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Target
Adenosine kinase
Ligand
BDBM50102925
Substrate
n/a
Meas. Tech.
ChEMBL_30641 (CHEMBL645534)
IC50
1.4±n/a nM
Citation
Zheng, GZ; Lee, C; Pratt, JK; Perner, RJ; Jiang, MQ; Gomtsyan, A; Matulenko, MA; Mao, Y; Koenig, JR; Kim, KH; Muchmore, S; Yu, H; Kohlhaas, K; Alexander, KM; McGaraughty, S; Chu, KL; Wismer, CT; Mikusa, J; Jarvis, MF; Marsh, K; Kowaluk, EA; Bhagwat, SS; Stewart, AO Pyridopyrimidine analogues as novel adenosine kinase inhibitors. Bioorg Med Chem Lett 11:2071-4 (2001) [PubMed] Article
More Info.:
Target
Name:
Adenosine kinase
Synonyms:
ADK | ADK_HUMAN
Type:
PROTEIN
Mol. Mass.:
40545.97
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1467841
Residue:
362
Sequence:
MAAAEEEPKPKKLKVEAPQALRENILFGMGNPLLDISAVVDKDFLDKYSLKPNDQILAEDKHKELFDELVKKFKVEYHAGGSTQNSIKVAQWMIQQPHKAATFFGCIGIDKFGEILKRKAAEAHVDAHYYEQNEQPTGTCAACITGDNRSLIANLAAANCYKKEKHLDLEKNWMLVEKARVCYIAGFFLTVSPESVLKVAHHASENNRIFTLNLSAPFISQFYKESLMKVMPYVDILFGNETEAATFAREQGFETKDIKEIAKKTQALPKMNSKRQRIVIFTQGRDDTIMATESEVTAFAVLDQDQKEIIDTNGAGDAFVGGFLSQLVSDKPLTECIRAGHYAASIIIRRTGCTFPEKPDFH
Inhibitor
Name:
BDBM50102925
Synonyms:
5-(3-Bromo-phenyl)-7-[6-(1,4-dioxa-8-aza-spiro[4.5]dec-8-yl)-pyridin-3-yl]-pyrido[2,3-d]pyrimidin-4-ylamine | CHEMBL65665
Type:
Small organic molecule
Emp. Form.:
C25H23BrN6O2
Mol. Mass.:
519.393
SMILES:
Nc1ncnc2nc(cc(-c3cccc(Br)c3)c12)-c1ccc(nc1)N1CCC2(CC1)OCCO2