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Found 170 with Last Name = 'michaux' and Initial = 'c'
TargetFatty-acid amide hydrolase 1 [30-579](Rattus norvegicus (rat))
Fundp

LigandPNGBDBM23316(7-phenyl-1-{pyrido[2,3-d][1,3]oxazol-2-yl}heptan-1...)
Affinity DataIC50:  0.316nMpH: 9.0 T: 2°CAssay Description:The effect of the test compounds on the enzymatic hydrolysis of [3H]anandamide was evaluated by using rat brain homogenate preparations. [3H]Ethanola...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Laboratoires Innothera

Curated by ChEMBL
LigandPNGBDBM50029593(CHEMBL7162 | N-(2-(cyclohexyloxy)-4-nitrophenyl)me...)
Affinity DataIC50:  1nMAssay Description:The compound was evaluated for its inhibitory activity against Prostaglandin G/H synthase 2 using osteosarcomes cellsMore data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Laboratoires Innothera

Curated by ChEMBL
LigandPNGBDBM22369(4-(4-methanesulfonylphenyl)-3-phenyl-2,5-dihydrofu...)
Affinity DataIC50:  1nMAssay Description:The compound was evaluated for prostaglandin E2 inhibition using recombinant Prostaglandin G/H synthase 2More data for this Ligand-Target Pair
TargetThromboxane A2 receptor(Homo sapiens (Human))
FacultéS Universitaires N.D. De La Paix

Curated by ChEMBL
LigandPNGBDBM50098926(1-(2-Cyclohexylamino-5-nitro-benzenesulfonyl)-3-pe...)
Affinity DataIC50:  1.10nMAssay Description:In vitro inhibitory concentration of compound against thromboxane A2 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Laboratoires Innothera

Curated by ChEMBL
LigandPNGBDBM50110484(3-((3-fluoro-5-(1-methoxycyclohexyl)phenoxy)methyl...)
Affinity DataIC50:  3nMAssay Description:The compound was evaluated for its inhibitory activity against 5-lipoxygenase using granulocytes-type cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFatty-acid amide hydrolase 1(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50425557(CHEMBL2313948)
Affinity DataIC50:  3.70nMAssay Description:Inhibition of human recombinant FAAH-mediated [3H]AEA hydrolysis after 10 mins by liquid scintillation assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThromboxane-A synthase(Homo sapiens (Human))
FacultéS Universitaires N.D. De La Paix

Curated by ChEMBL
LigandPNGBDBM50075624(6-{3-[1-(tert-butylamino)-2-cyano-(E)-1-iminomethy...)
Affinity DataIC50:  4nMAssay Description:In vitro inhibitory concentration of compound against thromboxane A2 synthaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFatty-acid amide hydrolase 1(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50299922(1-(Pent-4-enoyl)-(3S)-3-[1(R)-(4-phenylbutanoyloxy...)
Affinity DataIC50:  5nMAssay Description:Inhibition of human recombinant FAAH using [3H]anandamide by competitive hydrolysis assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFatty-acid amide hydrolase 1(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50393236(CHEMBL2151432)
Affinity DataIC50:  5.30nMAssay Description:Inhibition of human recombinant FAAH-mediated [3H]AEA hydrolysis after 10 mins by liquid scintillation assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFatty-acid amide hydrolase 1(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50425556(CHEMBL2313949)
Affinity DataIC50:  5.60nMAssay Description:Inhibition of human recombinant FAAH-mediated [3H]AEA hydrolysis after 10 mins by liquid scintillation assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFatty-acid amide hydrolase 1 [30-579](Rattus norvegicus (rat))
Fundp

LigandPNGBDBM23315(3-(3-carbamoylphenyl)phenyl N-(undec-10-yn-1-yl)ca...)
Affinity DataIC50:  10nMpH: 9.0 T: 2°CAssay Description:The effect of the test compounds on the enzymatic hydrolysis of [3H]anandamide was evaluated by using rat brain homogenate preparations. [3H]Ethanola...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFatty-acid amide hydrolase 1(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50299926(1-(Hexa-5-enoyl)-(3S)-3-[1(R)-(4-phenylbutanoyloxy...)
Affinity DataIC50:  10nMAssay Description:Inhibition of human recombinant FAAH using [3H]anandamide by competitive hydrolysis assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThromboxane A2 receptor(Homo sapiens (Human))
FacultéS Universitaires N.D. De La Paix

Curated by ChEMBL
LigandPNGBDBM50075624(6-{3-[1-(tert-butylamino)-2-cyano-(E)-1-iminomethy...)
Affinity DataIC50:  11nMAssay Description:In vitro inhibitory concentration of compound against thromboxane A2 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFatty-acid amide hydrolase 1(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50299923(1-(Pent-4-enoyl)-(3S)-3-[1(R)-(biphenylacetyloxy)-...)
Affinity DataIC50:  12nMAssay Description:Inhibition of human recombinant FAAH using [3H]anandamide by competitive hydrolysis assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFatty-acid amide hydrolase 1(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50425560(CHEMBL2313951)
Affinity DataIC50:  12nMAssay Description:Inhibition of human recombinant FAAH-mediated [3H]AEA hydrolysis after 10 mins by liquid scintillation assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFatty-acid amide hydrolase 1(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50425564(CHEMBL2313944)
Affinity DataIC50:  12nMAssay Description:Inhibition of human recombinant FAAH-mediated [3H]AEA hydrolysis after 10 mins by liquid scintillation assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFatty-acid amide hydrolase 1(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50299927(1-(Hexa-5-enoyl)-(3S)-3-[1(R)-(biphenylacetyloxy)-...)
Affinity DataIC50:  14nMAssay Description:Inhibition of human recombinant FAAH using [3H]anandamide by competitive hydrolysis assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFatty-acid amide hydrolase 1(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50425563(CHEMBL2313945)
Affinity DataIC50:  29nMAssay Description:Inhibition of human recombinant FAAH-mediated [3H]AEA hydrolysis after 10 mins by liquid scintillation assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFatty-acid amide hydrolase 1(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50425566(CHEMBL2313940)
Affinity DataIC50:  30nMAssay Description:Inhibition of human recombinant FAAH-mediated [3H]AEA hydrolysis after 10 mins by liquid scintillation assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
Facult£S Universitaires Notre-Dame De La Paix (Fundp)

Curated by ChEMBL
LigandPNGBDBM50483782(CHEMBL1770431)
Affinity DataIC50:  30nMAssay Description:Inhibition of HIV1 integrase strand transfer activity after 1 hr by gel based assay in presence of magnesiumMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetFatty-acid amide hydrolase 1(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50299917(1-(4-Phenylbutanoyl)-(3S)-3-[1(R)-(4-phenylbutanoy...)
Affinity DataIC50:  30nMAssay Description:Inhibition of human recombinant FAAH using [3H]anandamide by competitive hydrolysis assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
Facult£S Universitaires Notre-Dame De La Paix (Fundp)

Curated by ChEMBL
LigandPNGBDBM50483781(CHEMBL1770430)
Affinity DataIC50:  30nMAssay Description:Inhibition of HIV1 integrase strand transfer activity after 1 hr by gel based assay in presence of magnesiumMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetFatty-acid amide hydrolase 1(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50425567(CHEMBL2313952)
Affinity DataIC50:  31nMAssay Description:Inhibition of human recombinant FAAH-mediated [3H]AEA hydrolysis after 10 mins by liquid scintillation assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFatty-acid amide hydrolase 1(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50299919(1-(4-Phenylbutanoyl)-(3S)-3-[1(R)-(biphenylacetylo...)
Affinity DataIC50:  32nMAssay Description:Inhibition of human recombinant FAAH using [3H]anandamide by competitive hydrolysis assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFatty-acid amide hydrolase 1(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50299925(1-(Pent-4-enoyl)-(3S)-3-[1(R)-(hexa-5-enoyloxy)-et...)
Affinity DataIC50:  32nMAssay Description:Inhibition of human recombinant FAAH using [3H]anandamide by competitive hydrolysis assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFatty-acid amide hydrolase 1(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50425565(CHEMBL2313943)
Affinity DataIC50:  33nMAssay Description:Inhibition of human recombinant FAAH-mediated [3H]AEA hydrolysis after 10 mins by liquid scintillation assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFatty-acid amide hydrolase 1(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50299918(1-(4-Phenylbutanoyl)-(3S)-3-[1(R)-(5-phenylpentano...)
Affinity DataIC50:  45nMAssay Description:Inhibition of human recombinant FAAH using [3H]anandamide by competitive hydrolysis assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFatty-acid amide hydrolase 1(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50299913(1-(3-Phenylpropanoyl)-(3S)-3-[1(R)-(4-phenylbutano...)
Affinity DataIC50:  49nMAssay Description:Inhibition of human recombinant FAAH using [3H]anandamide by competitive hydrolysis assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Laboratoires Innothera

Curated by ChEMBL
LigandPNGBDBM50110484(3-((3-fluoro-5-(1-methoxycyclohexyl)phenoxy)methyl...)
Affinity DataIC50:  50nMAssay Description:The compound was evaluated for its inhibitory activity against Prostaglandin G/H synthase 2 using osteosarcomes cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
Facult£S Universitaires Notre-Dame De La Paix (Fundp)

Curated by ChEMBL
LigandPNGBDBM50483779(CHEMBL1770428)
Affinity DataIC50:  50nMAssay Description:Inhibition of HIV1 integrase strand transfer activity after 1 hr by gel based assay in presence of magnesiumMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetFatty-acid amide hydrolase 1(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50299915(1-(3-Phenylpropanoyl)-(3S)-3-[1(R)-(biphenylacetyl...)
Affinity DataIC50:  50nMAssay Description:Inhibition of human recombinant FAAH using [3H]anandamide by competitive hydrolysis assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFatty-acid amide hydrolase 1(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50299916(1-(4-Phenylbutanoyl)-(3S)-3-[1(R)-(3-phenylpropano...)
Affinity DataIC50:  57nMAssay Description:Inhibition of human recombinant FAAH using [3H]anandamide by competitive hydrolysis assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFatty-acid amide hydrolase 1(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50425559(CHEMBL2313941)
Affinity DataIC50:  71nMAssay Description:Inhibition of human recombinant FAAH-mediated [3H]AEA hydrolysis after 10 mins by liquid scintillation assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Laboratoires Innothera

Curated by ChEMBL
LigandPNGBDBM50158453(CHEMBL224400 | N-(3-Phenylamino-4-pyridinyl)triflu...)
Affinity DataIC50:  90nMAssay Description:Inhibition of COX2 in human whole blood assessed as inhibition of LPS-stimulated PGE2 productionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFatty-acid amide hydrolase 1(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50299914(1-(3-Phenylpropanoyl)-(3S)-3-[1(R)-(5-phenylpentan...)
Affinity DataIC50:  91nMAssay Description:Inhibition of human recombinant FAAH using [3H]anandamide by competitive hydrolysis assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFatty-acid amide hydrolase 1(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50299924(1-(Pent-4-enoyl)-(3S)-3-[1(R)-(pent-4-enoyloxy)-et...)
Affinity DataIC50:  98nMAssay Description:Inhibition of human recombinant FAAH using [3H]anandamide by competitive hydrolysis assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Laboratoires Innothera

Curated by ChEMBL
LigandPNGBDBM50110483(2-[3-Fluoro-5-(4-methoxy-tetrahydro-pyran-4-yl)-ph...)
Affinity DataIC50: <100nMAssay Description:The compound was evaluated for prostaglandin E2 inhibition using recombinant Prostaglandin G/H synthase 2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Laboratoires Innothera

Curated by ChEMBL
LigandPNGBDBM50110485(5-(4-Chloro-phenyl)-3-[3-fluoro-5-(4-methoxy-tetra...)
Affinity DataIC50: <100nMAssay Description:The compound was evaluated for prostaglandin E2 inhibition using recombinant Prostaglandin G/H synthase 2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Laboratoires Innothera

Curated by ChEMBL
LigandPNGBDBM50158450(CHEMBL224136 | N-[3-(2,4-dichlorophenoxy)-4-pyridi...)
Affinity DataIC50:  120nMAssay Description:Inhibition of COX2 in human whole blood assessed as inhibition of LPS-stimulated PGE2 productionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Laboratoires Innothera

Curated by ChEMBL
LigandPNGBDBM50158444(CHEMBL388628 | N-(3-(2-chlorophenoxy)-4-pyridinyl)...)
Affinity DataIC50:  130nMAssay Description:Inhibition of COX2 in human whole blood assessed as inhibition of LPS-stimulated PGE2 productionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 1(Homo sapiens (Human))
Université

Curated by ChEMBL
LigandPNGBDBM50120981(1,1,1-trifluoro-N-(3-phenoxypyridin-4-yl)methanesu...)
Affinity DataIC50:  140nMAssay Description:Inhibition of COX1 in human whole blood assessed as inhibition of calcium ionophore A-23187-stimulated platelet aggregation by measuring TXB2 product...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFatty-acid amide hydrolase 1(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50425568(CHEMBL2313950)
Affinity DataIC50:  146nMAssay Description:Inhibition of human recombinant FAAH-mediated [3H]AEA hydrolysis after 10 mins by liquid scintillation assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Laboratoires Innothera

Curated by ChEMBL
LigandPNGBDBM50110485(5-(4-Chloro-phenyl)-3-[3-fluoro-5-(4-methoxy-tetra...)
Affinity DataIC50:  150nMAssay Description:Inhibition of 5-lipoxygenase activity of compound evaluated as determined by the inhibition of calcium ionophore-induced leukotriene B4 production in...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Laboratoires Innothera

Curated by ChEMBL
LigandPNGBDBM50158451(CHEMBL224640 | N-[3-(2-chlorophenoxy)-4-pyridinyl]...)
Affinity DataIC50:  150nMAssay Description:Inhibition of COX2 in human whole blood assessed as inhibition of LPS-stimulated PGE2 productionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFatty-acid amide hydrolase 1(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50299912(1-(3-Phenylpropanoyl)-(3S)-3-[1(R)-(3-phenylpropan...)
Affinity DataIC50:  157nMAssay Description:Inhibition of human recombinant FAAH using [3H]anandamide by competitive hydrolysis assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 1(Homo sapiens (Human))
Université

Curated by ChEMBL
LigandPNGBDBM50158453(CHEMBL224400 | N-(3-Phenylamino-4-pyridinyl)triflu...)
Affinity DataIC50:  180nMAssay Description:Inhibition of COX1 in human whole blood assessed as inhibition of calcium ionophore A-23187-stimulated platelet aggregation by measuring TXB2 product...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFatty-acid amide hydrolase 1(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50299921(1-(5-Phenylpentanoyl)-(3S)-3-[1(R)-(biphenylacetyl...)
Affinity DataIC50:  236nMAssay Description:Inhibition of human recombinant FAAH using [3H]anandamide by competitive hydrolysis assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 1(Homo sapiens (Human))
Université

Curated by ChEMBL
LigandPNGBDBM50158443(CHEMBL374168 | N-[3-(4-bromophenoxy)-4-pyridinyl]t...)
Affinity DataIC50:  240nMAssay Description:Inhibition of COX1 in human whole blood assessed as inhibition of calcium ionophore A-23187-stimulated platelet aggregation by measuring TXB2 product...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 1(Homo sapiens (Human))
Université

Curated by ChEMBL
LigandPNGBDBM50158438(CHEMBL225092 | N-[3-(4-methoxyphenoxy)-4-pyridinyl...)
Affinity DataIC50:  260nMAssay Description:Inhibition of COX1 in human whole blood assessed as inhibition of calcium ionophore A-23187-stimulated platelet aggregation by measuring TXB2 product...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 1(Homo sapiens (Human))
Université

Curated by ChEMBL
LigandPNGBDBM50158451(CHEMBL224640 | N-[3-(2-chlorophenoxy)-4-pyridinyl]...)
Affinity DataIC50:  270nMAssay Description:Inhibition of COX1 in human whole blood assessed as inhibition of calcium ionophore A-23187-stimulated platelet aggregation by measuring TXB2 product...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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