Compile Data Set for Download or QSAR
Report error Found 18 Enz. Inhib. hit(s) with Target = 'cAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D' and Ligand = 'BDBM14775'
LigandPNGBDBM14775(3-(cyclopentyloxy)-N-(3,5-dichloropyridin-4-yl)-4-...)
Affinity DataIC50: 0.300nMAssay Description:Inhibition of phosphodiesterase 4More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/13/2018
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM14775(3-(cyclopentyloxy)-N-(3,5-dichloropyridin-4-yl)-4-...)
Affinity DataKi:  0.400nMAssay Description:Affinity for rolipram binding site of phosphodiesterase type IV (PDE4)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/10/2018
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM14775(3-(cyclopentyloxy)-N-(3,5-dichloropyridin-4-yl)-4-...)
Affinity DataKi:  0.400nMAssay Description:Binding affinity against PDE4 was determined using [3H]- rolipram in guinea pig brain membrane binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/8/2018
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM14775(3-(cyclopentyloxy)-N-(3,5-dichloropyridin-4-yl)-4-...)
Affinity DataKi:  0.850nMAssay Description:Inhibition of rolipram binding to phosphodiesterase 4More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/13/2018
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM14775(3-(cyclopentyloxy)-N-(3,5-dichloropyridin-4-yl)-4-...)
Affinity DataIC50: 1nMAssay Description:Concentration to inhibit 50% of Phosphodiesterase 4 (PDE-4) from guinea pig macrophagesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM14775(3-(cyclopentyloxy)-N-(3,5-dichloropyridin-4-yl)-4-...)
Affinity DataKi:  1nMAssay Description:Binding affinity at Phosphodiesterase 4 by measuring displacement of (+/-)-[3H]- Rolipram to guinea pig brain membranes.More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM14775(3-(cyclopentyloxy)-N-(3,5-dichloropyridin-4-yl)-4-...)
Affinity DataIC50: 1nMAssay Description:Inhibition of phosphodiesterase type IV (PDE4) activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/10/2018
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM14775(3-(cyclopentyloxy)-N-(3,5-dichloropyridin-4-yl)-4-...)
Affinity DataIC50: 1nMAssay Description:Inhibition of Phosphodiesterase 4 from human neutrophilsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/23/2018
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM14775(3-(cyclopentyloxy)-N-(3,5-dichloropyridin-4-yl)-4-...)
Affinity DataIC50: 1nMAssay Description:Inhibition of PDE4 from guinea pig macrophagesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/9/2018
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM14775(3-(cyclopentyloxy)-N-(3,5-dichloropyridin-4-yl)-4-...)
Affinity DataIC50: 1nMAssay Description:Inhibition of Phosphodiesterase type 4 (PDE4) from guinea-pig macrophageMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/8/2018
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM14775(3-(cyclopentyloxy)-N-(3,5-dichloropyridin-4-yl)-4-...)
Affinity DataIC50: 1nMAssay Description:Inhibition of Phosphodiesterase 4 (PDE4) from guinea pig macrophagesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/9/2018
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM14775(3-(cyclopentyloxy)-N-(3,5-dichloropyridin-4-yl)-4-...)
Affinity DataKi:  1nMAssay Description:Inhibition of Rolipram binding to Phosphodiesterase 4More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/9/2018
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM14775(3-(cyclopentyloxy)-N-(3,5-dichloropyridin-4-yl)-4-...)
Affinity DataIC50: 1nMAssay Description:Inhibition of human Phosphodiesterase 4More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/1/2018
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM14775(3-(cyclopentyloxy)-N-(3,5-dichloropyridin-4-yl)-4-...)
Affinity DataKi:  1.5nMAssay Description:Inhibition of rolipram binding to PDE4 from human neutrophilsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/23/2018
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM14775(3-(cyclopentyloxy)-N-(3,5-dichloropyridin-4-yl)-4-...)
Affinity DataKi:  1.5nMAssay Description:Inhibition of rolipram binding to PDE4More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/25/2018
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM14775(3-(cyclopentyloxy)-N-(3,5-dichloropyridin-4-yl)-4-...)
Affinity DataKi:  1.5nMAssay Description:Inhibition of rolipram binding to Phosphodiesterase 4More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/1/2018
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM14775(3-(cyclopentyloxy)-N-(3,5-dichloropyridin-4-yl)-4-...)
Affinity DataIC50: 9nMAssay Description:Inhibitory activity on human eosinophil phosphodiesterase 4.More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM14775(3-(cyclopentyloxy)-N-(3,5-dichloropyridin-4-yl)-4-...)
Affinity DataKi:  26nMAssay Description:Inhibition of [3H]rolipram binding to Phosphodiesterase 4 of rat forebrain membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/6/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)