Affinity DataKi: 2.90E+3nMAssay Description:Competitive inhibition of His-tagged human HK2 (17 to 916 residues) expressed in Escherichia coli BL21(DE3) assessed as formation of G6P by continuou...More data for this Ligand-Target Pair
Affinity DataIC50: 7.90nMAssay Description:Inhibition of His-tagged human HK1 (11 to 917 residues) expressed in Escherichia coli BL21(DE3) using glucose as substrate after 45 mins by ADP-glo a...More data for this Ligand-Target Pair
Affinity DataIC50: 7.90nMAssay Description:Inhibition of His-tagged human HK2 (17 to 916 residues) expressed in Escherichia coli BL21(DE3) using glucose as substrate after 45 mins by ADP-glo a...More data for this Ligand-Target Pair
Affinity DataIC50: 7.90nMAssay Description:Inhibition of His-tagged human HK1 (11 to 917 residues) expressed in Escherichia coli BL21(DE3) using glucose as substrate after 45 mins by ADP-glo a...More data for this Ligand-Target Pair
Affinity DataIC50: 10nMAssay Description:Inhibition of His-tagged human HK2 (17 to 916 residues) expressed in Escherichia coli BL21(DE3) using glucose as substrate after 45 mins by ADP-glo a...More data for this Ligand-Target Pair
Affinity DataIC50: 16nMAssay Description:Inhibition of His-tagged human HK1 (11 to 917 residues) expressed in Escherichia coli BL21(DE3) using glucose as substrate after 45 mins by ADP-glo a...More data for this Ligand-Target Pair
Affinity DataIC50: 20nMAssay Description:Inhibition of His-tagged human HK1 (11 to 917 residues) expressed in Escherichia coli BL21(DE3) using glucose as substrate after 45 mins by ADP-glo a...More data for this Ligand-Target Pair
Affinity DataIC50: 20nMAssay Description:Inhibition of His-tagged human HK1 (11 to 917 residues) expressed in Escherichia coli BL21(DE3) using glucose as substrate after 45 mins by ADP-glo a...More data for this Ligand-Target Pair
Affinity DataIC50: 25nMAssay Description:Inhibition of His-tagged human HK1 (11 to 917 residues) expressed in Escherichia coli BL21(DE3) using glucose as substrate after 45 mins by ADP-glo a...More data for this Ligand-Target Pair
Affinity DataIC50: 25nMAssay Description:Inhibition of His-tagged human HK2 (17 to 916 residues) expressed in Escherichia coli BL21(DE3) using glucose as substrate after 45 mins by ADP-glo a...More data for this Ligand-Target Pair
Affinity DataIC50: 25nMAssay Description:Inhibition of His-tagged human HK2 (17 to 916 residues) expressed in Escherichia coli BL21(DE3) using glucose as substrate after 45 mins by ADP-glo a...More data for this Ligand-Target Pair
Affinity DataIC50: 25nMAssay Description:Inhibition of His-tagged human HK2 (17 to 916 residues) expressed in Escherichia coli BL21(DE3) using glucose as substrate after 45 mins by ADP-glo a...More data for this Ligand-Target Pair
Affinity DataIC50: 30nMAssay Description:Inhibition of human recombinant AurKA after 4 hrs by ADP-Glo assayMore data for this Ligand-Target Pair
Affinity DataIC50: 32nMAssay Description:Inhibition of His-tagged human HK1 (11 to 917 residues) expressed in Escherichia coli BL21(DE3) using glucose as substrate after 45 mins by ADP-glo a...More data for this Ligand-Target Pair
Affinity DataIC50: 40nMAssay Description:Inhibition of His-tagged human HK1 (11 to 917 residues) expressed in Escherichia coli BL21(DE3) using glucose as substrate after 45 mins by ADP-glo a...More data for this Ligand-Target Pair
Affinity DataIC50: 40nMAssay Description:Inhibition of His-tagged human HK2 (17 to 916 residues) expressed in Escherichia coli BL21(DE3) using glucose as substrate after 45 mins by ADP-glo a...More data for this Ligand-Target Pair
Affinity DataIC50: 50nMAssay Description:Inhibition of His-tagged human HK2 (17 to 916 residues) expressed in Escherichia coli BL21(DE3) using glucose as substrate after 45 mins by ADP-glo a...More data for this Ligand-Target Pair
Affinity DataIC50: 50nMAssay Description:Inhibition of His-tagged human HK2 (17 to 916 residues) expressed in Escherichia coli BL21(DE3) using glucose as substrate after 45 mins by ADP-glo a...More data for this Ligand-Target Pair
Affinity DataIC50: 68nMAssay Description:Inhibition of human recombinant AurKB after 4 hrs by ADP-Glo assayMore data for this Ligand-Target Pair
Affinity DataIC50: 100nMAssay Description:Inhibition of His-tagged human HK2 (17 to 916 residues) expressed in Escherichia coli BL21(DE3) using glucose as substrate after 45 mins by ADP-glo a...More data for this Ligand-Target Pair
Affinity DataIC50: 100nMAssay Description:Inhibition of His-tagged human HK2 (17 to 916 residues) expressed in Escherichia coli BL21(DE3) using glucose as substrate after 45 mins by ADP-glo a...More data for this Ligand-Target Pair
Affinity DataIC50: 130nMAssay Description:Inhibition of His-tagged human HK2 (17 to 916 residues) expressed in Escherichia coli BL21(DE3) using glucose as substrate after 45 mins by ADP-glo a...More data for this Ligand-Target Pair
Affinity DataIC50: 130nMAssay Description:Inhibition of His-tagged human HK2 (17 to 916 residues) expressed in Escherichia coli BL21(DE3) using glucose as substrate after 45 mins by ADP-glo a...More data for this Ligand-Target Pair
Affinity DataIC50: 130nMAssay Description:Inhibition of His-tagged human HK2 (17 to 916 residues) expressed in Escherichia coli BL21(DE3) using glucose as substrate after 45 mins by ADP-glo a...More data for this Ligand-Target Pair
Affinity DataIC50: 160nMAssay Description:Inhibition of His-tagged human HK1 (11 to 917 residues) expressed in Escherichia coli BL21(DE3) using glucose as substrate after 45 mins by ADP-glo a...More data for this Ligand-Target Pair
Affinity DataIC50: 160nMAssay Description:Inhibition of His-tagged human HK1 (11 to 917 residues) expressed in Escherichia coli BL21(DE3) using glucose as substrate after 45 mins by ADP-glo a...More data for this Ligand-Target Pair
TargetReceptor-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
University of Antwerp
Curated by ChEMBL
University of Antwerp
Curated by ChEMBL
Affinity DataIC50: 167nMAssay Description:Inhibition of human recombinant RIPK1 after 4 hrs by ADP-Glo assayMore data for this Ligand-Target Pair
TargetReceptor-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
University of Antwerp
Curated by ChEMBL
University of Antwerp
Curated by ChEMBL
Affinity DataIC50: 178nMAssay Description:Inhibition of human recombinant RIPK1 after 4 hrs by ADP-Glo assayMore data for this Ligand-Target Pair
Affinity DataIC50: 200nMAssay Description:Inhibition of HK2 in human UM-UC-3 cells using 2FDG as substrate assessed as suppression of G6P production preincubated for 30 mins followed by subst...More data for this Ligand-Target Pair
TargetReceptor-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
University of Antwerp
Curated by ChEMBL
University of Antwerp
Curated by ChEMBL
Affinity DataIC50: 208nMAssay Description:Inhibition of RIPK1 in mouse L929sA cells transfected with human Fas assessed as inhibition in TNF-induced necroptosis pretreated for 24 hrs followed...More data for this Ligand-Target Pair
Affinity DataIC50: 210nMAssay Description:Inhibition of human recombinant AurKA after 4 hrs by ADP-Glo assayMore data for this Ligand-Target Pair
Affinity DataIC50: 229nMAssay Description:Inhibition of human recombinant AurKB after 4 hrs by ADP-Glo assayMore data for this Ligand-Target Pair
Affinity DataIC50: 293nMAssay Description:Inhibition of human recombinant AurKA after 4 hrs by ADP-Glo assayMore data for this Ligand-Target Pair
TargetReceptor-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
University of Antwerp
Curated by ChEMBL
University of Antwerp
Curated by ChEMBL
Affinity DataIC50: 295nMAssay Description:Inhibition of human recombinant RIPK1 after 4 hrs by ADP-Glo assayMore data for this Ligand-Target Pair
Affinity DataIC50: 310nMAssay Description:Inhibition of human recombinant AurKA after 4 hrs by ADP-Glo assayMore data for this Ligand-Target Pair
Affinity DataIC50: 320nMAssay Description:Inhibition of His-tagged human HK2 (17 to 916 residues) expressed in Escherichia coli BL21(DE3) using glucose as substrate after 45 mins by ADP-glo a...More data for this Ligand-Target Pair
TargetReceptor-interacting serine/threonine-protein kinase 1(Mus musculus)
University of Antwerp
Curated by ChEMBL
University of Antwerp
Curated by ChEMBL
Affinity DataIC50: 360nMAssay Description:Inhibition of RIPK1 in mouse L929sA cells transfected with human Fas assessed as inhibition in TNF-induced necroptosis pretreated for 0.5 hrs followe...More data for this Ligand-Target Pair
TargetReceptor-interacting serine/threonine-protein kinase 1(Mus musculus)
University of Antwerp
Curated by ChEMBL
University of Antwerp
Curated by ChEMBL
Affinity DataIC50: 380nMAssay Description:Inhibition of RIPK1 in mouse L929sA cells transfected with human Fas assessed as inhibition in TNF-induced necroptosis pretreated for 0.5 hrs followe...More data for this Ligand-Target Pair
TargetReceptor-interacting serine/threonine-protein kinase 1(Mus musculus)
University of Antwerp
Curated by ChEMBL
University of Antwerp
Curated by ChEMBL
Affinity DataIC50: 390nMAssay Description:Inhibition of RIPK1 in mouse L929sA cells transfected with human Fas assessed as inhibition in TNF-induced necroptosis pretreated for 0.5 hrs followe...More data for this Ligand-Target Pair
TargetReceptor-interacting serine/threonine-protein kinase 1(Mus musculus)
University of Antwerp
Curated by ChEMBL
University of Antwerp
Curated by ChEMBL
Affinity DataIC50: 430nMAssay Description:Inhibition of RIPK1 in mouse L929sA cells transfected with human Fas assessed as inhibition in TNF-induced necroptosis pretreated for 24 hrs followed...More data for this Ligand-Target Pair
TargetReceptor-interacting serine/threonine-protein kinase 1(Mus musculus)
University of Antwerp
Curated by ChEMBL
University of Antwerp
Curated by ChEMBL
Affinity DataIC50: 430nMAssay Description:Inhibition of RIPK1 in mouse L929sA cells transfected with human Fas assessed as inhibition in TNF-induced necroptosis pretreated for 0.5 hrs followe...More data for this Ligand-Target Pair
Affinity DataIC50: 430nMAssay Description:Inhibition of human recombinant AurKA after 4 hrs by ADP-Glo assayMore data for this Ligand-Target Pair
Affinity DataIC50: 470nMAssay Description:Inhibition of HK2 in human UM-UC-3 cells using 2FDG as substrate assessed as suppression of G6P production preincubated for 30 mins followed by subst...More data for this Ligand-Target Pair
Affinity DataIC50: 520nMAssay Description:Inhibition of HK2 in human UM-UC-3 cells using 2FDG as substrate assessed as suppression of G6P production preincubated for 30 mins followed by subst...More data for this Ligand-Target Pair
TargetReceptor-interacting serine/threonine-protein kinase 1(Mus musculus)
University of Antwerp
Curated by ChEMBL
University of Antwerp
Curated by ChEMBL
Affinity DataIC50: 530nMAssay Description:Inhibition of RIPK1 in mouse L929sA cells transfected with human Fas assessed as inhibition in TNF-induced necroptosis pretreated for 0.5 hrs followe...More data for this Ligand-Target Pair
Affinity DataIC50: 630nMAssay Description:Inhibition of His-tagged human HK2 (17 to 916 residues) expressed in Escherichia coli BL21(DE3) using glucose as substrate after 45 mins by ADP-glo a...More data for this Ligand-Target Pair
TargetReceptor-interacting serine/threonine-protein kinase 1(Mus musculus)
University of Antwerp
Curated by ChEMBL
University of Antwerp
Curated by ChEMBL
Affinity DataIC50: 640nMAssay Description:Inhibition of RIPK1 in mouse L929sA cells transfected with human Fas assessed as inhibition in TNF-induced necroptosis pretreated for 24 hrs followed...More data for this Ligand-Target Pair
TargetReceptor-interacting serine/threonine-protein kinase 1(Mus musculus)
University of Antwerp
Curated by ChEMBL
University of Antwerp
Curated by ChEMBL
Affinity DataIC50: 640nMAssay Description:Inhibition of RIPK1 in mouse L929sA cells transfected with human Fas assessed as inhibition in TNF-induced necroptosis pretreated for 24 hrs followed...More data for this Ligand-Target Pair
TargetReceptor-interacting serine/threonine-protein kinase 1(Mus musculus)
University of Antwerp
Curated by ChEMBL
University of Antwerp
Curated by ChEMBL
Affinity DataIC50: 680nMAssay Description:Inhibition of RIPK1 in mouse L929sA cells transfected with human Fas assessed as inhibition in TNF-induced necroptosis pretreated for 24 hrs followed...More data for this Ligand-Target Pair
TargetReceptor-interacting serine/threonine-protein kinase 1(Mus musculus)
University of Antwerp
Curated by ChEMBL
University of Antwerp
Curated by ChEMBL
Affinity DataIC50: 700nMAssay Description:Inhibition of RIPK1 in mouse L929sA cells transfected with human Fas assessed as inhibition in TNF-induced necroptosis pretreated for 0.5 hrs followe...More data for this Ligand-Target Pair