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Found 83 with Last Name = 'leberre' and Initial = 'n'
TargetDimer of Gag-Pol polyprotein [501-599](Human immunodeficiency virus type 1)
Ambrilia Biopharma

LigandPNGBDBM10173(lysine sulfonamide analogue 34 | pyridin-4-ylmethy...)
Affinity DataKi:  0.0200nM IC50:  0.390nMAssay Description:HIV-1 protease activity was measured by a continuous fluorometric assay. The proteolytic activity can be monitored by the increase in fluorescence in...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDimer of Gag-Pol polyprotein [501-599](Human immunodeficiency virus type 1)
Ambrilia Biopharma

LigandPNGBDBM10177((2S)-N-[(5R)-5-[(4-aminobenzene)(2-methylpropyl)su...)
Affinity DataKi:  0.330nM IC50:  0.330nMAssay Description:HIV-1 protease activity was measured by a continuous fluorometric assay. The proteolytic activity can be monitored by the increase in fluorescence in...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDimer of Gag-Pol polyprotein [501-599](Human immunodeficiency virus type 1)
Ambrilia Biopharma

LigandPNGBDBM10170((2S)-N-[(5R)-5-[(4-aminobenzene)(2-methylpropyl)su...)
Affinity DataKi:  0.340nM IC50:  0.240nMAssay Description:HIV-1 protease activity was measured by a continuous fluorometric assay. The proteolytic activity can be monitored by the increase in fluorescence in...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDimer of Gag-Pol polyprotein [501-599](Human immunodeficiency virus type 1)
Ambrilia Biopharma

LigandPNGBDBM10172(lysine sulfonamide analogue 33 | pyridin-3-ylmethy...)
Affinity DataKi:  0.360nM IC50:  0.480nMAssay Description:HIV-1 protease activity was measured by a continuous fluorometric assay. The proteolytic activity can be monitored by the increase in fluorescence in...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDimer of Gag-Pol polyprotein [501-599](Human immunodeficiency virus type 1)
Ambrilia Biopharma

LigandPNGBDBM10171(lysine sulfonamide analogue 32 | pyridin-2-ylmethy...)
Affinity DataKi:  0.400nM IC50:  0.120nMAssay Description:HIV-1 protease activity was measured by a continuous fluorometric assay. The proteolytic activity can be monitored by the increase in fluorescence in...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDimer of Gag-Pol polyprotein [501-599](Human immunodeficiency virus type 1)
Ambrilia Biopharma

LigandPNGBDBM10175((2S)-N-[(5R)-5-[(4-aminobenzene)(2-methylpropyl)su...)
Affinity DataKi:  0.400nM IC50:  0.400nMAssay Description:HIV-1 protease activity was measured by a continuous fluorometric assay. The proteolytic activity can be monitored by the increase in fluorescence in...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDimer of Gag-Pol polyprotein [501-599](Human immunodeficiency virus type 1)
Ambrilia Biopharma

LigandPNGBDBM10165((2S)-N-[(5R)-5-[(4-aminobenzene)(2-methylpropyl)su...)
Affinity DataKi:  0.400nM IC50:  0.400nMAssay Description:HIV-1 protease activity was measured by a continuous fluorometric assay. The proteolytic activity can be monitored by the increase in fluorescence in...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDimer of Gag-Pol polyprotein [501-599](Human immunodeficiency virus type 1)
Ambrilia Biopharma

LigandPNGBDBM10169((2S)-N-[(5R)-5-[(4-aminobenzene)(2-methylpropyl)su...)
Affinity DataKi:  0.400nM IC50:  0.5nMAssay Description:HIV-1 protease activity was measured by a continuous fluorometric assay. The proteolytic activity can be monitored by the increase in fluorescence in...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDimer of Gag-Pol polyprotein [501-599](Human immunodeficiency virus type 1)
Ambrilia Biopharma

LigandPNGBDBM10162((2S)-N-[(5R)-5-[(4-aminobenzene)(2-methylpropyl)su...)
Affinity DataKi:  0.440nM IC50:  0.460nMAssay Description:HIV-1 protease activity was measured by a continuous fluorometric assay. The proteolytic activity can be monitored by the increase in fluorescence in...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDimer of Gag-Pol polyprotein [501-599](Human immunodeficiency virus type 1)
Ambrilia Biopharma

LigandPNGBDBM10155((2S)-N-[(5R)-5-[(4-aminobenzene)(2-methylpropyl)su...)
Affinity DataKi:  0.450nM IC50:  0.430nMAssay Description:HIV-1 protease activity was measured by a continuous fluorometric assay. The proteolytic activity can be monitored by the increase in fluorescence in...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDimer of Gag-Pol polyprotein [501-599](Human immunodeficiency virus type 1)
Ambrilia Biopharma

LigandPNGBDBM10179((2S)-N-[(5R)-5-[(4-aminobenzene)(2-methylpropyl)su...)
Affinity DataKi:  0.450nM IC50:  0.5nMAssay Description:HIV-1 protease activity was measured by a continuous fluorometric assay. The proteolytic activity can be monitored by the increase in fluorescence in...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDimer of Gag-Pol polyprotein [501-599](Human immunodeficiency virus type 1)
Ambrilia Biopharma

LigandPNGBDBM10161((2S)-N-[(5R)-5-[(4-aminobenzene)(2-methylpropyl)su...)
Affinity DataKi:  0.470nM IC50:  0.430nMAssay Description:HIV-1 protease activity was measured by a continuous fluorometric assay. The proteolytic activity can be monitored by the increase in fluorescence in...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDimer of Gag-Pol polyprotein [501-599](Human immunodeficiency virus type 1)
Ambrilia Biopharma

LigandPNGBDBM10176((2S)-N-[(5R)-5-[(4-aminobenzene)(2-methylpropyl)su...)
Affinity DataKi:  0.470nM IC50:  0.530nMAssay Description:HIV-1 protease activity was measured by a continuous fluorometric assay. The proteolytic activity can be monitored by the increase in fluorescence in...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDimer of Gag-Pol polyprotein [501-599](Human immunodeficiency virus type 1)
Ambrilia Biopharma

LigandPNGBDBM10178((2S)-N-[(5R)-5-[(4-aminobenzene)(2-methylpropyl)su...)
Affinity DataKi:  0.480nM IC50:  0.560nMAssay Description:HIV-1 protease activity was measured by a continuous fluorometric assay. The proteolytic activity can be monitored by the increase in fluorescence in...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDimer of Gag-Pol polyprotein [501-599](Human immunodeficiency virus type 1)
Ambrilia Biopharma

LigandPNGBDBM10168((2S)-N-[(5R)-5-[(4-aminobenzene)(2-methylpropyl)su...)
Affinity DataKi:  0.5nM IC50:  0.400nMAssay Description:HIV-1 protease activity was measured by a continuous fluorometric assay. The proteolytic activity can be monitored by the increase in fluorescence in...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDimer of Gag-Pol polyprotein [501-599](Human immunodeficiency virus type 1)
Ambrilia Biopharma

LigandPNGBDBM10157(lysine sulfonamide analogue 18 | tert-butyl N-[(1S...)
Affinity DataKi:  0.5nM IC50:  0.400nMAssay Description:HIV-1 protease activity was measured by a continuous fluorometric assay. The proteolytic activity can be monitored by the increase in fluorescence in...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDimer of Gag-Pol polyprotein [501-599](Human immunodeficiency virus type 1)
Ambrilia Biopharma

LigandPNGBDBM10166((2S)-N-[(5R)-5-[(4-aminobenzene)(2-methylpropyl)su...)
Affinity DataKi:  0.5nM IC50:  0.400nMAssay Description:HIV-1 protease activity was measured by a continuous fluorometric assay. The proteolytic activity can be monitored by the increase in fluorescence in...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDimer of Gag-Pol polyprotein [501-599](Human immunodeficiency virus type 1)
Ambrilia Biopharma

LigandPNGBDBM10159((2S)-N-[(5R)-5-[(4-aminobenzene)(2-methylpropyl)su...)
Affinity DataKi:  0.550nM IC50:  0.510nMAssay Description:HIV-1 protease activity was measured by a continuous fluorometric assay. The proteolytic activity can be monitored by the increase in fluorescence in...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDimer of Gag-Pol polyprotein [501-599](Human immunodeficiency virus type 1)
Ambrilia Biopharma

LigandPNGBDBM10163((2S)-N-[(5R)-5-[(4-aminobenzene)(2-methylpropyl)su...)
Affinity DataKi:  0.550nM IC50:  0.680nMAssay Description:HIV-1 protease activity was measured by a continuous fluorometric assay. The proteolytic activity can be monitored by the increase in fluorescence in...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDimer of Gag-Pol polyprotein [501-599](Human immunodeficiency virus type 1)
Ambrilia Biopharma

LigandPNGBDBM10153((2S)-2-amino-N-[(5R)-5-[(4-aminobenzene)(2-methylp...)
Affinity DataKi:  0.560nM IC50:  0.5nMAssay Description:HIV-1 protease activity was measured by a continuous fluorometric assay. The proteolytic activity can be monitored by the increase in fluorescence in...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDimer of Gag-Pol polyprotein [501-599](Human immunodeficiency virus type 1)
Ambrilia Biopharma

LigandPNGBDBM10158((2S)-N-[(5R)-5-[(4-aminobenzene)(2-methylpropyl)su...)
Affinity DataKi:  0.580nM IC50:  0.440nMAssay Description:HIV-1 protease activity was measured by a continuous fluorometric assay. The proteolytic activity can be monitored by the increase in fluorescence in...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDimer of Gag-Pol polyprotein [501-599](Human immunodeficiency virus type 1)
Ambrilia Biopharma

LigandPNGBDBM10174((2S)-N-[(5R)-5-[(4-aminobenzene)(2-methylpropyl)su...)
Affinity DataKi:  0.580nM IC50:  0.630nMAssay Description:HIV-1 protease activity was measured by a continuous fluorometric assay. The proteolytic activity can be monitored by the increase in fluorescence in...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDimer of Gag-Pol polyprotein [501-599](Human immunodeficiency virus type 1)
Ambrilia Biopharma

LigandPNGBDBM10160((2S)-N-[(5R)-5-[(4-aminobenzene)(2-methylpropyl)su...)
Affinity DataKi:  0.600nM IC50:  0.520nMAssay Description:HIV-1 protease activity was measured by a continuous fluorometric assay. The proteolytic activity can be monitored by the increase in fluorescence in...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDimer of Gag-Pol polyprotein [501-599](Human immunodeficiency virus type 1)
Ambrilia Biopharma

LigandPNGBDBM10164((2S)-N-[(5R)-5-[(4-aminobenzene)(2-methylpropyl)su...)
Affinity DataKi:  0.660nM IC50:  0.650nMAssay Description:HIV-1 protease activity was measured by a continuous fluorometric assay. The proteolytic activity can be monitored by the increase in fluorescence in...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDimer of Gag-Pol polyprotein [501-599](Human immunodeficiency virus type 1)
Ambrilia Biopharma

LigandPNGBDBM10167((2S)-N-[(5R)-5-[(4-aminobenzene)(2-methylpropyl)su...)
Affinity DataKi:  0.700nM IC50:  0.900nMAssay Description:HIV-1 protease activity was measured by a continuous fluorometric assay. The proteolytic activity can be monitored by the increase in fluorescence in...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587,G537V,H558K,V571A](Human immunodeficiency virus)
Taimed Biologies

US Patent
LigandPNGBDBM122997(US8742158, EX 19)
Affinity DataIC50:  0.290nMAssay Description:This is a fluorometric assay based on the cleavage by protease of a substrate carrying a donor group (EDANS) and an acceptor group (DABCYL) on each s...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetGag-Pol polyprotein [489-587,G537V,H558K,V571A](Human immunodeficiency virus)
Taimed Biologies

US Patent
LigandPNGBDBM122988(US8742158, EX. 41)
Affinity DataIC50:  0.336nMAssay Description:This is a fluorometric assay based on the cleavage by protease of a substrate carrying a donor group (EDANS) and an acceptor group (DABCYL) on each s...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetGag-Pol polyprotein [489-587,G537V,H558K,V571A](Human immunodeficiency virus)
Taimed Biologies

US Patent
LigandPNGBDBM122987(US8742158, EX. 46)
Affinity DataIC50:  0.372nMAssay Description:This is a fluorometric assay based on the cleavage by protease of a substrate carrying a donor group (EDANS) and an acceptor group (DABCYL) on each s...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetGag-Pol polyprotein [489-587,G537V,H558K,V571A](Human immunodeficiency virus)
Taimed Biologies

US Patent
LigandPNGBDBM122977(US8742158, EX 58)
Affinity DataIC50:  0.436nMAssay Description:This is a fluorometric assay based on the cleavage by protease of a substrate carrying a donor group (EDANS) and an acceptor group (DABCYL) on each s...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGag-Pol polyprotein [489-587,G537V,H558K,V571A](Human immunodeficiency virus)
Taimed Biologies

US Patent
LigandPNGBDBM122978(US8742158, EX 61)
Affinity DataIC50:  0.465nMAssay Description:This is a fluorometric assay based on the cleavage by protease of a substrate carrying a donor group (EDANS) and an acceptor group (DABCYL) on each s...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetGag-Pol polyprotein [489-587,G537V,H558K,V571A](Human immunodeficiency virus)
Taimed Biologies

US Patent
LigandPNGBDBM122985(US8742158, EX. 44)
Affinity DataIC50:  0.471nMAssay Description:This is a fluorometric assay based on the cleavage by protease of a substrate carrying a donor group (EDANS) and an acceptor group (DABCYL) on each s...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetDimer of Gag-Pol polyprotein [501-599](Human immunodeficiency virus type 1)
Ambrilia Biopharma

LigandPNGBDBM10149(CHEMBL168640 | lysine sulfonamide analogue 13 | ly...)
Affinity DataIC50:  0.5nMpH: 4.7 T: 2°CAssay Description:HIV-1 protease activity was measured by a continuous fluorometric assay. The proteolytic activity can be monitored by the increase in fluorescence in...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587,G537V,H558K,V571A](Human immunodeficiency virus)
Taimed Biologies

US Patent
LigandPNGBDBM122993(US8742158, EX 36)
Affinity DataIC50:  0.503nMAssay Description:This is a fluorometric assay based on the cleavage by protease of a substrate carrying a donor group (EDANS) and an acceptor group (DABCYL) on each s...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetGag-Pol polyprotein [489-587,G537V,H558K,V571A](Human immunodeficiency virus)
Taimed Biologies

US Patent
LigandPNGBDBM122980(US8742158, EX. 7)
Affinity DataIC50:  0.507nMAssay Description:This is a fluorometric assay based on the cleavage by protease of a substrate carrying a donor group (EDANS) and an acceptor group (DABCYL) on each s...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetGag-Pol polyprotein [489-587,G537V,H558K,V571A](Human immunodeficiency virus)
Taimed Biologies

US Patent
LigandPNGBDBM122979(US8742158, EX 62)
Affinity DataIC50:  0.510nMAssay Description:This is a fluorometric assay based on the cleavage by protease of a substrate carrying a donor group (EDANS) and an acceptor group (DABCYL) on each s...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetDimer of Gag-Pol polyprotein [501-599](Human immunodeficiency virus type 1)
Ambrilia Biopharma

LigandPNGBDBM10148(lysine sulfonamide analogue 12 | methyl N-[(1S)-1-...)
Affinity DataIC50:  0.521nMpH: 4.7 T: 2°CAssay Description:HIV-1 protease activity was measured by a continuous fluorometric assay. The proteolytic activity can be monitored by the increase in fluorescence in...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587,G537V,H558K,V571A](Human immunodeficiency virus)
Taimed Biologies

US Patent
LigandPNGBDBM122991(US8742158, EX. 40)
Affinity DataIC50:  0.567nMAssay Description:This is a fluorometric assay based on the cleavage by protease of a substrate carrying a donor group (EDANS) and an acceptor group (DABCYL) on each s...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetGag-Pol polyprotein [489-587,G537V,H558K,V571A](Human immunodeficiency virus)
Taimed Biologies

US Patent
LigandPNGBDBM122990(US8742158, EX. 39)
Affinity DataIC50:  0.580nMAssay Description:This is a fluorometric assay based on the cleavage by protease of a substrate carrying a donor group (EDANS) and an acceptor group (DABCYL) on each s...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetGag-Pol polyprotein [489-587,G537V,H558K,V571A](Human immunodeficiency virus)
Taimed Biologies

US Patent
LigandPNGBDBM122983(US8742158, EX. 9)
Affinity DataIC50:  0.580nMAssay Description:This is a fluorometric assay based on the cleavage by protease of a substrate carrying a donor group (EDANS) and an acceptor group (DABCYL) on each s...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGag-Pol polyprotein [489-587,G537V,H558K,V571A](Human immunodeficiency virus)
Taimed Biologies

US Patent
LigandPNGBDBM123000(US8742158, EX 17)
Affinity DataIC50:  0.599nMAssay Description:This is a fluorometric assay based on the cleavage by protease of a substrate carrying a donor group (EDANS) and an acceptor group (DABCYL) on each s...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetGag-Pol polyprotein [489-587,G537V,H558K,V571A](Human immunodeficiency virus)
Taimed Biologies

US Patent
LigandPNGBDBM122996(US8742158, EX 18)
Affinity DataIC50:  0.600nMAssay Description:This is a fluorometric assay based on the cleavage by protease of a substrate carrying a donor group (EDANS) and an acceptor group (DABCYL) on each s...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetGag-Pol polyprotein [489-587,G537V,H558K,V571A](Human immunodeficiency virus)
Taimed Biologies

US Patent
LigandPNGBDBM122976(US8742158, EX 57)
Affinity DataIC50:  0.601nMAssay Description:This is a fluorometric assay based on the cleavage by protease of a substrate carrying a donor group (EDANS) and an acceptor group (DABCYL) on each s...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGag-Pol polyprotein [489-587,G537V,H558K,V571A](Human immunodeficiency virus)
Taimed Biologies

US Patent
LigandPNGBDBM122986(US8742158, EX. 45)
Affinity DataIC50:  0.615nMAssay Description:This is a fluorometric assay based on the cleavage by protease of a substrate carrying a donor group (EDANS) and an acceptor group (DABCYL) on each s...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetGag-Pol polyprotein [489-587,G537V,H558K,V571A](Human immunodeficiency virus)
Taimed Biologies

US Patent
LigandPNGBDBM122989(US8742158, EX. 42)
Affinity DataIC50:  0.618nMAssay Description:This is a fluorometric assay based on the cleavage by protease of a substrate carrying a donor group (EDANS) and an acceptor group (DABCYL) on each s...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetGag-Pol polyprotein [489-587,G537V,H558K,V571A](Human immunodeficiency virus)
Taimed Biologies

US Patent
LigandPNGBDBM122980(US8742158, EX. 7)
Affinity DataIC50:  0.652nMAssay Description:This is a fluorometric assay based on the cleavage by protease of a substrate carrying a donor group (EDANS) and an acceptor group (DABCYL) on each s...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetGag-Pol polyprotein [489-587,G537V,H558K,V571A](Human immunodeficiency virus)
Taimed Biologies

US Patent
LigandPNGBDBM122994(US8742158, EX 37)
Affinity DataIC50:  0.683nMAssay Description:This is a fluorometric assay based on the cleavage by protease of a substrate carrying a donor group (EDANS) and an acceptor group (DABCYL) on each s...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetGag-Pol polyprotein [489-587,G537V,H558K,V571A](Human immunodeficiency virus)
Taimed Biologies

US Patent
LigandPNGBDBM122992(US8742158, EX. 43)
Affinity DataIC50:  0.836nMAssay Description:This is a fluorometric assay based on the cleavage by protease of a substrate carrying a donor group (EDANS) and an acceptor group (DABCYL) on each s...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGag-Pol polyprotein [489-587,G537V,H558K,V571A](Human immunodeficiency virus)
Taimed Biologies

US Patent
LigandPNGBDBM122974(US8742158, EX 55)
Affinity DataIC50:  0.878nMAssay Description:This is a fluorometric assay based on the cleavage by protease of a substrate carrying a donor group (EDANS) and an acceptor group (DABCYL) on each s...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetGag-Pol polyprotein [489-587,G537V,H558K,V571A](Human immunodeficiency virus)
Taimed Biologies

US Patent
LigandPNGBDBM123002(US8742158, EX 32)
Affinity DataIC50:  0.899nMAssay Description:This is a fluorometric assay based on the cleavage by protease of a substrate carrying a donor group (EDANS) and an acceptor group (DABCYL) on each s...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGag-Pol polyprotein [489-587,G537V,H558K,V571A](Human immunodeficiency virus)
Taimed Biologies

US Patent
LigandPNGBDBM122995(US8742158, EX 38)
Affinity DataIC50:  0.920nMAssay Description:This is a fluorometric assay based on the cleavage by protease of a substrate carrying a donor group (EDANS) and an acceptor group (DABCYL) on each s...More data for this Ligand-Target Pair
In DepthDetails US Patent
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