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Found 242 with Last Name = 'malinowski' and Initial = 'j'
TargetCoagulation factor X(Homo sapiens (Human))
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM12751(1-(3-carbamimidoylphenyl)-3-methyl-N-[4-(2-sulfamo...)
Affinity DataKi:  0.0130nMAssay Description:Inhibitory activity of the compound against Coagulation factor Xa (serine protease) was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50113598((Z)-3-(3-Carbamimidoyl-4-fluoro-phenyl)-2-fluoro-b...)
Affinity DataKi:  0.180nMAssay Description:Inhibitory activity of the compound against factor Xa,activity expressed as Ki nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50123431(7-{7-[1-(1-Imino-ethyl)-piperidin-4-yloxy]-3-oxo-2...)
Affinity DataKi:  0.780nMAssay Description:Binding affinity of the compound towards factor XaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50103666(2-(3-Carbamimidoyl-phenoxy)-2-phenyl-N-[4-(pyrroli...)
Affinity DataIC50:  0.180nMAssay Description:In vitro inhibitory activity against coagulation factor XMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50113591((E)-3-(3-Carbamimidoyl-phenyl)-2-fluoro-but-2-enoi...)
Affinity DataIC50:  0.200nMAssay Description:Inhibitory activity against factor XaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50113590((E)-3-(3-Carbamimidoyl-phenyl)-2-fluoro-but-2-enoi...)
Affinity DataIC50:  0.5nMAssay Description:Inhibitory activity against factor XaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50113586((E)-3-(3-Carbamimidoyl-phenyl)-2-fluoro-but-2-enoi...)
Affinity DataIC50:  0.5nMAssay Description:Inhibitory activity against factor XaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50103665(2-(3-Carbamimidoyl-phenoxy)-2-phenyl-N-(2'-sulfamo...)
Affinity DataIC50:  0.550nMAssay Description:In vitro inhibitory activity against coagulation factor XMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50103676(2-(5-Carbamimidoyl-2-hydroxy-phenoxy)-N-[4-(pyrrol...)
Affinity DataIC50:  0.700nMAssay Description:In vitro inhibitory activity against coagulation factor XMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50113598((Z)-3-(3-Carbamimidoyl-4-fluoro-phenyl)-2-fluoro-b...)
Affinity DataIC50:  0.740nMAssay Description:Inhibitory activity against factor XaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50113593((Z)-3-(3-Carbamimidoyl-4-fluoro-phenyl)-2-fluoro-b...)
Affinity DataIC50:  0.75nMAssay Description:Inhibitory activity against factor XaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50123417(2-[({4-[1-(1-Imino-ethyl)-piperidin-4-yloxy]-pheny...)
Affinity DataIC50:  0.800nMAssay Description:Inhibitory concentration of the compound to factor XaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50103684(CHEMBL75333 | N-[2-Bromo-4-(pyrrolidine-1-carbonyl...)
Affinity DataIC50:  0.990nMAssay Description:In vitro inhibitory activity against coagulation factor XMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50113584((E)-3-(3-Carbamimidoyl-phenyl)-2-fluoro-but-2-enoi...)
Affinity DataIC50:  1nMAssay Description:Inhibitory activity against factor XaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50114494(4-Bromo-2-(3-carbamimidoyl-phenoxy)-N-(2'-sulfamoy...)
Affinity DataIC50:  1.20nMAssay Description:Tested in vitro for the inhibitory activity against Coagulation factor XaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50113612((Z)-3-(3-Carbamimidoyl-4-fluoro-phenyl)-2-fluoro-b...)
Affinity DataIC50:  1.5nMAssay Description:Inhibitory activity against factor XaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50114475(2-(3-Carbamimidoyl-phenoxy)-4-chloro-N-(2'-sulfamo...)
Affinity DataIC50:  1.5nMAssay Description:Tested in vitro for the inhibitory activity against Coagulation factor XaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50114477(2'-Sulfamoyl-biphenyl-4-carboxylic acid [5-bromo-2...)
Affinity DataIC50:  1.60nMAssay Description:Tested in vitro for the inhibitory activity against Coagulation factor XaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50114472(2'-Sulfamoyl-biphenyl-4-carboxylic acid [2-(3-carb...)
Affinity DataIC50:  1.60nMAssay Description:Tested in vitro for the inhibitory activity against Coagulation factor XaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50114459(2'-Sulfamoyl-biphenyl-4-carboxylic acid [2-(3-carb...)
Affinity DataIC50:  1.60nMAssay Description:Tested in vitro for the inhibitory activity against Coagulation factor XaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50114471(2'-Sulfamoyl-biphenyl-4-carboxylic acid [2-(3-carb...)
Affinity DataIC50:  1.80nMAssay Description:Tested in vitro for the inhibitory activity against Coagulation factor XaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50114487(2-(3-Carbamimidoyl-phenoxy)-5-nitro-N-(2'-sulfamoy...)
Affinity DataIC50:  1.90nMAssay Description:Tested in vitro for the inhibitory activity against Coagulation factor XMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50084617(((7-carbamimidoyl-naphthalen-2-ylmethyl)-{4-[1-(1-...)
Affinity DataIC50:  2nMAssay Description:Inhibitory concentration of the compound to factor XaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50123426(2-{7-[1-(1-Imino-ethyl)-piperidin-4-yloxy]-3-oxo-2...)
Affinity DataIC50:  2nMAssay Description:Inhibitory concentration of the compound to factor XaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50123412(1-Ethyl-2-{7-[1-(1-imino-ethyl)-piperidin-4-yloxy]...)
Affinity DataIC50:  2nMAssay Description:Inhibitory concentration of the compound to factor XaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50114469(2'-Sulfamoyl-biphenyl-4-carboxylic acid [4-bromo-2...)
Affinity DataIC50:  2.10nMAssay Description:Tested in vitro for the inhibitory activity against Coagulation factor XaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50103671(2-(5-Carbamimidoyl-2-hydroxy-phenoxy)-N-(2'-sulfam...)
Affinity DataIC50:  2.20nMAssay Description:In vitro inhibitory activity against coagulation factor XMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50114466(4-(3-Carbamimidoyl-phenoxy)-3-[(2'-sulfamoyl-biphe...)
Affinity DataIC50:  2.5nMAssay Description:Tested in vitro for the inhibitory activity against Coagulation factor XaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50114454(2'-Sulfamoyl-biphenyl-4-carboxylic acid [2-(3-carb...)
Affinity DataIC50:  2.5nMAssay Description:Tested in vitro for the inhibitory activity against Coagulation factor XaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50113611((Z)-3-(2-Amino-5-carbamimidoyl-phenyl)-2-fluoro-bu...)
Affinity DataIC50:  2.60nMAssay Description:Inhibitory activity against factor XaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50123429(((3'-Carbamimidoyl-biphenyl-3-ylmethyl)-{4-[1-(1-i...)
Affinity DataIC50:  3nMAssay Description:Inhibitory concentration of the compound to factor XaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50113603((E)-3-(3-Carbamimidoyl-phenyl)-2,4,4,4-tetrafluoro...)
Affinity DataIC50:  3nMAssay Description:Inhibitory activity against factor XaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50123414(((5-Carbamimidoyl-benzo[b]thiophen-2-ylmethyl)-{4-...)
Affinity DataIC50:  3nMAssay Description:Inhibitory concentration of the compound to factor XaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50103680(CHEMBL75287 | N-(3-Bromo-2'-sulfamoyl-biphenyl-4-y...)
Affinity DataIC50:  3.20nMAssay Description:In vitro inhibitory activity against coagulation factor XMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50114491(2'-Sulfamoyl-biphenyl-4-carboxylic acid [2-(3-carb...)
Affinity DataIC50:  3.40nMAssay Description:Tested in vitro for the inhibitory activity against Coagulation factor XaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50113585((Z)-3-(3-Carbamimidoyl-4-fluoro-phenyl)-2-fluoro-b...)
Affinity DataIC50:  3.60nMAssay Description:Inhibitory activity against factor XaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50114474(3-{2-[1-Oxo-5-(2-sulfamoyl-phenyl)-1,3-dihydro-iso...)
Affinity DataIC50:  3.60nMAssay Description:Tested in vitro for the inhibitory activity against Coagulation factor XaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50114479(2'-Sulfamoyl-biphenyl-4-carboxylic acid [2-(3-carb...)
Affinity DataIC50:  3.60nMAssay Description:Tested in vitro for the inhibitory activity against Coagulation factor XaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50113619((E)-3-(3-Carbamimidoyl-phenyl)-2-fluoro-4-hydroxy-...)
Affinity DataIC50:  3.70nMAssay Description:Inhibitory activity against factor XaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50114476(2'-Sulfamoyl-biphenyl-4-carboxylic acid [2-(3-carb...)
Affinity DataIC50:  3.90nMAssay Description:Tested in vitro for the inhibitory activity against Coagulation factor XaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50123427(3'-{7-[1-(1-Imino-ethyl)-piperidin-4-yloxy]-3-oxo-...)
Affinity DataIC50:  4nMAssay Description:Inhibitory concentration of the compound to factor XaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50113605((E)-3-(3-Carbamimidoyl-phenyl)-but-2-enoic acid (2...)
Affinity DataIC50:  4nMAssay Description:Inhibitory activity against factor XaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50114480(5-Bromo-2-(3-carbamimidoyl-phenoxy)-N-(2'-sulfamoy...)
Affinity DataIC50:  4.40nMAssay Description:Tested in vitro for the inhibitory activity against Coagulation factor XaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50103667(2-(3-Carbamimidoyl-phenoxy)-N-(3-fluoro-4-morpholi...)
Affinity DataIC50:  4.40nMAssay Description:In vitro inhibitory activity against coagulation factor XMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50114463(2'-Sulfamoyl-biphenyl-4-carboxylic acid [2-(3-carb...)
Affinity DataIC50:  4.5nMAssay Description:Tested in vitro for the inhibitory activity against Coagulation factor XaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50114496(2-(3-Carbamimidoyl-phenoxy)-4-nitro-N-(2'-sulfamoy...)
Affinity DataIC50:  4.80nMAssay Description:Tested in vitro for the inhibitory activity against Coagulation factor XaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50113613((E)-3-(3-Carbamimidoyl-phenyl)-5-methyl-hex-2-enoi...)
Affinity DataIC50:  5nMAssay Description:Inhibitory activity against factor XaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50114500(2-(3-Carbamimidoyl-phenoxy)-5-methanesulfonylamino...)
Affinity DataIC50:  5.40nMAssay Description:Tested in vitro for the inhibitory activity against Coagulation factor XaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50114483(2'-Sulfamoyl-biphenyl-4-carboxylic acid [1-(3-carb...)
Affinity DataIC50:  5.60nMAssay Description:Tested in vitro for the inhibitory activity against Coagulation factor XaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50123407(2-[({4-[1-(1-Imino-ethyl)-piperidin-4-yloxy]-pheny...)
Affinity DataIC50:  6nMAssay Description:Inhibitory concentration of the compound to factor XaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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