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Found 2230 with Last Name = 'liotta' and Initial = 'dc'
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Emory University

Curated by ChEMBL
LigandPNGBDBM50304090(CHEMBL594615 | N-(4-(3-(2-(3,4-Dichlorophenylamino...)
Affinity DataKi:  14nMAssay Description:Displacement of [3H]astemizole from human recombinant ERG expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 2B(Rattus norvegicus (Rat))
Emory University

Curated by ChEMBL
LigandPNGBDBM50304085(CHEMBL607819 | N-(2-(3,4-Dichlorophenylamino)ethyl...)
Affinity DataKi:  119nMAssay Description:Displacement of [3H]ifenprodil form NR2B receptor in Wistar rat cerebral cortex membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Emory University

Curated by ChEMBL
LigandPNGBDBM50304088(CHEMBL596046 | N-(4-(2-(2-(3,4-Dichlorophenylamino...)
Affinity DataKi:  300nMAssay Description:Displacement of [3H]astemizole from human recombinant ERG expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 2B(Rattus norvegicus (Rat))
Emory University

Curated by ChEMBL
LigandPNGBDBM50304087(CHEMBL596036 | N-(4-(2-(3-(3,4-Dichlorophenyl)-2-o...)
Affinity DataKi:  300nMAssay Description:Displacement of [3H]ifenprodil form NR2B receptor in Wistar rat cerebral cortex membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Emory University

Curated by ChEMBL
LigandPNGBDBM168618(US9079852, Table F, Compound 3)
Affinity DataKi:  553nMAssay Description:Compounds were evaluated for binding to the human ether-a-go-go potassium channel (hERG) expressed in HEK293 cells by displacement of 3[H]-astemizole...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGlutamate receptor ionotropic, NMDA 2B(Rattus norvegicus (Rat))
Emory University

Curated by ChEMBL
LigandPNGBDBM50304086(CHEMBL594417 | N-(4-(2-(4-(3,4-Dichlorophenyl)pipe...)
Affinity DataKi:  817nMAssay Description:Displacement of [3H]ifenprodil form NR2B receptor in Wistar rat cerebral cortex membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Emory University

Curated by ChEMBL
LigandPNGBDBM168620(US9079852, Table F, Compound 5)
Affinity DataKi:  1.00E+3nMAssay Description:Compounds were evaluated for binding to the human ether-a-go-go potassium channel (hERG) expressed in HEK293 cells by displacement of 3[H]-astemizole...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Emory University

Curated by ChEMBL
LigandPNGBDBM168617(US9079852, Table F, Compound 2)
Affinity DataKi:  1.60E+3nMAssay Description:Compounds were evaluated for binding to the human ether-a-go-go potassium channel (hERG) expressed in HEK293 cells by displacement of 3[H]-astemizole...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Emory University

Curated by ChEMBL
LigandPNGBDBM50304091(CHEMBL609857 | N-(3,4-Dichlorocinnamyl)-3-(4-(meth...)
Affinity DataKi:  3.00E+3nMAssay Description:Displacement of [3H]astemizole from human recombinant ERG expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Emory University

Curated by ChEMBL
LigandPNGBDBM50304089(CHEMBL595318 | N-(2-(3,4-Dichlorophenylamino)ethyl...)
Affinity DataKi:  4.62E+3nMAssay Description:Displacement of [3H]astemizole from human recombinant ERG expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Emory University

Curated by ChEMBL
LigandPNGBDBM168626(US9079852, Table F, Compound 11)
Affinity DataKi:  5.00E+3nMAssay Description:Compounds were evaluated for binding to the human ether-a-go-go potassium channel (hERG) expressed in HEK293 cells by displacement of 3[H]-astemizole...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Emory University

Curated by ChEMBL
LigandPNGBDBM168622(US9079852, Table F, Compound 7)
Affinity DataKi:  7.50E+3nMAssay Description:Compounds were evaluated for binding to the human ether-a-go-go potassium channel (hERG) expressed in HEK293 cells by displacement of 3[H]-astemizole...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Emory University

Curated by ChEMBL
LigandPNGBDBM168621(US9079852, Table F, Compound 6)
Affinity DataKi:  7.50E+3nMAssay Description:Compounds were evaluated for binding to the human ether-a-go-go potassium channel (hERG) expressed in HEK293 cells by displacement of 3[H]-astemizole...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Emory University

Curated by ChEMBL
LigandPNGBDBM168625(US9079852, Table F, Compound 10)
Affinity DataKi:  7.50E+3nMAssay Description:Compounds were evaluated for binding to the human ether-a-go-go potassium channel (hERG) expressed in HEK293 cells by displacement of 3[H]-astemizole...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Emory University

Curated by ChEMBL
LigandPNGBDBM168624(US9079852, Table F, Compound 9)
Affinity DataKi:  1.00E+4nMAssay Description:Compounds were evaluated for binding to the human ether-a-go-go potassium channel (hERG) expressed in HEK293 cells by displacement of 3[H]-astemizole...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHistamine H2 receptor(Homo sapiens (Human))
Emory University

Curated by ChEMBL
LigandPNGBDBM50440057(CHEMBL2426097)
Affinity DataKi: >1.00E+4nMAssay Description:Inhibition of histamine H2 receptor (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Emory University

Curated by ChEMBL
LigandPNGBDBM168619(US9079852, Table F, Compound 4)
Affinity DataKi:  1.30E+4nMAssay Description:Compounds were evaluated for binding to the human ether-a-go-go potassium channel (hERG) expressed in HEK293 cells by displacement of 3[H]-astemizole...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Emory University

Curated by ChEMBL
LigandPNGBDBM168616(US9079852, Table F, Compound 1)
Affinity DataKi:  3.90E+4nMAssay Description:Compounds were evaluated for binding to the human ether-a-go-go potassium channel (hERG) expressed in HEK293 cells by displacement of 3[H]-astemizole...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTyrosine-protein kinase ABL1(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL
LigandPNGBDBM50538441(CHEMBL4632471)
Affinity DataIC50:  0.300nMAssay Description:Inhibition of human ABL1 assessed as residual activity using EAIYAAPFAKKK as substrate by [gamma-33P]-ATP assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ABL1(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL
LigandPNGBDBM50322535(3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N...)
Affinity DataIC50:  0.310nMAssay Description:Inhibition of human ABL1 assessed as residual activity using EAIYAAPFAKKK as substrate by [gamma-33P]-ATP assayMore data for this Ligand-Target Pair
TargetTyrosine-protein kinase ABL1(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL
LigandPNGBDBM50538440(CHEMBL4642144)
Affinity DataIC50:  0.390nMAssay Description:Inhibition of human ABL1 assessed as residual activity using EAIYAAPFAKKK as substrate by [gamma-33P]-ATP assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetC-X-C chemokine receptor type 4(Homo sapiens (Human))
Emory University

Curated by ChEMBL
LigandPNGBDBM50225416(CHEMBL393882 | TN-14003)
Affinity DataIC50:  0.600nMAssay Description:Inhibition of CXCR4 in MDA-MB-231 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ABL1(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL
LigandPNGBDBM50538439(CHEMBL4637502)
Affinity DataIC50:  0.650nMAssay Description:Inhibition of human ABL1 assessed as residual activity using EAIYAAPFAKKK as substrate by [gamma-33P]-ATP assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetC-X-C chemokine receptor type 4(Homo sapiens (Human))
Emory University

Curated by ChEMBL
LigandPNGBDBM50347490(CHEMBL1802333)
Affinity DataIC50:  0.800nMAssay Description:Antagonist activity at human CXCR4 expressed in human U87 cells expressing CD4 assessed as inhibition of CXCL12-induced cAMP production pretreated fo...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-X-C chemokine receptor type 4(Homo sapiens (Human))
Emory University

Curated by ChEMBL
LigandPNGBDBM50443545(CHEMBL3091683)
Affinity DataIC50:  1nMAssay Description:Antagonist activity at CXCR4 in human Chem-1 cells assessed as inhibition of SDF-1alpha-mediated calcium flux preincubated for 10 mins by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ABL1(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL
LigandPNGBDBM50538442(CHEMBL4638981)
Affinity DataIC50:  1.30nMAssay Description:Inhibition of ABL1 (unknown origin) assessed as residual activity incubated for 5 mins in presence of [gamma-33ATP] by scintillation counting based r...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetC-X-C chemokine receptor type 4(Homo sapiens (Human))
Emory University

Curated by ChEMBL
LigandPNGBDBM50225415(CHEMBL237830 | N,N'-di-2-pyridinyl-1,4-benzenedime...)
Affinity DataIC50:  1.80nMAssay Description:Antagonist activity at human CXCR4 expressed in human U87 cells expressing CD4 assessed as inhibition of CXCL12-induced cAMP production pretreated fo...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-derived growth factor receptor alpha(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL
LigandPNGBDBM50538442(CHEMBL4638981)
Affinity DataIC50:  2nMAssay Description:Inhibition of PDGFRalpha (unknown origin) assessed as residual activity incubated for 5 mins in presence of [gamma-33ATP] by scintillation counting b...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetC-X-C chemokine receptor type 4(Homo sapiens (Human))
Emory University

Curated by ChEMBL
LigandPNGBDBM50125954(CHEMBL3627858)
Affinity DataIC50:  2nMAssay Description:Displacement of [125I]-SDF-1 from CXCR4 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-X-C chemokine receptor type 4(Homo sapiens (Human))
Emory University

Curated by ChEMBL
LigandPNGBDBM50125950(CHEMBL3627793)
Affinity DataIC50:  2nMAssay Description:Displacement of [125I]-SDF-1 from CXCR4 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-X-C chemokine receptor type 4(Homo sapiens (Human))
Emory University

Curated by ChEMBL
LigandPNGBDBM50125958(CHEMBL3627862)
Affinity DataIC50:  2nMAssay Description:Displacement of [125I]-SDF-1 from CXCR4 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-derived growth factor receptor alpha(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL
LigandPNGBDBM50538438(CHEMBL4640297)
Affinity DataIC50:  2.10nMAssay Description:Inhibition of PDGFRalpha (unknown origin) assessed as residual activity incubated for 5 mins in presence of [gamma-33ATP] by scintillation counting b...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetC-X-C chemokine receptor type 4(Homo sapiens (Human))
Emory University

Curated by ChEMBL
LigandPNGBDBM50449948(CHEMBL4173977)
Affinity DataIC50:  2.90nMAssay Description:Antagonist activity at CXCR4 in human CCRF-CEM cells assessed as inhibition of SDF-1alpha-induced calcium release preincubated for 25 mins followed b...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetC-X-C chemokine receptor type 4(Homo sapiens (Human))
Emory University

Curated by ChEMBL
LigandPNGBDBM50443541(CHEMBL3091687)
Affinity DataIC50:  3nMAssay Description:Antagonist activity at CXCR4 in human Chem-1 cells assessed as inhibition of SDF-1alpha-mediated calcium flux preincubated for 10 mins by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Homo sapiens (Human))
Imperial College

Curated by ChEMBL
LigandPNGBDBM50347388(CHEMBL1234833)
Affinity DataIC50:  3nMAssay Description:Inhibition of CDK2/cyclinE assessed as amount of ATP released by luciferase activity based PKLight assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-X-C chemokine receptor type 4(Homo sapiens (Human))
Emory University

Curated by ChEMBL
LigandPNGBDBM50443543(CHEMBL3091685)
Affinity DataIC50:  3nMAssay Description:Antagonist activity at CXCR4 in human Chem-1 cells assessed as inhibition of SDF-1alpha-mediated calcium flux preincubated for 10 mins by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ABL1(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL
LigandPNGBDBM50538438(CHEMBL4640297)
Affinity DataIC50:  3.10nMAssay Description:Inhibition of ABL1 (unknown origin) assessed as residual activity incubated for 5 mins in presence of [gamma-33ATP] by scintillation counting based r...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetC-X-C chemokine receptor type 4(Homo sapiens (Human))
Emory University

Curated by ChEMBL
LigandPNGBDBM50449934(CHEMBL4162609)
Affinity DataIC50:  3.60nMAssay Description:Antagonist activity at CXCR4 in human CCRF-CEM cells assessed as inhibition of SDF-1alpha-induced calcium release preincubated for 25 mins followed b...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetC-X-C chemokine receptor type 4(Homo sapiens (Human))
Emory University

Curated by ChEMBL
LigandPNGBDBM50270038(CHEMBL4062223)
Affinity DataIC50:  3.70nMAssay Description:Antagonist activity at human CXCR4 in CCRF-CEM cells assessed as decrease in SDF-1alpha stimulated Ca2+ flux preincubated for 25 mins followed by SDF...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetC-X-C chemokine receptor type 4(Homo sapiens (Human))
Emory University

Curated by ChEMBL
LigandPNGBDBM50443544(CHEMBL3091684)
Affinity DataIC50:  4nMAssay Description:Antagonist activity at CXCR4 in human Chem-1 cells assessed as inhibition of SDF-1alpha-mediated calcium flux preincubated for 10 mins by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-X-C chemokine receptor type 4(Homo sapiens (Human))
Emory University

Curated by ChEMBL
LigandPNGBDBM50449947(CHEMBL4159234)
Affinity DataIC50:  4.5nMAssay Description:Antagonist activity at CXCR4 in human CCRF-CEM cells assessed as inhibition of SDF-1alpha-induced calcium release preincubated for 25 mins followed b...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetC-X-C chemokine receptor type 4(Homo sapiens (Human))
Emory University

Curated by ChEMBL
LigandPNGBDBM50443541(CHEMBL3091687)
Affinity DataIC50:  5nMAssay Description:Antagonist activity at CXCR4 in human MAGI-CCR5 cells assessed as inhibition of HIV-1 3B entry after 2 to 6 days by beta-galactosidase reporter gene ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-X-C chemokine receptor type 4(Homo sapiens (Human))
Emory University

Curated by ChEMBL
LigandPNGBDBM50315305((S)-N-((1H-benzo[d]imidazol-2-yl)methyl)-N-(4-amin...)
Affinity DataIC50:  5nMAssay Description:Antagonist activity at CXCR4 in human CCRF-CEM cells assessed as inhibition of SDS1alpha-induced calcium flux pretreated for 25 mins followed by SDS1...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-X-C chemokine receptor type 4(Homo sapiens (Human))
Emory University

Curated by ChEMBL
LigandPNGBDBM50315305((S)-N-((1H-benzo[d]imidazol-2-yl)methyl)-N-(4-amin...)
Affinity DataIC50:  5.20nMAssay Description:Antagonist activity at CXCR4 receptor in human CCRF-CEM cells assessed as inhibition of SDF-1alpha-induced calcium release preincubated for 25 mins f...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-X-C chemokine receptor type 4(Homo sapiens (Human))
Emory University

Curated by ChEMBL
LigandPNGBDBM50347491(CHEMBL1802329)
Affinity DataIC50:  5.40nMAssay Description:Antagonist activity at human CXCR4 expressed in human U87 cells expressing CD4 assessed as inhibition of CXCL12-induced cAMP production pretreated fo...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-X-C chemokine receptor type 4(Mus musculus)
Emory University

Curated by ChEMBL
LigandPNGBDBM50270016(CHEMBL4070320)
Affinity DataIC50:  5.5nMAssay Description:Antagonist activity at mouse CXCR4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ABL1(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL
LigandPNGBDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)
Affinity DataIC50:  5.60nMAssay Description:Inhibition of human ABL1 assessed as residual activity using EAIYAAPFAKKK as substrate by [gamma-33P]-ATP assayMore data for this Ligand-Target Pair
TargetC-X-C chemokine receptor type 4(Homo sapiens (Human))
Emory University

Curated by ChEMBL
LigandPNGBDBM50125951(CHEMBL3627794)
Affinity DataIC50:  6nMAssay Description:Displacement of [125I]-SDF-1 from CXCR4 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-X-C chemokine receptor type 4(Homo sapiens (Human))
Emory University

Curated by ChEMBL
LigandPNGBDBM50286298(CHEMBL4171469)
Affinity DataIC50:  6nMAssay Description:Antagonist activity at CXCR4 in human CCRF-CEM cells assessed as inhibition of SDF1alpha-induced calcium flux pretreated for 25 mins followed by SDF1...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-X-C chemokine receptor type 4(Homo sapiens (Human))
Emory University

Curated by ChEMBL
LigandPNGBDBM50443541(CHEMBL3091687)
Affinity DataIC50:  6nMAssay Description:Antagonist activity at CXCR4 in human CCRF-CEM cells assessed as inhibition of SDS1alpha-induced calcium flux pretreated for 25 mins followed by SDS1...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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