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Found 178 with Last Name = 'lotarski' and Initial = 'sm'
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50084137(2-Methyl-6-(phenylethynyl)pyridine | 2-Methyl-6-ph...)
Affinity DataKi:  5.70nMAssay Description:Displacement of [3H]MPEP from mGlu5 receptor in rat brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50240692(CHEMBL4078588)
Affinity DataKi:  8nMAssay Description:Displacement of [3H]PT-1284 human muscarinic acetylcholine receptor M1 expressed in CHO cell membranes after 90 mins scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50240694(CHEMBL4067722)
Affinity DataKi:  16nMAssay Description:Displacement of [3H]PT-1284 human muscarinic acetylcholine receptor M1 expressed in CHO cell membranes after 90 mins scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50240693(CHEMBL4097569)
Affinity DataKi:  19nMAssay Description:Displacement of [3H]PT-1284 human muscarinic acetylcholine receptor M1 expressed in CHO cell membranes after 90 mins scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50216746(3-fluoro-5-(2-methylquinolin-7-yl)benzonitrile | C...)
Affinity DataKi:  22nMAssay Description:Displacement of [3H]MPEP from mGlu5 receptor in rat brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50135213(CHEMBL3747016)
Affinity DataKi:  40nMAssay Description:In vitro inhibitory activity against [3H]- (+)-3-PPP binding to Sigma opioid receptor in guinea pig brain membrane homogenatesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50210964(3-(2-methylquinolin-7-yl)benzonitrile | CHEMBL2447...)
Affinity DataKi:  72nMAssay Description:Displacement of [3H]MPEP from mGlu5 receptor in rat brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50084137(2-Methyl-6-(phenylethynyl)pyridine | 2-Methyl-6-ph...)
Affinity DataIC50:  0.200nMAssay Description:Activity at rat mGlu5 receptor expressed in CHO cells assessed as inhibition of quisqualate-stimulated calcium mobilization by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50216746(3-fluoro-5-(2-methylquinolin-7-yl)benzonitrile | C...)
Affinity DataIC50:  0.800nMAssay Description:Activity at rat mGlu5 receptor expressed in CHO cells assessed as inhibition of quisqualate-stimulated calcium mobilization by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50216762(3-chloro-5-(2-methylquinolin-7-yl)benzonitrile | C...)
Affinity DataIC50:  1.40nMAssay Description:Activity at rat mGlu5 receptor expressed in CHO cells assessed as inhibition of quisqualate-stimulated calcium mobilization by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50216758(3-methyl-5-(2-methylquinolin-7-yl)benzonitrile | C...)
Affinity DataIC50:  1.60nMAssay Description:Activity at rat mGlu5 receptor expressed in CHO cells assessed as inhibition of quisqualate-stimulated calcium mobilization by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50216749(3-(methoxymethyl)-5-(2-methylquinolin-7-yl)benzoni...)
Affinity DataIC50:  2nMAssay Description:Activity at rat mGlu5 receptor expressed in CHO cells assessed as inhibition of quisqualate-stimulated calcium mobilization by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50216750(5-(2-methylquinolin-7-yl)isophthalonitrile | CHEMB...)
Affinity DataIC50:  2nMAssay Description:Activity at rat mGlu5 receptor expressed in CHO cells assessed as inhibition of quisqualate-stimulated calcium mobilization by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50216761(3-methoxy-5-(2-methylquinolin-7-yl)benzonitrile | ...)
Affinity DataIC50:  2.40nMAssay Description:Activity at rat mGlu5 receptor expressed in CHO cells assessed as inhibition of quisqualate-stimulated calcium mobilization by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50210964(3-(2-methylquinolin-7-yl)benzonitrile | CHEMBL2447...)
Affinity DataIC50:  7.70nMAssay Description:Activity at rat mGlu5 receptor expressed in CHO cells assessed as inhibition of quisqualate-stimulated calcium mobilization by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50216741(3-bromo-5-(2-methylquinolin-7-yl)benzonitrile | CH...)
Affinity DataIC50:  13nMAssay Description:Activity at rat mGlu5 receptor expressed in CHO cells assessed as inhibition of quisqualate-stimulated calcium mobilization by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50216770(3-ethoxy-5-(2-methylquinolin-7-yl)benzonitrile | C...)
Affinity DataIC50:  17nMAssay Description:Activity at rat mGlu5 receptor expressed in CHO cells assessed as inhibition of quisqualate-stimulated calcium mobilization by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50216745(5-(2-methylquinolin-7-yl)nicotinonitrile | CHEMBL2...)
Affinity DataIC50:  23nMAssay Description:Activity at rat mGlu5 receptor expressed in CHO cells assessed as inhibition of quisqualate-stimulated calcium mobilization by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVoltage-dependent N-type calcium channel subunit alpha-1B(Homo sapiens (Human))
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50080037(Benzoic acid 4-((S)-2-{(S)-2-[(4-tert-butyl-benzyl...)
Affinity DataIC50:  36nMAssay Description:Inhibition of N-type calcium channels in IMR-32 human neuroblastoma cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50080153((1-Aminomethyl-cyclohexyl)-acetic acid | 2-(1-(ami...)
Affinity DataIC50:  70nMAssay Description:Displacement of [3H]gabapentin from alpha-2delta calcium channel in pig brain membraneMore data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50216752(3-(ethylthio)-5-(2-methylquinolin-7-yl)benzonitril...)
Affinity DataIC50:  72nMAssay Description:Activity at rat mGlu5 receptor expressed in CHO cells assessed as inhibition of quisqualate-stimulated calcium mobilization by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50216766(3-(2-methylquinolin-7-yl)-5-(trifluoromethoxy)benz...)
Affinity DataIC50:  75nMAssay Description:Activity at rat mGlu5 receptor expressed in CHO cells assessed as inhibition of quisqualate-stimulated calcium mobilization by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50216768(3-(2-methoxyethoxy)-5-(2-methylquinolin-7-yl)benzo...)
Affinity DataIC50:  82nMAssay Description:Activity at rat mGlu5 receptor expressed in CHO cells assessed as inhibition of quisqualate-stimulated calcium mobilization by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50168499((1-((1H-tetrazol-5-yl)methyl)cycloheptyl)methanami...)
Affinity DataIC50:  100nMAssay Description:Displacement of [3H]gabapentin from alpha-2delta calcium channel in pig brain membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50212317((1-((1H-tetrazol-5-yl)methyl)cyclohexyl)methanamin...)
Affinity DataIC50:  108nMAssay Description:Displacement of [3H]gabapentin from alpha-2delta calcium channel in pig brain membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVoltage-dependent N-type calcium channel subunit alpha-1B(Homo sapiens (Human))
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50080046(Benzoic acid 4-((S)-2-{(S)-2-[(4-bromo-benzyl)-met...)
Affinity DataIC50:  130nMAssay Description:Inhibition of N-type calcium channels in IMR-32 human neuroblastoma cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVoltage-dependent N-type calcium channel subunit alpha-1B(Homo sapiens (Human))
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50080305(Azepane-1-carboxylic acid (1-{4-[[4-(3,3-dimethyl-...)
Affinity DataIC50:  180nMAssay Description:Inhibition of N-type Voltage Sensitive Calcium Channel (VSCC) using IMR-32 assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVoltage-dependent N-type calcium channel subunit alpha-1B(Homo sapiens (Human))
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50080309(Azepane-1-carboxylic acid (1-{4-[(4-benzyloxy-phen...)
Affinity DataIC50:  190nMAssay Description:Inhibition of N-type Voltage Sensitive Calcium Channel (VSCC) using IMR-32 assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVoltage-dependent N-type calcium channel subunit alpha-1B(Homo sapiens (Human))
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50076117(Benzoic acid 4-{(S)-2-tert-butylcarbamoyl-2-[(S)-2...)
Affinity DataIC50:  200nMAssay Description:In vitro inhibitory activity against N-type calcium channel in the IMR-32 human neuroblastoma cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVoltage-dependent N-type calcium channel subunit alpha-1B(Homo sapiens (Human))
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50080035(Benzoic acid 4-((S)-2-tert-butylcarbamoyl-2-{(S)-2...)
Affinity DataIC50:  230nMAssay Description:Inhibition of N-type calcium channels in IMR-32 human neuroblastoma cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVoltage-dependent N-type calcium channel subunit alpha-1B(Homo sapiens (Human))
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50081687(Azepane-1-carboxylic acid ((S)-1-{2-[(4-benzyloxy-...)
Affinity DataIC50:  260nMAssay Description:Inhibition of N-type calcium channels in IMR32 human neuroblastoma cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVoltage-dependent N-type calcium channel subunit alpha-1B(Homo sapiens (Human))
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50076108(Benzoic acid 4-{(S)-2-tert-butylcarbamoyl-2-[(S)-2...)
Affinity DataIC50:  280nMAssay Description:In vitro inhibitory activity against N-type calcium channel in the IMR-32 human neuroblastoma cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVoltage-dependent N-type calcium channel subunit alpha-1B(Homo sapiens (Human))
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50080041(Benzoic acid 4-((S)-2-tert-butylcarbamoyl-2-{(S)-2...)
Affinity DataIC50:  280nMAssay Description:Inhibition of N-type calcium channels in IMR-32 human neuroblastoma cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVoltage-dependent N-type calcium channel subunit alpha-1B(Homo sapiens (Human))
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50080308(Azepane-1-carboxylic acid (1-{4-[[4-(cyclohexylmet...)
Affinity DataIC50:  290nMAssay Description:Inhibition of N-type Voltage Sensitive Calcium Channel (VSCC) using IMR-32 assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50216767(3-isopropoxy-5-(2-methylquinolin-7-yl)benzonitrile...)
Affinity DataIC50:  310nMAssay Description:Activity at rat mGlu5 receptor expressed in CHO cells assessed as inhibition of quisqualate-stimulated calcium mobilization by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVoltage-dependent N-type calcium channel subunit alpha-1B(Homo sapiens (Human))
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50076112(Benzoic acid 4-((S)-2-tert-butylcarbamoyl-2-{(S)-4...)
Affinity DataIC50:  320nMAssay Description:In vitro inhibitory activity against N-type calcium channel in the IMR-32 human neuroblastoma cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVoltage-dependent N-type calcium channel subunit alpha-1B(Homo sapiens (Human))
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50076106(Benzoic acid 4-((S)-2-{(S)-2-[(azepane-1-carbonyl)...)
Affinity DataIC50:  320nMAssay Description:Inhibition of N-type calcium channels in IMR32 human neuroblastoma cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVoltage-dependent N-type calcium channel subunit alpha-1B(Homo sapiens (Human))
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50076106(Benzoic acid 4-((S)-2-{(S)-2-[(azepane-1-carbonyl)...)
Affinity DataIC50:  320nMAssay Description:In vitro inhibitory activity against N-type calcium channel in the IMR-32 human neuroblastoma cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVoltage-dependent N-type calcium channel subunit alpha-1B(Homo sapiens (Human))
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50080314(Azepane-1-carboxylic acid ((S)-1-{4-[(4-benzyloxy-...)
Affinity DataIC50:  340nMAssay Description:Inhibition of N-type calcium channels in IMR32 human neuroblastoma cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVoltage-dependent N-type calcium channel subunit alpha-1B(Homo sapiens (Human))
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50080314(Azepane-1-carboxylic acid ((S)-1-{4-[(4-benzyloxy-...)
Affinity DataIC50:  340nMAssay Description:Inhibition of N-type Voltage Sensitive Calcium Channel (VSCC) using IMR-32 assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50216737(3-hydroxy-5-(2-methylquinolin-7-yl)benzonitrile | ...)
Affinity DataIC50:  360nMAssay Description:Activity at rat mGlu5 receptor expressed in CHO cells assessed as inhibition of quisqualate-stimulated calcium mobilization by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVoltage-dependent N-type calcium channel subunit alpha-1B(Homo sapiens (Human))
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50080040(Benzoic acid 4-{(S)-2-[(S)-2-(benzyl-methyl-amino)...)
Affinity DataIC50:  360nMAssay Description:Inhibition of N-type calcium channels in IMR-32 human neuroblastoma cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVoltage-dependent N-type calcium channel subunit alpha-1B(Homo sapiens (Human))
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50076110(Benzoic acid 4-{(S)-2-tert-butylcarbamoyl-2-[(S)-2...)
Affinity DataIC50:  380nMAssay Description:In vitro inhibitory activity against N-type calcium channel in the IMR-32 human neuroblastoma cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVoltage-dependent N-type calcium channel subunit alpha-1B(Homo sapiens (Human))
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50076101(Benzoic acid 4-((S)-2-tert-butylcarbamoyl-2-{(S)-2...)
Affinity DataIC50:  400nMAssay Description:In vitro inhibitory activity against N-type calcium channel in the IMR-32 human neuroblastoma cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVoltage-dependent N-type calcium channel subunit alpha-1B(Homo sapiens (Human))
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50080317(Azepane-1-carboxylic acid (1-{4-[(4-benzylamino-ph...)
Affinity DataIC50:  400nMAssay Description:Inhibition of N-type Voltage Sensitive Calcium Channel (VSCC) using IMR-32 assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50216769(2-(3-(2-methylquinolin-7-yl)phenyl)acetonitrile | ...)
Affinity DataIC50:  430nMAssay Description:Activity at rat mGlu5 receptor expressed in CHO cells assessed as inhibition of quisqualate-stimulated calcium mobilization by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVoltage-dependent N-type calcium channel subunit alpha-1B(Homo sapiens (Human))
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50081692(Azepane-1-carboxylic acid ((S)-1-{4-[benzyl-(4-ben...)
Affinity DataIC50:  430nMAssay Description:Inhibition of N-type calcium channels in IMR32 human neuroblastoma cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVoltage-dependent N-type calcium channel subunit alpha-1B(Homo sapiens (Human))
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50081689((S)-1-{4-[(4-Benzyloxy-phenyl)-(3-methyl-but-2-eny...)
Affinity DataIC50:  480nMAssay Description:Inhibition of N-type calcium channels in IMR32 human neuroblastoma cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVoltage-dependent N-type calcium channel subunit alpha-1B(Homo sapiens (Human))
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50080316(Azepane-1-carboxylic acid (1-{4-[[4-(4-dimethylami...)
Affinity DataIC50:  490nMAssay Description:Inhibition of N-type Voltage Sensitive Calcium Channel (VSCC) using IMR-32 assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVoltage-dependent N-type calcium channel subunit alpha-1B(Homo sapiens (Human))
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50080036(Benzoic acid 4-((S)-2-tert-butylcarbamoyl-2-{(S)-2...)
Affinity DataIC50:  500nMAssay Description:Inhibition of N-type calcium channels in IMR-32 human neuroblastoma cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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