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Found 421 with Last Name = 'mcgaraughty' and Initial = 's'
TargetAdenosine kinase(Rattus norvegicus (rat))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50095366(5-(2-Bromo-benzyl)-7-(6-morpholin-4-yl-pyridin-3-y...)
Affinity DataIC50:  0.170nMAssay Description:Inhibitory activity against cytosolic adenosine kinase by ADO phosphorylation assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine kinase(Rattus norvegicus (rat))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50095367(5-(2,3-Dimethyl-cyclohexyl)-7-(6-morpholin-4-yl-py...)
Affinity DataIC50:  0.230nMAssay Description:Inhibitory activity against cytosolic adenosine kinase by ADO phosphorylation assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine kinase(Rattus norvegicus (rat))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50095359(5-[1-(2-Bromo-phenyl)-ethyl]-7-(6-morpholin-4-yl-p...)
Affinity DataIC50:  0.25nMAssay Description:Inhibitory activity against cytosolic adenosine kinase by ADO phosphorylation assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine kinase(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50201834(5-benzo[b]thiophen-2-yl-6-(6-morpholin-4-ylpyridin...)
Affinity DataIC50:  0.400nMAssay Description:Inhibition of cytosolic adenosine kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine kinase(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50201865(1-(4-{5-[6-amino-5-(4-chlorophenyl)pyrimidin-4-yle...)
Affinity DataIC50:  1nMAssay Description:Inhibition of cytosolic adenosine kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine kinase(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50201825(5-(4-chlorophenyl)-6-{6-[(2-methoxyethyl)methylami...)
Affinity DataIC50:  1nMAssay Description:Inhibition of cytosolic adenosine kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine kinase(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50201814(5-benzofuran-2-yl-6-(6-morpholin-4-ylpyridin-3-yle...)
Affinity DataIC50:  1nMAssay Description:Inhibition of cytosolic adenosine kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine kinase(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50102928(5-(3-Bromo-phenyl)-7-(6-thiomorpholin-4-yl-pyridin...)
Affinity DataIC50:  1.30nMAssay Description:In vitro concentration required for 50% inhibition against Adenosine Kinase (AK) in the presence of intact cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine kinase(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50102925(5-(3-Bromo-phenyl)-7-[6-(1,4-dioxa-8-aza-spiro[4.5...)
Affinity DataIC50:  1.40nMAssay Description:In vitro concentration required for 50% inhibition against Adenosine Kinase (AK) in the presence of enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine kinase(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50094703(5-(3-Bromo-phenyl)-7-(6-morpholin-4-yl-pyridin-3-y...)
Affinity DataIC50:  1.70nMAssay Description:Tested for inhibitory activity against AK in an in vitro cell-free enzyme assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine kinase(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50102927(5'-[4-Amino-5-(3-bromo-phenyl)-pyrido[2,3-d]pyrimi...)
Affinity DataIC50:  1.80nMAssay Description:In vitro concentration required for 50% inhibition against Adenosine Kinase (AK) in the presence of enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine kinase(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM14488(5-[4-(dimethylamino)phenyl]-6-{2-[6-(morpholin-4-y...)
Affinity DataIC50:  2nMAssay Description:Inhibition of cytosolic adenosine kinaseMore data for this Ligand-Target Pair
TargetAdenosine kinase(Rattus norvegicus (rat))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50094703(5-(3-Bromo-phenyl)-7-(6-morpholin-4-yl-pyridin-3-y...)
Affinity DataIC50:  2nMAssay Description:Inhibitory activity against cytosolic adenosine kinase by ADO phosphorylation assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine kinase(Rattus norvegicus (rat))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50095377(5-Cyclopentyl-7-(6-morpholin-4-yl-pyridin-3-yl)-py...)
Affinity DataIC50:  2nMAssay Description:Inhibitory activity against cytosolic adenosine kinase by ADO phosphorylation assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine kinase(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50132280(5-(3-Bromo-phenyl)-7-{6-[4-(tetrahydro-pyran-4-ylo...)
Affinity DataIC50:  2.80nMAssay Description:Inhibitory concentration against adenosine kinase was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine kinase(Rattus norvegicus (rat))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50095379(5-Cyclohexyl-7-(6-morpholin-4-yl-pyridin-3-yl)-pyr...)
Affinity DataIC50:  3nMAssay Description:Inhibitory activity against intact cell adenosine kinase by ADO phosphorylation assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine kinase(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50201849(5-(4-chlorophenyl)-6-(4-dimethylaminophenylethynyl...)
Affinity DataIC50:  3nMAssay Description:Inhibition of cytosolic adenosine kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine kinase(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50201821(5-(4-bromophenyl)-6-(4-dimethylaminophenylethynyl)...)
Affinity DataIC50:  3nMAssay Description:Inhibition of cytosolic adenosine kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine kinase(Rattus norvegicus (rat))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50095362(5-(2-Bromo-phenyl)-7-(6-morpholin-4-yl-pyridin-3-y...)
Affinity DataIC50:  3nMAssay Description:Inhibitory activity against cytosolic adenosine kinase by ADO phosphorylation assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine kinase(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50201823(5-(4-chlorophenyl)-6-(6-morpholin-4-ylpyridin-3-yl...)
Affinity DataIC50:  3nMAssay Description:Inhibition of cytosolic adenosine kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine kinase(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50102924(5-(3-Bromo-phenyl)-7-(6-pyrrolidin-1-yl-pyridin-3-...)
Affinity DataIC50:  3.40nMAssay Description:In vitro concentration required for 50% inhibition against Adenosine Kinase (AK) in the presence of intact cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine kinase(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50102929(5-(3-Bromo-phenyl)-7-[6-((R)-2-methoxy-pyrrolidin-...)
Affinity DataIC50:  4.10nMAssay Description:In vitro concentration required for 50% inhibition against Adenosine Kinase (AK) in the presence of enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine kinase(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50102923(5-(3-Bromo-phenyl)-7-[6-(methyl-pyridin-3-ylmethyl...)
Affinity DataIC50:  4.10nMAssay Description:In vitro concentration required for 50% inhibition against Adenosine Kinase (AK) in the presence of enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine kinase(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50102929(5-(3-Bromo-phenyl)-7-[6-((R)-2-methoxy-pyrrolidin-...)
Affinity DataIC50:  4.12nMAssay Description:In vitro concentration required for 50% inhibition against Adenosine Kinase (AK) in the presence of enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine kinase(Rattus norvegicus (rat))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50095373(5-(2,3-Dichloro-phenyl)-7-(6-morpholin-4-yl-pyridi...)
Affinity DataIC50:  5nMAssay Description:Inhibitory activity against cytosolic adenosine kinase by ADO phosphorylation assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine kinase(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50201815(5-(4-dimethylaminophenyl)-6-(4-dimethylaminophenyl...)
Affinity DataIC50:  5nMAssay Description:Inhibition of cytosolic adenosine kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine kinase(Rattus norvegicus (rat))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50095384(5-(3-Bromo-phenyl)-7-(4-dimethylamino-phenyl)-pyri...)
Affinity DataIC50:  5nMAssay Description:Inhibitory activity against cytosolic adenosine kinase by ADO phosphorylation assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine kinase(Rattus norvegicus (rat))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50095384(5-(3-Bromo-phenyl)-7-(4-dimethylamino-phenyl)-pyri...)
Affinity DataIC50:  5nMAssay Description:Inhibitory activity against intact cell adenosine kinase by ADO phosphorylation assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine kinase(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50201854(5-(4-chlorophenyl)-6-(6-dimethylaminopyridin-3-yle...)
Affinity DataIC50:  6nMAssay Description:Inhibition of cytosolic adenosine kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine kinase(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50201830(CHEMBL387630 | {4-[5-(4-chlorophenyl)-6-morpholin-...)
Affinity DataIC50:  6nMAssay Description:Inhibition of cytosolic adenosine kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine kinase(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50201843(4-{5-[6-amino-5-(4-chlorophenyl)pyrimidin-4-ylethy...)
Affinity DataIC50:  6nMAssay Description:Inhibition of cytosolic adenosine kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine kinase(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50132273(1-{5-[4-Amino-5-(3-bromo-phenyl)-pyrido[2,3-d]pyri...)
Affinity DataIC50:  6.5nMAssay Description:Inhibitory concentration against adenosine kinase was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine kinase(Rattus norvegicus (rat))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50095358(7-(4-Dimethylamino-phenyl)-5-phenyl-pyrido[2,3-d]p...)
Affinity DataIC50:  7nMAssay Description:Inhibitory activity against intact cell adenosine kinase by ADO phosphorylation assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine kinase(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50132275(1-{6-[4-Amino-5-(3-bromo-phenyl)-pyrido[2,3-d]pyri...)
Affinity DataIC50:  7.10nMAssay Description:Inhibitory concentration against adenosine kinase was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine kinase(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50132279(5-(3-Bromo-phenyl)-7-[6-(3,4-diethoxy-pyrrolidin-1...)
Affinity DataIC50:  7.20nMAssay Description:Inhibitory concentration against adenosine kinase was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine kinase(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50132272(5-(3-Bromo-phenyl)-7-[6-(2-oxa-5-aza-bicyclo[2.2.1...)
Affinity DataIC50:  7.5nMAssay Description:Inhibitory concentration against adenosine kinase was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine kinase(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50132281(1-{5-[4-Amino-5-(3-bromo-phenyl)-pyrido[2,3-d]pyri...)
Affinity DataIC50:  7.5nMAssay Description:Inhibitory concentration against adenosine kinase was determined in cell assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine kinase(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50201863(5-(4-chlorophenyl)-6-(2-morpholin-4-ylpyrimidin-5-...)
Affinity DataIC50:  8nMAssay Description:Inhibition of cytosolic adenosine kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 10 subunit alpha(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50212239(5-(4-chlorophenyl)-N-(3,5-dimethoxyphenyl)furan-2-...)
Affinity DataIC50:  8nMAssay Description:Inhibition of human Nav1.8 channel expressed in human HEK293 cells by patch clamp methodMore data for this Ligand-Target Pair
TargetAdenosine kinase(Rattus norvegicus (rat))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50095372(5-Cyclohexyl-7-(4-dimethylamino-phenyl)-pyrido[2,3...)
Affinity DataIC50:  8nMAssay Description:Inhibitory activity against intact cell adenosine kinase by ADO phosphorylation assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine kinase(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50102926(5'-[4-Amino-5-(3-bromo-phenyl)-pyrido[2,3-d]pyrimi...)
Affinity DataIC50:  8nMAssay Description:In vitro concentration required for 50% inhibition against Adenosine Kinase (AK) in the presence of enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine kinase(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50201831(CHEMBL226504 | {4-[5-(4-chlorophenyl)-6-piperazin-...)
Affinity DataIC50:  8nMAssay Description:Inhibition of cytosolic adenosine kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 10 subunit alpha(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50212239(5-(4-chlorophenyl)-N-(3,5-dimethoxyphenyl)furan-2-...)
Affinity DataIC50:  8nMAssay Description:Inhibition of human Nav1.8 channel expressed in HEK293 cells at -40 mV by patch clamp methodMore data for this Ligand-Target Pair
TargetAdenosine kinase(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50201824(5-(4-chlorophenyl)-6-(5-morpholin-4-ylpyridin-3-yl...)
Affinity DataIC50:  8nMAssay Description:Inhibition of cytosolic adenosine kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine kinase(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50132285(3-{5'-[4-Amino-5-(3-bromo-phenyl)-pyrido[2,3-d]pyr...)
Affinity DataIC50:  8.10nMAssay Description:Inhibitory concentration against adenosine kinase was determined in cell assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine kinase(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50132276(5-(3-Bromo-phenyl)-7-[6-(1,3-dioxa-8-aza-spiro[4.5...)
Affinity DataIC50:  8.30nMAssay Description:Inhibitory concentration against adenosine kinase was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine kinase(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50201853(5-(4-chlorophenyl)-6-(3,4,5,6-tetrahydro-2H-[1,20]...)
Affinity DataIC50:  9nMAssay Description:Inhibition of cytosolic adenosine kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine kinase(Rattus norvegicus (rat))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50095364(5-(1-Ethyl-propyl)-7-(6-morpholin-4-yl-pyridin-3-y...)
Affinity DataIC50:  9nMAssay Description:Inhibitory activity against cytosolic adenosine kinase by ADO phosphorylation assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine kinase(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM14491(5-(2H-1,3-benzodioxol-5-yl)-6-{2-[4-(dimethylamino...)
Affinity DataIC50:  9nMAssay Description:Inhibition of cytosolic adenosine kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine kinase(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50201846(5-benzo[1,3]dioxol-5-yl-6-(6-morpholin-4-ylpyridin...)
Affinity DataIC50:  10nMAssay Description:Inhibition of cytosolic adenosine kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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