Reaction Details Report a problem with these data
Target
Coagulation factor X
Ligand
BDBM50084177
Substrate
n/a
Meas. Tech.
ChEMBL_49303 (CHEMBL661584)
Ki
18±n/a nM
Citation
 Guilford, WJ; Shaw, KJ; Dallas, JL; Koovakkat, S; Lee, W; Liang, A; Light, DR; McCarrick, MA; Whitlow, M; Ye, B; Morrissey, MM Synthesis, characterization, and structure-activity relationships of amidine-substituted (bis)benzylidene-cycloketone olefin isomers as potent and selective factor Xa inhibitors. J Med Chem 42:5415-25 (2000) [PubMed]  Article 
Target
Name:
Coagulation factor X
Synonyms:
Activated coagulation factor X (FXa) | Activated factor Xa heavy chain | Coagulation factor X precursor | Coagulation factor Xa | F10 | FA10_HUMAN | Factor X heavy chain | Factor X light chain | Factor Xa | Stuart factor | Stuart-Prower factor
Type:
Enzyme
Mol. Mass.:
54726.60
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
488
Sequence:
MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK
  
Inhibitor
Name:
BDBM50084177
Synonyms:
2-[1-[4-amino(imino)methylphenyl]-(Z)-methylidene]-7-[1-[4-dimethylamino(imino)methylphenyl]-(Z)-methylidene]-1-cycloheptanone | CHEMBL356466
Type:
Small organic molecule
Emp. Form.:
C25H28N4O
Mol. Mass.:
400.516
SMILES:
CN(C)C(=N)c1ccc(\C=C2\CCCC\C(=C\c3ccc(cc3)C(N)=N)C2=O)cc1
Structure:
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