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Found 152 with Last Name = 'lauria' and Initial = 'a'
TargetReplicase polyprotein 1ab(2019-nCoV)TBA
LigandPNGBDBM496902(CVD-0018409 | PF-07321332 | US11351149, Example 13...)
Affinity DataKi:  3nMAssay Description:Inhibitory activity against Dihydrofolate reductase enzyme purified from Plasmodium berghei.More data for this Ligand-Target Pair
TargetReplicase polyprotein 1ab(2019-nCoV)TBA
LigandPNGBDBM50405457(CHEMBL5283903)
Affinity DataKi:  13nMAssay Description:Inhibition of human platelet Thromboxane synthetaseMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)TBA
LigandPNGBDBM512571(acs.jmedchem.1c00409_ST.164)
Affinity DataKi:  31nMAssay Description:Inhibition of dihydrofolate reductasefrom rat liver at 1x10E6 MMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)TBA
LigandPNGBDBM50405456(CHEMBL5287345)
Affinity DataKi:  35nMAssay Description:Inhibitory activity against sheep seminal vesicle prostaglandin synthetaseMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)TBA
LigandPNGBDBM50405455(CHEMBL3427167)
Affinity DataKi:  36nMAssay Description:Inhibition of human platelet Thromboxane synthetaseMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)TBA
LigandPNGBDBM512583(acs.jmedchem.1c00409_ST.176)
Affinity DataKi:  78nMAssay Description:Inhibition of dihydrofolate reductasefrom rat liver at 1x10E6 MMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)TBA
LigandPNGBDBM419133(BDBM429386 | GC376)
Affinity DataKi:  94nMAssay Description:Inhibitory activity against Dihydrofolate reductase enzyme purified from rat liver.More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)TBA
LigandPNGBDBM12311((1R,5S)-N-[3-Amino-1-(cyclobutylmethyl)-2,3-dioxop...)
Affinity DataKi:  1.18E+3nMAssay Description:Competitive antagonism of Histamine H2 receptor in the isolated guinea pig atriumMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)TBA
LigandPNGBDBM496871(indole chloropyridinyl-ester derived, 2)
Affinity DataKi:  2.15E+3nMAssay Description:Inhibition of dihydrofolate reductasefrom rat liver at 1x10E6 MMore data for this Ligand-Target Pair
TargetReplicase polyprotein 1ab(2019-nCoV)TBA
LigandPNGBDBM15236(3,5,7-trihydroxy-2-(3,4,5-trihydroxyphenyl)-4H-chr...)
Affinity DataKi:  1.57E+4nMAssay Description:Inhibitory activity against Dihydrofolate reductase enzyme purified from Plasmodium berghei.More data for this Ligand-Target Pair
TargetReplicase polyprotein 1ab(2019-nCoV)TBA
LigandPNGBDBM496139(CVD-0013700 | PAU-WEI-5b8d5051-1)
Affinity DataKi:  3.84E+4nMAssay Description:Inhibitory activity against Dihydrofolate reductase enzyme purified from Plasmodium berghei.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetProcathepsin L(Homo sapiens (Human))TBA
LigandPNGBDBM50069985((S)-4-methyl-2-(3-phenyl-propionylamino)-pentanoic...)
Affinity DataIC50:  0.150nMAssay Description:In vitro inhibition of dihydropteroate synthase from Escherichia coli.More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetHistone deacetylase 6(Homo sapiens (Human))TBA
LigandPNGBDBM50202000(CHEMBL3973951)
Affinity DataIC50:  0.291nMAssay Description:Inhibition of HDAC6 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetProcathepsin L(Homo sapiens (Human))TBA
LigandPNGBDBM442762(MPI6)
Affinity DataIC50:  1.20nMAssay Description:In vitro inhibition of dihydropteroate synthase from Escherichia coli.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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LigandPNGBDBM50610586(CHEMBL5280445)
Affinity DataIC50:  1.5nMAssay Description:Inhibition of HDAC (unknown origin)More data for this Ligand-Target Pair
Ligand Info
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TargetHistone deacetylase 8(Homo sapiens (Human))TBA
LigandPNGBDBM50239858(CHEMBL4067006)
Affinity DataIC50:  1.70nMAssay Description:Inhibition of HDAC8 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetHistone deacetylase 6(Homo sapiens (Human))TBA
LigandPNGBDBM50247556(CHEMBL4104117)
Affinity DataIC50:  2.70nMAssay Description:Inhibition of HDAC6 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)TBA
LigandPNGBDBM50405463(CHEMBL5267069)
Affinity DataIC50:  7.60nMAssay Description:Inhibitory activity against sheep seminal vesicle prostaglandin synthetaseMore data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase EHMT2(Homo sapiens (Human))TBA
LigandPNGBDBM50457751(CHEMBL4217087)
Affinity DataIC50:  8nMAssay Description:Inhibition of G9a (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)TBA
LigandPNGBDBM423466(WO2006061714, P39.1 | WO2006061714-ID-11 | cmdc.20...)
Affinity DataIC50:  8.5nMAssay Description:In vitro inhibition of dihydropteroate synthase from Escherichia coli.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetHepatocyte growth factor receptor(Homo sapiens (Human))TBA
LigandPNGBDBM50610587(CHEMBL5269169)
Affinity DataIC50:  13nMAssay Description:Inhibition of c-MET (unknown origin)More data for this Ligand-Target Pair
Ligand Info
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TargetReplicase polyprotein 1ab(2019-nCoV)TBA
LigandPNGBDBM50405469(CHEMBL5267414)
Affinity DataIC50:  14nMAssay Description:In vitro inhibition of dihydropteroate synthase from Escherichia coli.More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)TBA
LigandPNGBDBM50405459(CHEMBL5290282)
Affinity DataIC50:  15nMAssay Description:Inhibition of human platelet Thromboxane synthetaseMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)TBA
LigandPNGBDBM50598148(CHEMBL5193976)
Affinity DataIC50:  15nMAssay Description:In vitro inhibition of dihydropteroate synthase from Escherichia coli.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)TBA
LigandPNGBDBM50405458(CHEMBL5290927)
Affinity DataIC50:  16nMAssay Description:Inhibitory activity against human platelet Thromboxane synthetaseMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)TBA
LigandPNGBDBM50405464(CHEMBL5270743)
Affinity DataIC50:  17nMAssay Description:Inhibition of human platelet Thromboxane synthetaseMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)TBA
LigandPNGBDBM496902(CVD-0018409 | PF-07321332 | US11351149, Example 13...)
Affinity DataIC50:  19nMAssay Description:In vitro inhibition of dihydropteroate synthase from Escherichia coli.More data for this Ligand-Target Pair
TargetReplicase polyprotein 1ab(2019-nCoV)TBA
LigandPNGBDBM50598146(CHEMBL5195364)
Affinity DataIC50:  28nMAssay Description:In vitro inhibition of dihydropteroate synthase from Escherichia coli.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
LigandPNGBDBM50610585(CHEMBL5267651)
Affinity DataIC50:  28nMAssay Description:Inhibition of HDAC (unknown origin)More data for this Ligand-Target Pair
Ligand Info
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TargetReplicase polyprotein 1ab(2019-nCoV)TBA
LigandPNGBDBM61971(5-bromanyl-2-phenyl-1,2-benzothiazol-3-one | 5-bro...)
Affinity DataIC50:  30nMAssay Description:In vitro inhibitory activity against Angiotensin I converting enzymeMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)TBA
LigandPNGBDBM512835(acs.jmedchem.1c00409_ST.430)
Affinity DataIC50:  34nMAssay Description:In vitro inhibition of dihydropteroate synthase from Escherichia coli.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)TBA
LigandPNGBDBM420297(acs.jmedchem.1c00409_ST.30 | med.21724, Compound 6...)
Affinity DataIC50:  40nMAssay Description:Inhibitory activity against Dihydrofolate reductase enzyme purified from Plasmodium berghei.More data for this Ligand-Target Pair
Ligand InfoPurchasePDB
TargetHistone-lysine N-methyltransferase SMYD3(Homo sapiens (Human))TBA
LigandPNGBDBM50610591(CHEMBL5275589)
Affinity DataIC50:  40nMAssay Description:Inhibition of SMYD3 (unknown origin)More data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)TBA
LigandPNGBDBM50405456(CHEMBL5287345)
Affinity DataIC50:  45nMAssay Description:Inhibition of human platelet Thromboxane synthetaseMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)TBA
LigandPNGBDBM50405455(CHEMBL3427167)
Affinity DataIC50:  45nMAssay Description:Antagonism of Histamine H1 receptor in the isolated guinea pig ileumMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)TBA
LigandPNGBDBM484194(UAWJ9-36-1)
Affinity DataIC50:  51nMAssay Description:In vitro inhibition of dihydropteroate synthase from Escherichia coli.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetReplicase polyprotein 1ab(2019-nCoV)TBA
LigandPNGBDBM420296(Advanced SARS-CoV-2 Inhibitor 11a | MPI10 | acs.jm...)
Affinity DataIC50:  53nMAssay Description:Tested for inhibition against dihydro folate reductase in Pigeon liverMore data for this Ligand-Target Pair
Ligand InfoPurchasePDB
TargetReplicase polyprotein 1ab(2019-nCoV)TBA
LigandPNGBDBM484195(UAWJ9-36-3)
Affinity DataIC50:  54nMAssay Description:In vitro inhibition of dihydropteroate synthase from Escherichia coli.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)TBA
LigandPNGBDBM429426(acs.jmedchem.1c00409_ST.429 | med.21724, Compound ...)
Affinity DataIC50:  55nMAssay Description:In vitro inhibition of dihydropteroate synthase from Escherichia coli.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)TBA
LigandPNGBDBM50405467(CHEMBL5278950)
Affinity DataIC50:  56nMAssay Description:In vitro inhibition of dihydropteroate synthase from Escherichia coli.More data for this Ligand-Target Pair
In DepthDetails PubMed
LigandPNGBDBM50475239(CHEMBL112234)
Affinity DataIC50:  72nMAssay Description:Inhibition of HDAC (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)TBA
LigandPNGBDBM512571(acs.jmedchem.1c00409_ST.164)
Affinity DataIC50:  74nMAssay Description:Antagonistic activity against beta-2 adrenergic receptor on isolated guinea pig tracheal stripsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)TBA
LigandPNGBDBM50405466(CHEMBL5281998)
Affinity DataIC50:  80nMAssay Description:In vitro inhibition of dihydropteroate synthase from Escherichia coli.More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)TBA
LigandPNGBDBM429299(MAC-5576 | jm5b01461, Compound 119)
Affinity DataIC50:  81nMAssay Description:In vitro inhibition of dihydropteroate synthase from Escherichia coli.More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetTelomerase reverse transcriptase(Homo sapiens (Human))TBA
LigandPNGBDBM50134030(9-[4-(N,N-dimethylamino)phenylamino]-3,6-bis(3-pyr...)
Affinity DataIC50:  95nMAssay Description:Inhibition of telomerase (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)TBA
LigandPNGBDBM442762(MPI6)
Affinity DataIC50:  105nMAssay Description:In vitro inhibition of dihydropteroate synthase from Escherichia coli.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)TBA
LigandPNGBDBM512583(acs.jmedchem.1c00409_ST.176)
Affinity DataIC50:  110nMAssay Description:Antagonistic activity against beta-2 adrenergic receptor on isolated guinea pig tracheal stripsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)TBA
LigandPNGBDBM46667(2-phenyl-1,2-benzothiazol-3-one | 2-phenyl-1,2-ben...)
Affinity DataIC50:  130nMAssay Description:In vitro inhibitory activity against Angiotensin I converting enzymeMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)TBA
LigandPNGBDBM50405472(CHEMBL5267356)
Affinity DataIC50:  151nMAssay Description:In vitro inhibition of dihydropteroate synthase from Escherichia coli.More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)TBA
LigandPNGBDBM50405477(CHEMBL5270421)
Affinity DataIC50:  160nMAssay Description:Antagonistic activity against beta-2 adrenergic receptor on isolated guinea pig tracheal stripsMore data for this Ligand-Target Pair
In DepthDetails PubMed
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