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Target
Prostaglandin E2 receptor EP4 subtype
Ligand
BDBM50012543
Substrate
n/a
Meas. Tech.
ChEMBL_1351394 (CHEMBL3266970)
Ki
0.600000±n/a nM
Citation
 Sutton, J; Clark, DE; Higgs, C; de Groot, MJ; Harris, NV; Taylor, A; Lockey, PM; Maubach, K; Woodrooffe, A; Davis, RJ; Coleman, RA; Clark, KL From virtual to clinical: The discovery of PGN-1531, a novel antagonist of the prostanoid EP4 receptor. Bioorg Med Chem Lett 24:2212-21 (2014) [PubMed]  Article 
Target
Name:
Prostaglandin E2 receptor EP4 subtype
Synonyms:
PE2R4_HUMAN | PGE receptor EP4 subtype | PGE2 receptor EP4 subtype | PTGER2 | PTGER4 | Prostaglandin E2 receptor | Prostanoid EP4 receptor
Type:
Enzyme
Mol. Mass.:
53134.53
Organism:
Homo sapiens (Human)
Description:
P35408
Residue:
488
Sequence:
MSTPGVNSSASLSPDRLNSPVTIPAVMFIFGVVGNLVAIVVLCKSRKEQKETTFYTLVCGLAVTDLLGTLLVSPVTIATYMKGQWPGGQPLCEYSTFILLFFSLSGLSIICAMSVERYLAINHAYFYSHYVDKRLAGLTLFAVYASNVLFCALPNMGLGSSRLQYPDTWCFIDWTTNVTAHAAYSYMYAGFSSFLILATVLCNVLVCGALLRMHRQFMRRTSLGTEQHHAAAAASVASRGHPAASPALPRLSDFRRRRSFRRIAGAEIQMVILLIATSLVVLICSIPLVVRVFVNQLYQPSLEREVSKNPDLQAIRIASVNPILDPWIYILLRKTVLSKAIEKIKCLFCRIGGSRRERSGQHCSDSQRTSSAMSGHSRSFISRELKEISSTSQTLLPDLSLPDLSENGLGGRNLLPGVPGMGLAQEDTTSLRTLRISETSDSSQGQDSESVLLVDEAGGSGRAGPAPKGSSLQVTFPSETLNLSEKCI
  
Inhibitor
Name:
BDBM50012543
Synonyms:
CHEMBL3260767
Type:
Small organic molecule
Emp. Form.:
C25H22F2N2O7S
Mol. Mass.:
532.513
SMILES:
Cc1noc(C)c1S(=O)(=O)NC(=O)c1cc(COc2ccc(cc2)-c2ccc(OC(F)F)cc2)c(C)o1
Structure:
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