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Found 313 with Last Name = 'maubach' and Initial = 'k'
TargetProstaglandin E2 receptor EP4 subtype(Homo sapiens (Human))
Argenta Discovery

Curated by ChEMBL
LigandPNGBDBM50012544(CHEMBL3260768)
Affinity DataKi:  0.300nMAssay Description:Displacement of [3H]PGE2 from human prostanoid EP4 receptor expressed in cell membranes by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGABA-A receptor; alpha-5/beta-3/gamma-2(Homo sapiens (Human))
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50110705(3-(2-Hydroxy-ethylsulfanyl)-6,6-dimethyl-1-pyridin...)
Affinity DataKi:  0.5nMAssay Description:Binding affinity to human GABA A alpha5-beta3-gamma2 receptor,using a [3H]-Ro- 15-1788 radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGABA-A receptor; alpha-5/beta-3/gamma-2(Homo sapiens (Human))
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50110705(3-(2-Hydroxy-ethylsulfanyl)-6,6-dimethyl-1-pyridin...)
Affinity DataKi:  0.5nMAssay Description:Displacement of [3H]- Ro 15-1788 binding from human GABA-A receptor alpha5-beta3-gamma2 subunitsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP4 subtype(Homo sapiens (Human))
Argenta Discovery

Curated by ChEMBL
LigandPNGBDBM50012543(CHEMBL3260767)
Affinity DataKi:  0.600nMAssay Description:Displacement of [3H]PGE2 from human prostanoid EP4 receptor expressed in cell membranes by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP4 subtype(Homo sapiens (Human))
Argenta Discovery

Curated by ChEMBL
LigandPNGBDBM50012532(CHEMBL3260463)
Affinity DataKi:  1.30nMAssay Description:Displacement of [3H]PGE2 from human prostanoid EP4 receptor expressed in cell membranes by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP4 subtype(Homo sapiens (Human))
Argenta Discovery

Curated by ChEMBL
LigandPNGBDBM50012502(CHEMBL3260457)
Affinity DataKi:  1.30nMAssay Description:Displacement of [3H]PGE2 from human prostanoid EP4 receptor expressed in cell membranes by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGamma-aminobutyric acid receptor subunit alpha-1/beta-3/gamma-2(Homo sapiens (Human))
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50173700(3-Phenyl-5-(2-pyridin-4-yl-pyrimidin-4-yl)-pyridaz...)
Affinity DataKi:  1.30nMpH: 7.4Assay Description:Displacement of [3H]-Ro- 15-1788 binding from human recombinant Gamma-aminobutyric-acid A receptor alpha1-beta3-gamma2 expressed in mouse fibroblast ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGABA-A receptor; alpha-5/beta-3/gamma-2(Homo sapiens (Human))
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50128250(6,6-Dimethyl-1-thiazol-2-yl-3-(thiazol-2-ylsulfany...)
Affinity DataKi:  1.40nMAssay Description:Binding affinity to human GABA A alpha5-beta3-gamma2 receptor,using a [3H]-Ro- 15-1788 radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGABA-A receptor; alpha-5/beta-3/gamma-2(Homo sapiens (Human))
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50110708(6,6-Dimethyl-1-(1H-pyrazol-3-yl)-3-(thiazol-2-yldi...)
Affinity DataKi:  1.40nMAssay Description:Displacement of [3H]- Ro 15-1788 binding from human GABA-A receptor alpha5-beta3-gamma2 subunitsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGABA-A receptor; alpha-5/beta-3/gamma-2(Homo sapiens (Human))
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50128245(6,6-Dimethyl-1-(1H-pyrazol-3-yl)-3-(thiazol-2-ylsu...)
Affinity DataKi:  1.40nMAssay Description:Binding affinity to human GABA A alpha5-beta3-gamma2 receptor,using a [3H]-Ro- 15-1788 radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGABA-A receptor; alpha-5/beta-3/gamma-2(Homo sapiens (Human))
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50110713(3-Ethylsulfanyl-6,6-dimethyl-1-(1H-pyrazol-3-yl)-6...)
Affinity DataKi:  1.60nMAssay Description:Displacement of [3H]- Ro 15-1788 binding from human GABA-A receptor alpha5-beta3-gamma2 subunitsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGABA-A receptor; alpha-5/beta-3/gamma-2(Homo sapiens (Human))
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50110713(3-Ethylsulfanyl-6,6-dimethyl-1-(1H-pyrazol-3-yl)-6...)
Affinity DataKi:  1.60nMAssay Description:Binding affinity to human GABA A alpha5-beta3-gamma2 receptor,using a [3H]-Ro- 15-1788 radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGABA-A receptor; alpha-5/beta-3/gamma-2(Homo sapiens (Human))
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50173700(3-Phenyl-5-(2-pyridin-4-yl-pyrimidin-4-yl)-pyridaz...)
Affinity DataKi:  1.60nMpH: 7.4Assay Description:Displacement of [3H]-Ro- 15-1788 binding from human recombinant Gamma-aminobutyric-acid A receptor alpha5-beta3-gamma2 expressed in mouse fibroblast ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGABA-A receptor; alpha-5/beta-3/gamma-2(Homo sapiens (Human))
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50110704(3-(2-Hydroxy-ethylsulfanyl)-6,6-dimethyl-1-thiazol...)
Affinity DataKi:  1.60nMAssay Description:Binding affinity to human GABA A alpha5-beta3-gamma2 receptor,using a [3H]-Ro- 15-1788 radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGABA-A receptor; alpha-5/beta-3/gamma-2(Homo sapiens (Human))
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50110704(3-(2-Hydroxy-ethylsulfanyl)-6,6-dimethyl-1-thiazol...)
Affinity DataKi:  1.60nMAssay Description:Displacement of [3H]- Ro 15-1788 binding from human GABA-A receptor alpha5-beta3-gamma2 subunitsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGABA-A receptor; alpha-5/beta-3/gamma-2(Homo sapiens (Human))
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50110706(6,6-Dimethyl-3-methylsulfanyl-1-pyridin-2-yl-6,7-d...)
Affinity DataKi:  1.70nMAssay Description:Binding affinity to human GABA A alpha5-beta3-gamma2 receptor,using a [3H]-Ro- 15-1788 radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGABA-A receptor; alpha-5/beta-3/gamma-2(Homo sapiens (Human))
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50110706(6,6-Dimethyl-3-methylsulfanyl-1-pyridin-2-yl-6,7-d...)
Affinity DataKi:  1.70nMAssay Description:Displacement of [3H]- Ro 15-1788 binding from human GABA-A receptor alpha5-beta3-gamma2 subunitsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGABA-A receptor; alpha-5/beta-3/gamma-2(Homo sapiens (Human))
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50110711(3-Isopropylsulfanyl-6,6-dimethyl-1-(1H-pyrazol-3-y...)
Affinity DataKi:  2nMAssay Description:Binding affinity to human GABA A alpha5-beta3-gamma2 receptor,using a [3H]-Ro- 15-1788 radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGABA-A receptor; alpha-5/beta-3/gamma-2(Homo sapiens (Human))
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50110711(3-Isopropylsulfanyl-6,6-dimethyl-1-(1H-pyrazol-3-y...)
Affinity DataKi:  2nMAssay Description:Displacement of [3H]- Ro 15-1788 binding from human GABA-A receptor alpha5-beta3-gamma2 subunitsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP4 subtype(Homo sapiens (Human))
Argenta Discovery

Curated by ChEMBL
LigandPNGBDBM50012542(CHEMBL3260766)
Affinity DataKi:  2nMAssay Description:Displacement of [3H]PGE2 from human prostanoid EP4 receptor expressed in cell membranes by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGABA-A receptor; alpha-5/beta-3/gamma-2(Homo sapiens (Human))
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50110707(6,6-Dimethyl-3-methylsulfanyl-1-thiazol-2-yl-6,7-d...)
Affinity DataKi:  2.20nMAssay Description:Displacement of [3H]- Ro 15-1788 binding from human GABA-A receptor alpha5-beta3-gamma2 subunitsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGABA-A receptor; alpha-5/beta-3/gamma-2(Homo sapiens (Human))
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50065229(4-Ethyl-6,7-dimethoxy-9H-beta-carboline-3-carboxyl...)
Affinity DataKi:  2.20nMAssay Description:Displacement of [3H]- Ro 15-1788 binding from human GABA-A receptor alpha5-beta3-gamma2 subunitsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGABA-A receptor; alpha-5/beta-3/gamma-2(Homo sapiens (Human))
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50065229(4-Ethyl-6,7-dimethoxy-9H-beta-carboline-3-carboxyl...)
Affinity DataKi:  2.20nMAssay Description:Binding affinity to human GABA A alpha5-beta3-gamma2 receptor,using a [3H]-Ro- 15-1788 radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGABA-A receptor; alpha-5/beta-3/gamma-2(Homo sapiens (Human))
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50110707(6,6-Dimethyl-3-methylsulfanyl-1-thiazol-2-yl-6,7-d...)
Affinity DataKi:  2.20nMAssay Description:Binding affinity to human GABA A alpha5-beta3-gamma2 receptor,using a [3H]-Ro- 15-1788 radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGABA-A receptor; alpha-5/beta-3/gamma-2(Homo sapiens (Human))
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50128255(6,6-Dimethyl-1-(1H-pyrazol-3-yl)-3-(thiophen-2-yls...)
Affinity DataKi:  2.40nMAssay Description:Binding affinity to human GABA A alpha5-beta3-gamma2 receptor,using a [3H]-Ro- 15-1788 radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGABA-A receptor; alpha-5/beta-3/gamma-2(Homo sapiens (Human))
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50110709(3-(2-Hydroxy-ethylsulfanyl)-6,6-dimethyl-1-(1H-pyr...)
Affinity DataKi:  2.90nMAssay Description:Binding affinity to human GABA A alpha5-beta3-gamma2 receptor,using a [3H]-Ro- 15-1788 radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGABA-A receptor; alpha-5/beta-3/gamma-2(Homo sapiens (Human))
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50110709(3-(2-Hydroxy-ethylsulfanyl)-6,6-dimethyl-1-(1H-pyr...)
Affinity DataKi:  2.90nMAssay Description:Displacement of [3H]- Ro 15-1788 binding from human GABA-A receptor alpha5-beta3-gamma2 subunitsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP4 subtype(Homo sapiens (Human))
Argenta Discovery

Curated by ChEMBL
LigandPNGBDBM50012534(CHEMBL3260758)
Affinity DataKi:  3nMAssay Description:Displacement of [3H]PGE2 from human prostanoid EP4 receptor expressed in cell membranes by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP4 subtype(Homo sapiens (Human))
Argenta Discovery

Curated by ChEMBL
LigandPNGBDBM50012545(BGC-201531 | CHEMBL1628698)
Affinity DataKi:  3nMAssay Description:Displacement of [3H]PGE2 from human prostanoid EP4 receptor expressed in cell membranes by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP4 subtype(Homo sapiens (Human))
Argenta Discovery

Curated by ChEMBL
LigandPNGBDBM50012548(CHEMBL3260771)
Affinity DataKi:  3nMAssay Description:Displacement of [3H]PGE2 from human prostanoid EP4 receptor expressed in cell membranes by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGamma-aminobutyric acid receptor subunit alpha-3/beta-3/gamma-2(Homo sapiens (Human))
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50173700(3-Phenyl-5-(2-pyridin-4-yl-pyrimidin-4-yl)-pyridaz...)
Affinity DataKi:  3.10nMpH: 7.4Assay Description:Displacement of [3H]-Ro- 15-1788 binding from human recombinant Gamma-aminobutyric-acid A receptor alpha3-beta3-gamma2 expressed in mouse fibroblast ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGABA-A receptor; alpha-5/beta-3/gamma-2(Homo sapiens (Human))
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50173674(3-[6-(2-Fluoro-phenyl)-pyridazin-4-yl]-benzonitril...)
Affinity DataKi:  3.40nMpH: 7.4Assay Description:Displacement of [3H]-Ro- 15-1788 binding from human recombinant Gamma-aminobutyric-acid A receptor alpha5-beta3-gamma2 expressed in mouse fibroblast ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGamma-aminobutyric acid receptor subunit alpha-1/beta-3/gamma-2(Homo sapiens (Human))
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50173681(CHEMBL197883 | [5-(3-Bromo-phenyl)-pyridazin-3-yl]...)
Affinity DataKi:  3.5nMpH: 7.4Assay Description:Displacement of [3H]-Ro- 15-1788 binding from human recombinant Gamma-aminobutyric-acid A receptor alpha1-beta3-gamma2 expressed in mouse fibroblast ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP4 subtype(Homo sapiens (Human))
Argenta Discovery

Curated by ChEMBL
LigandPNGBDBM50012533(CHEMBL3260757)
Affinity DataKi:  3.60nMAssay Description:Displacement of [3H]PGE2 from human prostanoid EP4 receptor expressed in cell membranes by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGamma-aminobutyric acid receptor subunit alpha-1/beta-3/gamma-2(Homo sapiens (Human))
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50110705(3-(2-Hydroxy-ethylsulfanyl)-6,6-dimethyl-1-pyridin...)
Affinity DataKi:  3.60nMAssay Description:Displacement of [3H]- Ro 15-1788 binding from human GABA-A receptor alpha1-beta3-gamma2 subunitsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGamma-aminobutyric acid receptor subunit alpha-1/beta-3/gamma-2(Homo sapiens (Human))
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50110705(3-(2-Hydroxy-ethylsulfanyl)-6,6-dimethyl-1-pyridin...)
Affinity DataKi:  3.60nMAssay Description:Binding affinity to human gamma-aminobutyric-acid A receptor alpha1beta3gamma2, determined using [3H]-Ro- 15-1788 radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGABA-A receptor; alpha-5/beta-3/gamma-2(Homo sapiens (Human))
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50173681(CHEMBL197883 | [5-(3-Bromo-phenyl)-pyridazin-3-yl]...)
Affinity DataKi:  3.80nMpH: 7.4Assay Description:Displacement of [3H]-Ro- 15-1788 binding from human recombinant Gamma-aminobutyric-acid A receptor alpha5-beta3-gamma2 expressed in mouse fibroblast ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGABA-A receptor; alpha-5/beta-3/gamma-2(Homo sapiens (Human))
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50128263(3-Isopropylamino-6,6-dimethyl-1-(1H-pyrazol-3-yl)-...)
Affinity DataKi:  3.90nMAssay Description:Binding affinity to human GABA A alpha5-beta3-gamma2 receptor,using a [3H]-Ro- 15-1788 radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGABA-A receptor; alpha-5/beta-3/gamma-2(Homo sapiens (Human))
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50173695(3-[6-(3-Fluoro-phenyl)-pyridazin-4-yl]-benzonitril...)
Affinity DataKi:  4nMpH: 7.4Assay Description:Displacement of [3H]-Ro- 15-1788 binding from human recombinant Gamma-aminobutyric-acid A receptor alpha5-beta3-gamma2 expressed in mouse fibroblast ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGamma-aminobutyric acid receptor subunit alpha-1/beta-3/gamma-2(Homo sapiens (Human))
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50128245(6,6-Dimethyl-1-(1H-pyrazol-3-yl)-3-(thiazol-2-ylsu...)
Affinity DataKi:  4.30nMAssay Description:Binding affinity to human gamma-aminobutyric-acid A receptor alpha1beta3gamma2, determined using [3H]-Ro- 15-1788 radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGamma-aminobutyric acid receptor subunit alpha-1/beta-3/gamma-2(Homo sapiens (Human))
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50110708(6,6-Dimethyl-1-(1H-pyrazol-3-yl)-3-(thiazol-2-yldi...)
Affinity DataKi:  4.30nMAssay Description:Displacement of [3H]- Ro 15-1788 binding from human GABA-A receptor alpha1-beta3-gamma2 subunitsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGABA-A receptor; alpha-5/beta-3/gamma-2(Homo sapiens (Human))
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50128261(6,6-Dimethyl-3-propylsulfanyl-1-(1H-pyrazol-3-yl)-...)
Affinity DataKi:  4.60nMAssay Description:Binding affinity to human GABA A alpha5-beta3-gamma2 receptor,using a [3H]-Ro- 15-1788 radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGABA-A receptor; alpha-5/beta-3/gamma-2(Homo sapiens (Human))
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50128248(3-(3-Hydroxy-propylsulfanyl)-6,6-dimethyl-1-(1H-py...)
Affinity DataKi:  4.70nMAssay Description:Binding affinity to human GABA A alpha5-beta3-gamma2 receptor,using a [3H]-Ro- 15-1788 radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGABA-A receptor; alpha-5/beta-3/gamma-2(Homo sapiens (Human))
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50128256(3-(3-Hydroxy-propylsulfanyl)-6,6-dimethyl-1-thiazo...)
Affinity DataKi:  4.70nMAssay Description:Binding affinity to human GABA A alpha5-beta3-gamma2 receptor,using a [3H]-Ro- 15-1788 radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP4 subtype(Homo sapiens (Human))
Argenta Discovery

Curated by ChEMBL
LigandPNGBDBM50012501(CHEMBL3260456)
Affinity DataKi:  5nMAssay Description:Displacement of [3H]PGE2 from human prostanoid EP4 receptor expressed in cell membranes by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGamma-aminobutyric acid receptor subunit alpha-1/beta-3/gamma-2(Homo sapiens (Human))
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50110711(3-Isopropylsulfanyl-6,6-dimethyl-1-(1H-pyrazol-3-y...)
Affinity DataKi:  5nMAssay Description:Displacement of [3H]- Ro 15-1788 binding from human GABA-A receptor alpha1-beta3-gamma2 subunitsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP4 subtype(Homo sapiens (Human))
Argenta Discovery

Curated by ChEMBL
LigandPNGBDBM50012530(CHEMBL3260461)
Affinity DataKi:  5nMAssay Description:Displacement of [3H]PGE2 from human prostanoid EP4 receptor expressed in cell membranes by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGamma-aminobutyric acid receptor subunit alpha-1/beta-3/gamma-2(Homo sapiens (Human))
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50110711(3-Isopropylsulfanyl-6,6-dimethyl-1-(1H-pyrazol-3-y...)
Affinity DataKi:  5nMAssay Description:Binding affinity to human gamma-aminobutyric-acid A receptor alpha1beta3gamma2, determined using [3H]-Ro- 15-1788 radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGABA-A receptor; alpha-5/beta-3/gamma-2(Homo sapiens (Human))
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50173691(3-(6-Phenyl-pyridazin-4-yl)-benzonitrile | CHEMBL1...)
Affinity DataKi:  5.20nMpH: 7.4Assay Description:Displacement of [3H]-Ro- 15-1788 binding from human recombinant Gamma-aminobutyric-acid A receptor alpha5-beta3-gamma2 expressed in mouse fibroblast ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGABA-A receptor; alpha-2/beta-3/gamma-2(Homo sapiens (Human))
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50110705(3-(2-Hydroxy-ethylsulfanyl)-6,6-dimethyl-1-pyridin...)
Affinity DataKi:  5.20nMAssay Description:Binding affinity to human gamma-amino butyric-acid A receptor alpha2beta3gamma2, using a [3H]-Ro- 15-1788 radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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