing protein 4 [44-167](Homo sapiens (Human))
Tensha Therapeutics

US Patent
LigandPNGBDBM205429( (R)-JQ1 (3) | US10407441, Compound (R)-JQ1 | US10...)
Affinity DataIC50:  8.35E+6nMAssay Description:The binding activity of lead compounds with the BRD4 site 1 was determined by Alpha-assay with a 12-point dose response curveMore data for this Ligand-Target Pair
In DepthDetails US Patent
TargetBromodomain-containing protein 4 [349-460](Homo sapiens (Human))
Tensha Therapeutics

US Patent
LigandPNGBDBM205429( (R)-JQ1 (3) | US10407441, Compound (R)-JQ1 | US10...)
Affinity DataIC50:  5.21E+7nMAssay Description:The binding activity of lead compounds with the BRD4 site 2 was determined by Alpha-assay with a 12-point dose response curveMore data for this Ligand-Target Pair
In DepthDetails US Patent
TargetIsoform C of Bromodomain-containing protein 4 (Short)(Homo sapiens (Human))
Tensha Therapeutics

US Patent
LigandPNGBDBM298351(US10124009, Compound 7)
Affinity DataKd:  2.10E+3nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBromodomain-containing protein 4(Homo sapiens (Human))
Tensha Therapeutics

US Patent
LigandPNGBDBM298351(US10124009, Compound 7)
Affinity DataKd:  1.50E+3nMAssay Description:A BROMOscan binding assay was utilized to test the in vitro binding activity of (S)-Compounds 1, 2, 3, 4, 5 and 7 to the first and second bromodomain...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetIsoform C of Bromodomain-containing protein 4 (Short)(Homo sapiens (Human))
Tensha Therapeutics

US Patent
LigandPNGBDBM298350(US10124009, Compound 5)
Affinity DataKd:  400nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBromodomain-containing protein 4(Homo sapiens (Human))
Tensha Therapeutics

US Patent
LigandPNGBDBM298350(US10124009, Compound 5)
Affinity DataKd:  430nMAssay Description:A BROMOscan binding assay was utilized to test the in vitro binding activity of (S)-Compounds 1, 2, 3, 4, 5 and 7 to the first and second bromodomain...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetIsoform C of Bromodomain-containing protein 4 (Short)(Homo sapiens (Human))
Tensha Therapeutics

US Patent
LigandPNGBDBM298349(US10124009, Compound 4)
Affinity DataKd:  1.30E+3nMMore data for this Ligand-Target Pair
In DepthDetails US Patent
TargetBromodomain-containing protein 4(Homo sapiens (Human))
Tensha Therapeutics

US Patent
LigandPNGBDBM298349(US10124009, Compound 4)
Affinity DataKd:  1.10E+3nMAssay Description:A BROMOscan binding assay was utilized to test the in vitro binding activity of (S)-Compounds 1, 2, 3, 4, 5 and 7 to the first and second bromodomain...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetIsoform C of Bromodomain-containing protein 4 (Short)(Homo sapiens (Human))
Tensha Therapeutics

US Patent
LigandPNGBDBM298348(US10124009, Compound 3)
Affinity DataKd:  1.20E+3nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBromodomain-containing protein 4(Homo sapiens (Human))
Tensha Therapeutics

US Patent
LigandPNGBDBM298348(US10124009, Compound 3)
Affinity DataKd:  1.10E+3nMAssay Description:A BROMOscan binding assay was utilized to test the in vitro binding activity of (S)-Compounds 1, 2, 3, 4, 5 and 7 to the first and second bromodomain...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetIsoform C of Bromodomain-containing protein 4 (Short)(Homo sapiens (Human))
Tensha Therapeutics

US Patent
LigandPNGBDBM298347(US10124009, Compound 2)
Affinity DataKd:  1.90E+3nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBromodomain-containing protein 4(Homo sapiens (Human))
Tensha Therapeutics

US Patent
LigandPNGBDBM298347(US10124009, Compound 2)
Affinity DataKd:  1.90E+3nMAssay Description:A BROMOscan binding assay was utilized to test the in vitro binding activity of (S)-Compounds 1, 2, 3, 4, 5 and 7 to the first and second bromodomain...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetIsoform C of Bromodomain-containing protein 4 (Short)(Homo sapiens (Human))
Tensha Therapeutics

US Patent
LigandPNGBDBM298346(US10124009, Compound 1)
Affinity DataKd:  1.50E+3nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBromodomain-containing protein 4(Homo sapiens (Human))
Tensha Therapeutics

US Patent
LigandPNGBDBM298346(US10124009, Compound 1)
Affinity DataKd:  1.30E+3nMAssay Description:A BROMOscan binding assay was utilized to test the in vitro binding activity of (S)-Compounds 1, 2, 3, 4, 5 and 7 to the first and second bromodomain...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBromodomain-containing protein 4(Homo sapiens (Human))
Tensha Therapeutics

US Patent
LigandPNGBDBM50365262((+)-JQ1 | (S)-JQ1 (1) | CHEMBL1957266 | JQ1 | US10...)
Affinity DataKd:  3.60E+3nMAssay Description:A BROMOscan binding assay was utilized to test the in vitro binding activity of (S)-Compounds 1, 2, 3, 4, 5 and 7 to the first and second bromodomain...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetIsoform C of Bromodomain-containing protein 4 (Short)(Homo sapiens (Human))
Tensha Therapeutics

US Patent
LigandPNGBDBM50365262((+)-JQ1 | (S)-JQ1 (1) | CHEMBL1957266 | JQ1 | US10...)
Affinity DataKd:  3.80E+3nMMore data for this Ligand-Target Pair
In DepthDetails US Patent