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Found 256 with Last Name = 'lubin' and Initial = 'ml'
LigandPNGBDBM50086717(JNJ-39439335 | Mavatrep)
Affinity DataKi:  6.5nMAssay Description:Displacement of [3H]-RTX from human TRPV1 transfected in HEK293 cells after 60 mins by scintillation spectroscopic analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 2(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM10887(Sulfamate 7 | Topiramate (TPM) | US11535599, Examp...)
Affinity DataKi:  300nMAssay Description:Inhibition of human carbonic anhydrase 2 by ThermoFluor methodMore data for this Ligand-Target Pair
TargetTransient receptor potential M8 protein(Canis lupus familiaris (Dog))
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM50335165(3-[2-(1-Oxa-2-aza-spiro[4.5]dec-2-en-3-yl)-6-(2-tr...)
Affinity DataIC50:  0.200nMAssay Description:Antagonist activity at canine TRPM8 expressed in HEK293 cells assessed as inhibition of intracellular calcium accumulation by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily M member 8(Homo sapiens (Human))
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM50335157(3-[7-Trifluoromethyl-5-(2-trifluoromethyl-phenyl)-...)
Affinity DataIC50:  0.413nMAssay Description:Inhibition of human TRPM8 expressed in HEK293 cells assessed as inhibition of cold-induced channel current by whole cell electrophysiologyMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential M8 protein(Canis lupus familiaris (Dog))
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM50335170(3-[5-(2-Fluoro-6-trifluoromethylphenyl)-1H-benzimi...)
Affinity DataIC50:  0.600nMAssay Description:Antagonist activity at canine TRPM8 expressed in HEK293 cells assessed as inhibition of intracellular calcium accumulation by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential M8 protein(Canis lupus familiaris (Dog))
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM50335160(2-(1-Oxa-2-aza-spiro[4.5]dec-2-en-3-yl)-6-(2-trifl...)
Affinity DataIC50:  0.700nMAssay Description:Antagonist activity at canine TRPM8 expressed in HEK293 cells assessed as inhibition of intracellular calcium accumulation by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential M8 protein(Canis lupus familiaris (Dog))
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM50335171(3-[5-(2-Fluoro-6-trifluoromethoxyphenyl)-1H-benzim...)
Affinity DataIC50:  0.800nMAssay Description:Antagonist activity at canine TRPM8 expressed in HEK293 cells assessed as inhibition of intracellular calcium accumulation by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential M8 protein(Canis lupus familiaris (Dog))
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM50335157(3-[7-Trifluoromethyl-5-(2-trifluoromethyl-phenyl)-...)
Affinity DataIC50:  0.800nMAssay Description:Antagonist activity at canine TRPM8 expressed in HEK293 cells assessed as inhibition of intracellular calcium accumulation by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential M8 protein(Canis lupus familiaris (Dog))
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM50335173(8,8-Difluoro-3-[5-(2-trifluoromethylphenyl)-1H-ben...)
Affinity DataIC50:  0.900nMAssay Description:Antagonist activity at canine TRPM8 expressed in HEK293 cells assessed as inhibition of intracellular calcium accumulation by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVoltage-dependent N-type calcium channel subunit alpha-1B(Homo sapiens (Human))
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM50465794(CHEMBL4288564)
Affinity DataIC50:  1nMAssay Description:Inhibition of Cav2.2 (unknown origin) expressed in HEK293 cells assessed as decrease in KCl depolarization-induced Ca2+ influx measured for 5 mins by...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetVoltage-dependent N-type calcium channel subunit alpha-1B(Homo sapiens (Human))
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM50465792(CHEMBL4279774)
Affinity DataIC50:  1nMAssay Description:Inhibition of Cav2.2 (unknown origin) expressed in HEK293 cells assessed as decrease in KCl depolarization-induced Ca2+ influx measured for 5 mins by...More data for this Ligand-Target Pair
TargetVoltage-dependent N-type calcium channel subunit alpha-1B(Homo sapiens (Human))
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM50465788(CHEMBL4292697)
Affinity DataIC50:  1nMAssay Description:Inhibition of Cav2.2 (unknown origin) expressed in HEK293 cells assessed as decrease in KCl depolarization-induced Ca2+ influx measured for 5 mins by...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTransient receptor potential M8 protein(Canis lupus familiaris (Dog))
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM50335164(3-[5-(2-Chlorophenyl)-7-trifluoromethyl-1H-benzimi...)
Affinity DataIC50:  1nMAssay Description:Antagonist activity at canine TRPM8 expressed in HEK293 cells assessed as inhibition of intracellular calcium accumulation by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential M8 protein(Canis lupus familiaris (Dog))
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM50335154(3-[5-(2-Trifluoromethoxyphenyl)-1H-benzimidazol-2-...)
Affinity DataIC50:  1.10nMAssay Description:Antagonist activity at canine TRPM8 expressed in HEK293 cells assessed as inhibition of intracellular calcium accumulation by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential M8 protein(Canis lupus familiaris (Dog))
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM50335163(3-[5-(2-Trifluoromethoxyphenyl)-7-trifluoromethyl-...)
Affinity DataIC50:  1.20nMAssay Description:Antagonist activity at canine TRPM8 expressed in HEK293 cells assessed as inhibition of intracellular calcium accumulation by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential M8 protein(Canis lupus familiaris (Dog))
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM50335174(3-[7-Trifluoromethyl-5-(2-trifluoromethylphenyl)-1...)
Affinity DataIC50:  1.40nMAssay Description:Antagonist activity at canine TRPM8 expressed in HEK293 cells assessed as inhibition of intracellular calcium accumulation by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential M8 protein(Canis lupus familiaris (Dog))
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM50335162(3-[5-(2-Fluorophenyl)-7-trifluoromethyl-1H-benzimi...)
Affinity DataIC50:  1.70nMAssay Description:Antagonist activity at canine TRPM8 expressed in HEK293 cells assessed as inhibition of intracellular calcium accumulation by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVoltage-dependent N-type calcium channel subunit alpha-1B(Homo sapiens (Human))
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM50465791(CHEMBL4289288)
Affinity DataIC50:  2nMAssay Description:Inhibition of Cav2.2 (unknown origin) expressed in HEK293 cells assessed as decrease in KCl depolarization-induced Ca2+ influx measured for 5 mins by...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetVoltage-dependent N-type calcium channel subunit alpha-1B(Homo sapiens (Human))
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM50465796(CHEMBL4290426)
Affinity DataIC50:  2nMAssay Description:Inhibition of Cav2.2 (unknown origin) expressed in HEK293 cells assessed as decrease in KCl depolarization-induced Ca2+ influx measured for 5 mins by...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetVoltage-dependent N-type calcium channel subunit alpha-1B(Homo sapiens (Human))
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM50465800(CHEMBL4282095)
Affinity DataIC50:  2nMAssay Description:Inhibition of Cav2.2 (unknown origin) expressed in HEK293 cells assessed as decrease in KCl depolarization-induced Ca2+ influx measured for 5 mins by...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50086728(CHEMBL3426347)
Affinity DataIC50:  2nMAssay Description:Antagonist activity at recombinant human TRPV1 expressed in HEK293 cells assessed as inhibition of capsaicin-induced Ca2+ influx preincubated for 5 m...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential M8 protein(Canis lupus familiaris (Dog))
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM50335158(3-[7-Fluoro-5-(2-trifluoromethylphenyl)-1H-benzimi...)
Affinity DataIC50:  2.20nMAssay Description:Antagonist activity at canine TRPM8 expressed in HEK293 cells assessed as inhibition of intracellular calcium accumulation by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential M8 protein(Canis lupus familiaris (Dog))
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM50335169(3-[5-(2,6-Difluorophenyl)-1H-benzimidazol-2-yl]-1-...)
Affinity DataIC50:  2.30nMAssay Description:Antagonist activity at canine TRPM8 expressed in HEK293 cells assessed as inhibition of intracellular calcium accumulation by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential M8 protein(Canis lupus familiaris (Dog))
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM50335151(3-[5-(2-Chlorophenyl)-1H-benzimidazol-2-yl]-1-oxa-...)
Affinity DataIC50:  2.40nMAssay Description:Antagonist activity at canine TRPM8 expressed in HEK293 cells assessed as inhibition of intracellular calcium accumulation by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential M8 protein(Canis lupus familiaris (Dog))
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM50335153(3-[5-(2-Difluoromethoxyphenyl)-1H-benzimidazol-2-y...)
Affinity DataIC50:  2.5nMAssay Description:Antagonist activity at canine TRPM8 expressed in HEK293 cells assessed as inhibition of intracellular calcium accumulation by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential M8 protein(Canis lupus familiaris (Dog))
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM50335161(3-[7-Bromo-5-(2-trifluoromethylphenyl)-1H-benzimid...)
Affinity DataIC50:  2.70nMAssay Description:Antagonist activity at canine TRPM8 expressed in HEK293 cells assessed as inhibition of intracellular calcium accumulation by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50086744(CHEMBL3426376)
Affinity DataIC50:  2.80nMAssay Description:Antagonist activity at recombinant human TRPV1 expressed in HEK293 cells assessed as inhibition of capsaicin-induced Ca2+ influx preincubated for 5 m...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50086740(CHEMBL3426378)
Affinity DataIC50:  2.80nMAssay Description:Antagonist activity at recombinant human TRPV1 expressed in HEK293 cells assessed as inhibition of capsaicin-induced Ca2+ influx preincubated for 5 m...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential M8 protein(Canis lupus familiaris (Dog))
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM50335155(3-[5-(2-Fluorophenyl)-1H-benzimidazol-2-yl]-1-oxa-...)
Affinity DataIC50:  2.90nMAssay Description:Antagonist activity at canine TRPM8 expressed in HEK293 cells assessed as inhibition of intracellular calcium accumulation by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily M member 8(Homo sapiens (Human))
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM50335157(3-[7-Trifluoromethyl-5-(2-trifluoromethyl-phenyl)-...)
Affinity DataIC50:  3nMAssay Description:Antagonist activity at human TRPM8 expressed in HEK293 cells assessed as inhibition of intracellular calcium accumulation at 0.2 uM by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVoltage-dependent N-type calcium channel subunit alpha-1B(Homo sapiens (Human))
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM50465798(CHEMBL4278633)
Affinity DataIC50:  3nMAssay Description:Inhibition of Cav2.2 (unknown origin) expressed in HEK293 cells assessed as decrease in KCl depolarization-induced Ca2+ influx measured for 5 mins by...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetVoltage-dependent N-type calcium channel subunit alpha-1B(Homo sapiens (Human))
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM50465789(CHEMBL4293756)
Affinity DataIC50:  3nMAssay Description:Inhibition of Cav2.2 (unknown origin) expressed in HEK293 cells assessed as decrease in KCl depolarization-induced Ca2+ influx measured for 5 mins by...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTransient receptor potential M8 protein(Canis lupus familiaris (Dog))
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM50431484(CHEMBL2348660)
Affinity DataIC50:  3nMAssay Description:Antagonist activity at dog TRPM8 expressed in HEK293 cells assessed as inhibition of icilin-induced calcium influx incubated for 5 mins prior to icil...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential M8 protein(Canis lupus familiaris (Dog))
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM50335156(3-[5-(2-Trifluoromethyl-phenyl)-1H-benzimidazol-2-...)
Affinity DataIC50:  3.10nMAssay Description:Antagonist activity at canine TRPM8 expressed in HEK293 cells assessed as inhibition of intracellular calcium accumulation by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential M8 protein(Canis lupus familiaris (Dog))
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM50335159(3-[7-Chloro-5-(2-trifluoromethylphenyl)-1H-benzimi...)
Affinity DataIC50:  3.30nMAssay Description:Antagonist activity at canine TRPM8 expressed in HEK293 cells assessed as inhibition of intracellular calcium accumulation by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential M8 protein(Canis lupus familiaris (Dog))
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM50335175(3-[7-Chloro-5-(2-trifluoromethyl-phenyl)-1H-benzim...)
Affinity DataIC50:  4nMAssay Description:Antagonist activity at canine TRPM8 expressed in HEK293 cells assessed as inhibition of intracellular calcium accumulation by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily M member 8(Rattus norvegicus (Rat))
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM50335157(3-[7-Trifluoromethyl-5-(2-trifluoromethyl-phenyl)-...)
Affinity DataIC50:  4nMAssay Description:Antagonist activity at rat TRPM8 expressed in HEK293 cells assessed as inhibition of intracellular calcium accumulation at 0.2 uM by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50086739(CHEMBL3426379)
Affinity DataIC50:  4.5nMAssay Description:Antagonist activity at recombinant human TRPV1 expressed in HEK293 cells assessed as inhibition of capsaicin-induced Ca2+ influx preincubated for 5 m...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50086717(JNJ-39439335 | Mavatrep)
Affinity DataIC50:  4.60nMAssay Description:Antagonist activity at recombinant human TRPV1 expressed in HEK293 cells assessed as inhibition of capsaicin-induced Ca2+ influx preincubated for 5 m...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50086716(CHEMBL3426361)
Affinity DataIC50:  4.90nMAssay Description:Antagonist activity at recombinant human TRPV1 expressed in HEK293 cells assessed as inhibition of capsaicin-induced Ca2+ influx preincubated for 5 m...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVoltage-dependent N-type calcium channel subunit alpha-1B(Homo sapiens (Human))
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM50465786(CHEMBL4283590)
Affinity DataIC50:  5nMAssay Description:Inhibition of Cav2.2 (unknown origin) expressed in HEK293 cells assessed as decrease in KCl depolarization-induced Ca2+ influx measured for 5 mins by...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTransient receptor potential M8 protein(Canis lupus familiaris (Dog))
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM50431489(CHEMBL2348666)
Affinity DataIC50:  5nMAssay Description:Antagonist activity at dog TRPM8 expressed in HEK293 cells assessed as inhibition of icilin-induced calcium influx incubated for 5 mins prior to icil...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential M8 protein(Canis lupus familiaris (Dog))
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM50431488(CHEMBL2348665)
Affinity DataIC50:  5nMAssay Description:Antagonist activity at dog TRPM8 expressed in HEK293 cells assessed as inhibition of icilin-induced calcium influx incubated for 5 mins prior to icil...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50086713(CHEMBL3426364)
Affinity DataIC50:  5.70nMAssay Description:Antagonist activity at recombinant human TRPV1 expressed in HEK293 cells assessed as inhibition of capsaicin-induced Ca2+ influx preincubated for 5 m...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50086714(CHEMBL3426363)
Affinity DataIC50:  5.90nMAssay Description:Antagonist activity at recombinant human TRPV1 expressed in HEK293 cells assessed as inhibition of capsaicin-induced Ca2+ influx preincubated for 5 m...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVoltage-dependent N-type calcium channel subunit alpha-1B(Homo sapiens (Human))
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM50465802(CHEMBL4294178)
Affinity DataIC50:  6nMAssay Description:Inhibition of Cav2.2 (unknown origin) expressed in HEK293 cells assessed as decrease in KCl depolarization-induced Ca2+ influx measured for 5 mins by...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTransient receptor potential M8 protein(Canis lupus familiaris (Dog))
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM50335166(2-(5-(2-(Trifluoromethyl)phenyl)-1H-benzo[d]imidaz...)
Affinity DataIC50:  6nMAssay Description:Antagonist activity at canine TRPM8 expressed in HEK293 cells assessed as inhibition of intracellular calcium accumulation by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVoltage-dependent N-type calcium channel subunit alpha-1B(Homo sapiens (Human))
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM50465793(CHEMBL4277584)
Affinity DataIC50:  6nMAssay Description:Inhibition of Cav2.2 (unknown origin) expressed in HEK293 cells assessed as decrease in KCl depolarization-induced Ca2+ influx measured for 5 mins by...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTransient receptor potential M8 protein(Canis lupus familiaris (Dog))
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM50431473(CHEMBL2348325)
Affinity DataIC50:  6nMAssay Description:Antagonist activity at dog TRPM8 expressed in HEK293 cells assessed as inhibition of icilin-induced calcium influx incubated for 5 mins prior to icil...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50086742(CHEMBL3426377)
Affinity DataIC50:  6nMAssay Description:Antagonist activity at recombinant human TRPV1 expressed in HEK293 cells assessed as inhibition of capsaicin-induced Ca2+ influx preincubated for 5 m...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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