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Found 142 with Last Name = 'linton' and Initial = 'o'
TargetGlucocorticoid receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM18627((10S,11S,14S,15S,17R)-17-[4-(dimethylamino)phenyl]...)
Affinity DataKi:  1nMAssay Description:Antagonist activity at glucocorticoid receptor expressed in human A549 cells assessed as inhibition of corticoid-induced transcription by glucocortic...More data for this Ligand-Target Pair
TargetGlucocorticoid receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50203582((8S,11R,13S,14S,17S)-11-(4-(diphenylphosphoryl)phe...)
Affinity DataKi:  3nMAssay Description:Antagonist activity at glucocorticoid receptor expressed in human A549 cells assessed as inhibition of corticoid-induced transcription by glucocortic...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50203580(CHEMBL250751 | diethyl 4-((8S,11R,13S,14S,17S)-17-...)
Affinity DataKi:  9nMAssay Description:Antagonist activity at glucocorticoid receptor expressed in human A549 cells assessed as inhibition of corticoid-induced transcription by glucocortic...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50203579(CHEMBL250750 | diethyl 4-((8S,11R,13S,14S,17R)-17-...)
Affinity DataKi:  10nMAssay Description:Antagonist activity at glucocorticoid receptor expressed in human A549 cells assessed as inhibition of corticoid-induced transcription by glucocortic...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50203577((8S,11R,13S,14S,17R)-17-allyl-11-(4-(diphenylphosp...)
Affinity DataKi:  10nMAssay Description:Antagonist activity at glucocorticoid receptor expressed in human A549 cells assessed as inhibition of corticoid-induced transcription by glucocortic...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50203584((8S,11R,13S,14S,17S)-11-(4-(diphenylphosphoryl)phe...)
Affinity DataKi:  20nMAssay Description:Antagonist activity at glucocorticoid receptor expressed in human A549 cells assessed as inhibition of corticoid-induced transcription by glucocortic...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50203586(CHEMBL400047 | diethyl {4-[(2R,10'S,11'S,15'S,17'R...)
Affinity DataKi:  56.3nMAssay Description:Antagonist activity at glucocorticoid receptor expressed in human A549 cells assessed as inhibition of corticoid-induced transcription by glucocortic...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50203578(CHEMBL413806 | ethyl methyl({4-[(2R,10'S,11'S,15'S...)
Affinity DataKi:  59.8nMAssay Description:Antagonist activity at glucocorticoid receptor expressed in human A549 cells assessed as inhibition of corticoid-induced transcription by glucocortic...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50203583(CHEMBL250949 | ethoxy({4-[(2R,10'S,11'S,15'S,17'R)...)
Affinity DataKi: >3.00E+3nMAssay Description:Antagonist activity at glucocorticoid receptor expressed in human A549 cells assessed as inhibition of corticoid-induced transcription by glucocortic...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50203581(CHEMBL401477 | methyl({4-[(2R,10'S,11'S,15'S,17'R)...)
Affinity DataKi: >3.00E+3nMAssay Description:Antagonist activity at glucocorticoid receptor expressed in human A549 cells assessed as inhibition of corticoid-induced transcription by glucocortic...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProgesterone receptor(Homo sapiens (Human))
Rti International

Curated by ChEMBL
LigandPNGBDBM18627((10S,11S,14S,15S,17R)-17-[4-(dimethylamino)phenyl]...)
Affinity DataIC50:  0.0540nMAssay Description:Antagonist activity at progesterone receptor expressed in human T47D cells assessed as inhibition of promegestone-induced alkaline phosphatase activi...More data for this Ligand-Target Pair
TargetProgesterone receptor(Homo sapiens (Human))
Rti International

Curated by ChEMBL
LigandPNGBDBM50206106((8S,11R,13S,14R)-11-(4-dimethylamino-phenyl)-17-(4...)
Affinity DataIC50:  0.270nMAssay Description:Antagonist activity at human progesterone receptor assessed as inhibition of alkaline phosphatase activity in human T47D cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProgesterone receptor(Homo sapiens (Human))
Rti International

Curated by ChEMBL
LigandPNGBDBM50295639((1R,3S,3aR,3bS,10R)-10-(4-Dimethylamino-phenyl)-1-...)
Affinity DataIC50:  0.300nMAssay Description:Antagonist activity at progesterone receptor in human T47D cells assessed as inhibition of progesterone-induced alkaline phosphatase activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProgesterone receptor(Homo sapiens (Human))
Rti International

Curated by ChEMBL
LigandPNGBDBM50222089((3S,10'S,11'S,15'S,17'R)-17'-(4-acetylphenyl)-5-et...)
Affinity DataIC50:  0.340nMAssay Description:Antagonist activity at progesterone receptor expressed in human T47D cells assessed as inhibition of promegestone-induced alkaline phosphatase activi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProgesterone receptor(Homo sapiens (Human))
Rti International

Curated by ChEMBL
LigandPNGBDBM50222091((3S,10'S,11'S,15'S,17'R)-17'-(4-acetylphenyl)-5,15...)
Affinity DataIC50:  0.590nMAssay Description:Antagonist activity at progesterone receptor expressed in human T47D cells assessed as inhibition of promegestone-induced alkaline phosphatase activi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProgesterone receptor(Homo sapiens (Human))
Rti International

Curated by ChEMBL
LigandPNGBDBM50206114((8S,11R,13S,14R,17S)-17-(4-chloro-phenylethynyl)-1...)
Affinity DataIC50:  0.610nMAssay Description:Antagonist activity at human progesterone receptor assessed as inhibition of alkaline phosphatase activity in human T47D cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProgesterone receptor(Homo sapiens (Human))
Rti International

Curated by ChEMBL
LigandPNGBDBM50222086((3S,10'S,11'S,15'S,17'R)-17'-[4-(dimethylamino)phe...)
Affinity DataIC50:  0.630nMAssay Description:Antagonist activity at progesterone receptor expressed in human T47D cells assessed as inhibition of promegestone-induced alkaline phosphatase activi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProgesterone receptor(Homo sapiens (Human))
Rti International

Curated by ChEMBL
LigandPNGBDBM50206108((8S,11R,13S,14R,17S)-11-(4-dimethylamino-phenyl)-1...)
Affinity DataIC50:  0.75nMAssay Description:Antagonist activity at human progesterone receptor assessed as inhibition of alkaline phosphatase activity in human T47D cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProgesterone receptor(Homo sapiens (Human))
Rti International

Curated by ChEMBL
LigandPNGBDBM50206097((8S,11R,13S,14R,17S)-17-(3,5-difluoro-phenylethyny...)
Affinity DataIC50:  0.910nMAssay Description:Antagonist activity at human progesterone receptor assessed as inhibition of alkaline phosphatase activity in human T47D cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProgesterone receptor(Homo sapiens (Human))
Rti International

Curated by ChEMBL
LigandPNGBDBM50206109((8S,11R,13S,14R,17S)-17-(4-bromo-phenylethynyl)-11...)
Affinity DataIC50:  0.940nMAssay Description:Antagonist activity at human progesterone receptor assessed as inhibition of alkaline phosphatase activity in human T47D cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProgesterone receptor(Homo sapiens (Human))
Rti International

Curated by ChEMBL
LigandPNGBDBM50222092((3S,10'S,11'S,15'S,17'R)-17'-[4-(dimethylamino)phe...)
Affinity DataIC50:  0.980nMAssay Description:Antagonist activity at progesterone receptor expressed in human T47D cells assessed as inhibition of promegestone-induced alkaline phosphatase activi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProgesterone receptor(Homo sapiens (Human))
Rti International

Curated by ChEMBL
LigandPNGBDBM50295646((1'S,2R,2'S,6'R,9'R)-9'-[4-(dimethylamino)phenyl]-...)
Affinity DataIC50:  1nMAssay Description:Antagonist activity at progesterone receptor in human T47D cells assessed as inhibition of progesterone-induced alkaline phosphatase activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProgesterone receptor(Homo sapiens (Human))
Rti International

Curated by ChEMBL
LigandPNGBDBM50222088((3S,10'S,11'S,15'S,17'R)-5-ethyl-17'-(3-fluoro-4-m...)
Affinity DataIC50:  1nMAssay Description:Antagonist activity at progesterone receptor expressed in human T47D cells assessed as inhibition of promegestone-induced alkaline phosphatase activi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProgesterone receptor(Homo sapiens (Human))
Rti International

Curated by ChEMBL
LigandPNGBDBM50206101((8S,11R,13S,14R,17S)-11-(4-dimethylamino-phenyl)-1...)
Affinity DataIC50:  1nMAssay Description:Antagonist activity at human progesterone receptor assessed as inhibition of alkaline phosphatase activity in human T47D cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProgesterone receptor(Homo sapiens (Human))
Rti International

Curated by ChEMBL
LigandPNGBDBM50206098((8S,11R,13S,14R,17S)-17-(2-chloro-phenylethynyl)-1...)
Affinity DataIC50:  1.10nMAssay Description:Antagonist activity at human progesterone receptor assessed as inhibition of alkaline phosphatase activity in human T47D cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProgesterone receptor(Homo sapiens (Human))
Rti International

Curated by ChEMBL
LigandPNGBDBM50206100((8S,11R,13S,14R,17S)-11-(4-dimethylamino-phenyl)-1...)
Affinity DataIC50:  1.40nMAssay Description:Antagonist activity at human progesterone receptor assessed as inhibition of alkaline phosphatase activity in human T47D cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProgesterone receptor(Homo sapiens (Human))
Rti International

Curated by ChEMBL
LigandPNGBDBM18627((10S,11S,14S,15S,17R)-17-[4-(dimethylamino)phenyl]...)
Affinity DataIC50:  1.40nMAssay Description:Antagonist activity at progesterone receptor in human T47D cells assessed as inhibition of progesterone-induced alkaline phosphatase activityMore data for this Ligand-Target Pair
TargetProgesterone receptor(Homo sapiens (Human))
Rti International

Curated by ChEMBL
LigandPNGBDBM18627((10S,11S,14S,15S,17R)-17-[4-(dimethylamino)phenyl]...)
Affinity DataIC50:  1.40nMAssay Description:Antagonist activity at human progesterone receptor assessed as inhibition of alkaline phosphatase activity in human T47D cellsMore data for this Ligand-Target Pair
TargetProgesterone receptor(Homo sapiens (Human))
Rti International

Curated by ChEMBL
LigandPNGBDBM50200660((8S,11R,13S,14R,17S)-11-(4-Dimethylamino-phenyl)-1...)
Affinity DataIC50:  1.40nMAssay Description:Antagonist activity at progesterone receptor in human T47D cells assessed as inhibition of progesterone-induced alkaline phosphatase activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProgesterone receptor(Homo sapiens (Human))
Rti International

Curated by ChEMBL
LigandPNGBDBM50200660((8S,11R,13S,14R,17S)-11-(4-Dimethylamino-phenyl)-1...)
Affinity DataIC50:  1.40nMAssay Description:Antagonist activity at human progesterone receptor assessed as inhibition of alkaline phosphatase activity in human T47D cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProgesterone receptor(Homo sapiens (Human))
Rti International

Curated by ChEMBL
LigandPNGBDBM18627((10S,11S,14S,15S,17R)-17-[4-(dimethylamino)phenyl]...)
Affinity DataIC50:  1.40nMAssay Description:Antagonist activity at progesterone receptor in human T47D cells assessed as inhibition of progesterone-induced alkaline phosphatase activityMore data for this Ligand-Target Pair
TargetGlucocorticoid receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM18627((10S,11S,14S,15S,17R)-17-[4-(dimethylamino)phenyl]...)
Affinity DataIC50:  1.60nMAssay Description:Antagonist activity at human glucocorticoid receptor assessed as inhibition of corticoid-induced transcription in human A549 cells by GRE-linked luci...More data for this Ligand-Target Pair
TargetGlucocorticoid receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM18627((10S,11S,14S,15S,17R)-17-[4-(dimethylamino)phenyl]...)
Affinity DataIC50:  1.60nMAssay Description:Antagonist activity at glucocorticoid receptor in human A549 cells assessed as inhibition of corticoid-induced transcription after 16 hrs by glucocor...More data for this Ligand-Target Pair
TargetGlucocorticoid receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM18627((10S,11S,14S,15S,17R)-17-[4-(dimethylamino)phenyl]...)
Affinity DataIC50:  1.60nMAssay Description:Antagonist activity at glucocorticoid receptor in human A549 cells assessed as inhibition of corticoid-induced GRE-linked luciferase reporter gene ac...More data for this Ligand-Target Pair
TargetProgesterone receptor(Homo sapiens (Human))
Rti International

Curated by ChEMBL
LigandPNGBDBM50203578(CHEMBL413806 | ethyl methyl({4-[(2R,10'S,11'S,15'S...)
Affinity DataIC50:  1.60nMAssay Description:Antagonist activity at progesterone receptor expressed in human T47 cells assessed as blockade of progesterone-induced alkaline phosphatase activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProgesterone receptor(Homo sapiens (Human))
Rti International

Curated by ChEMBL
LigandPNGBDBM50206115((8S,11R,13S,14R,17S)-11-(4-dimethylamino-phenyl)-1...)
Affinity DataIC50:  1.60nMAssay Description:Antagonist activity at human progesterone receptor assessed as inhibition of alkaline phosphatase activity in human T47D cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProgesterone receptor(Homo sapiens (Human))
Rti International

Curated by ChEMBL
LigandPNGBDBM50206107((8S,11R,13S,14R,17S)-11-(4-dimethylamino-phenyl)-1...)
Affinity DataIC50:  1.60nMAssay Description:Antagonist activity at human progesterone receptor assessed as inhibition of alkaline phosphatase activity in human T47D cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProgesterone receptor(Homo sapiens (Human))
Rti International

Curated by ChEMBL
LigandPNGBDBM18627((10S,11S,14S,15S,17R)-17-[4-(dimethylamino)phenyl]...)
Affinity DataIC50:  2.60nMAssay Description:Antagonist activity at progesterone receptor expressed in human T47 cells assessed as blockade of progesterone-induced alkaline phosphatase activityMore data for this Ligand-Target Pair
TargetProgesterone receptor(Homo sapiens (Human))
Rti International

Curated by ChEMBL
LigandPNGBDBM50206102((8S,11R,13S,14R,17S)-11-(4-dimethylamino-phenyl)-1...)
Affinity DataIC50:  2.70nMAssay Description:Antagonist activity at human progesterone receptor assessed as inhibition of alkaline phosphatase activity in human T47D cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProgesterone receptor(Homo sapiens (Human))
Rti International

Curated by ChEMBL
LigandPNGBDBM50206111((8S,11R,13S,14R,17S)-11-(4-dimethylamino-phenyl)-1...)
Affinity DataIC50:  2.90nMAssay Description:Antagonist activity at human progesterone receptor assessed as inhibition of alkaline phosphatase activity in human T47D cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProgesterone receptor(Homo sapiens (Human))
Rti International

Curated by ChEMBL
LigandPNGBDBM50206104((8S,11R,13S,14R,17S)-11-(4-dimethylamino-phenyl)-1...)
Affinity DataIC50:  3.20nMAssay Description:Antagonist activity at human progesterone receptor assessed as inhibition of alkaline phosphatase activity in human T47D cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProgesterone receptor(Homo sapiens (Human))
Rti International

Curated by ChEMBL
LigandPNGBDBM50206117((8S,11R,13S,14R,17S)-11-(4-dimethylamino-phenyl)-1...)
Affinity DataIC50:  3.20nMAssay Description:Antagonist activity at human progesterone receptor assessed as inhibition of alkaline phosphatase activity in human T47D cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProgesterone receptor(Homo sapiens (Human))
Rti International

Curated by ChEMBL
LigandPNGBDBM50295637((1R,3S,3aR,3bS,10R)-1-Hydroxy-1-isopropenyl-12a-me...)
Affinity DataIC50:  3.30nMAssay Description:Antagonist activity at progesterone receptor in human T47D cells assessed as inhibition of progesterone-induced alkaline phosphatase activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProgesterone receptor(Homo sapiens (Human))
Rti International

Curated by ChEMBL
LigandPNGBDBM50206113(4-[(8S,11R,13S,14R,17S)-11-(4-dimethylamino-phenyl...)
Affinity DataIC50:  3.70nMAssay Description:Antagonist activity at human progesterone receptor assessed as inhibition of alkaline phosphatase activity in human T47D cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProgesterone receptor(Homo sapiens (Human))
Rti International

Curated by ChEMBL
LigandPNGBDBM50222087((3S,10'S,11'S,15'S,17'R)-17'-(3-fluoro-4-methoxyph...)
Affinity DataIC50:  4.60nMAssay Description:Antagonist activity at progesterone receptor expressed in human T47D cells assessed as inhibition of promegestone-induced alkaline phosphatase activi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProgesterone receptor(Homo sapiens (Human))
Rti International

Curated by ChEMBL
LigandPNGBDBM50206099((8S,11R,13S,14R,17S)-11-(4-dimethylamino-phenyl)-1...)
Affinity DataIC50:  5.80nMAssay Description:Antagonist activity at human progesterone receptor assessed as inhibition of alkaline phosphatase activity in human T47D cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM18627((10S,11S,14S,15S,17R)-17-[4-(dimethylamino)phenyl]...)
Affinity DataIC50:  6nMAssay Description:Antagonist activity at glucocorticoid receptor expressed in A549 cells assessed as inhibition of corticoid-induced gene transcription by luciferase r...More data for this Ligand-Target Pair
TargetGlucocorticoid receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50295638((1S,3S,3aR,3bS,10R)-1-Hydroxy-12a-methyl-10-(4-met...)
Affinity DataIC50:  7nMAssay Description:Antagonist activity at glucocorticoid receptor in human A549 cells assessed as inhibition of corticoid-induced transcription after 16 hrs by glucocor...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProgesterone receptor(Homo sapiens (Human))
Rti International

Curated by ChEMBL
LigandPNGBDBM50295645((1'S,2R,2'S,6'R,9'R)-9'-(4-methoxyphenyl)-6'-methy...)
Affinity DataIC50:  7nMAssay Description:Antagonist activity at progesterone receptor in human T47D cells assessed as inhibition of progesterone-induced alkaline phosphatase activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProgesterone receptor(Homo sapiens (Human))
Rti International

Curated by ChEMBL
LigandPNGBDBM50200655((8S,11R,13S,14R,17S)-11-(4-Dimethylamino-phenyl)-1...)
Affinity DataIC50:  7.5nMAssay Description:Antagonist activity at human progesterone receptor assessed as inhibition of alkaline phosphatase activity in human T47D cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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