Affinity DataKi: 0nMAssay Description:Inhibitory activity was measured on pig kidney Aminopeptidase N (activity for A+B stereoisomer)More data for this Ligand-Target Pair
Affinity DataKi: 0nMAssay Description:Inhibitory activity was measured on pig kidney Aminopeptidase N (activity for C+D stereoisomer)More data for this Ligand-Target Pair
Affinity DataKi: >0nMAssay Description:Inhibitory activity was measured on Aminopeptidase B using Arg p.NA as substrateMore data for this Ligand-Target Pair
Affinity DataKi: 0nMAssay Description:Inhibitory activity was measured on Aminopeptidase using GluNA as substrateMore data for this Ligand-Target Pair
Affinity DataKi: >0nMAssay Description:Inhibitory activity was measured on Aminopeptidase B using Arg p.NA as substrateMore data for this Ligand-Target Pair
Affinity DataKi: 0nMAssay Description:Inhibitory activity was measured on pig kidney Aminopeptidase N (activity for C+D stereoisomer)More data for this Ligand-Target Pair
TargetGamma-aminobutyric acid receptor subunit alpha-5(Homo sapiens (Human))
Roche Palo Alto
US Patent
Roche Palo Alto
US Patent
Affinity DataKi: 0.100nM ΔG°: -53.1kJ/molepH: 7.5 T: 2°CAssay Description:Radioligand binding assays were carried out in a volume of 200 mL (96-well plates) which contained 100 mL of cell memebranes, [3H]flumazenil at a con...More data for this Ligand-Target Pair
TargetGamma-aminobutyric acid receptor subunit alpha-5(Homo sapiens (Human))
Roche Palo Alto
US Patent
Roche Palo Alto
US Patent
Affinity DataKi: 0.200nM ΔG°: -51.5kJ/molepH: 7.5 T: 2°CAssay Description:Radioligand binding assays were carried out in a volume of 200 mL (96-well plates) which contained 100 mL of cell memebranes, [3H]flumazenil at a con...More data for this Ligand-Target Pair
TargetGamma-aminobutyric acid receptor subunit alpha-5(Homo sapiens (Human))
Roche Palo Alto
US Patent
Roche Palo Alto
US Patent
Affinity DataKi: 0.300nM ΔG°: -50.5kJ/molepH: 7.5 T: 2°CAssay Description:Radioligand binding assays were carried out in a volume of 200 mL (96-well plates) which contained 100 mL of cell memebranes, [3H]flumazenil at a con...More data for this Ligand-Target Pair
TargetGamma-aminobutyric acid receptor subunit alpha-5(Homo sapiens (Human))
Roche Palo Alto
US Patent
Roche Palo Alto
US Patent
Affinity DataKi: 0.300nM ΔG°: -50.5kJ/molepH: 7.5 T: 2°CAssay Description:Radioligand binding assays were carried out in a volume of 200 mL (96-well plates) which contained 100 mL of cell memebranes, [3H]flumazenil at a con...More data for this Ligand-Target Pair
TargetGamma-aminobutyric acid receptor subunit alpha-5(Homo sapiens (Human))
Roche Palo Alto
US Patent
Roche Palo Alto
US Patent
Affinity DataKi: 0.300nM ΔG°: -50.5kJ/molepH: 7.5 T: 2°CAssay Description:Radioligand binding assays were carried out in a volume of 200 mL (96-well plates) which contained 100 mL of cell memebranes, [3H]flumazenil at a con...More data for this Ligand-Target Pair
TargetGamma-aminobutyric acid receptor subunit alpha-5(Homo sapiens (Human))
Roche Palo Alto
US Patent
Roche Palo Alto
US Patent
Affinity DataKi: 0.300nM ΔG°: -50.5kJ/molepH: 7.5 T: 2°CAssay Description:Radioligand binding assays were carried out in a volume of 200 mL (96-well plates) which contained 100 mL of cell memebranes, [3H]flumazenil at a con...More data for this Ligand-Target Pair
TargetGamma-aminobutyric acid receptor subunit alpha-5(Homo sapiens (Human))
Roche Palo Alto
US Patent
Roche Palo Alto
US Patent
Affinity DataKi: 0.300nM ΔG°: -50.5kJ/molepH: 7.5 T: 2°CAssay Description:Radioligand binding assays were carried out in a volume of 200 mL (96-well plates) which contained 100 mL of cell memebranes, [3H]flumazenil at a con...More data for this Ligand-Target Pair
TargetGamma-aminobutyric acid receptor subunit alpha-5(Homo sapiens (Human))
Roche Palo Alto
US Patent
Roche Palo Alto
US Patent
Affinity DataKi: 0.300nM ΔG°: -50.5kJ/molepH: 7.5 T: 2°CAssay Description:Radioligand binding assays were carried out in a volume of 200 mL (96-well plates) which contained 100 mL of cell memebranes, [3H]flumazenil at a con...More data for this Ligand-Target Pair
TargetGamma-aminobutyric acid receptor subunit alpha-5(Homo sapiens (Human))
Roche Palo Alto
US Patent
Roche Palo Alto
US Patent
Affinity DataKi: 0.400nM ΔG°: -49.9kJ/molepH: 7.5 T: 2°CAssay Description:Radioligand binding assays were carried out in a volume of 200 mL (96-well plates) which contained 100 mL of cell memebranes, [3H]flumazenil at a con...More data for this Ligand-Target Pair
TargetGamma-aminobutyric acid receptor subunit alpha-5(Homo sapiens (Human))
Roche Palo Alto
US Patent
Roche Palo Alto
US Patent
Affinity DataKi: 0.400nM ΔG°: -49.9kJ/molepH: 7.5 T: 2°CAssay Description:Radioligand binding assays were carried out in a volume of 200 mL (96-well plates) which contained 100 mL of cell memebranes, [3H]flumazenil at a con...More data for this Ligand-Target Pair
Affinity DataKi: 0.400nMAssay Description:Inhibition of SERT (unknown origin)More data for this Ligand-Target Pair
TargetGamma-aminobutyric acid receptor subunit alpha-5(Homo sapiens (Human))
Roche Palo Alto
US Patent
Roche Palo Alto
US Patent
Affinity DataKi: 0.400nM ΔG°: -49.9kJ/molepH: 7.5 T: 2°CAssay Description:Radioligand binding assays were carried out in a volume of 200 mL (96-well plates) which contained 100 mL of cell memebranes, [3H]flumazenil at a con...More data for this Ligand-Target Pair
TargetGamma-aminobutyric acid receptor subunit alpha-5(Homo sapiens (Human))
Roche Palo Alto
US Patent
Roche Palo Alto
US Patent
Affinity DataKi: 0.400nM ΔG°: -49.9kJ/molepH: 7.5 T: 2°CAssay Description:Radioligand binding assays were carried out in a volume of 200 mL (96-well plates) which contained 100 mL of cell memebranes, [3H]flumazenil at a con...More data for this Ligand-Target Pair
TargetGamma-aminobutyric acid receptor subunit alpha-5(Homo sapiens (Human))
Roche Palo Alto
US Patent
Roche Palo Alto
US Patent
Affinity DataKi: 0.400nM ΔG°: -49.9kJ/molepH: 7.5 T: 2°CAssay Description:Radioligand binding assays were carried out in a volume of 200 mL (96-well plates) which contained 100 mL of cell memebranes, [3H]flumazenil at a con...More data for this Ligand-Target Pair
TargetGamma-aminobutyric acid receptor subunit alpha-5(Homo sapiens (Human))
Roche Palo Alto
US Patent
Roche Palo Alto
US Patent
Affinity DataKi: 0.5nM ΔG°: -49.3kJ/molepH: 7.5 T: 2°CAssay Description:Radioligand binding assays were carried out in a volume of 200 mL (96-well plates) which contained 100 mL of cell memebranes, [3H]flumazenil at a con...More data for this Ligand-Target Pair
TargetGamma-aminobutyric acid receptor subunit alpha-5(Homo sapiens (Human))
Roche Palo Alto
US Patent
Roche Palo Alto
US Patent
Affinity DataKi: 0.5nM ΔG°: -49.3kJ/molepH: 7.5 T: 2°CAssay Description:Radioligand binding assays were carried out in a volume of 200 mL (96-well plates) which contained 100 mL of cell memebranes, [3H]flumazenil at a con...More data for this Ligand-Target Pair
TargetGamma-aminobutyric acid receptor subunit alpha-5(Homo sapiens (Human))
Roche Palo Alto
US Patent
Roche Palo Alto
US Patent
Affinity DataKi: 0.5nM ΔG°: -49.3kJ/molepH: 7.5 T: 2°CAssay Description:Radioligand binding assays were carried out in a volume of 200 mL (96-well plates) which contained 100 mL of cell memebranes, [3H]flumazenil at a con...More data for this Ligand-Target Pair
TargetGamma-aminobutyric acid receptor subunit alpha-5(Homo sapiens (Human))
Roche Palo Alto
US Patent
Roche Palo Alto
US Patent
Affinity DataKi: 0.5nM ΔG°: -49.3kJ/molepH: 7.5 T: 2°CAssay Description:Radioligand binding assays were carried out in a volume of 200 mL (96-well plates) which contained 100 mL of cell memebranes, [3H]flumazenil at a con...More data for this Ligand-Target Pair
TargetGamma-aminobutyric acid receptor subunit alpha-5(Homo sapiens (Human))
Roche Palo Alto
US Patent
Roche Palo Alto
US Patent
Affinity DataKi: 0.5nM ΔG°: -49.3kJ/molepH: 7.5 T: 2°CAssay Description:Radioligand binding assays were carried out in a volume of 200 mL (96-well plates) which contained 100 mL of cell memebranes, [3H]flumazenil at a con...More data for this Ligand-Target Pair
TargetGamma-aminobutyric acid receptor subunit alpha-5(Homo sapiens (Human))
Roche Palo Alto
US Patent
Roche Palo Alto
US Patent
Affinity DataKi: 0.600nM ΔG°: -48.9kJ/molepH: 7.5 T: 2°CAssay Description:Radioligand binding assays were carried out in a volume of 200 mL (96-well plates) which contained 100 mL of cell memebranes, [3H]flumazenil at a con...More data for this Ligand-Target Pair
TargetGamma-aminobutyric acid receptor subunit alpha-5(Homo sapiens (Human))
Roche Palo Alto
US Patent
Roche Palo Alto
US Patent
Affinity DataKi: 0.600nM ΔG°: -48.9kJ/molepH: 7.5 T: 2°CAssay Description:Radioligand binding assays were carried out in a volume of 200 mL (96-well plates) which contained 100 mL of cell memebranes, [3H]flumazenil at a con...More data for this Ligand-Target Pair
TargetGamma-aminobutyric acid receptor subunit alpha-5(Homo sapiens (Human))
Roche Palo Alto
US Patent
Roche Palo Alto
US Patent
Affinity DataKi: 0.600nM ΔG°: -48.9kJ/molepH: 7.5 T: 2°CAssay Description:Radioligand binding assays were carried out in a volume of 200 mL (96-well plates) which contained 100 mL of cell memebranes, [3H]flumazenil at a con...More data for this Ligand-Target Pair
TargetGamma-aminobutyric acid receptor subunit alpha-5(Homo sapiens (Human))
Roche Palo Alto
US Patent
Roche Palo Alto
US Patent
Affinity DataKi: 0.600nM ΔG°: -48.9kJ/molepH: 7.5 T: 2°CAssay Description:Radioligand binding assays were carried out in a volume of 200 mL (96-well plates) which contained 100 mL of cell memebranes, [3H]flumazenil at a con...More data for this Ligand-Target Pair
TargetGamma-aminobutyric acid receptor subunit alpha-5(Homo sapiens (Human))
Roche Palo Alto
US Patent
Roche Palo Alto
US Patent
Affinity DataKi: 0.600nM ΔG°: -48.9kJ/molepH: 7.5 T: 2°CAssay Description:Radioligand binding assays were carried out in a volume of 200 mL (96-well plates) which contained 100 mL of cell memebranes, [3H]flumazenil at a con...More data for this Ligand-Target Pair
TargetGamma-aminobutyric acid receptor subunit alpha-5(Homo sapiens (Human))
Roche Palo Alto
US Patent
Roche Palo Alto
US Patent
Affinity DataKi: 0.600nM ΔG°: -48.9kJ/molepH: 7.5 T: 2°CAssay Description:Radioligand binding assays were carried out in a volume of 200 mL (96-well plates) which contained 100 mL of cell memebranes, [3H]flumazenil at a con...More data for this Ligand-Target Pair
TargetGamma-aminobutyric acid receptor subunit alpha-5(Homo sapiens (Human))
Roche Palo Alto
US Patent
Roche Palo Alto
US Patent
Affinity DataKi: 0.600nM ΔG°: -48.9kJ/molepH: 7.5 T: 2°CAssay Description:Radioligand binding assays were carried out in a volume of 200 mL (96-well plates) which contained 100 mL of cell memebranes, [3H]flumazenil at a con...More data for this Ligand-Target Pair
TargetGamma-aminobutyric acid receptor subunit alpha-5(Homo sapiens (Human))
Roche Palo Alto
US Patent
Roche Palo Alto
US Patent
Affinity DataKi: 0.700nM ΔG°: -48.6kJ/molepH: 7.5 T: 2°CAssay Description:Radioligand binding assays were carried out in a volume of 200 mL (96-well plates) which contained 100 mL of cell memebranes, [3H]flumazenil at a con...More data for this Ligand-Target Pair
Affinity DataKi: 0.700nMAssay Description:In vivo inhibitory potency against neutral endopeptidase by displacement of [3H]-HACBOGly binding in mouse kidneyMore data for this Ligand-Target Pair
Affinity DataKi: 0.700nMAssay Description:Inhibition of human recombinant NEP using Suc-Ala-Ala-Phe-AMC as substrate after 30 mins by fluorimetryMore data for this Ligand-Target Pair
TargetGamma-aminobutyric acid receptor subunit alpha-5(Homo sapiens (Human))
Roche Palo Alto
US Patent
Roche Palo Alto
US Patent
Affinity DataKi: 0.700nM ΔG°: -48.6kJ/molepH: 7.5 T: 2°CAssay Description:Radioligand binding assays were carried out in a volume of 200 mL (96-well plates) which contained 100 mL of cell memebranes, [3H]flumazenil at a con...More data for this Ligand-Target Pair
TargetGamma-aminobutyric acid receptor subunit alpha-5(Homo sapiens (Human))
Roche Palo Alto
US Patent
Roche Palo Alto
US Patent
Affinity DataKi: 0.700nM ΔG°: -48.6kJ/molepH: 7.5 T: 2°CAssay Description:Radioligand binding assays were carried out in a volume of 200 mL (96-well plates) which contained 100 mL of cell memebranes, [3H]flumazenil at a con...More data for this Ligand-Target Pair
TargetGamma-aminobutyric acid receptor subunit alpha-5(Homo sapiens (Human))
Roche Palo Alto
US Patent
Roche Palo Alto
US Patent
Affinity DataKi: 0.700nM ΔG°: -48.6kJ/molepH: 7.5 T: 2°CAssay Description:Radioligand binding assays were carried out in a volume of 200 mL (96-well plates) which contained 100 mL of cell memebranes, [3H]flumazenil at a con...More data for this Ligand-Target Pair
Affinity DataKi: 0.700nMAssay Description:In vivo inhibitory potency against neutral endopeptidase by displacement of [3H]-HACBOGly binding in mouse kidneyMore data for this Ligand-Target Pair
TargetGamma-aminobutyric acid receptor subunit alpha-5(Homo sapiens (Human))
Roche Palo Alto
US Patent
Roche Palo Alto
US Patent
Affinity DataKi: 0.700nM ΔG°: -48.6kJ/molepH: 7.5 T: 2°CAssay Description:Radioligand binding assays were carried out in a volume of 200 mL (96-well plates) which contained 100 mL of cell memebranes, [3H]flumazenil at a con...More data for this Ligand-Target Pair
Affinity DataKi: 0.700nM ΔG°: -54.4kJ/molepH: 7.4 T: 2°CAssay Description:NEP was preincubated in black 96-well microplates with or without increasing concentrations of inhibitors. DGPA was added, and the reaction was stopp...More data for this Ligand-Target Pair
Affinity DataKi: 0.700nMAssay Description:In vitro inhibition of Neutral endopeptidase.More data for this Ligand-Target Pair
TargetGamma-aminobutyric acid receptor subunit alpha-5(Homo sapiens (Human))
Roche Palo Alto
US Patent
Roche Palo Alto
US Patent
Affinity DataKi: 0.800nM ΔG°: -48.3kJ/molepH: 7.5 T: 2°CAssay Description:Radioligand binding assays were carried out in a volume of 200 mL (96-well plates) which contained 100 mL of cell memebranes, [3H]flumazenil at a con...More data for this Ligand-Target Pair
TargetGamma-aminobutyric acid receptor subunit alpha-5(Homo sapiens (Human))
Roche Palo Alto
US Patent
Roche Palo Alto
US Patent
Affinity DataKi: 0.800nM ΔG°: -48.3kJ/molepH: 7.5 T: 2°CAssay Description:Radioligand binding assays were carried out in a volume of 200 mL (96-well plates) which contained 100 mL of cell memebranes, [3H]flumazenil at a con...More data for this Ligand-Target Pair
TargetGamma-aminobutyric acid receptor subunit alpha-5(Homo sapiens (Human))
Roche Palo Alto
US Patent
Roche Palo Alto
US Patent
Affinity DataKi: 0.800nM ΔG°: -48.3kJ/molepH: 7.5 T: 2°CAssay Description:Radioligand binding assays were carried out in a volume of 200 mL (96-well plates) which contained 100 mL of cell memebranes, [3H]flumazenil at a con...More data for this Ligand-Target Pair
TargetGamma-aminobutyric acid receptor subunit alpha-5(Homo sapiens (Human))
Roche Palo Alto
US Patent
Roche Palo Alto
US Patent
Affinity DataKi: 0.800nM ΔG°: -48.3kJ/molepH: 7.5 T: 2°CAssay Description:Radioligand binding assays were carried out in a volume of 200 mL (96-well plates) which contained 100 mL of cell memebranes, [3H]flumazenil at a con...More data for this Ligand-Target Pair
TargetGamma-aminobutyric acid receptor subunit alpha-5(Homo sapiens (Human))
Roche Palo Alto
US Patent
Roche Palo Alto
US Patent
Affinity DataKi: 0.800nM ΔG°: -48.3kJ/molepH: 7.5 T: 2°CAssay Description:Radioligand binding assays were carried out in a volume of 200 mL (96-well plates) which contained 100 mL of cell memebranes, [3H]flumazenil at a con...More data for this Ligand-Target Pair