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Found 282 with Last Name = 'maycock' and Initial = 'a'
TargetNeutrophil elastase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50029699(2,6-Dichloro-benzoic acid 4-isopropyl-6-methoxy-1,...)
Affinity DataKi:  0.0230nMAssay Description:Evaluated for inhibitory activity against Human leukocyte elastase (HLE)More data for this Ligand-Target Pair
In DepthDetails Article
TargetNeutrophil elastase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50286326(2,6-Dichloro-benzoic acid 6-fluoro-4-isopropyl-1,1...)
Affinity DataKi:  0.0300nMAssay Description:Evaluated for inhibitory activity against Human leukocyte elastase (HLE)More data for this Ligand-Target Pair
In DepthDetails Article
TargetNeutrophil elastase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50039631(2,6-Dichloro-benzoic acid 4-isopropyl-1,1,3-trioxo...)
Affinity DataKi:  0.0300nMAssay Description:Evaluated for inhibitory activity against Human leukocyte elastase (HLE)More data for this Ligand-Target Pair
In DepthDetails Article
TargetKappa-type opioid receptor(Homo sapiens (Human))
Adolor

Curated by ChEMBL
LigandPNGBDBM50007344((S)-2-(3,4-Dichloro-phenyl)-N-methyl-N-(1-phenyl-2...)
Affinity DataKi:  0.0430nMAssay Description:In vitro binding affinity for human kappa opioid receptor was determined by using [3H]-diprenorphine as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
Adolor

Curated by ChEMBL
LigandPNGBDBM50007344((S)-2-(3,4-Dichloro-phenyl)-N-methyl-N-(1-phenyl-2...)
Affinity DataKi:  0.0540nMAssay Description:In vitro binding affinity towards Opioid receptor kappa 1 by displacement of bound [3H]U69,593More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
Adolor

Curated by ChEMBL
LigandPNGBDBM50093965(CHEMBL86324 | N-Methyl-N-((S)-1-phenyl-2-pyrrolidi...)
Affinity DataKi:  0.0580nMAssay Description:In vitro binding affinity towards Opioid receptor kappa 1 by displacement of bound [3H]U69,593More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
Adolor

Curated by ChEMBL
LigandPNGBDBM50093965(CHEMBL86324 | N-Methyl-N-((S)-1-phenyl-2-pyrrolidi...)
Affinity DataKi:  0.0580nMAssay Description:Displacement of bound [3H]-diprenorphine from membranes expressing cloned human kappa opioid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
Adolor

Curated by ChEMBL
LigandPNGBDBM50093964(CHEMBL313484 | N-Methyl-N-((S)-1-phenyl-2-pyrrolid...)
Affinity DataKi:  0.0640nMAssay Description:In vitro binding affinity towards Opioid receptor kappa 1 by displacement of bound [3H]U69,593More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
Adolor

Curated by ChEMBL
LigandPNGBDBM50093969(CHEMBL82919 | N-Methyl-2-(3-nitro-phenyl)-N-((S)-1...)
Affinity DataKi:  0.0650nMAssay Description:In vitro binding affinity towards Opioid receptor kappa 1 by displacement of bound [3H]U69,593More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
Adolor

Curated by ChEMBL
LigandPNGBDBM50090002(CHEMBL411003 | Dynorphin A (1-11)-NH2H-Tyr-Gly-Gly...)
Affinity DataKi:  0.0740nMAssay Description:Binding affinity towards cloned human Opioid receptor kappa 1 in CHO cell membranes.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
Adolor

Curated by ChEMBL
LigandPNGBDBM50093958(2-(2-Amino-3,4-dichloro-phenyl)-N-methyl-N-((S)-1-...)
Affinity DataKi:  0.0860nMAssay Description:In vitro binding affinity towards Opioid receptor kappa 1 by displacement of bound [3H]U69,593More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
Adolor

Curated by ChEMBL
LigandPNGBDBM50093966(2-(3,4-Dichloro-2-nitro-phenyl)-N-methyl-N-((S)-1-...)
Affinity DataKi:  0.0910nMAssay Description:In vitro binding affinity towards Opioid receptor kappa 1 by displacement of bound [3H]U69,593More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
Adolor

Curated by ChEMBL
LigandPNGBDBM50093970(2-(3,4-Dichloro-2-dimethanesulfonylamino-phenyl)-N...)
Affinity DataKi:  0.0960nMAssay Description:In vitro binding affinity towards Opioid receptor kappa 1 by displacement of bound [3H]U69,593More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
Adolor

Curated by ChEMBL
LigandPNGBDBM50093962(CHEMBL87306 | N-Methyl-N-((S)-1-phenyl-2-pyrrolidi...)
Affinity DataKi:  0.130nMAssay Description:In vitro binding affinity towards Opioid receptor kappa 1 by displacement of bound [3H]U69,593More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
Adolor

Curated by ChEMBL
LigandPNGBDBM50090003(CHEMBL405190 | Tyr-Gly-[D-Ala]-Phe-Leu-Arg-Arg-Ile...)
Affinity DataKi:  0.150nMAssay Description:Human Opioid receptor kappa 1 mediated stimulation of [35S]- GTPgammaS binding in CHO cells (Agonist potency).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50286333(5,6-Dimethoxy-1,1-dioxo-2-(1-phenyl-1H-tetrazol-5-...)
Affinity DataKi:  0.200nMAssay Description:Evaluated for inhibitory activity against Human leukocyte elastase (HLE)More data for this Ligand-Target Pair
In DepthDetails Article
TargetNeutrophil elastase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50029703(4-Isopropyl-6-methoxy-1,1-dioxo-2-(1-phenyl-1H-tet...)
Affinity DataKi:  0.270nMAssay Description:Evaluated for inhibitory activity against Human leukocyte elastase (HLE)More data for this Ligand-Target Pair
In DepthDetails Article
TargetNeutrophil elastase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50282874(4-Isopropyl-1,1-dioxo-2-(1-phenyl-1H-tetrazol-5-yl...)
Affinity DataKi:  0.300nMAssay Description:Ratio of Koff to that of Kon was determined on human leukocyte elastase(HLE)More data for this Ligand-Target Pair
In DepthDetails Article
TargetKappa-type opioid receptor(Homo sapiens (Human))
Adolor

Curated by ChEMBL
LigandPNGBDBM50160834(CHEMBL183248 | N-[(S)-1-(3-Amino-phenyl)-2-pyrroli...)
Affinity DataKi:  0.310nMAssay Description:Displacement of bound [3H]-diprenorphine from membranes expressing cloned human kappa opioid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
Adolor

Curated by ChEMBL
LigandPNGBDBM82551(C18130 | CAS_105618-26-6 | NOR-BNI (HCI)2 | NORBNI)
Affinity DataKi:  0.360nMAssay Description:Human Opioid receptor kappa 1 mediated stimulation of [35S]- GTPgammaS binding in CHO cells (Agonist potency).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
Adolor

Curated by ChEMBL
LigandPNGBDBM50160840(CHEMBL365486 | N-[(S)-1-(3-Methanesulfonylamino-ph...)
Affinity DataKi:  0.360nMAssay Description:Displacement of bound [3H]-diprenorphine from membranes expressing cloned human kappa opioid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
Adolor

Curated by ChEMBL
LigandPNGBDBM50093968(CHEMBL87207 | N-Methyl-2-(2-nitro-phenyl)-N-((S)-1...)
Affinity DataKi:  0.410nMAssay Description:In vitro binding affinity towards Opioid receptor kappa 1 by displacement of bound [3H]U69,593More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
Adolor

Curated by ChEMBL
LigandPNGBDBM50160832(CHEMBL181279 | N-[1-(3-Hydroxy-phenyl)-2-pyrrolidi...)
Affinity DataKi:  0.440nMAssay Description:Displacement of bound [3H]-diprenorphine from membranes expressing cloned human kappa opioid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
Adolor

Curated by ChEMBL
LigandPNGBDBM50160842(CHEMBL362248 | N-[(S)-1-(3-aminosulfonylamino-phen...)
Affinity DataKi:  0.480nMAssay Description:Displacement of bound [3H]-diprenorphine from membranes expressing cloned human kappa opioid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
Adolor

Curated by ChEMBL
LigandPNGBDBM50160836(CHEMBL180803 | N-[1-(3-Methoxy-phenyl)-2-pyrrolidi...)
Affinity DataKi:  0.530nMAssay Description:Displacement of bound [3H]-diprenorphine from membranes expressing cloned human kappa opioid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
Adolor

Curated by ChEMBL
LigandPNGBDBM50093971(2-(2-Amino-phenyl)-N-methyl-N-((S)-1-phenyl-2-pyrr...)
Affinity DataKi:  0.580nMAssay Description:In vitro binding affinity towards Opioid receptor kappa 1 by displacement of bound [3H]U69,593More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50282873(4-sec-Butyl-1,1-dioxo-2-(1-phenyl-1H-tetrazol-5-yl...)
Affinity DataKi:  0.600nMAssay Description:Ratio of Koff to that of Kon was determined on human leukocyte elastase(HLE)More data for this Ligand-Target Pair
In DepthDetails Article
TargetNeutrophil elastase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50286327(4,6-Dimethoxy-1,1-dioxo-2-(1-phenyl-1H-tetrazol-5-...)
Affinity DataKi:  0.600nMAssay Description:Ratio of Koff to that of Kon was determined on human leukocyte elastase(HLE)More data for this Ligand-Target Pair
In DepthDetails Article
TargetKappa-type opioid receptor(Homo sapiens (Human))
Adolor

Curated by ChEMBL
LigandPNGBDBM50160838(CHEMBL365198 | N-Methyl-N-[(S)-1-(3-nitro-phenyl)-...)
Affinity DataKi:  0.630nMAssay Description:Displacement of bound [3H]-diprenorphine from membranes expressing cloned human kappa opioid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50282868(1,1-Dioxo-2-(1-phenyl-1H-tetrazol-5-ylsulfanylmeth...)
Affinity DataKi:  0.700nMAssay Description:Ratio of Koff to that of Kon was determined on human leukocyte elastase(HLE)More data for this Ligand-Target Pair
In DepthDetails Article
TargetKappa-type opioid receptor(Homo sapiens (Human))
Adolor

Curated by ChEMBL
LigandPNGBDBM50161317(3,4-Dichloro-N-({[(S)-2-((R)-3-hydroxy-pyrrolidin-...)
Affinity DataKi:  0.830nMAssay Description:In vitro binding affinity for human kappa opioid receptor was determined by using [3H]-diprenorphine as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
Adolor

Curated by ChEMBL
LigandPNGBDBM50093963(2-(4-Amino-phenyl)-N-methyl-N-((S)-1-phenyl-2-pyrr...)
Affinity DataKi:  0.930nMAssay Description:In vitro binding affinity towards Opioid receptor kappa 1 by displacement of bound [3H]U69,593More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
Adolor

Curated by ChEMBL
LigandPNGBDBM50093967(2-(3-Amino-phenyl)-N-methyl-N-((S)-1-phenyl-2-pyrr...)
Affinity DataKi:  0.930nMAssay Description:In vitro binding affinity towards Opioid receptor kappa 1 by displacement of bound [3H]U69,593More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
Adolor

Curated by ChEMBL
LigandPNGBDBM50093972(CHEMBL87986 | N-Methyl-2-(4-nitro-phenyl)-N-((S)-1...)
Affinity DataKi:  1.10nMAssay Description:In vitro binding affinity towards Opioid receptor kappa 1 by displacement of bound [3H]U69,593More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50286329(2,6-Dichloro-benzoic acid 4-isopropyl-6-(4-methyl-...)
Affinity DataKi:  1.10nMAssay Description:Evaluated for inhibitory activity against Human leukocyte elastase (HLE)More data for this Ligand-Target Pair
In DepthDetails Article
TargetNeutrophil elastase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50282866(4-Ethyl-1,1-dioxo-2-(1-phenyl-1H-tetrazol-5-ylsulf...)
Affinity DataKi:  2nMAssay Description:Ratio of Koff to that of Kon was determined on human leukocyte elastase(HLE)More data for this Ligand-Target Pair
In DepthDetails Article
TargetKappa-type opioid receptor(Homo sapiens (Human))
Adolor

Curated by ChEMBL
LigandPNGBDBM50161315(CHEMBL179627 | N-({[(S)-2-((R)-3-Hydroxy-pyrrolidi...)
Affinity DataKi:  2nMAssay Description:In vitro binding affinity for human kappa opioid receptor was determined by using [3H]-diprenorphine as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50286330(4,5-Dimethoxy-1,1-dioxo-2-(1-phenyl-1H-tetrazol-5-...)
Affinity DataKi:  2nMAssay Description:Ratio of Koff to that of Kon was determined on human leukocyte elastase(HLE)More data for this Ligand-Target Pair
In DepthDetails Article
TargetNeutrophil elastase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50286328(2,6-Dichloro-benzoic acid 6-dimethylamino-4-isopro...)
Affinity DataKi:  2.20nMAssay Description:Evaluated for inhibitory activity against Human leukocyte elastase (HLE)More data for this Ligand-Target Pair
In DepthDetails Article
TargetKappa-type opioid receptor(Homo sapiens (Human))
Adolor

Curated by ChEMBL
LigandPNGBDBM83435(2-[3-[1-[2-(3,4-dichlorophenyl)ethanoyl-methyl-ami...)
Affinity DataKi:  2.69nMAssay Description:Displacement of bound [3H]-diprenorphine from membranes expressing cloned human kappa opioid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
Adolor

Curated by ChEMBL
LigandPNGBDBM50090006(CHEMBL407389 | [Pro3] Dynorphin A (1-11)-NH2H-Tyr-...)
Affinity DataKi:  2.70nMAssay Description:Human Opioid receptor kappa 1 mediated stimulation of [35S]- GTPgammaS binding in CHO cells (Agonist potency).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM50090002(CHEMBL411003 | Dynorphin A (1-11)-NH2H-Tyr-Gly-Gly...)
Affinity DataKi:  2.90nMAssay Description:Binding affinity towards cloned human Opioid receptor delta 1 in CHO cell membranes.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
Adolor

Curated by ChEMBL
LigandPNGBDBM50160833(CHEMBL360678 | [3-(1-{Methyl-[2-(4-trifluoromethyl...)
Affinity DataKi:  2.90nMAssay Description:Displacement of bound [3H]-diprenorphine from membranes expressing cloned human kappa opioid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
Adolor

Curated by ChEMBL
LigandPNGBDBM50161320(3,4-Dichloro-N-{[methyl-((S)-1-phenyl-2-pyrrolidin...)
Affinity DataKi:  3.60nMAssay Description:In vitro binding affinity for human kappa opioid receptor was determined by using [3H]-diprenorphine as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
Adolor

Curated by ChEMBL
LigandPNGBDBM50160835(CHEMBL185554 | [3-(1-{Methyl-[2-(4-trifluoromethyl...)
Affinity DataKi:  3.70nMAssay Description:Displacement of bound [3H]-diprenorphine from membranes expressing cloned human kappa opioid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
Adolor

Curated by ChEMBL
LigandPNGBDBM50161316(1-Oxy-benzo[1,2,5]oxadiazole-5-carboxylic acid {[m...)
Affinity DataKi:  4.60nMAssay Description:In vitro binding affinity for human kappa opioid receptor was determined by using [3H]-diprenorphine as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50286332(4-Isopropyl-5,6-dimethoxy-1,1-dioxo-2-(1-phenyl-1H...)
Affinity DataKi:  5.20nMAssay Description:Evaluated for inhibitory activity against Human leukocyte elastase (HLE)More data for this Ligand-Target Pair
In DepthDetails Article
TargetKappa-type opioid receptor(Homo sapiens (Human))
Adolor

Curated by ChEMBL
LigandPNGBDBM50093961(2-(3-Dimethanesulfonylamino-phenyl)-N-methyl-N-((S...)
Affinity DataKi:  6nMAssay Description:In vitro binding affinity towards Opioid receptor kappa 1 by displacement of bound [3H]U69,593More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
Adolor

Curated by ChEMBL
LigandPNGBDBM50161313(CHEMBL178359 | N-{[Methyl-((S)-1-phenyl-2-pyrrolid...)
Affinity DataKi:  6.70nMAssay Description:In vitro binding affinity for human kappa opioid receptor was determined by using [3H]-diprenorphine as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
Adolor

Curated by ChEMBL
LigandPNGBDBM50090006(CHEMBL407389 | [Pro3] Dynorphin A (1-11)-NH2H-Tyr-...)
Affinity DataKi:  7.5nMAssay Description:Binding affinity at Opioid receptor kappa 1 by to cloned human opioid receptors expressed in CHO cell membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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