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Found 2967 with Last Name = 'lu' and Initial = 'mc'
TargetGlutamyl aminopeptidase(Sus scrofa)
University Of Paris

Curated by ChEMBL
LigandPNGBDBM50078120((R)-1-{[(S)-2-((S)-1-Carboxy-1-methyl-2-phenyl-eth...)
Affinity DataKi:  0nMAssay Description:Inhibitory activity was measured on pig kidney Aminopeptidase N (activity for A+B stereoisomer)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAminopeptidase N(Sus scrofa (Pig))
University Of Paris

Curated by ChEMBL
LigandPNGBDBM50078120((R)-1-{[(S)-2-((S)-1-Carboxy-1-methyl-2-phenyl-eth...)
Affinity DataKi:  0nMAssay Description:Inhibitory activity was measured on pig kidney Aminopeptidase N (activity for C+D stereoisomer)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAminopeptidase B(Mus musculus)
University Of Paris

Curated by ChEMBL
LigandPNGBDBM50078122((R)-1-{[(S)-2-((S)-1-Carboxy-1-methyl-2-phenyl-eth...)
Affinity DataKi: >0nMAssay Description:Inhibitory activity was measured on Aminopeptidase B using Arg p.NA as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamyl aminopeptidase(Sus scrofa)
University Of Paris

Curated by ChEMBL
LigandPNGBDBM50078122((R)-1-{[(S)-2-((S)-1-Carboxy-1-methyl-2-phenyl-eth...)
Affinity DataKi:  0nMAssay Description:Inhibitory activity was measured on Aminopeptidase using GluNA as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAminopeptidase B(Mus musculus)
University Of Paris

Curated by ChEMBL
LigandPNGBDBM50078120((R)-1-{[(S)-2-((S)-1-Carboxy-1-methyl-2-phenyl-eth...)
Affinity DataKi: >0nMAssay Description:Inhibitory activity was measured on Aminopeptidase B using Arg p.NA as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAminopeptidase N(Sus scrofa (Pig))
University Of Paris

Curated by ChEMBL
LigandPNGBDBM50078122((R)-1-{[(S)-2-((S)-1-Carboxy-1-methyl-2-phenyl-eth...)
Affinity DataKi:  0nMAssay Description:Inhibitory activity was measured on pig kidney Aminopeptidase N (activity for C+D stereoisomer)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGamma-aminobutyric acid receptor subunit alpha-5(Homo sapiens (Human))
Roche Palo Alto

US Patent
LigandPNGBDBM133600(US8846719, 311)
Affinity DataKi:  0.100nM ΔG°:  -53.1kJ/molepH: 7.5 T: 2°CAssay Description:Radioligand binding assays were carried out in a volume of 200 mL (96-well plates) which contained 100 mL of cell memebranes, [3H]flumazenil at a con...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetGamma-aminobutyric acid receptor subunit alpha-5(Homo sapiens (Human))
Roche Palo Alto

US Patent
LigandPNGBDBM133597(US8846719, 308)
Affinity DataKi:  0.200nM ΔG°:  -51.5kJ/molepH: 7.5 T: 2°CAssay Description:Radioligand binding assays were carried out in a volume of 200 mL (96-well plates) which contained 100 mL of cell memebranes, [3H]flumazenil at a con...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM50414600(CHEMBL570317)
Affinity DataKi:  0.251nMAssay Description:Inhibition of SERTMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGamma-aminobutyric acid receptor subunit alpha-5(Homo sapiens (Human))
Roche Palo Alto

US Patent
LigandPNGBDBM10517(US8846719, 302)
Affinity DataKi:  0.300nM ΔG°:  -50.5kJ/molepH: 7.5 T: 2°CAssay Description:Radioligand binding assays were carried out in a volume of 200 mL (96-well plates) which contained 100 mL of cell memebranes, [3H]flumazenil at a con...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetGamma-aminobutyric acid receptor subunit alpha-5(Homo sapiens (Human))
Roche Palo Alto

US Patent
LigandPNGBDBM10484(US11091471, Example RO-301 | US8846719, 301)
Affinity DataKi:  0.300nM ΔG°:  -50.5kJ/molepH: 7.5 T: 2°CAssay Description:Radioligand binding assays were carried out in a volume of 200 mL (96-well plates) which contained 100 mL of cell memebranes, [3H]flumazenil at a con...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetGamma-aminobutyric acid receptor subunit alpha-5(Homo sapiens (Human))
Roche Palo Alto

US Patent
LigandPNGBDBM10467(US8846719, 294)
Affinity DataKi:  0.300nM ΔG°:  -50.5kJ/molepH: 7.5 T: 2°CAssay Description:Radioligand binding assays were carried out in a volume of 200 mL (96-well plates) which contained 100 mL of cell memebranes, [3H]flumazenil at a con...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetGamma-aminobutyric acid receptor subunit alpha-5(Homo sapiens (Human))
Roche Palo Alto

US Patent
LigandPNGBDBM10673(US8846719, 289)
Affinity DataKi:  0.300nM ΔG°:  -50.5kJ/molepH: 7.5 T: 2°CAssay Description:Radioligand binding assays were carried out in a volume of 200 mL (96-well plates) which contained 100 mL of cell memebranes, [3H]flumazenil at a con...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetGamma-aminobutyric acid receptor subunit alpha-5(Homo sapiens (Human))
Roche Palo Alto

US Patent
LigandPNGBDBM10521(US8846719, 303)
Affinity DataKi:  0.300nM ΔG°:  -50.5kJ/molepH: 7.5 T: 2°CAssay Description:Radioligand binding assays were carried out in a volume of 200 mL (96-well plates) which contained 100 mL of cell memebranes, [3H]flumazenil at a con...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetGamma-aminobutyric acid receptor subunit alpha-5(Homo sapiens (Human))
Roche Palo Alto

US Patent
LigandPNGBDBM133596(US8846719, 306)
Affinity DataKi:  0.300nM ΔG°:  -50.5kJ/molepH: 7.5 T: 2°CAssay Description:Radioligand binding assays were carried out in a volume of 200 mL (96-well plates) which contained 100 mL of cell memebranes, [3H]flumazenil at a con...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetGamma-aminobutyric acid receptor subunit alpha-5(Homo sapiens (Human))
Roche Palo Alto

US Patent
LigandPNGBDBM10672(US8846719, 288)
Affinity DataKi:  0.400nM ΔG°:  -49.9kJ/molepH: 7.5 T: 2°CAssay Description:Radioligand binding assays were carried out in a volume of 200 mL (96-well plates) which contained 100 mL of cell memebranes, [3H]flumazenil at a con...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetGamma-aminobutyric acid receptor subunit alpha-5(Homo sapiens (Human))
Roche Palo Alto

US Patent
LigandPNGBDBM10468(US8846719, 295)
Affinity DataKi:  0.400nM ΔG°:  -49.9kJ/molepH: 7.5 T: 2°CAssay Description:Radioligand binding assays were carried out in a volume of 200 mL (96-well plates) which contained 100 mL of cell memebranes, [3H]flumazenil at a con...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM50274953(5-(3-benzylpyrrolidin-3-yl)-1H-indole-2-carbonitri...)
Affinity DataKi:  0.400nMAssay Description:Inhibition of SERT (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGamma-aminobutyric acid receptor subunit alpha-5(Homo sapiens (Human))
Roche Palo Alto

US Patent
LigandPNGBDBM10711(US8846719, 292)
Affinity DataKi:  0.400nM ΔG°:  -49.9kJ/molepH: 7.5 T: 2°CAssay Description:Radioligand binding assays were carried out in a volume of 200 mL (96-well plates) which contained 100 mL of cell memebranes, [3H]flumazenil at a con...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetGamma-aminobutyric acid receptor subunit alpha-5(Homo sapiens (Human))
Roche Palo Alto

US Patent
LigandPNGBDBM133599(US8846719, 310)
Affinity DataKi:  0.400nM ΔG°:  -49.9kJ/molepH: 7.5 T: 2°CAssay Description:Radioligand binding assays were carried out in a volume of 200 mL (96-well plates) which contained 100 mL of cell memebranes, [3H]flumazenil at a con...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetGamma-aminobutyric acid receptor subunit alpha-5(Homo sapiens (Human))
Roche Palo Alto

US Patent
LigandPNGBDBM133578(US8846719, 270)
Affinity DataKi:  0.400nM ΔG°:  -49.9kJ/molepH: 7.5 T: 2°CAssay Description:Radioligand binding assays were carried out in a volume of 200 mL (96-well plates) which contained 100 mL of cell memebranes, [3H]flumazenil at a con...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetGamma-aminobutyric acid receptor subunit alpha-5(Homo sapiens (Human))
Roche Palo Alto

US Patent
LigandPNGBDBM10667(US8846719, 284)
Affinity DataKi:  0.5nM ΔG°:  -49.3kJ/molepH: 7.5 T: 2°CAssay Description:Radioligand binding assays were carried out in a volume of 200 mL (96-well plates) which contained 100 mL of cell memebranes, [3H]flumazenil at a con...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetGamma-aminobutyric acid receptor subunit alpha-5(Homo sapiens (Human))
Roche Palo Alto

US Patent
LigandPNGBDBM133568(US8846719, 260)
Affinity DataKi:  0.5nM ΔG°:  -49.3kJ/molepH: 7.5 T: 2°CAssay Description:Radioligand binding assays were carried out in a volume of 200 mL (96-well plates) which contained 100 mL of cell memebranes, [3H]flumazenil at a con...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetGamma-aminobutyric acid receptor subunit alpha-5(Homo sapiens (Human))
Roche Palo Alto

US Patent
LigandPNGBDBM10483(US8846719, 297)
Affinity DataKi:  0.5nM ΔG°:  -49.3kJ/molepH: 7.5 T: 2°CAssay Description:Radioligand binding assays were carried out in a volume of 200 mL (96-well plates) which contained 100 mL of cell memebranes, [3H]flumazenil at a con...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetGamma-aminobutyric acid receptor subunit alpha-5(Homo sapiens (Human))
Roche Palo Alto

US Patent
LigandPNGBDBM133565(US8846719, 257)
Affinity DataKi:  0.5nM ΔG°:  -49.3kJ/molepH: 7.5 T: 2°CAssay Description:Radioligand binding assays were carried out in a volume of 200 mL (96-well plates) which contained 100 mL of cell memebranes, [3H]flumazenil at a con...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetGamma-aminobutyric acid receptor subunit alpha-5(Homo sapiens (Human))
Roche Palo Alto

US Patent
LigandPNGBDBM133594(US8846719, 299)
Affinity DataKi:  0.5nM ΔG°:  -49.3kJ/molepH: 7.5 T: 2°CAssay Description:Radioligand binding assays were carried out in a volume of 200 mL (96-well plates) which contained 100 mL of cell memebranes, [3H]flumazenil at a con...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM84745(CAS_136434-34-9 | DULOXETINE | LY-248686 | LY24868...)
Affinity DataKi:  0.501nMAssay Description:Inhibition of SERTMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetGamma-aminobutyric acid receptor subunit alpha-5(Homo sapiens (Human))
Roche Palo Alto

US Patent
LigandPNGBDBM133581(US8846719, 273)
Affinity DataKi:  0.600nM ΔG°:  -48.9kJ/molepH: 7.5 T: 2°CAssay Description:Radioligand binding assays were carried out in a volume of 200 mL (96-well plates) which contained 100 mL of cell memebranes, [3H]flumazenil at a con...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetGamma-aminobutyric acid receptor subunit alpha-5(Homo sapiens (Human))
Roche Palo Alto

US Patent
LigandPNGBDBM133598(US8846719, 309)
Affinity DataKi:  0.600nM ΔG°:  -48.9kJ/molepH: 7.5 T: 2°CAssay Description:Radioligand binding assays were carried out in a volume of 200 mL (96-well plates) which contained 100 mL of cell memebranes, [3H]flumazenil at a con...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetGamma-aminobutyric acid receptor subunit alpha-5(Homo sapiens (Human))
Roche Palo Alto

US Patent
LigandPNGBDBM133593(US8846719, 305)
Affinity DataKi:  0.600nM ΔG°:  -48.9kJ/molepH: 7.5 T: 2°CAssay Description:Radioligand binding assays were carried out in a volume of 200 mL (96-well plates) which contained 100 mL of cell memebranes, [3H]flumazenil at a con...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetGamma-aminobutyric acid receptor subunit alpha-5(Homo sapiens (Human))
Roche Palo Alto

US Patent
LigandPNGBDBM133595(US8846719, 298)
Affinity DataKi:  0.600nM ΔG°:  -48.9kJ/molepH: 7.5 T: 2°CAssay Description:Radioligand binding assays were carried out in a volume of 200 mL (96-well plates) which contained 100 mL of cell memebranes, [3H]flumazenil at a con...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetGamma-aminobutyric acid receptor subunit alpha-5(Homo sapiens (Human))
Roche Palo Alto

US Patent
LigandPNGBDBM10677(US8846719, 290)
Affinity DataKi:  0.600nM ΔG°:  -48.9kJ/molepH: 7.5 T: 2°CAssay Description:Radioligand binding assays were carried out in a volume of 200 mL (96-well plates) which contained 100 mL of cell memebranes, [3H]flumazenil at a con...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetGamma-aminobutyric acid receptor subunit alpha-5(Homo sapiens (Human))
Roche Palo Alto

US Patent
LigandPNGBDBM11505(US8846719, 307)
Affinity DataKi:  0.600nM ΔG°:  -48.9kJ/molepH: 7.5 T: 2°CAssay Description:Radioligand binding assays were carried out in a volume of 200 mL (96-well plates) which contained 100 mL of cell memebranes, [3H]flumazenil at a con...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetGamma-aminobutyric acid receptor subunit alpha-5(Homo sapiens (Human))
Roche Palo Alto

US Patent
LigandPNGBDBM133542(US8846719, 234)
Affinity DataKi:  0.600nM ΔG°:  -48.9kJ/molepH: 7.5 T: 2°CAssay Description:Radioligand binding assays were carried out in a volume of 200 mL (96-well plates) which contained 100 mL of cell memebranes, [3H]flumazenil at a con...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetGamma-aminobutyric acid receptor subunit alpha-5(Homo sapiens (Human))
Roche Palo Alto

US Patent
LigandPNGBDBM133507(US8846719, 196)
Affinity DataKi:  0.700nM ΔG°:  -48.6kJ/molepH: 7.5 T: 2°CAssay Description:Radioligand binding assays were carried out in a volume of 200 mL (96-well plates) which contained 100 mL of cell memebranes, [3H]flumazenil at a con...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetNeprilysin(Homo sapiens (Human))
University Of Paris

Curated by ChEMBL
LigandPNGBDBM50407297(CHEMBL2052008)
Affinity DataKi:  0.700nMAssay Description:In vivo inhibitory potency against neutral endopeptidase by displacement of [3H]-HACBOGly binding in mouse kidneyMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeprilysin(Homo sapiens (Human))
University Of Paris

Curated by ChEMBL
LigandPNGBDBM50024101((S)-2-((S)-2-Mercaptomethyl-3-phenyl-propionylamin...)
Affinity DataKi:  0.700nMAssay Description:Inhibition of human recombinant NEP using Suc-Ala-Ala-Phe-AMC as substrate after 30 mins by fluorimetryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGamma-aminobutyric acid receptor subunit alpha-5(Homo sapiens (Human))
Roche Palo Alto

US Patent
LigandPNGBDBM133433(US8846719, 119)
Affinity DataKi:  0.700nM ΔG°:  -48.6kJ/molepH: 7.5 T: 2°CAssay Description:Radioligand binding assays were carried out in a volume of 200 mL (96-well plates) which contained 100 mL of cell memebranes, [3H]flumazenil at a con...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetGamma-aminobutyric acid receptor subunit alpha-5(Homo sapiens (Human))
Roche Palo Alto

US Patent
LigandPNGBDBM133567(US8846719, 259)
Affinity DataKi:  0.700nM ΔG°:  -48.6kJ/molepH: 7.5 T: 2°CAssay Description:Radioligand binding assays were carried out in a volume of 200 mL (96-well plates) which contained 100 mL of cell memebranes, [3H]flumazenil at a con...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetGamma-aminobutyric acid receptor subunit alpha-5(Homo sapiens (Human))
Roche Palo Alto

US Patent
LigandPNGBDBM133422(US8846719, 107)
Affinity DataKi:  0.700nM ΔG°:  -48.6kJ/molepH: 7.5 T: 2°CAssay Description:Radioligand binding assays were carried out in a volume of 200 mL (96-well plates) which contained 100 mL of cell memebranes, [3H]flumazenil at a con...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetNeprilysin(Homo sapiens (Human))
University Of Paris

Curated by ChEMBL
LigandPNGBDBM50407297(CHEMBL2052008)
Affinity DataKi:  0.700nMAssay Description:In vivo inhibitory potency against neutral endopeptidase by displacement of [3H]-HACBOGly binding in mouse kidneyMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGamma-aminobutyric acid receptor subunit alpha-5(Homo sapiens (Human))
Roche Palo Alto

US Patent
LigandPNGBDBM133518(US8846719, 208)
Affinity DataKi:  0.700nM ΔG°:  -48.6kJ/molepH: 7.5 T: 2°CAssay Description:Radioligand binding assays were carried out in a volume of 200 mL (96-well plates) which contained 100 mL of cell memebranes, [3H]flumazenil at a con...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetNeprilysin(Oryctolagus cuniculus (rabbit))
Cnrs

LigandPNGBDBM21653((2S)-2-[(2R)-2-[(1R)-2,3-dihydro-1H-inden-1-yl]-3-...)
Affinity DataKi:  0.700nM ΔG°:  -54.4kJ/molepH: 7.4 T: 2°CAssay Description:NEP was preincubated in black 96-well microplates with or without increasing concentrations of inhibitors. DGPA was added, and the reaction was stopp...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeprilysin(Oryctolagus cuniculus (rabbit))
Cnrs

LigandPNGBDBM21653((2S)-2-[(2R)-2-[(1R)-2,3-dihydro-1H-inden-1-yl]-3-...)
Affinity DataKi:  0.700nMAssay Description:In vitro inhibition of Neutral endopeptidase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM50414593(CHEMBL560535)
Affinity DataKi:  0.794nMAssay Description:Inhibition of SERTMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGamma-aminobutyric acid receptor subunit alpha-5(Homo sapiens (Human))
Roche Palo Alto

US Patent
LigandPNGBDBM133564(US8846719, 256)
Affinity DataKi:  0.800nM ΔG°:  -48.3kJ/molepH: 7.5 T: 2°CAssay Description:Radioligand binding assays were carried out in a volume of 200 mL (96-well plates) which contained 100 mL of cell memebranes, [3H]flumazenil at a con...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetGamma-aminobutyric acid receptor subunit alpha-5(Homo sapiens (Human))
Roche Palo Alto

US Patent
LigandPNGBDBM133563(US8846719, 255)
Affinity DataKi:  0.800nM ΔG°:  -48.3kJ/molepH: 7.5 T: 2°CAssay Description:Radioligand binding assays were carried out in a volume of 200 mL (96-well plates) which contained 100 mL of cell memebranes, [3H]flumazenil at a con...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetGamma-aminobutyric acid receptor subunit alpha-5(Homo sapiens (Human))
Roche Palo Alto

US Patent
LigandPNGBDBM133424(US8846719, 109)
Affinity DataKi:  0.800nM ΔG°:  -48.3kJ/molepH: 7.5 T: 2°CAssay Description:Radioligand binding assays were carried out in a volume of 200 mL (96-well plates) which contained 100 mL of cell memebranes, [3H]flumazenil at a con...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetGamma-aminobutyric acid receptor subunit alpha-5(Homo sapiens (Human))
Roche Palo Alto

US Patent
LigandPNGBDBM133435(US8846719, 121)
Affinity DataKi:  0.800nM ΔG°:  -48.3kJ/molepH: 7.5 T: 2°CAssay Description:Radioligand binding assays were carried out in a volume of 200 mL (96-well plates) which contained 100 mL of cell memebranes, [3H]flumazenil at a con...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetGamma-aminobutyric acid receptor subunit alpha-5(Homo sapiens (Human))
Roche Palo Alto

US Patent
LigandPNGBDBM133561(US8846719, 253)
Affinity DataKi:  0.800nM ΔG°:  -48.3kJ/molepH: 7.5 T: 2°CAssay Description:Radioligand binding assays were carried out in a volume of 200 mL (96-well plates) which contained 100 mL of cell memebranes, [3H]flumazenil at a con...More data for this Ligand-Target Pair
In DepthDetails US Patent
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