TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
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Curated by ChEMBL
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Curated by ChEMBL
Affinity DataKi: 1nMAssay Description:Inhibition of Rolipram binding to Phosphodiesterase 4More data for this Ligand-Target Pair
Affinity DataKi: 2nMAssay Description:The enzyme reactions were initiated by the addition of substrate, and the color developed from the release of p-nitroanilide from each chromogenic su...More data for this Ligand-Target Pair
Affinity DataKi: 3nM ΔG°: -48.2kJ/molepH: 7.5 T: 2°CAssay Description:The enzyme reactions were initiated by the addition of substrate, and the color developed from the release of p-nitroanilide from each chromogenic su...More data for this Ligand-Target Pair
Affinity DataKi: 3nMAssay Description:The enzyme reactions were initiated by the addition of substrate, and the color developed from the release of p-nitroanilide from each chromogenic su...More data for this Ligand-Target Pair
Affinity DataKi: 4nM ΔG°: -47.5kJ/molepH: 7.5 T: 2°CAssay Description:The enzyme reactions were initiated by the addition of substrate, and the color developed from the release of p-nitroanilide from each chromogenic su...More data for this Ligand-Target Pair
Affinity DataKi: 4nMAssay Description:Inhibitory activity against human leukocyte elastaseMore data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
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Curated by ChEMBL
Rh£Ne-Poulenc Rorer
Curated by ChEMBL
Affinity DataKi: 4.30nMAssay Description:Affinity for phosphodiesterase (PDE IV) in guinea pig brain membrane using [3H]rolipram displacement.More data for this Ligand-Target Pair
Affinity DataKi: 6nMAssay Description:The enzyme reactions were initiated by the addition of substrate, and the color developed from the release of p-nitroanilide from each chromogenic su...More data for this Ligand-Target Pair
Affinity DataKi: 6nM ΔG°: -46.5kJ/molepH: 7.5 T: 2°CAssay Description:The enzyme reactions were initiated by the addition of substrate, and the color developed from the release of p-nitroanilide from each chromogenic su...More data for this Ligand-Target Pair
Affinity DataKi: 6.90nM ΔG°: -46.1kJ/molepH: 7.5 T: 2°CAssay Description:The enzyme reactions were initiated by the addition of substrate, and the color developed from the release of p-nitroanilide from each chromogenic su...More data for this Ligand-Target Pair
Affinity DataKi: 7nMAssay Description:The enzyme reactions were initiated by the addition of substrate, and the color developed from the release of p-nitroanilide from each chromogenic su...More data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
Rh£Ne-Poulenc Rorer
Curated by ChEMBL
Rh£Ne-Poulenc Rorer
Curated by ChEMBL
Affinity DataKi: 7.5nMAssay Description:Affinity for phosphodiesterase (PDE IV) in guinea pig brain membrane using [3H]rolipram displacement.More data for this Ligand-Target Pair
Affinity DataKi: 8nM ΔG°: -45.7kJ/molepH: 7.5 T: 2°CAssay Description:The enzyme reactions were initiated by the addition of substrate, and the color developed from the release of p-nitroanilide from each chromogenic su...More data for this Ligand-Target Pair
Affinity DataKi: 12nM ΔG°: -44.8kJ/molepH: 7.5 T: 2°CAssay Description:The enzyme reactions were initiated by the addition of substrate, and the color developed from the release of p-nitroanilide from each chromogenic su...More data for this Ligand-Target Pair
Affinity DataKi: 17nMAssay Description:Inhibitory activity against human leukocyte elastaseMore data for this Ligand-Target Pair
Affinity DataKi: 20nMAssay Description:Inhibitory activity against human leukocyte elastaseMore data for this Ligand-Target Pair
Affinity DataKi: 22nM ΔG°: -43.3kJ/molepH: 7.5 T: 2°CAssay Description:The enzyme reactions were initiated by the addition of substrate, and the color developed from the release of p-nitroanilide from each chromogenic su...More data for this Ligand-Target Pair
Affinity DataKi: 41nMAssay Description:The enzyme reactions were initiated by the addition of substrate, and the color developed from the release of p-nitroanilide from each chromogenic su...More data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
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Curated by ChEMBL
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Curated by ChEMBL
Affinity DataKi: 43nMAssay Description:Affinity for phosphodiesterase (PDE IV) in guinea pig brain membrane using [3H]rolipram displacement.More data for this Ligand-Target Pair
Affinity DataKi: 47nM ΔG°: -41.4kJ/molepH: 7.5 T: 2°CAssay Description:The enzyme reactions were initiated by the addition of substrate, and the color developed from the release of p-nitroanilide from each chromogenic su...More data for this Ligand-Target Pair
Affinity DataKi: 49nMAssay Description:The enzyme reactions were initiated by the addition of substrate, and the color developed from the release of p-nitroanilide from each chromogenic su...More data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
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Curated by ChEMBL
Rh£Ne-Poulenc Rorer
Curated by ChEMBL
Affinity DataKi: 51nMAssay Description:Affinity for phosphodiesterase (PDE IV) in guinea pig brain membrane using [3H]rolipram displacement.More data for this Ligand-Target Pair
Affinity DataKi: 55nMAssay Description:The enzyme reactions were initiated by the addition of substrate, and the color developed from the release of p-nitroanilide from each chromogenic su...More data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
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Curated by ChEMBL
Rh£Ne-Poulenc Rorer
Curated by ChEMBL
Affinity DataKi: 80nMAssay Description:Affinity for phosphodiesterase (PDE IV) in guinea pig brain membrane using [3H]rolipram displacement.More data for this Ligand-Target Pair
Affinity DataKi: 100nMAssay Description:Inhibitory activity against human leukocyte elastaseMore data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
Rh£Ne-Poulenc Rorer
Curated by ChEMBL
Rh£Ne-Poulenc Rorer
Curated by ChEMBL
Affinity DataKi: 113nMAssay Description:Affinity for phosphodiesterase (PDE IV) in guinea pig brain membrane using [3H]rolipram displacement.More data for this Ligand-Target Pair
Affinity DataKi: 120nMAssay Description:Inhibitory activity against human leukocyte elastaseMore data for this Ligand-Target Pair
Affinity DataKi: 130nMAssay Description:The enzyme reactions were initiated by the addition of substrate, and the color developed from the release of p-nitroanilide from each chromogenic su...More data for this Ligand-Target Pair
Affinity DataKi: 130nMAssay Description:The enzyme reactions were initiated by the addition of substrate, and the color developed from the release of p-nitroanilide from each chromogenic su...More data for this Ligand-Target Pair
Affinity DataKi: 130nMAssay Description:Inhibitory activity against human leukocyte elastaseMore data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
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Curated by ChEMBL
Rh£Ne-Poulenc Rorer
Curated by ChEMBL
Affinity DataKi: 137nMAssay Description:Affinity for phosphodiesterase (PDE IV) in guinea pig brain membrane using [3H]rolipram displacement.More data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
Rh£Ne-Poulenc Rorer
Curated by ChEMBL
Rh£Ne-Poulenc Rorer
Curated by ChEMBL
Affinity DataKi: 139nMAssay Description:Affinity for phosphodiesterase (PDE IV) in guinea pig brain membrane using [3H]rolipram displacement.More data for this Ligand-Target Pair
Affinity DataKi: 140nMAssay Description:The enzyme reactions were initiated by the addition of substrate, and the color developed from the release of p-nitroanilide from each chromogenic su...More data for this Ligand-Target Pair
Affinity DataKi: 150nMAssay Description:The enzyme reactions were initiated by the addition of substrate, and the color developed from the release of p-nitroanilide from each chromogenic su...More data for this Ligand-Target Pair
Affinity DataKi: 150nM ΔG°: -38.6kJ/molepH: 7.5 T: 2°CAssay Description:The enzyme reactions were initiated by the addition of substrate, and the color developed from the release of p-nitroanilide from each chromogenic su...More data for this Ligand-Target Pair
Affinity DataKi: 160nM ΔG°: -38.4kJ/molepH: 7.5 T: 2°CAssay Description:The enzyme reactions were initiated by the addition of substrate, and the color developed from the release of p-nitroanilide from each chromogenic su...More data for this Ligand-Target Pair
Affinity DataKi: 189nM ΔG°: -38.0kJ/molepH: 7.5 T: 2°CAssay Description:The enzyme reactions were initiated by the addition of substrate, and the color developed from the release of p-nitroanilide from each chromogenic su...More data for this Ligand-Target Pair
Affinity DataKi: 190nMAssay Description:Binding Affinity of the compound to inhibit HLEMore data for this Ligand-Target Pair
Affinity DataKi: 200nMAssay Description:Inhibitory activity against human leukocyte elastaseMore data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
Rh£Ne-Poulenc Rorer
Curated by ChEMBL
Rh£Ne-Poulenc Rorer
Curated by ChEMBL
Affinity DataKi: 210nMAssay Description:Affinity for phosphodiesterase (PDE IV) in guinea pig brain membrane using [3H]rolipram displacement.More data for this Ligand-Target Pair
Affinity DataKi: 210nMAssay Description:The enzyme reactions were initiated by the addition of substrate, and the color developed from the release of p-nitroanilide from each chromogenic su...More data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
Rh£Ne-Poulenc Rorer
Curated by ChEMBL
Rh£Ne-Poulenc Rorer
Curated by ChEMBL
Affinity DataKi: 217nMAssay Description:Affinity for phosphodiesterase (PDE IV) in guinea pig brain membrane using [3H]rolipram displacement.More data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
Rh£Ne-Poulenc Rorer
Curated by ChEMBL
Rh£Ne-Poulenc Rorer
Curated by ChEMBL
Affinity DataKi: 217nMAssay Description:Affinity for phosphodiesterase (PDE IV) in guinea pig brain membrane using [3H]rolipram displacement.More data for this Ligand-Target Pair
Affinity DataKi: 240nMpH: 7.5Assay Description:Inhibition of thrombin at pH 7.5 in HEPES buffer containing 200 mM NaCl with substrate Bz-Phe-Val-Arg-pNA.More data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
Rh£Ne-Poulenc Rorer
Curated by ChEMBL
Rh£Ne-Poulenc Rorer
Curated by ChEMBL
Affinity DataKi: 274nMAssay Description:Affinity for phosphodiesterase (PDE IV) in guinea pig brain membrane using [3H]rolipram displacement.More data for this Ligand-Target Pair
Affinity DataKi: 299nM ΔG°: -36.9kJ/molepH: 7.5 T: 2°CAssay Description:The enzyme reactions were initiated by the addition of substrate, and the color developed from the release of p-nitroanilide from each chromogenic su...More data for this Ligand-Target Pair
Affinity DataKi: 305nM ΔG°: -36.8kJ/molepH: 7.5 T: 2°CAssay Description:The enzyme reactions were initiated by the addition of substrate, and the color developed from the release of p-nitroanilide from each chromogenic su...More data for this Ligand-Target Pair
Affinity DataKi: 330nMAssay Description:The enzyme reactions were initiated by the addition of substrate, and the color developed from the release of p-nitroanilide from each chromogenic su...More data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
Rh£Ne-Poulenc Rorer
Curated by ChEMBL
Rh£Ne-Poulenc Rorer
Curated by ChEMBL
Affinity DataKi: 337nMAssay Description:Affinity for phosphodiesterase (PDE IV) in guinea pig brain membrane using [3H]rolipram displacement.More data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
Rh£Ne-Poulenc Rorer
Curated by ChEMBL
Rh£Ne-Poulenc Rorer
Curated by ChEMBL
Affinity DataKi: 367nMAssay Description:Affinity for phosphodiesterase (PDE IV) in guinea pig brain membrane using [3H]rolipram displacement.More data for this Ligand-Target Pair