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Found 377 with Last Name = 'light' and Initial = 'dr'
TargetCoagulation factor X(Homo sapiens (Human))
Berlex

LigandPNGBDBM17280(1-[2-(5-carbamimidoyl-2-hydroxyphenoxy)-3,5-difluo...)
Affinity DataKi:  0.110nM ΔG°:  -56.3kJ/molepH: 7.5 T: 2°CAssay Description:The enzyme activities were determined kinetically as the initial rate of cleavage of a peptide p-nitroanilide. Km for enzyme and substrate was determ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Berlex

LigandPNGBDBM17284(2-{[2-(5-carbamimidoyl-2-hydroxyphenoxy)-3,5-diflu...)
Affinity DataKi:  0.110nMAssay Description:Inhibitory potency was measured against human coagulation factor XMore data for this Ligand-Target Pair
TargetCoagulation factor X(Homo sapiens (Human))
Berlex

LigandPNGBDBM17284(2-{[2-(5-carbamimidoyl-2-hydroxyphenoxy)-3,5-diflu...)
Affinity DataKi:  0.110nMAssay Description:In vitro inhibition of human coagulation factor Xa (Xa) in a purified enzyme system.More data for this Ligand-Target Pair
TargetCoagulation factor X(Homo sapiens (Human))
Berlex

LigandPNGBDBM17284(2-{[2-(5-carbamimidoyl-2-hydroxyphenoxy)-3,5-diflu...)
Affinity DataKi:  0.110nM ΔG°:  -56.3kJ/molepH: 7.5 T: 2°CAssay Description:The enzyme activities were determined kinetically as the initial rate of cleavage of a peptide p-nitroanilide. Km for enzyme and substrate was determ...More data for this Ligand-Target Pair
TargetCoagulation factor X(Homo sapiens (Human))
Berlex

LigandPNGBDBM17280(1-[2-(5-carbamimidoyl-2-hydroxyphenoxy)-3,5-difluo...)
Affinity DataKi:  0.110nM ΔG°:  -56.3kJ/molepH: 7.5 T: 2°CAssay Description:The enzyme activities were determined kinetically as the initial rate of cleavage of a peptide p-nitroanilide. Km for enzyme and substrate was determ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Berlex

LigandPNGBDBM50066635((4-{2-(5-Carbamimidoyl-2-hydroxy-phenoxy)-3,5-difl...)
Affinity DataKi:  0.240nMAssay Description:Inhibitory potency was measured against human coagulation factor XMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Berlex

LigandPNGBDBM50066619(({2-(5-Carbamimidoyl-2-hydroxy-phenoxy)-3,5-difluo...)
Affinity DataKi:  0.260nMAssay Description:Inhibitory potency was measured against human coagulation factor XMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Berlex

LigandPNGBDBM17282(7-({6-[(1-ethanimidoylpiperidin-4-yl)oxy]-2-methyl...)
Affinity DataKi:  0.270nM ΔG°:  -54.1kJ/molepH: 7.5 T: 2°CAssay Description:The enzyme activities were determined kinetically as the initial rate of cleavage of a peptide p-nitroanilide. Km for enzyme and substrate was determ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Berlex

LigandPNGBDBM50066634((4-{2-(5-Carbamimidoyl-2-hydroxy-phenoxy)-3,5-difl...)
Affinity DataKi:  0.310nMAssay Description:Inhibitory potency was measured against human coagulation factor XMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Berlex

LigandPNGBDBM50066641((2S,4R)-4-{2-(5-Carbamimidoyl-2-hydroxy-phenoxy)-3...)
Affinity DataKi:  0.330nMAssay Description:Inhibitory potency was measured against human coagulation factor XMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Berlex

LigandPNGBDBM50066623(CHEMBL72318 | {[2-(5-Carbamimidoyl-2-hydroxy-pheno...)
Affinity DataKi:  0.410nMAssay Description:Inhibitory potency was measured against human coagulation factor XMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Berlex

LigandPNGBDBM50066639((2S,4R)-4-{2-(5-Carbamimidoyl-2-hydroxy-phenoxy)-3...)
Affinity DataKi:  0.430nMAssay Description:Inhibitory potency was measured against human coagulation factor XMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Berlex

LigandPNGBDBM50066625(CHEMBL120438 | {4-[2-(5-Carbamimidoyl-2-hydroxy-ph...)
Affinity DataKi:  0.650nMAssay Description:Inhibitory potency was measured against human coagulation factor XMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Berlex

LigandPNGBDBM17277((Z,Z)BABCH | 4-{[(1Z,3Z)-3-[(4-carbamimidoylphenyl...)
Affinity DataKi:  0.660nMAssay Description:Inhibitory potency was measured against human coagulation factor XMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Berlex

LigandPNGBDBM17277((Z,Z)BABCH | 4-{[(1Z,3Z)-3-[(4-carbamimidoylphenyl...)
Affinity DataKi:  0.660nMAssay Description:Compound (isomer) was tested in the absence of light for inhibitory activity against Human Coagulation factor XMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Berlex

LigandPNGBDBM17277((Z,Z)BABCH | 4-{[(1Z,3Z)-3-[(4-carbamimidoylphenyl...)
Affinity DataKi:  0.660nM ΔG°:  -51.9kJ/molepH: 7.5 T: 2°CAssay Description:The enzyme activities were determined kinetically as the initial rate of cleavage of a peptide p-nitroanilide. Km for enzyme and substrate was determ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Berlex

LigandPNGBDBM17277((Z,Z)BABCH | 4-{[(1Z,3Z)-3-[(4-carbamimidoylphenyl...)
Affinity DataKi:  0.660nMAssay Description:In vitro inhibition of human coagulation factor Xa (Xa) in a purified enzyme system.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Berlex

LigandPNGBDBM50066628((2S,4R)-4-[2-(5-Carbamimidoyl-2-hydroxy-phenoxy)-6...)
Affinity DataKi:  0.710nMAssay Description:Inhibitory potency was measured against human coagulation factor XMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Berlex

LigandPNGBDBM50066638(3-[6-(5-Carbamimidoyl-2-hydroxy-phenoxy)-3,5-diflu...)
Affinity DataKi:  1.20nMAssay Description:Inhibitory potency was measured against human coagulation factor XMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Berlex

LigandPNGBDBM17281(7-({2-[(1-ethanimidoylpiperidin-4-yl)oxy]-9H-carba...)
Affinity DataKi:  1.60nM ΔG°:  -49.7kJ/molepH: 7.5 T: 2°CAssay Description:The enzyme activities were determined kinetically as the initial rate of cleavage of a peptide p-nitroanilide. Km for enzyme and substrate was determ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Berlex

LigandPNGBDBM50066637(2-(5-Carbamimidoyl-2-hydroxy-phenoxy)-6-[3-(1-meth...)
Affinity DataKi:  2.40nMAssay Description:Inhibitory potency was measured against human coagulation factor XMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Berlex

LigandPNGBDBM50084175(3,5-Bis-[1-(4-carbamimidoyl-phenyl)-meth-(Z)-ylide...)
Affinity DataKi:  2.5nMAssay Description:In vitro inhibition of human coagulation factor Xa (Xa) in a purified enzyme system.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Berlex

LigandPNGBDBM50084186(2,9-di[1-[4-amino(imino)methylphenyl]-(Z)-methylid...)
Affinity DataKi:  2.80nMAssay Description:In vitro inhibition of human coagulation factor Xa (Xa) in a purified enzyme system.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Berlex

LigandPNGBDBM50066622(2-(5-Carbamimidoyl-2-hydroxy-phenoxy)-6-(3-dimethy...)
Affinity DataKi:  3.90nMAssay Description:Inhibitory potency was measured against human coagulation factor XMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Berlex

LigandPNGBDBM50084174(2,8-di[1-[4-amino(imino)methylphenyl]-(Z)-methylid...)
Affinity DataKi:  4.60nMAssay Description:In vitro inhibition of human coagulation factor Xa (Xa) in a purified enzyme system.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Berlex

LigandPNGBDBM50084192(3,5-Bis-[1-(4-carbamimidoyl-phenyl)-meth-(Z)-ylide...)
Affinity DataKi:  4.80nMAssay Description:In vitro inhibition of human coagulation factor Xa (Xa) in a purified enzyme system.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Berlex

LigandPNGBDBM50084163(2,6-di[1-[4-amino(imino)methylphenyl]-(Z)-methylid...)
Affinity DataKi:  5.20nMAssay Description:In vitro inhibition of human coagulation factor Xa (Xa) in a purified enzyme system.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Berlex

LigandPNGBDBM50066616((Z,Z)-2,7-Bis(4-amidinobenzylidine)cycloheptan-1-o...)
Affinity DataKi:  5.60nMAssay Description:In vitro inhibition of human coagulation factor Xa (Xa) in a purified enzyme system.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Berlex

LigandPNGBDBM50066616((Z,Z)-2,7-Bis(4-amidinobenzylidine)cycloheptan-1-o...)
Affinity DataKi:  5.60nMAssay Description:Compound (isomer) was tested in the absence of light for inhibitory activity against Human Coagulation factor XMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Berlex

LigandPNGBDBM50084170(3,5-Bis-[1-(4-carbamimidoyl-phenyl)-meth-(Z)-ylide...)
Affinity DataKi:  6.90nMAssay Description:In vitro inhibition of human coagulation factor Xa (Xa) in a purified enzyme system.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Berlex

LigandPNGBDBM50066636(2-(5-Carbamimidoyl-2-hydroxy-phenoxy)-6-[3-(1-meth...)
Affinity DataKi:  9nMAssay Description:Inhibitory potency was measured against human coagulation factor XMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Berlex

LigandPNGBDBM50081365(3-(5-{3-[(Z)-amino(imino)methyl]phenoxy}-2,4-diflu...)
Affinity DataKi:  12nMAssay Description:Inhibitory constant of the compound against Coagulation factor Xa (factor Xa)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Berlex

LigandPNGBDBM50084164(2-[1-[4-amino(imino)methylphenyl]-(Z)-methylidene]...)
Affinity DataKi:  12nMAssay Description:In vitro inhibition of human coagulation factor Xa (Xa) in a purified enzyme system.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Berlex

LigandPNGBDBM17278(3-{[6-(3-carbamimidoylphenoxy)-3,5-difluoro-4-meth...)
Affinity DataKi:  13nMAssay Description:Inhibitory potency was measured against human coagulation factor XMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Berlex

LigandPNGBDBM17278(3-{[6-(3-carbamimidoylphenoxy)-3,5-difluoro-4-meth...)
Affinity DataKi:  14nM ΔG°:  -44.4kJ/molepH: 7.5 T: 2°CAssay Description:The enzyme activities were determined kinetically as the initial rate of cleavage of a peptide p-nitroanilide. Km for enzyme and substrate was determ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Berlex

LigandPNGBDBM50066627(3-[6-(2-Amino-5-carbamimidoyl-phenoxy)-3,5-difluor...)
Affinity DataKi:  14nMAssay Description:Inhibitory potency was measured against human coagulation factor XMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine protease 1(Bos taurus (bovine))
Berlex Biosciences

Curated by ChEMBL
LigandPNGBDBM50084160(2-[1-[4-amino(imino)methylphenyl]-(E)-methylidene]...)
Affinity DataKi:  15nMAssay Description:In vitro inhibition of bovine trypsin(Trp).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Berlex

LigandPNGBDBM50084176(2,6-di[1-[4-amino(imino)methylphenyl]-(Z)-methylid...)
Affinity DataKi:  18nMAssay Description:In vitro inhibition of human coagulation factor Xa (Xa) in a purified enzyme system.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine protease 1(Bos taurus (bovine))
Berlex Biosciences

Curated by ChEMBL
LigandPNGBDBM17282(7-({6-[(1-ethanimidoylpiperidin-4-yl)oxy]-2-methyl...)
Affinity DataKi:  18nM ΔG°:  -43.8kJ/molepH: 7.5 T: 2°CAssay Description:The enzyme activities were determined kinetically as the initial rate of cleavage of a peptide p-nitroanilide. Km for enzyme and substrate was determ...More data for this Ligand-Target Pair
TargetCoagulation factor X(Homo sapiens (Human))
Berlex

LigandPNGBDBM50084177(2-[1-[4-amino(imino)methylphenyl]-(Z)-methylidene]...)
Affinity DataKi:  18nMAssay Description:In vitro inhibition of human coagulation factor Xa (Xa) in a purified enzyme system.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Berlex

LigandPNGBDBM17283((2S)-3-(7-carbamimidoylnaphthalen-2-yl)-2-(4-{[(3S...)
Affinity DataKi:  20nM ΔG°:  -43.5kJ/molepH: 7.5 T: 2°CAssay Description:The enzyme activities were determined kinetically as the initial rate of cleavage of a peptide p-nitroanilide. Km for enzyme and substrate was determ...More data for this Ligand-Target Pair
TargetSerine protease 1(Bos taurus (bovine))
Berlex Biosciences

Curated by ChEMBL
LigandPNGBDBM50084175(3,5-Bis-[1-(4-carbamimidoyl-phenyl)-meth-(Z)-ylide...)
Affinity DataKi:  20nMAssay Description:In vitro inhibition of bovine trypsin(Trp).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Berlex

LigandPNGBDBM50066640(3-{6-[3-amino(imino)methylphenoxy]-3,5-difluoro-2-...)
Affinity DataKi:  24nMAssay Description:Inhibitory potency was measured against human coagulation factor XMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Berlex

LigandPNGBDBM50066617(2-(5-Carbamimidoyl-2-hydroxy-phenoxy)-6-(3-imidazo...)
Affinity DataKi:  26nMAssay Description:Inhibitory potency was measured against human coagulation factor XMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine protease 1(Bos taurus (bovine))
Berlex Biosciences

Curated by ChEMBL
LigandPNGBDBM50066615((E,Z)-2,7-Bis(4-amidinobenzylidine)cycloheptan-1-o...)
Affinity DataKi:  29nMAssay Description:Compound (isomer) was tested in the absence of light for inhibitory activity against trypsin.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine protease 1(Bos taurus (bovine))
Berlex Biosciences

Curated by ChEMBL
LigandPNGBDBM50066615((E,Z)-2,7-Bis(4-amidinobenzylidine)cycloheptan-1-o...)
Affinity DataKi:  29nMAssay Description:In vitro inhibition of bovine trypsin(Trp).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine protease 1(Bos taurus (bovine))
Berlex Biosciences

Curated by ChEMBL
LigandPNGBDBM50084191(2-[1-[4-amino(imino)methylphenyl]-(E)-methylidene]...)
Affinity DataKi:  30nMAssay Description:In vitro inhibition of bovine trypsin(Trp).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine protease 1(Bos taurus (bovine))
Berlex Biosciences

Curated by ChEMBL
LigandPNGBDBM50084164(2-[1-[4-amino(imino)methylphenyl]-(Z)-methylidene]...)
Affinity DataKi:  30nMAssay Description:In vitro inhibition of bovine trypsin(Trp).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine protease 1(Bos taurus (bovine))
Berlex Biosciences

Curated by ChEMBL
LigandPNGBDBM17277((Z,Z)BABCH | 4-{[(1Z,3Z)-3-[(4-carbamimidoylphenyl...)
Affinity DataKi:  33nMAssay Description:In vitro inhibition of bovine trypsin(Trp).More data for this Ligand-Target Pair
TargetSerine protease 1(Bos taurus (bovine))
Berlex Biosciences

Curated by ChEMBL
LigandPNGBDBM17277((Z,Z)BABCH | 4-{[(1Z,3Z)-3-[(4-carbamimidoylphenyl...)
Affinity DataKi:  33nMAssay Description:Compound (isomer) was tested in the absence of light for inhibitory activity against trypsin.More data for this Ligand-Target Pair
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