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Found 232 with Last Name = 'martin' and Initial = 'll'
TargetCholinesterase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM10972((3aS,8aR)-1,3a,8-trimethyl-1H,2H,3H,3aH,8H,8aH-pyr...)
Affinity DataIC50:  0.690nMAssay Description:Compound was evaluated in vitro for the inhibition of human serum Butyrylcholinesterase using butyrylthiocholine as substrate; 0.00029-0.001More data for this Ligand-Target Pair
In DepthDetails Article
TargetAmine oxidase [flavin-containing] A(Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50367064(CHEMBL1204338)
Affinity DataIC50: >1nMAssay Description:Compound was tested in vitro for inhibition of rat brain mitochondrial monoamine oxidase A.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmine oxidase [flavin-containing] B(Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50367064(CHEMBL1204338)
Affinity DataIC50: >1nMAssay Description:Compound was tested in vitro for inhibition of rat brain mitochondrial monoamine oxidase BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M1/M2/M3/M4/M5(RAT)
Hoechst-Roussel Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50452855(Isoptpo Hyoscine | Scopolamine)
Affinity DataIC50:  4nMAssay Description:Inhibition of [3H]quinuclidinyl benzilate (QNB) binding from rat forebrain membranes in the presence of ZnMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M1/M2/M3/M4/M5(RAT)
Hoechst-Roussel Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50452855(Isoptpo Hyoscine | Scopolamine)
Affinity DataIC50:  4nMAssay Description:Inhibition of [3H]quinuclidinyl benzilate (QNB) binding from rat forebrain membranes in the absence of ZnMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50048608(CHEMBL154488 | Indol-1-yl-pyridin-4-yl-amine)
Affinity DataIC50:  8nMAssay Description:Inhibitory activity against [3H]clonidine binding to Alpha-2 adrenergic receptor in rat cortexMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM10972((3aS,8aR)-1,3a,8-trimethyl-1H,2H,3H,3aH,8H,8aH-pyr...)
Affinity DataIC50:  9nMAssay Description:Compound was evaluated in vitro in rats for the inhibition of brain (striatal) acetylcholinesterase (AChEI) using acetylthiocholine as substrate; 0.0...More data for this Ligand-Target Pair
In DepthDetails Article
TargetTransporter(Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50009717(CHEMBL436281)
Affinity DataIC50:  10nMAssay Description:Inhibition of NET-mediated norepinephrine uptake in rat brain synaptosomesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Rattus norvegicus)
Hoechst-Roussel Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50048999(CHEMBL82292 | N-Hydroxy-N-methyl-3-(11-oxo-6,11-di...)
Affinity DataIC50:  10nMAssay Description:Inhibition of 5-lipoxygenase by measuring 5-HETE levels in RBL-1 cell-free supernatantMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Rattus norvegicus)
Hoechst-Roussel Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50048989(3-(6,11-Dihydro-dibenzo[b,e]oxepin-2-yl)-N-hydroxy...)
Affinity DataIC50:  20nMAssay Description:Inhibition of 5-lipoxygenase by measuring 5-HETE levels in RBL-1 cell-free supernatantMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50048589(CHEMBL152842 | Indol-1-yl-methyl-pyridin-4-yl-amin...)
Affinity DataIC50:  24nMAssay Description:Inhibitory activity against [3H]clonidine binding to Alpha-2 adrenergic receptor in rat cortexMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCholinesterase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50290392(Benzyl-carbamic acid 1-[(3-fluoro-pyridin-4-yl)-pr...)
Affinity DataIC50:  27nMAssay Description:Compound was evaluated in vitro for the inhibition of human serum Butyrylcholinesterase using butyrylthiocholine as substrate; 0.01-0.069More data for this Ligand-Target Pair
In DepthDetails Article
TargetCholinesterase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50290391(CHEMBL42531 | Methyl-carbamic acid 1-[(3-fluoro-py...)
Affinity DataIC50:  31nMAssay Description:Compound was evaluated in vitro for the inhibition of human serum Butyrylcholinesterase using butyrylthiocholine as substrate; 0.023-0.041More data for this Ligand-Target Pair
In DepthDetails Article
TargetAcetylcholinesterase(Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50290392(Benzyl-carbamic acid 1-[(3-fluoro-pyridin-4-yl)-pr...)
Affinity DataIC50:  43nMAssay Description:Compound was evaluated in vitro in rats for the inhibition of brain (striatal) acetylcholinesterase (AChEI) using acetylthiocholine as substrate; 0.0...More data for this Ligand-Target Pair
In DepthDetails Article
TargetAcetylcholinesterase(Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50290391(CHEMBL42531 | Methyl-carbamic acid 1-[(3-fluoro-py...)
Affinity DataIC50:  58nMAssay Description:Compound was evaluated in vitro in rats for the inhibition of brain (striatal) acetylcholinesterase (AChEI) using acetylthiocholine as substrate; 0.0...More data for this Ligand-Target Pair
In DepthDetails Article
LigandPNGBDBM50048600(CHEMBL154541 | Ethyl-indol-1-yl-pyridin-4-yl-amine)
Affinity DataIC50:  110nMAssay Description:Inhibitory activity against [3H]clonidine binding to Alpha-2 adrenergic receptor in rat cortexMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Rattus norvegicus)
Hoechst-Roussel Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM32020(4-[4-(3,4-dihydroxyphenyl)-2,3-dimethyl-butyl]pyro...)
Affinity DataIC50:  120nMAssay Description:Inhibition of 5-lipoxygenase by measuring 5-HETE levels in RBL-1 cell-free supernatantMore data for this Ligand-Target Pair
TargetAcetylcholinesterase(Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50290389(CHEMBL295462 | Methyl-carbamic acid 1-(3-fluoro-py...)
Affinity DataIC50:  130nMAssay Description:Compound was evaluated in vitro in rats for the inhibition of brain (striatal) acetylcholinesterase (AChEI) using acetylthiocholine as substrate; 0.0...More data for this Ligand-Target Pair
In DepthDetails Article
TargetPolyunsaturated fatty acid 5-lipoxygenase(Rattus norvegicus)
Hoechst-Roussel Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50048997(2-[2-(Hydroxy-isopropyl-amino)-ethyl]-6H-dibenzo[b...)
Affinity DataIC50:  130nMAssay Description:Inhibition of 5-lipoxygenase by measuring 5-HETE levels in RBL-1 cell-free supernatantMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50048580(CHEMBL29835 | Indol-1-yl-propyl-pyridin-4-yl-amine...)
Affinity DataIC50:  140nMAssay Description:Inhibitory activity against [3H]idazoxan binding to Alpha-2 adrenergic receptor in rat cortex, in the presence of GPPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Rattus norvegicus)
Hoechst-Roussel Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50048998(CHEMBL83425 | N-Ethyl-N-hydroxy-3-(11-oxo-6,11-dih...)
Affinity DataIC50:  150nMAssay Description:Inhibition of 5-lipoxygenase by measuring 5-HETE levels in RBL-1 cell-free supernatantMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCholinesterase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50290389(CHEMBL295462 | Methyl-carbamic acid 1-(3-fluoro-py...)
Affinity DataIC50:  190nMAssay Description:Compound was evaluated in vitro for the inhibition of human serum Butyrylcholinesterase using butyrylthiocholine as substrate; 0.15-0.22More data for this Ligand-Target Pair
In DepthDetails Article
TargetPolyunsaturated fatty acid 5-lipoxygenase(Rattus norvegicus)
Hoechst-Roussel Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50048990(CHEMBL314856 | N-Hydroxy-N-[2-(11-oxo-6,11-dihydro...)
Affinity DataIC50:  190nMAssay Description:Inhibition of 5-lipoxygenase by measuring 5-HETE levels in RBL-1 cell-free supernatantMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Rattus norvegicus)
Hoechst-Roussel Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50049003(CHEMBL85455 | N-Hydroxy-N-(11-oxo-6,11-dihydro-dib...)
Affinity DataIC50:  210nMAssay Description:Inhibition of 5-lipoxygenase by measuring 5-HETE levels in RBL-1 cell-free supernatantMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Rattus norvegicus)
Hoechst-Roussel Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50048992(2-[2-(Hydroxy-methyl-amino)-ethyl]-6H-dibenzo[b,e]...)
Affinity DataIC50:  240nMAssay Description:Inhibition of 5-lipoxygenase by measuring 5-HETE levels in RBL-1 cell-free supernatantMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Hoechst-Roussel Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50048600(CHEMBL154541 | Ethyl-indol-1-yl-pyridin-4-yl-amine)
Affinity DataIC50:  250nMAssay Description:Inhibitory activity against norepinephrine (NE) uptake in rat whole brain synaptosome preparationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50048580(CHEMBL29835 | Indol-1-yl-propyl-pyridin-4-yl-amine...)
Affinity DataIC50:  250nMAssay Description:Inhibitory activity against [3H]yohimbine binding to Alpha-2 adrenergic receptor in rat cortexMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM8961(1,2,3,4-tetrahydro-9-acridinamine | 1,2,3,4-tetrah...)
Affinity DataIC50:  320nMAssay Description:Inhibitory activity against acetylcholinesterase in rat striatal preparationMore data for this Ligand-Target Pair
TargetPolyunsaturated fatty acid 5-lipoxygenase(Rattus norvegicus)
Hoechst-Roussel Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50048991(CHEMBL84599 | N-[2-(6,11-Dihydro-dibenzo[b,e]oxepi...)
Affinity DataIC50:  320nMAssay Description:Inhibition of 5-lipoxygenase by measuring 5-HETE levels in RBL-1 cell-free supernatantMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50048580(CHEMBL29835 | Indol-1-yl-propyl-pyridin-4-yl-amine...)
Affinity DataIC50:  330nMAssay Description:Inhibitory activity against [3H]clonidine binding to Alpha-2 adrenergic receptor in rat cortexMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Hoechst-Roussel Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50048576(Butyl-indol-1-yl-pyridin-4-yl-amine | CHEMBL155109)
Affinity DataIC50:  430nMAssay Description:Inhibitory activity against norepinephrine (NE) uptake in rat whole brain synaptosome preparationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Hoechst-Roussel Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50048580(CHEMBL29835 | Indol-1-yl-propyl-pyridin-4-yl-amine...)
Affinity DataIC50:  430nMAssay Description:Inhibitory activity against norepinephrine (NE) uptake in rat whole brain synaptosome preparationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Rattus norvegicus)
Hoechst-Roussel Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50049008(2-[2-(Ethyl-hydroxy-amino)-ethyl]-6,11-dihydro-dib...)
Affinity DataIC50:  450nMAssay Description:Inhibition of 5-lipoxygenase by measuring 5-HETE levels in RBL-1 cell-free supernatantMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M1/M2/M3/M4/M5(RAT)
Hoechst-Roussel Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50048580(CHEMBL29835 | Indol-1-yl-propyl-pyridin-4-yl-amine...)
Affinity DataIC50:  460nMAssay Description:Inhibitory activity against [3H]oxotremorine-M binding to muscarinic receptors in rat forebrain membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50048580(CHEMBL29835 | Indol-1-yl-propyl-pyridin-4-yl-amine...)
Affinity DataIC50:  470nMAssay Description:Inhibitory activity against [3H]-idazoxan binding to Alpha-2 adrenergic receptor in rat cortexMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Rattus norvegicus)
Hoechst-Roussel Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50006817(9-Phenyl-nonanoic acid hydroxyamide | BMY-30094 | ...)
Affinity DataIC50:  480nMAssay Description:Inhibition of 5-lipoxygenase by measuring 5-HETE levels in RBL-1 cell-free supernatantMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Rattus norvegicus)
Hoechst-Roussel Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50048994(2-[2-(Ethyl-hydroxy-amino)-ethyl]-6H-dibenzo[b,e]o...)
Affinity DataIC50:  480nMAssay Description:Inhibition of 5-lipoxygenase by measuring 5-HETE levels in RBL-1 cell-free supernatantMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M1/M2/M3/M4/M5(RAT)
Hoechst-Roussel Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50048610(CHEMBL435034 | Carbazol-9-yl-propyl-pyridin-4-yl-a...)
Affinity DataIC50:  500nMAssay Description:Inhibition of [3H]quinuclidinyl benzilate (QNB) binding from rat forebrain membranes in the presence of ZnMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50048602(CHEMBL348034 | Indol-1-yl-prop-2-ynyl-pyridin-4-yl...)
Affinity DataIC50:  500nMAssay Description:Inhibitory activity against [3H]clonidine binding to Alpha-2 adrenergic receptor in rat cortexMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Rattus norvegicus (rat))
Hoechst-Roussel Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50048608(CHEMBL154488 | Indol-1-yl-pyridin-4-yl-amine)
Affinity DataIC50:  510nMAssay Description:Inhibitory activity against [3H]WB-4101 binding to Alpha-1 adrenergic receptor in rat whole brain membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50048610(CHEMBL435034 | Carbazol-9-yl-propyl-pyridin-4-yl-a...)
Affinity DataIC50:  540nMAssay Description:Inhibitory activity against [3H]clonidine binding to Alpha-2 adrenergic receptor in rat cortexMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Hoechst-Roussel Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50048575((5-Methoxy-indol-1-yl)-propyl-pyridin-4-yl-amine |...)
Affinity DataIC50:  570nMAssay Description:Inhibitory activity against norepinephrine (NE) uptake in rat whole brain synaptosome preparationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Rattus norvegicus)
Hoechst-Roussel Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50049006(CHEMBL85113 | N-Hydroxy-N-isopropyl-3-(11-oxo-6,11...)
Affinity DataIC50:  580nMAssay Description:Inhibition of 5-lipoxygenase by measuring 5-HETE levels in RBL-1 cell-free supernatantMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Rattus norvegicus)
Hoechst-Roussel Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50048996(CHEMBL86214 | N-Ethyl-N-hydroxy-2-(11-oxo-6,11-dih...)
Affinity DataIC50:  580nMAssay Description:Inhibition of 5-lipoxygenase by measuring 5-HETE levels in RBL-1 cell-free supernatantMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Rattus norvegicus)
Hoechst-Roussel Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50049007(2-[3-(Hydroxy-methyl-amino)-propyl]-6H-dibenzo[b,e...)
Affinity DataIC50:  620nMAssay Description:Inhibition of 5-lipoxygenase by measuring 5-HETE levels in RBL-1 cell-free supernatantMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50048576(Butyl-indol-1-yl-pyridin-4-yl-amine | CHEMBL155109)
Affinity DataIC50:  630nMAssay Description:Inhibitory activity against [3H]clonidine binding to Alpha-2 adrenergic receptor in rat cortexMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M1/M2/M3/M4/M5(RAT)
Hoechst-Roussel Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50048590(CHEMBL154319 | Indol-1-yl-isopropyl-pyridin-4-yl-a...)
Affinity DataIC50:  630nMAssay Description:Inhibition of [3H]quinuclidinyl benzilate (QNB) binding from rat forebrain membranes in the presence of ZnMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M2(RAT)
Hoechst-Roussel Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50048580(CHEMBL29835 | Indol-1-yl-propyl-pyridin-4-yl-amine...)
Affinity DataIC50:  650nMAssay Description:Inhibitory activity against [3H]N-methyl-scopolamine in rat Muscarinic acetylcholine receptor M2 cerebellum in the presence GPP(NH)PMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Rattus norvegicus)
Hoechst-Roussel Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50049000(CHEMBL311433 | N-Hydroxy-2,2,N-trimethyl-3-(11-oxo...)
Affinity DataIC50:  660nMAssay Description:Inhibition of 5-lipoxygenase by measuring 5-HETE levels in RBL-1 cell-free supernatantMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M1/M2/M3/M4/M5(RAT)
Hoechst-Roussel Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50004665((oxotremorine)1-(4-Pyrrolidin-1-yl-but-2-ynyl)-pyr...)
Affinity DataIC50:  660nMAssay Description:Inhibition of [3H]quinuclidinyl benzilate (QNB) binding from rat forebrain membranes in the presence of ZnMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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